Zhi‐Hong Wen
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View article: Induced bleaching enhances cold tolerance in coral larvae: a potential strategy for cryopreservation optimization
Induced bleaching enhances cold tolerance in coral larvae: a potential strategy for cryopreservation optimization Open
View article: Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation
Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation Open
Neuropathic pain poses a significant societal and clinical burden and is closely linked to neuroinflammation of the central nervous system. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of inflammatory proce…
View article: Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study
Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study Open
Our findings revealed that MCP is significantly associated with a higher risk of asthma, which is partially mediated by immune cells.
View article: NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization
NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization Open
Vascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells from a contractile to an osteogenic phenotype. NEXN, a protein highly associated with heart funct…
View article: Cultivated Pocillopora acuta coral as a sustainable and effective biomaterial: enhanced osteogenic potential and structural integrity
Cultivated Pocillopora acuta coral as a sustainable and effective biomaterial: enhanced osteogenic potential and structural integrity Open
View article: Understanding the landscape of cross-species transmission, epidemiology, phylogenetics, and antigenicity of HPAI strain A(H5N1) causing a recent outbreak in the USA
Understanding the landscape of cross-species transmission, epidemiology, phylogenetics, and antigenicity of HPAI strain A(H5N1) causing a recent outbreak in the USA Open
H5N1 virus infections have repeatedly been reported among wild birds in the USA and throughout the globe. Therefore, the recent outbreak of HPAI strain A(H5N1) in the USA is a global concern that spread among twelve states and three humans…
View article: Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling
Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling Open
Rationale: Mitochondrial dysfunction in ovarian granulosa cells (GCs) and cumulus cells (CCs) is a defining feature of reproductive aging, contributing to impaired oocyte quality and reduced fertility. This study investigates whethe…
View article: Varying Analgesic Effectiveness of Systemic and Central Intrathecal Administration of Cyclooxygenase‐2 Inhibitors in Different Phases of Osteoarthritic Pain in Rats
Varying Analgesic Effectiveness of Systemic and Central Intrathecal Administration of Cyclooxygenase‐2 Inhibitors in Different Phases of Osteoarthritic Pain in Rats Open
Background Osteoarthritis (OA) contributes to heightened pain perception by disrupting the normal function of peripheral nerves and spinal nociceptive circuits. Although selective cyclooxygenase‐2 (COX‐2) inhibitors reduce OA‐associated pa…
View article: The Neuroprotective Effects of the Crinoid Natural Compound Rhodoptilometrin in Parkinson’s Disease Experimental Models: Implications for ER Stress and Autophagy Modulation
The Neuroprotective Effects of the Crinoid Natural Compound Rhodoptilometrin in Parkinson’s Disease Experimental Models: Implications for ER Stress and Autophagy Modulation Open
The pathogenesis of Parkinson's disease (PD) involves cellular processes such as endoplasmic reticulum (ER) stress, unfolded protein response, autophagy imbalance, and apoptosis, and identifying drugs that can regulate these molecular mech…
View article: Deep learning in next-generation vaccine development for infectious diseases
Deep learning in next-generation vaccine development for infectious diseases Open
The landscape of vaccine development was changed in the genomic era with the help of computer science. Computer-aided vaccine epitope selection has become a foundation of rational vaccine design. Similarly, artificial intelligence (AI) is …
View article: Unlocking the dual power of Charybdis natator shell: antiviral and larvicidal activities
Unlocking the dual power of Charybdis natator shell: antiviral and larvicidal activities Open
View article: Identification of housekeeping gene for future studies exploring effects of cryopreservation on gene expression in shrimp
Identification of housekeeping gene for future studies exploring effects of cryopreservation on gene expression in shrimp Open
View article: Looking beyond the origin of SARS-CoV-2: Significant strategic aspects during the five-year journey of COVID-19 vaccine development
Looking beyond the origin of SARS-CoV-2: Significant strategic aspects during the five-year journey of COVID-19 vaccine development Open
View article: The emergent property of inhibitory control: implications of intermittent network-based fNIRS neurofeedback training
The emergent property of inhibitory control: implications of intermittent network-based fNIRS neurofeedback training Open
Background Studies have shown that inhibitory control is supported by frontal cortex and small-world brain networks. However, it remains unclear how regulating the topology changes the inhibitory control. We investigated the effects of sma…
View article: Single-cell transcriptome atlas of peripheral immune features to Omicron breakthrough infection under booster vaccination strategies
Single-cell transcriptome atlas of peripheral immune features to Omicron breakthrough infection under booster vaccination strategies Open
Introduction The high percentage of Omicron breakthrough infection in vaccinees is an emerging problem, of which we have a limited understanding of the phenomenon. Methods We performed single-cell transcriptome coupled with T-cell/B-cell r…
View article: Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review Open
Several cancer drugs show drug resistance, which is a significant concern for cancer therapy. Therefore, new molecules are required for cancer treatment as anticancer drugs. Recently, several natural bioactive components from medicinal pla…
