Shiyu Li
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View article: Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNA
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNA Open
View article: 3D printing combined with thermally induced phase separation for engineering hierarchical osteogenic PLA scaffolds
3D printing combined with thermally induced phase separation for engineering hierarchical osteogenic PLA scaffolds Open
View article: Prediction of TBM Performance Under Imbalanced Geological Conditions Using Resampling and Data Synthesis Techniques
Prediction of TBM Performance Under Imbalanced Geological Conditions Using Resampling and Data Synthesis Techniques Open
Predicting Tunnel Boring Machine (TBM) working parameters, such as cutterhead torque, is crucial for ensuring safe and efficient tunneling. However, complex and changing geological conditions pose a significant challenge to this study, lea…
View article: Engineering genetic elements for microbial protein expression systems: Advances, challenges, applications, and prospects
Engineering genetic elements for microbial protein expression systems: Advances, challenges, applications, and prospects Open
View article: Surgical Decompression in a 32-Year-Old Man with Chronic Onset of Thoracic Spontaneous Spinal Epidural Hematoma: A Case Report
Surgical Decompression in a 32-Year-Old Man with Chronic Onset of Thoracic Spontaneous Spinal Epidural Hematoma: A Case Report Open
View article: Research on the Impact of AIGC on Traditional Media Audiences and Symbiotic Paths Based on Logistic Regression Model
Research on the Impact of AIGC on Traditional Media Audiences and Symbiotic Paths Based on Logistic Regression Model Open
Under the background of the rapid development of artificial intelligence technology and the unstoppable wave of digitalization, AIGC has impacted the mode and core position of "gathering, editing and broadcasting" of traditional media. In …
View article: Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion
Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion Open
View article: Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Mitochondrial dysfunction: Related diseases, influencing factors, and detection Open
Mitochondria are the foundation of cellular energy metabolism and are crucial for cell growth and development. Mitochondrial dysfunction can disrupt cellular energy metabolism and normal cellular functions, contributing to the onset of rel…
View article: H<sub>2</sub>O<sub>2</sub>‐Dependent Methyl Jasmonate Regulates H<sub>2</sub>S‐Induced Resistance to <i>Fusarium oxysporum</i> f. sp. <i>niveum</i> Race 2 in <i>Citrullus lanatus</i>
H<sub>2</sub>O<sub>2</sub>‐Dependent Methyl Jasmonate Regulates H<sub>2</sub>S‐Induced Resistance to <i>Fusarium oxysporum</i> f. sp. <i>niveum</i> Race 2 in <i>Citrullus lanatus</i> Open
Fusarium wilt, caused by Fusarium oxysporum (Fo), is a destructive fungal disease that reduces crop yield and quality. Hydrogen sulphide (H 2 S), a critical signalling molecule, modulates plant defence responses; however, its role and mech…
View article: 3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration
3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration Open
Current Ti‐6Al‐4V bone implants lack trabecular structure and pro‑angiogenic cues, both essential for regeneration. Herein, a dual biomimetic strategy is devised that integrates a 3D‐printed biomimetic trabecular porous Ti‐6Al‐4V scaffold …
View article: A Novel Transcription Factor of Regulating Ag-8 Biocontrol to Grapevine Crown Gall
A Novel Transcription Factor of Regulating Ag-8 Biocontrol to Grapevine Crown Gall Open
Grapevine crown gall (GCG) is a major disease caused by the Allorhizobium vitis that causes significant losses in the grape industry. In this study, a strain of Agrobacterium tumefaciens (Ag-8) from soil was found to have a significant eff…
View article: In vitro study on the promotion of osteogenic differentiation by mitochondrial-derived vesicles through activation of inflammation and reprogramming of metabolic pathways
In vitro study on the promotion of osteogenic differentiation by mitochondrial-derived vesicles through activation of inflammation and reprogramming of metabolic pathways Open
