Zoe Kolics
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View article: Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner
Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner Open
Advanced colorectal cancer (CRC) continues to present with poor survival and treatment options remain limited. We have shown that increased activin A (activin) expression in the tumor microenvironment (TME) is associated with poor outcome …
View article: Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis
Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis Open
Acute Pancreatitis (AP) is associated with high mortality and current treatment options are limited to supportive care. We found that blockade of activin A (activin) in mice improves outcomes in two murine models of AP. To test the hypothe…
View article: Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance
Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance Open
We have shown that activin A (activin), a TGF-β superfamily member, has pro-metastatic effects in colorectal cancer (CRC). In lung cancer, activin activates pro-metastatic pathways to enhance tumor cell survival and migration while augment…