Zhu Yuan
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View article: The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis
The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis Open
Background Sarcopenia, a geriatric syndrome characterized by progressive loss of muscle mass, strength, and physical performance, elevates risks of functional decline and mortality. This study aims to investigate the co-occurrence patterns…
View article: A New Ensemble Strategy Based on Surprisingly Popular Algorithm and Classifier Prediction Confidence
A New Ensemble Strategy Based on Surprisingly Popular Algorithm and Classifier Prediction Confidence Open
Traditional ensemble methods rely on majority voting, which may fail to recognize correct answers held by a minority in scenarios requiring specialized knowledge. Therefore, this paper proposes two novel ensemble methods for supervised cla…
View article: Healthcare professionals' perceptions and experiences of fertility preservation in cancer patients: a meta-synthesis (Preprint)
Healthcare professionals' perceptions and experiences of fertility preservation in cancer patients: a meta-synthesis (Preprint) Open
BACKGROUND The growing global cancer burden impacts young individuals as early-onset rates rise. Advances in treatment improve survival but often harm reproductive function. Fertility preservation (FP) techniques are crucial, yet research…
View article: Melittin inhibits MPP<sup>+</sup>-induced HT22 cell death by suppressing Bax activation and improving mitochondrial function
Melittin inhibits MPP<sup>+</sup>-induced HT22 cell death by suppressing Bax activation and improving mitochondrial function Open
Melittin (MEL) is the main bioactive component of bee venom and has been reported to have various pharmacological effects. This study investigates the protective effect of MEL on MPP+-injured HT22 cells and the possible mechanis…
View article: Impact of different weaning strategies of high-frequency ventilation (HFV) on neonatal cerebral oxygen saturation and hemodynamics: protocol for a prospective randomized controlled trial
Impact of different weaning strategies of high-frequency ventilation (HFV) on neonatal cerebral oxygen saturation and hemodynamics: protocol for a prospective randomized controlled trial Open
View article: Association between sarcopenia and osteoporosis: the cross-sectional study from NHANES 1999–2020 and a bi-directions Mendelian randomization study
Association between sarcopenia and osteoporosis: the cross-sectional study from NHANES 1999–2020 and a bi-directions Mendelian randomization study Open
Background Osteoporosis (OP) and sarcopenia are prevalent musculoskeletal conditions among the elderly. Nevertheless, the causal relationship between sarcopenia and OP remains a subject of controversy and uncertainty. In this study, we emp…
View article: Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor‐mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation
Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor‐mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation Open
Melanoma's high metastatic potential, especially to the brain, poses significant challenges to patient survival. The blood‒brain barrier (BBB) is a major obstacle to the effective treatment of melanoma brain metastases. We screened antipsy…
View article: The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review
The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review Open
JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun. As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress-activated kinase (SAPK) because it can be activated …
View article: Postoperative chemoradiotherapy with capecitabine and oxaliplatin vs. capecitabine for pathological stage N2 rectal cancer
Postoperative chemoradiotherapy with capecitabine and oxaliplatin vs. capecitabine for pathological stage N2 rectal cancer Open
Our results indicated that adding oxaliplatin to capecitabine-based postoperative CRT is safe and effective in patients with pathological stage N2 rectal cancer.