The secretion of mitochondrial-derived vesicles (MDVs) has been found to increase during osteogenic differentiation, but their role in intercellular communication and osteogenic promotion remains unclear. In this study, we extracted transl…
View article: Enhanced Side Pole Impact Protection: Crashworthiness Optimization for Electric Micro Commercial Vehicles
Enhanced Side Pole Impact Protection: Crashworthiness Optimization for Electric Micro Commercial Vehicles Open
This study presents a novel optimization framework applying the multi-objective response surface method to enhance the safety of electric micro commercial vehicles (E-MCVs) during side pole impacts. By focusing on seven critical load-beari…
View article: Association between neutrophil to high-density lipoprotein ratio and no-reflow after coronary intervention: A cross-sectional study
Association between neutrophil to high-density lipoprotein ratio and no-reflow after coronary intervention: A cross-sectional study Open
Inflammatory responses and lipid metabolism disorders are key components in the development of coronary artery disease and contribute to no-reflow after coronary intervention. This study aimed to investigate the association between the neu…
View article: Extracellular Mitochondrial‐Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction
Extracellular Mitochondrial‐Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction Open
Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cy…
View article: Binding of Neonicotinoid Compounds to Apis Mellifera Chemosensory Protein 3 (Amelcsp3): Insight into the Molecular Toxicity of Compounds with Both Risk and Potential
Binding of Neonicotinoid Compounds to Apis Mellifera Chemosensory Protein 3 (Amelcsp3): Insight into the Molecular Toxicity of Compounds with Both Risk and Potential Open
View article: Molecular mechanisms of cis-oxygen bridge neonicotinoids to Apis mellifera Linnaeus chemosensory protein: Surface plasmon resonance, multiple spectroscopy techniques, and molecular modeling
Molecular mechanisms of cis-oxygen bridge neonicotinoids to Apis mellifera Linnaeus chemosensory protein: Surface plasmon resonance, multiple spectroscopy techniques, and molecular modeling Open
Honeybees, essential pollinators for maintaining biodiversity, are experiencing a sharp population decline, which has become a pressing environmental concern. Among the factors implicated in this decline, neonicotinoid pesticides, particul…
View article: Effect of Nitrogen Fertilizer on the Rhizosphere and Endosphere Bacterial Communities of Rice at Different Growth Stages
Effect of Nitrogen Fertilizer on the Rhizosphere and Endosphere Bacterial Communities of Rice at Different Growth Stages Open
This study aimed to investigate the impact of nitrogen (N) fertilizer on bacterial community composition and diversity in the rhizosphere and endosphere of rice at different growth stages. Two treatments, N0 (no N application) and N1 (270 …
View article: Association between triglyceride-glucose-body mass index (TyG-BMI) and in-stent restenosis after coronary interventions: a retrospective cross-sectional study
Association between triglyceride-glucose-body mass index (TyG-BMI) and in-stent restenosis after coronary interventions: a retrospective cross-sectional study Open
Background Insulin resistance has been confirmed to be an independent predictor of cardiovascular diseases. Earlier research have confirmed that triglyceride glucose body mass index (TyG-BMI) can be used as an alternative factor of insulin…
View article: Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex
Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex Open
Emerging evidence suggests that the sterile alpha‐motif (SAM) and histidine‐aspartate (HD) domain‐containing protein 1 (SAMHD1) is implicated in various cancers, including hepatocellular carcinoma (HCC). However, its precise role in tumor …
View article: Dietary Fiber’s Physicochemical Properties and Gut Bacterial Dysbiosis Determine Fiber Metabolism in the Gut
Dietary Fiber’s Physicochemical Properties and Gut Bacterial Dysbiosis Determine Fiber Metabolism in the Gut Open
A fiber-rich diet is considered beneficial for gut health. An inflamed gut with a dysbiotic bacterial community can result in altered fiber metabolism depending on the fiber’s physicochemical properties. This study examined the effect of f…
