Zheng Su
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View article: Unpredictability in caregiver–child relationships: Impact on child verbal abilities and externalizing problems.
Unpredictability in caregiver–child relationships: Impact on child verbal abilities and externalizing problems. Open
This study examined longitudinal associations between caregiver-child dyadic unpredictability, children's verbal abilities, and externalizing problems, and the moderating role of temperamental surgency. Participants were 235 families with …
View article: Unpredictability in Caregiver-child Relationships: Impact on Child Verbal Abilities and Externalizing Problems
Unpredictability in Caregiver-child Relationships: Impact on Child Verbal Abilities and Externalizing Problems Open
This study examined longitudinal associations between caregiver-child dyadic unpredictability, children’s verbal abilities, and externalizing problems, and the moderating role of temperamental surgency. Participants were 235 families with …
View article: Post-transcriptional regulation supports the homeostatic expression of mature RNA
Post-transcriptional regulation supports the homeostatic expression of mature RNA Open
Gene expression regulation is a sophisticated, multi-stage process, and its robustness is critical to normal cell function and the survival of an organism. Previous studies indicate that differential gene expression at the RNA level is typ…
View article: Amyotrophic lateral sclerosis diagnosis using machine learning and multi-omic data integration
Amyotrophic lateral sclerosis diagnosis using machine learning and multi-omic data integration Open
Amyotrophic Lateral Sclerosis (ALS) is a complex and rare neurodegenerative disorder characterized by significant genetic, molecular, and clinical heterogeneity. Despite numerous endeavors to discover the genetic factors underlying ALS, a …
View article: Genes in Humans and Mice: Insights from Deep learning of 777K Bulk Transcriptomes
Genes in Humans and Mice: Insights from Deep learning of 777K Bulk Transcriptomes Open
Mice are widely used as animal models in biomedical research, favored for their small size, ease of breeding, and anatomical and physiological similarities to humans 1,2 . However, discrepancies between mouse gene experimental results and …
View article: Multifaceted Representation of Genes via Deep Learning of Gene Expression Networks
Multifaceted Representation of Genes via Deep Learning of Gene Expression Networks Open
Accurate predictive modeling of human gene relationships would fundamentally transform our ability to uncover the molecular mechanisms that underpin key biological and disease processes. Recent studies have employed advanced AI techniques …
View article: The Universal Consciousness Code Theory: Exploring the Physical Basis of Consciousness and Potential Decoding with AI Technologies
The Universal Consciousness Code Theory: Exploring the Physical Basis of Consciousness and Potential Decoding with AI Technologies Open
Consciousness pervades our daily experiences, yet it remains largely unaccounted for in contemporary physics and chemistry theories. Several existing theories, such as the Integrated Information Theory (IIT), Global Workspace Theory (GWT),…
View article: DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies Open
Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. I…
View article: VIPPID: a gene-specific single nucleotide variant pathogenicity prediction tool for primary immunodeficiency diseases
VIPPID: a gene-specific single nucleotide variant pathogenicity prediction tool for primary immunodeficiency diseases Open
Distinguishing pathogenic variants from non-pathogenic ones remains a major challenge in clinical genetic testing of primary immunodeficiency (PID) patients. Most of the existing mutation pathogenicity prediction tools treat all mutations …
View article: T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects
T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects Open
Both DNA damage response and methylation play a crucial role in antigen receptor recombination by creating a diverse repertoire in developing lymphocytes, but how their defects relate to T cell repertoire and phenotypic heterogeneity of im…
View article: Molecular Classification and Interpretation of Amyotrophic Lateral Sclerosis Using Deep Convolution Neural Networks and Shapley Values
Molecular Classification and Interpretation of Amyotrophic Lateral Sclerosis Using Deep Convolution Neural Networks and Shapley Values Open
Amyotrophic lateral sclerosis (ALS) is a prototypical neurodegenerative disease characterized by progressive degeneration of motor neurons to severely effect the functionality to control voluntary muscle movement. Most of the non-additive …
View article: Molecular Classification and Interpretation of Amyotrophic Lateral Sclerosis Using Deep Convolution Neural Networks and Shapley Values
Molecular Classification and Interpretation of Amyotrophic Lateral Sclerosis Using Deep Convolution Neural Networks and Shapley Values Open
Amyotrophic Lateral Sclerosis (ALS) is a prototypical neurodegenerative disease characterized by progressive degeneration of motor neurons to severely effect the functionality to control voluntary muscle movement. Most of the non additive …
View article: Molecular Basis of Allogeneic Pluripotent Stem Cell Treatment of a Patient with Sporadic ALS
Molecular Basis of Allogeneic Pluripotent Stem Cell Treatment of a Patient with Sporadic ALS Open
There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. Here we describe an ALS patient, who by choice, received all…
View article: Panoramic Visualization of Circulating MicroRNAs Across Neurodegenerative Diseases in Humans
Panoramic Visualization of Circulating MicroRNAs Across Neurodegenerative Diseases in Humans Open
Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and dementia pose one of the greatest health challenges this century. Although these…
View article: New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin
New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin Open
Importance Although a few studies have reported the effects of several polymorphisms on major adverse cardiovascular events (MACE) in patients with acute coronary syndromes (ACS) and those undergoing percutaneous coronary intervention (PCI…
View article: Systematic Comparative Evaluation of Methods for Investigating the TCRβ Repertoire
Systematic Comparative Evaluation of Methods for Investigating the TCRβ Repertoire Open
High-throughput sequencing has recently been applied to profile the high diversity of antibodyome/B cell receptors (BCRs) and T cell receptors (TCRs) among immune cells. To date, Multiplex PCR (MPCR) and 5'RACE are predominately used to en…
View article: IMonitor: A Robust Pipeline for TCR and BCR Repertoire Analysis
IMonitor: A Robust Pipeline for TCR and BCR Repertoire Analysis Open
The advance of next generation sequencing (NGS) techniques provides an unprecedented opportunity to probe the enormous diversity of the immune repertoire by deep sequencing T-cell receptors (TCRs) and B-cell receptors (BCRs). However, an e…