Explanipedia

An Efficient Algorithm for Learning-Based Visual Localization Open

Jian Zhong, Ziyuan Guo, Hongxia Wang, Huanshui Zhang · 2025

This paper addresses the visual localization problem in Global Positioning System (GPS)-denied environments, where computational resources are often limited. To achieve efficient and robust performance under these constraints, we propose a…

An extremely soft and weak fast X-ray transient associated with a luminous supernova Open

W. -X. Li, Z. -P. Zhu, Xingzhu Zou, Jin-Jun Geng, L. -D. Liu , et al. · 2025

Long gamma-ray bursts (LGRBs), including their subclasses of low-luminosity GRBs (LL-GRBs) and X-ray flashes (XRFs) characterized by low spectral peak energies, are known to be associated with broad-lined Type Ic supernovae (SNe Ic-BL), wh…

Target-Driven Distillation: Consistency Distillation with Target Timestep Selection and Decoupled Guidance Open

Cunzheng Wang, Ziyuan Guo, Yuxuan Duan, Huaxia Li, Nemo Chen , et al. · 2025

Consistency distillation methods have demonstrated significant success in accelerating generative tasks of diffusion models. However, since previous consistency distillation methods use simple and straightforward strategies in selecting ta…

Author Correction: Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC Open

Ling‐Shuang Zhu, Chuan Lai, Chao-Wen Zhou, Hui-Yang Chen, Zhiqiang Liu , et al. · 2025

Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics Open

Chuan Lai, Kai Chen, He‐Zhou Huang, Xian Huang, Juan Zhang , et al. · 2025

Competitive interactions are pervasive within biological populations, where individuals engage in fierce disputes over vital resources for survival. Before the establishment of a social hierarchy within the population, this competition bec…

Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration Open

Tongyu Rui, He‐Zhou Huang, Kai Zheng, Hong‐Wei Fan, Juan Zhang , et al. · 2025

Dietary high salt intake is increasingly recognized as a risk factor for cognitive decline and dementia, including Alzheimer’s disease (AD). Recent studies have identified a population of disease‐associated astrocytes (DAA)‐like astrocytes…

Cpeb1 remodels cell type–specific translational program to promote fear extinction Open

Juan Zhang, Chunqing Yang, Zhiqiang Liu, Shiping Wu, Zuguang Li , et al. · 2025

Protein translation is crucial for fear extinction, a process vital for adaptive behavior and mental health, yet the underlying cell-specific mechanisms remain elusive. Using a Tet-On 3G genetic approach, we achieved precise temporal contr…

Information Entropy-Guided Knowledge Graph Recommendation Open

Jie Guo, Xin Tan, Ziyuan Guo, Yunfei Zhao, Bin Song · 2025

Distributed Optimization Method Based On Optimal Control Open

Ziyuan Guo, Yue Sun, Yeming Xu, Liping Zhang, Huanshui Zhang · 2024

In this paper, a novel distributed optimization framework has been proposed. The key idea is to convert optimization problems into optimal control problems where the objective of each agent is to design the current control input minimizing…

An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m<sup>6</sup>A- mediated epi-transcriptomic dysregulation underlying synaptic dysfunction Open

Lu Lu, Avijite Kumer Sarkar, Lan T.M. Dao, Yanchen Liu, Chunlong Ma , et al. · 2024

Fragile X syndrome (FXS), the leading genetic cause of intellectual disability, arises from FMR1 gene silencing and loss of the FMRP protein. N6-methyladenosine (m 6 A) is a prevalent mRNA modification essential for post-transcriptional re…

GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disorders Open

Ziyuan Guo, Yijing Su, Wei‐Kai Huang, Xiang Sean Yao, Hong Yan , et al. · 2024

“GABA dysfunction” is a major hypothesis for the biological basis of schizophrenia with indirect supporting evidence from human post-mortem brain and genetic studies. Patient-derived induced pluripotent stem cells (iPSCs) have emerged as a…

Distributed Optimization Algorithm with Superlinear Convergence Rate Open

Yeming Xu, Ziyuan Guo, Kaihong Lu, Huanshui Zhang · 2024

This paper considers distributed optimization problems, where each agent cooperatively minimizes the sum of local objective functions through the communication with its neighbors. The widely adopted distributed gradient method in solving t…

Target-Driven Distillation: Consistency Distillation with Target Timestep Selection and Decoupled Guidance Open

Cunzheng Wang, Ziyuan Guo, Yuxuan Duan, Huaxia Li, Nemo Chen , et al. · 2024

Consistency distillation methods have demonstrated significant success in accelerating generative tasks of diffusion models. However, since previous consistency distillation methods use simple and straightforward strategies in selecting ta…

Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC Open

Ling‐Shuang Zhu, Chuan Lai, Chao-Wen Zhou, Hui-Yang Chen, Zhiqiang Liu , et al. · 2024

Individuals’ continuous success in competitive interactions with conspecifics strongly affects their social hierarchy. Medial prefrontal cortex (mPFC) is the key brain region mediating both social competition and hierarchy. However, the mo…

Differential Signal-Amplitude-Modulated Multi-Beam Remote Optical Touch Based on Grating Antenna Open

