Zoe R. Donaldson
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View article: Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens
Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens Open
Oxytocin (Oxtr) and dopamine (Drd1, Drd2) receptors provide a canonical example for how differences in neuromodulatory receptors drive individual and species-level behavioral variation. These systems exhibit striking and functionally relev…
View article: Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage
Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage Open
Prairie voles ( Microtus ochrogaster ) are a powerful model for studying the neurobiology of social bonding, yet tools for region- and cell type-specific gene regulation remain underdeveloped in this species. Here, we present a lentivirus-…
View article: Lentiviral CRISPRa/i in the adult Prairie Vole Brain: Modulating Neuronal Gene Expression Without DNA Cleavage
Lentiviral CRISPRa/i in the adult Prairie Vole Brain: Modulating Neuronal Gene Expression Without DNA Cleavage Open
Prairie voles ( Microtus ochrogaster ) are a powerful model for studying the neurobiology of social bonding, yet tools for region- and cell type-specific gene regulation remain underdeveloped in this species. Here, we present a lentivirus-…
View article: Exposure to novel females increases fecundity in adult male prairie voles
Exposure to novel females increases fecundity in adult male prairie voles Open
Social circuitry of the mammalian brain can influence male reproductive physiology. This often manifests as plasticity in sperm production or allocation, particularly in response to male-male competition. However, socially mediated testicu…
View article: The impact of locus coeruleus degeneration on pair bonding and other Alzheimer’s disease‐relevant phenotypes in monogamous prairie voles
The impact of locus coeruleus degeneration on pair bonding and other Alzheimer’s disease‐relevant phenotypes in monogamous prairie voles Open
Background Alzheimer’s disease (AD) fractures social relationships, extending the burden of disease beyond the affected individual and onto caregivers and loved ones. One brain region known to be crucial in regulating social behaviors is t…
View article: Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles
Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles Open
View article: Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles
Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles Open
Pair bonds powerfully modulate health, which becomes particularly important when facing the detrimental effects of aging. To examine the impact of aging on relationship formation and response to loss, we examined behavior in 6-, 12-, and 1…
View article: Larry J. Young (1967–2024)
Larry J. Young (1967–2024) Open
View article: Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner
Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner Open
Loss of a loved one is a painful event that substantially elevates the risk for physical and mental illness and impaired daily function. Socially monogamous prairie voles are laboratory‐amenable rodents that form life‐long pair bonds and e…
View article: Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships
Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships Open
As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexp…
View article: Nucleus accumbens dopamine release reflects the selective nature of pair bonds
Nucleus accumbens dopamine release reflects the selective nature of pair bonds Open
View article: Neurobiology and treatment advances for prolonged grief disorder
Neurobiology and treatment advances for prolonged grief disorder Open
View article: PhAT: A Flexible Open‐Source GUI‐Driven Toolkit for Photometry Analysis
PhAT: A Flexible Open‐Source GUI‐Driven Toolkit for Photometry Analysis Open
Photometry approaches detect sensor‐mediated changes in fluorescence as a proxy for rapid molecular changes within the brain. As a flexible technique with a relatively low cost to implement, photometry is rapidly being incorporated into ne…
View article: PhAT: A flexible open-source GUI-driven toolkit for photometry analysis
PhAT: A flexible open-source GUI-driven toolkit for photometry analysis Open
Photometry approaches detect sensor-mediated changes in fluorescence as a proxy for rapid molecular changes within the brain. As a flexible technique with a relatively low cost to implement, photometry is rapidly being incorporated into ne…
View article: Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles
Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles Open
The loss of a spouse is often cited as the most traumatic event in a person’s life. However, for most people, the severity of grief and its maladaptive effects subside over time via an understudied adaptive process. Like humans, socially m…
View article: Author response: Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles
Author response: Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The loss …
View article: Nucleus Accumbens Dopamine Release Reflects the Selective Nature of Pair Bonds
Nucleus Accumbens Dopamine Release Reflects the Selective Nature of Pair Bonds Open
View article: Nucleus accumbens dopamine release reflects the selective nature of pair bonds
Nucleus accumbens dopamine release reflects the selective nature of pair bonds Open
In monogamous species, prosocial behaviors directed towards partners are dramatically different from those directed towards unknown individuals and potential threats. Dopamine release in the nucleus accumbens plays an important role in gui…
View article: Prairie vole pair bonding and plasticity of the social brain
Prairie vole pair bonding and plasticity of the social brain Open
View article: Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors
Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors Open
View article: Sex differences in the reward value of familiar mates in prairie voles
Sex differences in the reward value of familiar mates in prairie voles Open
The rewarding properties of social interactions facilitate relationship formation and maintenance. Prairie voles are one of the few laboratory species that form selective relationships, manifested as “partner preferences” for familiar part…
View article: Emergent intra‐pair sex differences and organized behavior in pair bonded prairie voles (<i>Microtus ochrogaster</i>)
Emergent intra‐pair sex differences and organized behavior in pair bonded prairie voles (<i>Microtus ochrogaster</i>) Open
In pair bonding animals, coordinated behavior between partners is required for the pair to accomplish shared goals such as raising young. Despite this, experimental designs rarely assess the behavior of both partners within a bonded pair. …
View article: Emergent intra-pair sex differences and behavioral coordination in pair bonded prairie voles
Emergent intra-pair sex differences and behavioral coordination in pair bonded prairie voles Open
In pair bonding animals, coordinated behavior between partners is required for the pair to accomplish shared goals such as raising young. Despite this, experimental designs rarely assess the behavior of both partners within a bonded pair. …
View article: Sex differences in the reward value of familiar mates in prairie voles
Sex differences in the reward value of familiar mates in prairie voles Open
The rewarding properties of social interactions facilitate relationship formation and maintenance. Prairie voles are one of the few laboratory species that form selective relationships, manifested as “partner preferences” for familiar part…
View article: Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles
Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles Open
The loss of a spouse is often cited as the most traumatic event in a person’s life. However, for most people, the severity of grief and its maladaptive effects subside over time via an understudied adaptive process. Like humans, socially m…
View article: Wireless multilateral devices for optogenetic studies of individual and social behaviors
Wireless multilateral devices for optogenetic studies of individual and social behaviors Open
View article: Finding the one: what prairie voles can tell us about the drive to seek out our romantic partner
Finding the one: what prairie voles can tell us about the drive to seek out our romantic partner Open
Like us, monogamous prairie voles can form lifelong pair bonds. We asked how these long-term bonds change brain activity in brain regions associated with reward and motivation. We discovered a set of cells that are active when a vole appro…
View article: Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia
Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia Open
Pair bonds represent some of the strongest attachments we form as humans. These relationships positively modulate health and well-being. Conversely, the loss of a spouse is an emotionally painful event that leads to numerous deleterious ph…
View article: How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles
How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles Open
View article: How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles
How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles Open
Monogamous prairie voles ( Microtus ochrogaster ) form mating-based pair bonds. Although wild prairie voles rarely re-pair following loss of a partner, laboratory studies have shown that previous pairing and mating does not negate the abil…