Zachary Smith
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View article: A qualitative examination of the evolving role of sports technology in collegiate coaching
A qualitative examination of the evolving role of sports technology in collegiate coaching Open
Coaches play a central role in shaping athlete performance and development. In collegiate sports, coaches must balance competitive goals with the broader needs of student-athletes. As technology becomes more available in sports, it is beco…
View article: Consensus recommendations for the integration of critical care pharmacists on intensive care unit teams: Endorsed by the American Association of Critical‐Care Nurses, American College of Clinical Pharmacy, American Society of Health‐System Pharmacists, Institute for Safe Medication Practices, and Society of Critical Care Medicine
Consensus recommendations for the integration of critical care pharmacists on intensive care unit teams: Endorsed by the American Association of Critical‐Care Nurses, American College of Clinical Pharmacy, American Society of Health‐System Pharmacists, Institute for Safe Medication Practices, and Society of Critical Care Medicine Open
The care of critically ill patients requires an interprofessional team. Critical care pharmacists are essential members of that interprofessional team. The purpose of these Consensus Recommendations is to present standards and guidance for…
View article: Room-Temperature Sputtered Cerium-Doped Indium Oxide Transparent Conducting Electrodes for Bifacial Perovskite Solar Cells: Albedo Utilization and Perovskite/Silicon Tandems
Room-Temperature Sputtered Cerium-Doped Indium Oxide Transparent Conducting Electrodes for Bifacial Perovskite Solar Cells: Albedo Utilization and Perovskite/Silicon Tandems Open
Bifacial perovskite solar cells (PSCs) offer the potential for higher power output through tandem configurations with silicon solar cells or by harvesting light from both sides. A high-transmittance and low-resistance transparent electrode…
View article: Non-invasive Assessment of Coronary Artery Disease: The Role of AI in the Current Status and Future Directions
Non-invasive Assessment of Coronary Artery Disease: The Role of AI in the Current Status and Future Directions Open
Coronary artery disease (CAD) remains a significant public health concern due to its high morbidity and mortality rates. Early detection and timely evaluation are crucial for improving patient outcomes. While both invasive and non-invasive…
View article: Evaluation of Alcohol Withdrawal Assessment in Mechanically Ventilated Patients in the Trauma/Surgical Intensive Care Unit
Evaluation of Alcohol Withdrawal Assessment in Mechanically Ventilated Patients in the Trauma/Surgical Intensive Care Unit Open
View article: Effectiveness of Bivalent mRNA Vaccines in Preventing Symptomatic SARS‐CoV‐2 Infection—Increasing Community Access to Testing Program, United States, January–September 2023
Effectiveness of Bivalent mRNA Vaccines in Preventing Symptomatic SARS‐CoV‐2 Infection—Increasing Community Access to Testing Program, United States, January–September 2023 Open
Background On September 2, 2022, bivalent COVID‐19 mRNA vaccines, were recommended to address reduced effectiveness of COVID‐19 monovalent vaccines during SARS‐CoV‐2 Omicron variant predominance. Methods Using national pharmacy‐based SARS‐…
View article: Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Open
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many di…
View article: Engineering Education in Support of Urban Gardening
Engineering Education in Support of Urban Gardening Open
University engineering programs can complement urban gardening spaces through reciprocal support. These urban gardens serve the communities they host in numerous ways, yet university engineering programs in garden contexts are often predom…
View article: Early Estimates of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccine Effectiveness Against Symptomatic SARS-CoV-2 Infection Attributable to Co-Circulating Omicron Variants Among Immunocompetent Adults — Increasing Community Access to Testing Program, United States, September 2023–January 2024
Early Estimates of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccine Effectiveness Against Symptomatic SARS-CoV-2 Infection Attributable to Co-Circulating Omicron Variants Among Immunocompetent Adults — Increasing Community Access to Testing Program, United States, September 2023–January 2024 Open
On September 12, 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (updated) COVID-19 vaccination with a monovalent XBB.1.5-derived vaccine for all persons aged ≥6 months to prevent COVID-19, including …
View article: Quantification of observable behaviors following oral administration of oxycodone and nalfurafine in male rhesus monkeys