Yanwen Huang, Weiqiang Lin, Peijin Wu, Yongxin Wang, Ziyuan Guo , et al. · 2024

As screen sizes are becoming larger and larger, exceeding human physical limitations for direct interaction via touching, remote control is inevitable. However, among the current solutions, inertial gyroscopes are susceptible to positional…

Differential Signal Amplitude Modulated Multi-beam Remote Optical Touch Based on Grating Antenna Open

Yanwen Huang, Weiqiang Lin, Peijin Wu, Yongxin Wang, Ziyuan Guo , et al. · 2024

As screen sizes are becoming larger and larger, which are beyond human’s physical limitation for direct touching interaction, remote controls are inevitable. However, as techniques applied so far, inertial gyroscopes are susceptible to pos…

Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway Open

Haiyan He, Ming He, Yunxia wang, Haojun Xiong, Yu Xiong , et al. · 2024

Pirarubicin (THP) is a new generation of cell cycle non-specific anthracycline-based anticancer drug. In the clinic, THP and THP combination therapies have been shown to be effective in hepatocellular carcinoma (HCC) patients with transcat…

Retraction notice to “Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation” [Transl. Res. 226 (2020) 83–95] Open

Ziyuan Guo, Zhuo Zhao, Chuang Yang, Chunli Song · 2024

Superlinear Optimization Algorithms Open

Hongxia Wang, Yeming Xu, Ziyuan Guo, Huanshui Zhang · 2024

This paper proposes several novel optimization algorithms for minimizing a nonlinear objective function. The algorithms are enlightened by the optimal state trajectory of an optimal control problem closely related to the minimized objectiv…

Recalibrating the Why and Whom of Animal Models in Parkinson Disease: A Clinician’s Perspective Open

Andrea Sturchio, Emily M. Rocha, Marcelo Kauffman, Luca Marsili, Abhimanyu Mahajan , et al. · 2024

Animal models have been used to gain pathophysiologic insights into Parkinson’s disease (PD) and aid in the translational efforts of interventions with therapeutic potential in human clinical trials. However, no disease-modifying therapy f…

The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice Open

Xiya Shen, Juan Zhang, He‐Zhou Huang, Shaodan Li, Ling Zhou , et al. · 2024

The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing a principal components analysis-based approach, we differentiated the mice into extinction-resistant and susceptible groups. We d…

An iPSC Model of Fragile X Syndrome Reflects Clinical Phenotypes and Reveals m6A-Mediated Epi-Transcriptomic Dysregulation Underlying Synaptic Dysfunction Open

Lu Lu, Avijite Kumer Sarkar, Lan T.M. Dao, Yanchen Liu, Chunlong Ma , et al. · 2024

Highly Precise Strategy of Polygalacturonic Acid Microcarriers Functionalized with Zwitterions and Specific Peptides for Mscs Screening Open

Jianchao Li, Ziyuan Guo, Zhenxv Wu, Yu Wang, Zongliang Wang , et al. · 2024

CircRNA regulates the liquid-liquid phase separation of ATG4B, a novel strategy to inhibit cancer metastasis? Open

Ziyuan Guo, Yang Chen, Yaran Wu, Jiqin Lian · 2024

Anoikis is a common programmed death for most of detached cells, but cancer cells can obtain anoikis resistance to facilitate their distant metastasis through the circulation system. Researches have indicated that enhanced autophagic flux …

Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice Open

He‐Zhou Huang, Wen-Qing Ai, Na Wei, Ling‐Shuang Zhu, Zhiqiang Liu , et al. · 2023

Sporadic or late-onset Alzheimer’s disease (LOAD) accounts for more than 95% of Alzheimer’s disease (AD) cases without any family history. Although genome-wide association studies have identified associated risk genes and loci for LOAD, nu…

Optimization Method Based On Optimal Control Open

Yeming Xu, Ziyuan Guo, Hongxia Wang, Huanshui Zhang · 2023

In this paper, we focus on a method based on optimal control to address the optimization problem. The objective is to find the optimal solution that minimizes the objective function. We transform the optimization problem into optimal contr…

A Comparative Study on Deep Learning Models for COVID-19 Forecast Open

Ziyuan Guo, Qingyi Lin, Xuhui Meng · 2023

The COVID-19 pandemic has led to a global health crisis with significant morbidity, mortality, and socioeconomic disruptions. Understanding and predicting the dynamics of COVID-19 are crucial for public health interventions, resource alloc…

A general design of pyridinium-based fluorescent probes for enhancing two-photon microscopy Open

Rui Chen, Kangqiang Qiu, Daniel C.Y. Leong, Bidyut Kumar Kundu, Chengying Zhang , et al. · 2023

Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s disease Open

Lanting Zhou, Dan Liu, Huicong Kang, Lu Lu, He‐Zhou Huang , et al. · 2023

The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau,…

A General Design of Pyridinium-Based Fluorescent Probes for Enhancing Two-Photon Microscopy Open

Rui Chen, Kangqiang Qiu, Daniel C.Y. Leong, Bidyut Kumar Kundu, Chengying Zhang , et al. · 2023

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