Zuojie Luo
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View article: Phenotyping obesity through a two-dimensional tree structure reveals cardiometabolic heterogeneity
Phenotyping obesity through a two-dimensional tree structure reveals cardiometabolic heterogeneity Open
Obesity, a major public health challenge, is characterized by substantial phenotypic heterogeneity. Here, we employ the discriminative dimensionality reduction tree (DDRTree) method to routine clinical data from 18,733 Chinese individuals …
View article: Heterogeneity of diabetes and disease progression with a tree-like representation: findings from the China Cardiometabolic Disease and Cancer Cohort (4C) study
Heterogeneity of diabetes and disease progression with a tree-like representation: findings from the China Cardiometabolic Disease and Cancer Cohort (4C) study Open
These findings characterise the heterogeneity of diabetes phenotypes and complication risks in the Chinese population, suggesting potential implications for personalised diabetes care. Given the observed phenotypic differences, management …
View article: GAD65 antibody-associated autoimmune encephalitis with autoimmune polyendocrine gland syndrome type II: case report and literature review
GAD65 antibody-associated autoimmune encephalitis with autoimmune polyendocrine gland syndrome type II: case report and literature review Open
Purpose: This report presents a case of autoimmune encephalitis associated with glutamic acid decarboxylase 65 (GAD65) antibodies, complicated by autoimmune polyendocrine syndrome type II (APS-II), aiming to elucidate the clinical spectrum…
View article: A Review of Survey Research on Adolescent Depression
A Review of Survey Research on Adolescent Depression Open
In recent years, adolescent depression has become a significant public health issue globally, profoundly affecting the quality of life, academic performance, and social functioning of adolescents. According to the China National Mental Hea…
View article: Gender Disparities in the Association Between Educational Attainment and Cardiovascular-Kidney-Metabolic Syndrome: Cross-Sectional Study
Gender Disparities in the Association Between Educational Attainment and Cardiovascular-Kidney-Metabolic Syndrome: Cross-Sectional Study Open
Background Cardiovascular-kidney-metabolic (CKM) health is affected by social determinants of health, especially education. CKM syndrome has not been evaluated in Chinese population, and the association of education with CKM syndrome in di…
View article: Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study
Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study Open
Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies. We aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationw…
View article: Meta-Analysis on the Association Between DPP-4 Inhibitors and Bone Mineral Density and Osteoporosis
Meta-Analysis on the Association Between DPP-4 Inhibitors and Bone Mineral Density and Osteoporosis Open
Background Type 2 Diabetes Mellitus (T2DM) frequently coexists with osteoporosis and reduced bone mineral density (BMD). Dipeptidyl peptidase-4 inhibitors (DPP-4i), a class of antihyperglycemic agents, are commonly employed in T2DM treatme…
View article: Parity and later life adherence to healthy lifestyles concerning all-cause and cause-specific mortality
Parity and later life adherence to healthy lifestyles concerning all-cause and cause-specific mortality Open
Background and Aims: Whether parity related mortality risk can be mitigated by healthy lifestyles in later life remains unclear. We aimed to examine the combined association and interaction between parity and lifestyle factors in later lif…
View article: A higher TyG index level is more likely to have enhanced incidence of T2DM and HTN comorbidity in elderly Chinese people: a prospective observational study from the Reaction Study
A higher TyG index level is more likely to have enhanced incidence of T2DM and HTN comorbidity in elderly Chinese people: a prospective observational study from the Reaction Study Open
Background Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking TyG index to incidence of T2DM and HTN comorbidity remains unclear. The aim of this study wa…
View article: Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults Open
Importance Spouses share common socioeconomic, environmental, and lifestyle factors, and multiple studies have found that spousal diabetes status was associated with diabetes prevalence. But the association of spousal diabetes status and i…
View article: Body roundness index is related to the low estimated glomerular filtration rate in Chinese population: A cross-sectional study
Body roundness index is related to the low estimated glomerular filtration rate in Chinese population: A cross-sectional study Open
Background Kidney disease is related to visceral obesity. As a new indicator of obesity, body roundness index (BRI) has not been fully revealed with kidney disease. This study’s objective is to assess the relationship between estimated glo…
View article: Blood Pressure Levels, Cardiovascular Events, and Renal Outcomes in Chronic Kidney Disease Without Antihypertensive Therapy: A Nationwide Population-Based Cohort Study
Blood Pressure Levels, Cardiovascular Events, and Renal Outcomes in Chronic Kidney Disease Without Antihypertensive Therapy: A Nationwide Population-Based Cohort Study Open
