Zoe C. Yeoh
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View article: The Structural and Biochemical Role of ZAP and Binding Partners KHNYN and TRIM25 in the Antiviral Response to CpG-replete RNA
The Structural and Biochemical Role of ZAP and Binding Partners KHNYN and TRIM25 in the Antiviral Response to CpG-replete RNA Open
The human genome is CpG-suppressed due to the methylation and subsequent deamination of cytosines to thymines in open chromatin, leading to the conversion of the complementary nucleotide to an adenine by DNA repair pathways. During a viral…
View article: A minimal complex of KHNYN and zinc-finger antiviral protein binds and degrades single-stranded RNA
A minimal complex of KHNYN and zinc-finger antiviral protein binds and degrades single-stranded RNA Open
Detecting viral infection is a key role of the innate immune system. The genomes of some RNA viruses have a high CpG dinucleotide content relative to most vertebrate cell RNAs, making CpGs a molecular marker of infection. The human zinc-fi…
View article: Expanding the HDAC druggable landscape beyond enzymatic activity
Expanding the HDAC druggable landscape beyond enzymatic activity Open
Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity and high toxicity due to targeting multiple enzyme paralog…
View article: A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer
A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer Open
Dysregulated Wnt/β-catenin signaling is implicated in the pathogenesis of many human cancers, including colorectal cancer (CRC), making it an attractive clinical target. With the aim of inhibiting oncogenic Wnt activity, we developed a hig…
View article: NMR chemical shift assignments of RNA oligonucleotides to expand the RNA chemical shift database
NMR chemical shift assignments of RNA oligonucleotides to expand the RNA chemical shift database Open
RNAs play myriad functional and regulatory roles in the cell. Despite their significance, three-dimensional structure elucidation of RNA molecules lags significantly behind that of proteins. NMR-based studies are often rate-limited by the …
View article: Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival Open
Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal axons where they undergo local translation. However, the mechanism that enables lon…
View article: Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration
Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration Open
Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal axons where they undergo local translation. However, the mechanism that enables lon…