View article: Evaluation of B7-H3 Targeted Immunotherapy in a 3D Organoid Model of Craniopharyngioma
Evaluation of B7-H3 Targeted Immunotherapy in a 3D Organoid Model of Craniopharyngioma Open
A craniopharyngioma (CP) is a rare epithelial tumor of the sellar and parasellar region. CPs are difficult to treat due to their anatomical proximity to critical nervous structures, which limits the ability of the surgeon to completely res…
View article: Composition, diversity and environmental drivers of soil cyanobacterial communities in rice fields in Jilin Province, China
Composition, diversity and environmental drivers of soil cyanobacterial communities in rice fields in Jilin Province, China Open
View article: New Developments in Exosomal lncRNAs in Cardiovascular Diseases
New Developments in Exosomal lncRNAs in Cardiovascular Diseases Open
Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths >200 nt and are involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes are secreted and produced by various cell types. Exosome contents inc…
View article: Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice
Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice Open
In Alzheimer's disease and ischemic stroke, intranasal insulin can act as a neuroprotective agent. However, whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanisms remain poorly unde…
View article: Clinical and Microbiological Characteristics of Invasive and Hypervirulent Klebsiella pneumoniae Infections in a Teaching Hospital in China
Clinical and Microbiological Characteristics of Invasive and Hypervirulent Klebsiella pneumoniae Infections in a Teaching Hospital in China Open
Lijuan Li, Ziyang Yuan, Danna Chen, Xiaoyan Xie, Bashan Zhang Department of Clinical Laboratory, Affiliated Dongguan People’s Hospital, Southern Medical University, Dongguan, Guangdong 523059, People’s Republic of ChinaCorrespondence: Bash…
View article: Serum creatinine/cystatin C ratio as a case-finding tool for low handgrip strength in Chinese middle-aged and older adults
Serum creatinine/cystatin C ratio as a case-finding tool for low handgrip strength in Chinese middle-aged and older adults Open
Measuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accura…
View article: Qualitative Evaluation of Virtual Touch Imaging Quantification: A Simple and Useful Method in the Diagnosis of Breast Lesions
Qualitative Evaluation of Virtual Touch Imaging Quantification: A Simple and Useful Method in the Diagnosis of Breast Lesions Open
Ying Zhu,* Xiao-hong Jia,* Wei Zhou, Wei-wei Zhan, Jian-qiao Zhou Department of Ultrasound, Shanghai Ruijin Hospital Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, People’s Republic of China*These authors…
View article: Diosgenin exhibits tumor suppressive function via down-regulation of EZH2 in pancreatic cancer cells
Diosgenin exhibits tumor suppressive function via down-regulation of EZH2 in pancreatic cancer cells Open
Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies worldwide. Although significant progress has been made in oncology treatment, this refractory disease is still become intractable. Natural herb product diosgenin …
View article: ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis
ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis Open
View article: Long non-coding RNA SPRY4-IT1 promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells
Long non-coding RNA SPRY4-IT1 promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells Open
Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) play a critical role in the development of human cancers including pancreatic cancer. Long non-coding RNA SPRY4-IT1 (sprouty4-intron transcript 1) has been reported…
View article: Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism Open
The mitogen-activated protein kinase (MAPK) pathway is frequently aberrantly activated in advanced cancers, including metastatic prostate cancer (CaP). However, activating mutations or gene rearrangements among MAPK signaling components, s…
View article: Identification of Heat-Induced Proteomes in Tomato Microspores Using LCM- Proteomics Analysis
Identification of Heat-Induced Proteomes in Tomato Microspores Using LCM- Proteomics Analysis Open
Pollen development is highly susceptible to heat stress (HS) and the production of inviable pollen causes reduction in seed-and fruit-set in plants.This study was carried out to identify HS-induced pollen proteins and the associated biolog…
View article: Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells Open
Da‐Cheng‐Qi‐Decoction (DCQD) has been used in the treatment of acute pancreatitis (AP) in China for many years. The aim of the current study was to examine the principal ingredient rhubarb of DCQD and its potential link to the pancreatic r…
View article: Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma
Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma Open
DESI2 (also known as PNAS-4) is a novel pro-apoptotic gene activated during the early response to DNA damage. We previously reported that overexpression of DESI2 induces S phase arrest and apoptosis by activating checkpoint kinases. The pr…
View article: Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression Open
View article: <i>EMP2</i> re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma
<i>EMP2</i> re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma Open
Although radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful treatment in many cases, and the exact underlying molecular mechanisms are still ill-defined. EMP2, ep…
View article: The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells
The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells Open
PUMA is a member of the "BH3-only" branch of the BCL-2 family. Our previous study suggests a therapeutic potential of PUMA in treating ovarian cancer, however, the action mechanism of PUMA remains elusive. In this work, we found that in PU…
View article: Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells
Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells Open
The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death in hematopoieti…
View article: Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid
Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid Open
View article: Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner
Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner Open
Chemoresistance in cancer has previously been attributed to gene mutations or deficiencies. Bax or p53 deficiency can lead to resistance to cancer drugs. We aimed to find an agent to overcome chemoresistance induced by Bax or p53 deficienc…
View article: PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells
PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells Open
PNAS-4, a novel pro-apoptotic gene, was activated during the early response to DNA damage. Our previous study has shown that PNAS-4 induces S phase arrest and apoptosis when overexpressed in A549 lung cancer cells. However, the underlying …