Zoë Jamet
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View article: Positive Allosteric Modulation of NMDARs Prevents the Altered Surface Dynamics Caused by Patients' Antibodies
Positive Allosteric Modulation of NMDARs Prevents the Altered Surface Dynamics Caused by Patients' Antibodies Open
We demonstrate that SGE-301 upregulates NMDAR surface diffusion and antagonizes the pathogenic effects of patients' IgG on NMDAR membrane organization. These findings suggest a potential therapeutic strategy for NMDARe.
View article: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment
NMDA receptor autoantibodies primarily impair the extrasynaptic compartment Open
Autoantibodies directed against the N-methyl-D-aspartate receptor (NMDAR-Ab) are pathogenic immunoglobulins detected in patients suffering from NMDAR encephalitis. NMDAR-Ab alter the receptor membrane trafficking, synaptic transmission and…
View article: Molecular impact of anti-NMDA receptor autoantibodies
Molecular impact of anti-NMDA receptor autoantibodies Open
The N-methyl-D-aspartate receptor (NMDAR) plays a pivotal role in both health anddisease, serving as a crucial mediator of synaptic plasticity and memory while also being implicated invarious neurological and psychiatric disorders when dys…