Zoltán Péterfi
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View article: Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala
Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala Open
The basolateral amygdala is a cortical structure involved in various cognitive functions. Despite numerous studies on amygdala operation, the properties of its excitatory principal neurons (PNs) are not fully characterized. Here, we combin…
View article: Distinct Gut Microbiota Profiles in Unruptured and Ruptured Intracranial Aneurysms: Focus on Butyrate-Producing Bacteria
Distinct Gut Microbiota Profiles in Unruptured and Ruptured Intracranial Aneurysms: Focus on Butyrate-Producing Bacteria Open
Background: Gut microbiome composition may influence the risk of intracranial aneurysm rupture. Methods: This study analyzed the gut microbiota of 48 patients—24 with ruptured aneurysms (RA) and 24 with unruptured intracranial aneurysms (U…
View article: Effects of Aneurysmal Subarachnoid Hemorrhage in Patients Without In-Hospital Infection on FABP-I, LBP, and sCD-14
Effects of Aneurysmal Subarachnoid Hemorrhage in Patients Without In-Hospital Infection on FABP-I, LBP, and sCD-14 Open
Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition complicated by delayed cerebral ischemia (DCI), where inflammation plays a key role. Although altered gut permeability is noted in other conditions, its significance in aSAH …
View article: Concomitant virus infection increases mortality and worsens outcome of acute pancreatitis: A systematic review and meta-analysis
Concomitant virus infection increases mortality and worsens outcome of acute pancreatitis: A systematic review and meta-analysis Open
View article: A meningoencephalitis outbreak associated with echovirus type 18 (E18) in south-western Hungary in mid-2023
A meningoencephalitis outbreak associated with echovirus type 18 (E18) in south-western Hungary in mid-2023 Open
View article: Confirmed Case of Autochthonous Human Babesiosis, Hungary
Confirmed Case of Autochthonous Human Babesiosis, Hungary Open
We report a case of autochthonous human babesiosis in Hungary, confirmed by PCR and partial sequencing of the Babesia spp. 18S rRNA gene. Babesiosis should be considered during the differential diagnosis of febrile illnesses, and periphera…
View article: Pszichiátriai osztályon diagnosztizált, AIDS talaján kialakult progresszív multifokális leukoencephalopathia
Pszichiátriai osztályon diagnosztizált, AIDS talaján kialakult progresszív multifokális leukoencephalopathia Open
A progresszív multifokális leukoencephalopathiát a John Cunningham-vírus reaktiválódása okozza, amely szinte kizárólag immunhiányos betegeknél fordul elő. A betegség tüneteit elsősorban a demyelinisatiós gócok lokalizációja határozza meg; …
View article: Encapsulation protocol for fecal microbiota transplantation
Encapsulation protocol for fecal microbiota transplantation Open
Introduction Clostridioides difficile infections (CDI) continue to pose a challenge for clinicians. Fecal microbiota transplantation (FMT) is an effective treatment option in CDI. Furthermore, recent and ongoing studies suggest potential b…
View article: A mikrobiom és a kardiovaszkuláris egészség
A mikrobiom és a kardiovaszkuláris egészség Open
A bél mikrobiom fontos szerepet játszik számos betegség kialakulásában vagy annak progressziójában. Egy kevésbé ismert terület a kardiovaszkuláris rendszer betegségei és a mikrobiom közötti kapcsolat, a bél–szív tengely és ateroszklerózis …
View article: Referee report. For: Lyophilized fecal microbiome transfer for primary Clostridioides difficile infection: a multicenter randomized controlled trial (DONATE Study) [version 1; peer review: 1 approved with reservations]
Referee report. For: Lyophilized fecal microbiome transfer for primary Clostridioides difficile infection: a multicenter randomized controlled trial (DONATE Study) [version 1; peer review: 1 approved with reservations] Open
View article: Diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala
Diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala Open
The basolateral amygdala is a non-layered cortical structure playing a role in various cognitive processes. Despite many studies focusing on local information processing within the circuits of the basolateral amygdala, the characteristics …
View article: The Role of the Intestinal Microbiome in Multiple Sclerosis—Lessons to Be Learned from Hippocrates
The Role of the Intestinal Microbiome in Multiple Sclerosis—Lessons to Be Learned from Hippocrates Open
Based on recent advances in research of chronic inflammatory conditions, there is a growing body of evidence that suggests a close correlation between the microbiota of the gastrointestinal tract and the physiologic activity of the immune …
View article: Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex Open
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by disti…
View article: Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation
Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation Open
Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which devel…
View article: Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia
Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia Open
Az epehólyag és az epeutak betegségei a leggyakrabban előforduló tápcsatornai kórképek közé tartoznak a fejlett országokban. Az epehólyag, illetve az epeutak heveny gyulladása potenciálisan súlyos, akár életet veszélyeztető állapot, melyne…