Quantification of observable behaviors following oral administration of oxycodone and nalfurafine in male rhesus monkeys Open
View article: Density functional theory investigation of mechanisms of degradation reactions of sulfonated PEEK membranes with OH radicals in fuel cells: addition–elimination reactions and acid catalyzed water elimination
Density functional theory investigation of mechanisms of degradation reactions of sulfonated PEEK membranes with OH radicals in fuel cells: addition–elimination reactions and acid catalyzed water elimination Open
Sulfonated polyether (ether) ketone or sulfonated PEEK (sPEEK) membranes are one possible candidate for proton-transfer membranes in hydrogen fuel cells. Reaction with hydroxy radicals is expected to be a significant source of degradation …
View article: Effectiveness of Booster Doses of Monovalent mRNA COVID-19 Vaccine Against Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children, Adolescents, and Adults During Omicron Subvariant BA.2/BA.2.12.1 and BA.4/BA.5 Predominant Periods
Effectiveness of Booster Doses of Monovalent mRNA COVID-19 Vaccine Against Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children, Adolescents, and Adults During Omicron Subvariant BA.2/BA.2.12.1 and BA.4/BA.5 Predominant Periods Open
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2/BA.2.12.1 and BA.4/BA.5 subvariants have mutations associated with increased capacity to evade immunity when compared with prior variants. We evaluated mRNA m…
View article: Preliminary Estimates of Effectiveness of Monovalent mRNA Vaccines in Preventing Symptomatic SARS-CoV-2 Infection Among Children Aged 3–5 Years — Increasing Community Access to Testing Program, United States, July 2022–February 2023
Preliminary Estimates of Effectiveness of Monovalent mRNA Vaccines in Preventing Symptomatic SARS-CoV-2 Infection Among Children Aged 3–5 Years — Increasing Community Access to Testing Program, United States, July 2022–February 2023 Open
On June 18, 2022, the Advisory Committee on Immunization Practices (ACIP) issued interim recommendations for use of the 2-dose monovalent Moderna COVID-19 vaccine as a primary series for children aged 6 months-5 years* and the 3-dose monov…
View article: Glutathione supports lipid abundance<i>in vivo</i>
Glutathione supports lipid abundance<i>in vivo</i> Open
SUMMARY Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in…
View article: Density functional theory investigation of mechanisms of degradation reactions of sulfonated PEEK membranes with OH radicals in fuel cells: Addition-elimination reactions and acid catalyzed water elimination
Density functional theory investigation of mechanisms of degradation reactions of sulfonated PEEK membranes with OH radicals in fuel cells: Addition-elimination reactions and acid catalyzed water elimination Open
Sulfonated polyether (ether) ketone, or sulfonated PEEK (sPEEK) membranes are one possible candidate for proton-transfer membranes in hydrogen fuel cells. Reaction with hydroxy radicals is expected to be a significant source of degradation…
View article: Early Estimates of Bivalent mRNA Booster Dose Vaccine Effectiveness in Preventing Symptomatic SARS-CoV-2 Infection Attributable to Omicron BA.5– and XBB/XBB.1.5–Related Sublineages Among Immunocompetent Adults — Increasing Community Access to Testing Program, United States, December 2022–January 2023
Early Estimates of Bivalent mRNA Booster Dose Vaccine Effectiveness in Preventing Symptomatic SARS-CoV-2 Infection Attributable to Omicron BA.5– and XBB/XBB.1.5–Related Sublineages Among Immunocompetent Adults — Increasing Community Access to Testing Program, United States, December 2022–January 2023 Open
The SARS-CoV-2 Omicron sublineage XBB was first detected in the United States in August 2022.* XBB together with a sublineage, XBB.1.5, accounted for >50% of sequenced lineages in the Northeast by December 31, 2022, and 52% of sequenced li…
View article: Spike Gene Target Amplification in a Diagnostic Assay as a Marker for Public Health Monitoring of Emerging SARS-CoV-2 Variants — United States, November 2021–January 2023
Spike Gene Target Amplification in a Diagnostic Assay as a Marker for Public Health Monitoring of Emerging SARS-CoV-2 Variants — United States, November 2021–January 2023 Open
Monitoring emerging SARS-CoV-2 lineages and their epidemiologic characteristics helps to inform public health decisions regarding vaccine policy, the use of therapeutics, and health care capacity. When the SARS-CoV-2 Alpha variant emerged …
View article: Effectiveness of Bivalent mRNA Vaccines in Preventing Symptomatic SARS-CoV-2 Infection — Increasing Community Access to Testing Program, United States, September–November 2022
