Zoe Dimond
YOU?
Author Swipe
View article: A platform supporting generation and isolation of random transposon mutants in <i>Chlamydia trachomatis</i>
A platform supporting generation and isolation of random transposon mutants in <i>Chlamydia trachomatis</i> Open
Chlamydia species represent a paradigm for understanding successful obligate intracellular parasitism. Despite limited genetic malleability, development of genetic tools has facilitated the elucidation of molecular mechanisms governing inf…
View article: Chlamydia trachomatis Alters Mitochondrial Protein Composition and Secretes Effector Proteins That Target Mitochondria
Chlamydia trachomatis Alters Mitochondrial Protein Composition and Secretes Effector Proteins That Target Mitochondria Open
Obligate intracellular bacteria have evolved multiple means to promote their intracellular survival and replication within the otherwise harsh environment of the eukaryotic cell. Nutrient acquisition and avoidance of cellular defense mecha…
View article: Inter‐species lateral gene transfer focused on the <i>Chlamydia</i> plasticity zone identifies loci associated with immediate cytotoxicity and inclusion stability
Inter‐species lateral gene transfer focused on the <i>Chlamydia</i> plasticity zone identifies loci associated with immediate cytotoxicity and inclusion stability Open
Chlamydia muridarum actively grows in murine mucosae and is a representative model of human chlamydial genital tract disease. In contrast, C. trachomatis infections in mice are limited and rarely cause disease. The factors that contribute …
View article: Bacterial Unknown Project in the COVID19 Era: Transition from in-Person Lab Experience to Online Environment
Bacterial Unknown Project in the COVID19 Era: Transition from in-Person Lab Experience to Online Environment Open
The eruption of the COVID-19 pandemic forced many universities to quickly transition traditional in-person laboratory courses to an online format for remote learning. Consequently, learning objectives focused on hands-on laboratory skills …
View article: Comprehensive genome analysis and comparisons of the swine pathogen, <i>Chlamydia suis</i> reveals unique ORFs and candidate host-specificity factors
Comprehensive genome analysis and comparisons of the swine pathogen, <i>Chlamydia suis</i> reveals unique ORFs and candidate host-specificity factors Open
Chlamydia suis, a ubiquitous swine pathogen, has the potential for zoonotic transmission to humans and often encodes for resistance to the primary treatment antibiotic, tetracycline. Because of this emerging threat, comparative genomics fo…
View article: Structural and ligand binding analyses of the periplasmic sensor domain of RsbU in <i>Chlamydia trachomatis</i> support a role in TCA cycle regulation
Structural and ligand binding analyses of the periplasmic sensor domain of RsbU in <i>Chlamydia trachomatis</i> support a role in TCA cycle regulation Open
Summary Chlamydia trachomatis is an obligate intracellular bacteria that undergo dynamic morphologic and physiologic conversions upon gaining an access to a eukaryotic cell. These conversions likely require the detection of key environment…
View article: Chromosomal Recombination Targets in <i>Chlamydia</i> Interspecies Lateral Gene Transfer
Chromosomal Recombination Targets in <i>Chlamydia</i> Interspecies Lateral Gene Transfer Open
Genome sequence analysis has demonstrated that there is widespread lateral gene transfer among strains within the species C. trachomatis and with other closely related Chlamydia species in laboratory experiments. This is in contrast to the…
View article: Development of Transposon Mutagenesis for Chlamydia muridarum
Development of Transposon Mutagenesis for Chlamydia muridarum Open
Historical issues with genetic manipulation of Chlamydia have prevented rigorous functional genetic characterization of the ∼1,000 genes in chlamydial genomes. Here, we report the development of a transposon mutagenesis system for C. murid…
View article: Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer
Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer Open
Chlamydia trachomatis infections have an immense impact on public health; however, understanding the basic biology and pathogenesis of this organism has been stalled by the limited repertoire of genetic tools. This report describes the suc…
View article: Comparative genomics of swine pathogen Chlamydia suis with human- and mouse-adapted Chlamydia spp
Comparative genomics of swine pathogen Chlamydia suis with human- and mouse-adapted Chlamydia spp Open
Background The phylum, Chlamydiae, contains a unique set of obligately intracellular bacteria with specific host ranges, despite high genomic relatedness between species. Chlamydia suis, a ubiquitous swine pathogen, has the potential for z…
View article: Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense
Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense Open
Obligate intracellular Chlamydia trachomatis replicate in a membrane-bound vacuole called inclusion, which serves as a signaling interface with the host cell. Here, we show that the chlamydial deubiquitinating enzyme (Cdu) 1 localizes in t…
View article: Demonstration of Persistent Infections and Genome Stability by Whole-Genome Sequencing of Repeat-Positive, Same-Serovar Chlamydia trachomatis Collected From the Female Genital Tract
Demonstration of Persistent Infections and Genome Stability by Whole-Genome Sequencing of Repeat-Positive, Same-Serovar Chlamydia trachomatis Collected From the Female Genital Tract Open
These data demonstrate examples of long-term persistence in patients in the face of repeated antibiotic therapy and show that pathogen mutational strategies are not important in persistence of this pathogen in patients.
View article: Author response: Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense
Author response: Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense Open
Full text Figures and data Side by side Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Obligate intracellular Chlamydia trachomatis …