View article: Quercetin, Isoquercitrin, and Quercetin‐3‐Rutinoside: Understanding the Pharmacological, Organoleptic, ADME Properties, Human Health Toxicity, Ecological Risk, and Cosmetic Risk of Using Integrative Bioinformatics
Quercetin, Isoquercitrin, and Quercetin‐3‐Rutinoside: Understanding the Pharmacological, Organoleptic, ADME Properties, Human Health Toxicity, Ecological Risk, and Cosmetic Risk of Using Integrative Bioinformatics Open
Bioactive flavonoids have been presently used from therapeutics to cosmetics. Such bioactive flavonoids are Quercetin and its derivatives, (Isoquercitrin and Quercetin‐3‐rutinoside). The present study evaluated the physicochemical and medi…
View article: Nicotinamide riboside alleviates doxorubicin-induced hepatotoxicity and nephrotoxicity by inhibiting ferroptosis
Nicotinamide riboside alleviates doxorubicin-induced hepatotoxicity and nephrotoxicity by inhibiting ferroptosis Open
View article: Novel insecticidal properties of bioactive zoochemicals extracted from sea urchin <i>Salmacis virgulata</i>
Novel insecticidal properties of bioactive zoochemicals extracted from sea urchin <i>Salmacis virgulata</i> Open
The present investigation assessed the insecticidal potential of zoo chemicals extracted from the test (skeleton) and spines of the sea urchin Salmacis virgulata against Tribolium castaneum , Aedes aegypti , and the Sf-9 cell line through …
View article: Predicting the potential distribution of Astragali Radix in China under climate change adopting the MaxEnt model
Predicting the potential distribution of Astragali Radix in China under climate change adopting the MaxEnt model Open
Introduction Astragali Radix is the dried root of Astragalus mongoliae or Astragalus membranaceus, a leguminous plant. Since ancient times, Astragali Radix has been widely used in Chinese traditional Chinese medicine. As people become more…
View article: Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis Open
View article: Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats
Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats Open
Introduction: Neuropathic pain (NP) affects countless people worldwide; however, few effective treatments are currently available. Histone deacetylases (HDACs) participate in epigenetic modifications in neuropathy-induced nociceptive sensi…
View article: Transcriptome Profiles Characteristics of the Peripheral Immune in Patients with Severe Fever with Thrombocytopenia Syndrome
Transcriptome Profiles Characteristics of the Peripheral Immune in Patients with Severe Fever with Thrombocytopenia Syndrome Open
Overall, our research findings systematically observed potential immune mechanisms underlying clinical symptom heterogeneity and noteworthily revealed multiple signaling pathways leading to coagulation dysfunction in fatal outcomes, not ju…
View article: Correction: Cuproptosis-Related Gene FDX1 Identified as a Potential Target for Human Ovarian Aging
Correction: Cuproptosis-Related Gene FDX1 Identified as a Potential Target for Human Ovarian Aging Open
View article: Graphene-Doped Piezoelectric Transducers by Kriging Optimal Model for Detecting Various Types of Laryngeal Movements
Graphene-Doped Piezoelectric Transducers by Kriging Optimal Model for Detecting Various Types of Laryngeal Movements Open
This study fabricated piezoelectric fibers of polyvinylidene fluoride (PVDF) with graphene using near-field electrospinning (NFES) technology. A uniform experimental design table U*774 was applied, considering weight percentage (1–13 wt%),…
View article: Soft Corals-derived Dihydrosinularin Attenuates Neuronal Apoptosis in 6-hydroxydopamine-induced Cell Model of Parkinson's Disease by Regulating the PI3K Pathway
Soft Corals-derived Dihydrosinularin Attenuates Neuronal Apoptosis in 6-hydroxydopamine-induced Cell Model of Parkinson's Disease by Regulating the PI3K Pathway Open
Background: Parkinson's disease (PD) is an irreversible, progressive disorder that profoundly impacts both motor and non-motor functions, thereby significantly diminishing the individual’s quality of life. Dihydrosinularin (DHS), a natural…
View article: The changing scenario of drug discovery using AI to deep learning: Recent advancement, success stories, collaborations, and challenges
The changing scenario of drug discovery using AI to deep learning: Recent advancement, success stories, collaborations, and challenges Open
Due to the transformation of artificial intelligence (AI) tools and technologies, AI-driven drug discovery has come to the forefront. It reduces the time and expenditure. Due to these advantages, pharmaceutical industries are concentrating…
View article: Graphene-Doped Piezoelectric Transducers by Kriging Optimal Model for Detecting Various Types of Laryngeal Movements
Graphene-Doped Piezoelectric Transducers by Kriging Optimal Model for Detecting Various Types of Laryngeal Movements Open
This study fabricated piezoelectric fibers of polyvinylidene fluoride (PVDF) with graphene using near-field electrospinning (NFES) technology. A uniform experimental design table U*7 (7^4 ) was applied, considering weight percentage (1-13 …
View article: Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases
Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases Open
Objective Mounting evidence suggests that histone deacetylases (HDAC) inhibitors reduce cartilage destruction in animal models of osteoarthritis (OA). Tumor necrosis factor (TNF)-α-blocking treatment for OA may provide effective joint prot…
View article: Gene expression profiling and the isocitrate dehydrogenase mutational landscape of temozolomide‑resistant glioblastoma
Gene expression profiling and the isocitrate dehydrogenase mutational landscape of temozolomide‑resistant glioblastoma Open
Glioblastoma multiforme (GBM) is an aggressive brain cancer that occurs more frequently than other brain tumors. The present study aimed to reveal a novel mechanism of temozolomide resistance in GBM using bioinformatics and wet lab analyse…