View article: Spatiotemporal delivery of BMP-2 and FGF-18 in 3D-bioprinted tri-phasic osteochondral scaffolds enhanced compartmentalized osteogenic and chondrogenic differentiation of mesenchymal stem cells isolated from rats with varied organizational morphologies
Spatiotemporal delivery of BMP-2 and FGF-18 in 3D-bioprinted tri-phasic osteochondral scaffolds enhanced compartmentalized osteogenic and chondrogenic differentiation of mesenchymal stem cells isolated from rats with varied organizational morphologies Open
Replicating the heterogeneous structure and promoting compartmentalized osteogenesis/chondrogenesis are critical considerations in designing scaffolds for osteochondral tissue regeneration. However, desirable osteochondral regeneration can…
View article: Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects
Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects Open
Herb compatibility is the soul of traditional Chinese Medicine prescriptions. Coptidis rhizoma (CR) ( Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao, or Coptis teeta Wall.; family Ranunculaceae), is a well-known herb. The bi…
View article: Personalized Piezoresistive Anti‐Scar Orthosis with Precise Pressure Monitoring Function Based on Embedded 3D Printing
Personalized Piezoresistive Anti‐Scar Orthosis with Precise Pressure Monitoring Function Based on Embedded 3D Printing Open
Hyperplastic scars, especially keloids, have posed a significant clinical challenge due to their high recurrence rate. Compression therapy, a cost‐effective treatment, has demonstrated efficacy in reducing scarring and preventing recurrenc…
View article: Correction for Zhang et al., “A novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis”
Correction for Zhang et al., “A novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis” Open
View article: Logic‐Based Strategy for Spatiotemporal Release of Dual Extracellular Vesicles in Osteoarthritis Treatment
Logic‐Based Strategy for Spatiotemporal Release of Dual Extracellular Vesicles in Osteoarthritis Treatment Open
To effectively treat osteoarthritis (OA), the existing inflammation must be reduced before the cartilage damage can be repaired; this cannot be achieved with a single type of extracellular vesicles (EVs). Here, a hydrogel complex with logi…
View article: A Gnotobiotic Mouse Model with Divergent Equol-Producing Phenotypes: Potential for Determining Microbial-Driven Health Impacts of Soy Isoflavone Daidzein
A Gnotobiotic Mouse Model with Divergent Equol-Producing Phenotypes: Potential for Determining Microbial-Driven Health Impacts of Soy Isoflavone Daidzein Open
The implications of soy consumption on human health have been a subject of debate, largely due to the mixed evidence regarding its benefits and potential risks. The variability in responses to soy has been partly attributed to differences …
View article: Photosynthetic co‐culture system of algae and human umbilical vein endothelial cells: The effect on alleviating hypoxia and hypoxia/reoxygenation injury
Photosynthetic co‐culture system of algae and human umbilical vein endothelial cells: The effect on alleviating hypoxia and hypoxia/reoxygenation injury Open
It is a developed photosynthetic co‐culture system to alleviate the hypoxia and hypoxia/reoxygenation (H/R)‐injured human umbilical vein endothelial cells (HUVECs). The algae, Chlorella vulgaris , were encapsulated to slow their growth whi…
View article: SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes
SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes Open
Tumor cells with damaged mitochondria undergo metabolic reprogramming, but gene therapy targeting mitochondria has not been comprehensively reported. In this study, plasmids targeting the normal hepatocyte cell line (L-O2) and hepatocellul…
View article: A gnotobiotic mouse model with divergent equol-producing phenotype: potential for determining microbial-driven health impacts of soy isoflavone daidzein
A gnotobiotic mouse model with divergent equol-producing phenotype: potential for determining microbial-driven health impacts of soy isoflavone daidzein Open
The implications of soy consumption on human health have been a subject of debate, largely due to the mixed evidence regarding its benefits and potential risks. The variability in responses to soy has been partly attributed to differences …