Background: High blood pressure (BP) is highly prevalent in patients with chronic kidney disease. However, the thresholds to initiate BP-lowering treatment in this population are unclear. We aimed to examine the associations between BP lev…
View article: The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study
The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study Open
Supplementary Table 1：Details of 23 SNPs used as IVs for MR analysis of SLE on GD. Supplementary Table 2：Details of 25 SNPs used as IVs for MR analysis of SLE on T2DM. Supplementary Table 3：Details of 27 SNPs used as IVs for MR analysis of…
View article: Examining the Linear Association Between Blood Pressure Levels and Cardiovascular Diseases in the Absence of Major Risk Factors in China
Examining the Linear Association Between Blood Pressure Levels and Cardiovascular Diseases in the Absence of Major Risk Factors in China Open
Background: Many studies demonstrate a J-shaped association between blood pressure and cardiovascular diseases (CVDs), but the findings are plagued by confounding from other traditional cardiovascular risk factors (CVRFs). Our aims were to…
View article: Se-Methylselenocysteine inhibits proliferation and migration of anaplastic thyroid carcinoma cells through the ROS-ERK1/2 signaling pathway
Se-Methylselenocysteine inhibits proliferation and migration of anaplastic thyroid carcinoma cells through the ROS-ERK1/2 signaling pathway Open
Se-Methylselenocysteine (MSC) is a major organic selenium compound that possesses anticancer activity. However, the antitumor effect of MSC in anaplastic thyroid carcinoma (ATC) remains to be investigated. In this study, the two human ATC …
View article: The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults
The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults Open
Background Obesity, especially visceral obesity, seems to be one of the most decisive risk factors for chronic kidney disease. A Body Shape Index (ABSI) is an emerging body size measurement marker of visceral obesity. This study aimed to e…
View article: Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events
Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events Open
Backgrounds Whether longitudinal changes in metabolic status influence the effect of kidney stones on cardiovascular disease (CVD) remains unclarified. We investigated the modification effect of status changes in metabolic syndrome (MetS) …
View article: The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study Open
Aim To determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk. Methods 35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for averag…
View article: Chinese Visceral Adiposity Index Is More Closely Associated With Hypertension and Prehypertension Than Traditional Adiposity Indices in Chinese Population: Results From the REACTION Study
Chinese Visceral Adiposity Index Is More Closely Associated With Hypertension and Prehypertension Than Traditional Adiposity Indices in Chinese Population: Results From the REACTION Study Open
Purpose The optimal adiposity index that is strongly associated with hypertension or prehypertension remains inconclusive in Chinese population. This study aimed to investigate the relationship between Chinese visceral adiposity index (CVA…
View article: Association Between Insulin Resistance and Cardiovascular Disease Risk Varies According to Glucose Tolerance Status: A Nationwide Prospective Cohort Study
Association Between Insulin Resistance and Cardiovascular Disease Risk Varies According to Glucose Tolerance Status: A Nationwide Prospective Cohort Study Open
OBJECTIVE To investigate whether the association between insulin resistance and cardiovascular disease (CVD) differs by glucose tolerance status. RESEARCH DESIGN AND METHODS We analyzed a nationwide sample of 111,576 adults without CVD at …
View article: Depression Status, Lifestyle, and Metabolic Factors With Subsequent Risk for Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study
Depression Status, Lifestyle, and Metabolic Factors With Subsequent Risk for Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study Open
Background We aimed to evaluate the association between depression and major cardiovascular events and test whether the relationship between depression and cardiovascular events is influenced by lifestyle or metabolic risk factors. Methods…
View article: The Resting-State Brain Network Functional Connectivity Changes in Patients With Acute Thyrotoxic Myopathy Based on Independent Component Analysis
The Resting-State Brain Network Functional Connectivity Changes in Patients With Acute Thyrotoxic Myopathy Based on Independent Component Analysis Open
Objective The independent component analysis (ICA) was applied to explore the correlation between clinical manifestation and the functional connectivity changes of the sensorimotor network (SMN) and left frontoparietal network (LFPN) in pa…
View article: Metabolic Score for Insulin Resistance, a novel score to evaluate insulin sensitivity, is associated with the urinary albumin‐to‐creatinine ratio in Chinese adults: A cross‐sectional REACTION study
Metabolic Score for Insulin Resistance, a novel score to evaluate insulin sensitivity, is associated with the urinary albumin‐to‐creatinine ratio in Chinese adults: A cross‐sectional REACTION study Open
Aims/Introduction The Metabolic Score for Insulin Resistance (METS‐IR) is a novel non‐insulin‐based metabolic index used as a substitution marker of insulin resistance. However, whether METS‐IR is associated with the urinary albumin‐to‐cre…