Ziwan Ning
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View article: Inhibition of peripheral serotonin synthesis by a gut microbe-derived TPH1 inhibitor, hyodeoxycholic acid, alleviates irritable bowel syndrome
Inhibition of peripheral serotonin synthesis by a gut microbe-derived TPH1 inhibitor, hyodeoxycholic acid, alleviates irritable bowel syndrome Open
Gut dysbiosis significantly contributes to the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D) by enhancing serotonin (5-HT) biosynthesis, which exacerbates diarrhea symptoms. Current treatments aimed at peripheral 5-…
View article: Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial
Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial Open
gov no: NCT03457324.
View article: A Novel Multiple-Network Analysis Integrating Metabolomics and Pharmacology for Mechanism Study of Medicine: A Case Study of CDD-2101 Against Constipation
A Novel Multiple-Network Analysis Integrating Metabolomics and Pharmacology for Mechanism Study of Medicine: A Case Study of CDD-2101 Against Constipation Open
Constipation affects more than 14% of the global population with complex pathogenesis. Compound Traditional Chinese medicines (TCM), such as CDD-2101, a manufactured version of a time-tested TCM, hold great promise for constipation treatme…
View article: Efficacy and safety of Chinese herbal formula CDD-2103 for remission maintenance of ulcerative colitis: Study protocol for a randomized, double-blinded, placebo-controlled trial
Efficacy and safety of Chinese herbal formula CDD-2103 for remission maintenance of ulcerative colitis: Study protocol for a randomized, double-blinded, placebo-controlled trial Open
Ulcerative colitis (UC) is a chronic lifelong disorder and a prominent subtype of inflammatory bowel disease (IBD) globally. Studies have indicated that Chinese herbal medicines (CHM) may offer advantages in alleviating the clinical sympto…
View article: Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome
Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome Open
The incidence of metabolic syndrome is significantly higher in patients with irritable bowel syndrome (IBS), but the mechanisms involved remain unclear. Gut microbiota has been causatively linked with the development of both metabolic dysf…
View article: Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats
Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats Open
Cinnamon protects against irritable bowel syndrome with diarrhea (IBS-D) in humans, but its efficacy and underlying mechanism of action remain poorly understood. Maternally separated (MS) IBS-D rat model and 2,4,6-trinitrobenzene sulfonic …
View article: Gut microbiota-derived tryptamine impairs insulin sensitivity
Gut microbiota-derived tryptamine impairs insulin sensitivity Open
Summary Gut-microbiota plays a pivotal role in development of type 2 diabetes (T2D), yet the molecular mechanism remains elusive. Here, we show that tryptamine, a microbial metabolite of tryptophan, impairs glucose tolerance and insulin se…
View article: Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis
Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis Open
Summary Despite the strong association between gut microbial dysbiosis, serotonin (5-HT) dysregulation and diarrhea-predominant irritable bowel syndrome (IBS-D), the mechanism by which changes in the gut microbiota contribute to the pathog…
View article: Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches
Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches Open
We demonstrated that the therapeutic effects of ZWBQD on experimental colitis are mediated by regulating multiple signaling pathways and modulation of gut microbiota. Our study employed an integrative strategy to elucidate novel mechanisms…
View article: Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity
Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity Open
Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; howe…
View article: Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium–Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity
Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium–Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity Open
Ulcerative colitis (UC) causes chronic inflammation and damage to the colonic mucosal layer. Recent studies have reported significant changes in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) in UC patients and oral administrat…
View article: Author Correction: Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis
Author Correction: Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Integrated Multi-Omics Data Analysis Reveals Altered Metabolome Activity and Microbiome Composition in Irritable Bowel Syndrome
Integrated Multi-Omics Data Analysis Reveals Altered Metabolome Activity and Microbiome Composition in Irritable Bowel Syndrome Open
Background: Irritable bowel syndrome (IBS) is one of functional gastrointestinal disorders mainly characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to me…
View article: Chinese Herbal Medicine (MaZiRenWan) Improves Bowel Movement in Functional Constipation Through Down-Regulating Oleamide
Chinese Herbal Medicine (MaZiRenWan) Improves Bowel Movement in Functional Constipation Through Down-Regulating Oleamide Open
In a prospective, randomized, three-arms, controlled clinical study, Chinese Herbal Medicine MaZiRenWan (MZRW, also known as Hemp Seed Pill) demonstrates comparable efficacy with Senna for functional constipation (FC) during an 8-week trea…
View article: A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome Open
An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the factors causing excessive BA excretion remain incompletely studied. Given the importance of …
View article: A <i>Clostridia</i>-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome
A <i>Clostridia</i>-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome Open
Objective An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the factors causing excessive BA excretion remains unclear. Given the importance of gu…
View article: Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study
Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study Open
Hyperlipidemia and hepatic steatosis afflict over 75% of patients with type 2 diabetes, causing diabetic dyslipidemia. Cyclocarya paliurus (CP) leaf is a herbal tea which has long been consumed by the Chinese population, particularly peopl…
View article: Uncovering the Mechanisms of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation by Focused Network Pharmacology Approach
Uncovering the Mechanisms of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation by Focused Network Pharmacology Approach Open
MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects.…