Effectiveness of Bivalent mRNA Vaccines in Preventing Symptomatic SARS-CoV-2 Infection — Increasing Community Access to Testing Program, United States, September–November 2022 Open
On September 1, 2022, bivalent COVID-19 mRNA vaccines, composed of components from the SARS-CoV-2 ancestral and Omicron BA.4/BA.5 strains, were recommended by the Advisory Committee on Immunization Practices (ACIP) to address reduced effec…
View article: Impact of Pharmacists to Improve Patient Care in the Critically Ill: A Large Multicenter Analysis Using Meaningful Metrics With the Medication Regimen Complexity-ICU (MRC-ICU) Score*
Impact of Pharmacists to Improve Patient Care in the Critically Ill: A Large Multicenter Analysis Using Meaningful Metrics With the Medication Regimen Complexity-ICU (MRC-ICU) Score* Open
OBJECTIVES: Despite the established role of the critical care pharmacist on the ICU multiprofessional team, critical care pharmacist workloads are likely not optimized in the ICU. Medication regimen complexity (as measured by the Medicatio…
View article: Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron
Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron Open
Effectiveness of Homologous and Heterologous Covid-19 Boosters against OmicronTo the Editor: For persons who received a single dose of the Ad26.COV2.S vaccine (Johnson & Johnson-Janssen) against coronavirus disease 2019 (Covid-19), a boost…
View article: Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection in Children and Adolescents During Omicron Predominance
Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection in Children and Adolescents During Omicron Predominance Open
Among children and adolescents, estimated VE for 2 doses of BNT162b2 against symptomatic infection was modest and decreased rapidly. Among adolescents, the estimated effectiveness increased after a booster dose.
View article: Association of COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection by Time Since Vaccination and Delta Variant Predominance
Association of COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection by Time Since Vaccination and Delta Variant Predominance Open
Among adults, the OR for the association between symptomatic SARS-CoV-2 infection and COVID-19 vaccination (as an estimate of vaccine effectiveness) was higher during Delta variant predominance, suggesting lower protection. For mRNA vaccin…
View article: Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants
Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants Open
Among individuals seeking testing for COVID-like illness in the US in December 2021, receipt of 3 doses of mRNA COVID-19 vaccine (compared with unvaccinated and with receipt of 2 doses) was less likely among cases with symptomatic SARS-CoV…
View article: Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation Open
Background Chromatin state provides a clear decipherable blueprint for maintenance of transcriptional patterns, exemplifying a mitotically stable form of cellular programming in dividing cells. In this regard, genomic studies of chromatin …
View article: Low- Versus High-Dose Methylprednisolone in Adult Patients With Coronavirus Disease 2019: Less Is More
Low- Versus High-Dose Methylprednisolone in Adult Patients With Coronavirus Disease 2019: Less Is More Open
Background Corticosteroids use in severe coronavirus disease 2019 (COVID-19) improves survival; however, the optimal dose is not established. We aim to evaluate clinical outcomes in patients with severe COVID-19 receiving high-dose cortico…
View article: 497. Moderate Versus High Dose Corticosteroids in Adult Patients with Severe COVID-19: Less Is More
497. Moderate Versus High Dose Corticosteroids in Adult Patients with Severe COVID-19: Less Is More Open
Background The early administration of corticosteroids (CS) in patients with severe COVID-19 (hospitalized with need for supplemental oxygen) has been the only therapy to improve survival. However, the optimal dosing of CS remains unclear.…
View article: A CASE OF DEXMEDETOMIDINE-INDUCED DRUG FEVER: AN IMPORTANT AND PRESS-EDEX-ING ISSUE
A CASE OF DEXMEDETOMIDINE-INDUCED DRUG FEVER: AN IMPORTANT AND PRESS-EDEX-ING ISSUE Open
View article: Serious illness conversations in pulmonary hypertension
Serious illness conversations in pulmonary hypertension Open
Pulmonary arterial hypertension has evolved from a fatal disease with few treatment options to a chronic condition with improved survival. This improvement is possible through development of effective therapies as well as the expansion of …
View article: Table of Contents
Table of Contents Open
View article: Telehealth follow up in emergency department patients discharged with COVID-like illness and exertional hypoxia
Telehealth follow up in emergency department patients discharged with COVID-like illness and exertional hypoxia Open