Zoe M. Lyon
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View article: Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes
Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes Open
Rationale: Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as "hyperinflammatory" or "hypoinflammatory" de…
View article: A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Open
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes acro…
View article: A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Open
Summary Altered myeloid inflammation and lymphopenia are hallmarks of severe infections, including SARS-CoV-2. Here, we identified a gene program, defined by correlation with EN-RAGE ( S100A12 ) gene expression, which was up-regulated in p…
View article: Distinct respiratory tract biological pathways characterizing ARDS molecular phenotypes
Distinct respiratory tract biological pathways characterizing ARDS molecular phenotypes Open
Background Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as “hyperinflammatory” or “hypoinflammatory” depends o…
View article: Enabling patient communication for hospitalised patients during and beyond the COVID-19 pandemic
Enabling patient communication for hospitalised patients during and beyond the COVID-19 pandemic Open
As COVID-19 spread across the globe, hospitals restricted visitors to protect patients and healthcare providers.1 The absence of in-person visitors, who play a central role in patient well-being and clinical decision making by clarifying m…
View article: Rapid Implementation of a Volunteer-Run Service to Combat Social Isolation in Hospitalized Patients During the COVID-19 Pandemic
Rapid Implementation of a Volunteer-Run Service to Combat Social Isolation in Hospitalized Patients During the COVID-19 Pandemic Open
Lyon, Zoe M. BA; Yang, Rachel BSE; Savoie, Marissa B. BA; Schear, Sarah MS; Dong, Jessica MD, MBA; Javaherian, Kavon MD, MBA; Hauser, Karen MD, MPH; Sarkar, Urmimala MD, MPH; Garcia-Grossman, Ilana MD Author Information
View article: Effect of Financial Bonus Size, Loss Aversion, and Increased Social Pressure on Physician Pay-for-Performance
Effect of Financial Bonus Size, Loss Aversion, and Increased Social Pressure on Physician Pay-for-Performance Open
ClinicalTrials.gov Identifier: NCT02634879.
View article: Association of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extremity Joint Replacement Episodes
Association of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extremity Joint Replacement Episodes Open
In this observational study of Medicare beneficiaries who underwent LEJR, hospital participation in Bundled Payments for Care Improvement was not associated with changes in market-level lower extremity joint replacement volume and largely …
View article: Comparison Of Hospitals Participating In Medicare’s Voluntary And Mandatory Orthopedic Bundle Programs
Comparison Of Hospitals Participating In Medicare’s Voluntary And Mandatory Orthopedic Bundle Programs Open
We analyzed data from Medicare and the American Hospital Association Annual Survey to compare characteristics and baseline performance among hospitals in Medicare's voluntary (Bundled Payments for Care Improvement initiative, or BPCI) and …
View article: Characteristics of Hospitals Earning Savings in the First Year of Mandatory Bundled Payment for Hip and Knee Surgery
Characteristics of Hospitals Earning Savings in the First Year of Mandatory Bundled Payment for Hip and Knee Surgery Open
This study uses Medicare data to compare the characteristics of hospitals that did vs did not realize episodes savings under the Centers for Medicare & Medicaid Services’ Comprehensive Care for Joint Replacement program, which bundled paym…