View article: Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer
Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer Open
Background and aims Faecal microbiota transfer (FMT) has managed to earn its place in the Clostridioides difficile infection (CDI) guidelines by having comparable efficacy and recurrence rate of fidaxomicin. After more than 100 successful …
View article: Adverse Reactions after Booster SARS-CoV-2 Vaccination Have Less Impact on Antibody Response than after Basic Vaccination Scheme
Adverse Reactions after Booster SARS-CoV-2 Vaccination Have Less Impact on Antibody Response than after Basic Vaccination Scheme Open
Background: It is known that adverse reactions following SARS-CoV-2 vaccinations show a positive correlation with the subsequent antibody titer. However, it is not clear how the adverse reactions following the booster vaccination are relat…
View article: Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial
Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial Open
View article: Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex Open
Neocortical layer 1 (L1) is a site of convergence between pyramidal neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by disti…
View article: A hepatitis C-vírus szűrésének és kezelésének 10 éves tapasztalata a börtönökben
A hepatitis C-vírus szűrésének és kezelésének 10 éves tapasztalata a börtönökben Open
Bevezetés és célkitűzés: Az Európai Unióban a hepatitis C-vírussal (HCV) fertőzött betegek kétharmada nem tud a fertőzöttségéről. A WHO célja 2030-ra az új krónikus hepatitises esetek számának 90%-os csökkentése. A börtönökben a HCV-fertőz…
View article: Hepatitis C Screening and Treatment Program in Hungarian Prisons in the Era of Direct Acting Antiviral Agents
Hepatitis C Screening and Treatment Program in Hungarian Prisons in the Era of Direct Acting Antiviral Agents Open
A hepatitis C virus (HCV) screening and treatment program was conducted in Hungarian prisons on a voluntary basis. After HCV-RNA testing and genotyping for anti-HCV positives, treatments with direct-acting antiviral agents were commenced b…
View article: Efficacy and Safety of Baricitinib for the Treatment of Hospitalized Adults with Severe or Critical COVID-19 (Bari-SolidAct): A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Trial
Efficacy and Safety of Baricitinib for the Treatment of Hospitalized Adults with Severe or Critical COVID-19 (Bari-SolidAct): A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Trial Open
View article: Inflammatory Biomarkers Are Inaccurate Indicators of Bacterial Infection on Admission in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease—A Systematic Review and Diagnostic Accuracy Network Meta-Analysis
Inflammatory Biomarkers Are Inaccurate Indicators of Bacterial Infection on Admission in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease—A Systematic Review and Diagnostic Accuracy Network Meta-Analysis Open
Introduction: The value of inflammatory biomarkers in the diagnosis of bacterial infection induced acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is currently unclear. Our objective was to investigate the diagnostic a…
View article: Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms
Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms Open
Background: Post-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the…
View article: How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods
How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods Open
Purpose Metronidazol and vancomycin were long the two best options against Clostridioides (formerly Clostridium ) difficile infections (CDI). Now, the cost of new drugs such as fidaxomicin directs us towards alternative treatment options, …
View article: Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis Open
With repeated positivity being an undiscovered and major concern, we aimed to evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patient…
View article: Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases
Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases Open
Repeated positivity and reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a significant concern. Our study aimed to evaluate the clinical significance of repeatedly positive testing after coronavirus disease …
View article: Fecal Microbiota Transplantation May Be the Best Option in Treating Multiple Clostridioides difficile Infection: A Network Meta-Analysis
Fecal Microbiota Transplantation May Be the Best Option in Treating Multiple Clostridioides difficile Infection: A Network Meta-Analysis Open
Vancomycin + FMT is perhaps the most effective option for the treatment and prevention of mrCDI, while tolevamer is also effective in preventing recurrence.
View article: Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial
Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial Open
View article: Personalised health education against health damage of COVID-19 epidemic in the elderly hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial.
Personalised health education against health damage of COVID-19 epidemic in the elderly hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial. Open
Background: Early reports indicate that COVID-19 may require intensive care unit (ICU) admission in 5-26% and overall mortality can rise to 11% of the recognized cases, particularly affecting the elderly. There is a lack of evidence-based …