Zongwu Lin
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View article: Machine learning-based definition of cellular senescence reveals pro-senescence potential implication in lung adenocarcinoma
Machine learning-based definition of cellular senescence reveals pro-senescence potential implication in lung adenocarcinoma Open
Despite growing evidence implicating cellular senescence in tumor progression, methodological challenges in objectively quantifying senescent cell burden across cancer types continue to limit mechanistic studies and clinical translation. T…
View article: FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling
FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling Open
This study provides the first comprehensive characterization of FGFR genomic alterations in CRC through large-scale profiling (n = 7606), establishing FGFR1 amplification as the predominant alteration. Unlike FGFR2/3-driven malignancies, F…
View article: Survival benefit of surgery vs radiotherapy alone to patients with stage IA lung adenocarcinoma: a propensity score-matched analysis
Survival benefit of surgery vs radiotherapy alone to patients with stage IA lung adenocarcinoma: a propensity score-matched analysis Open
View article: Analysis of the Clinicopathological Characteristics, Genetic Phenotypes, and Prognostics of Primary Pulmonary and Bronchial Adenoid Cystic Carcinoma
Analysis of the Clinicopathological Characteristics, Genetic Phenotypes, and Prognostics of Primary Pulmonary and Bronchial Adenoid Cystic Carcinoma Open
Background Primary pulmonary and bronchial adenoid cystic carcinoma (PACC) is a rare, low‐grade malignant tumor of the lung. However, the relationship between its clinical features, surgical prognosis, and genetic phenotype has not been fu…
View article: Author response: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Author response: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
View article: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy and immunoth…
View article: Author response: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Author response: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
View article: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Background Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy a…
View article: The efficacy and assessment value of the level of thyroglobulin wash-out after fine-needle aspiration cytodiagnosis in the evaluation of lymph node metastasis in papillary thyroid carcinoma
The efficacy and assessment value of the level of thyroglobulin wash-out after fine-needle aspiration cytodiagnosis in the evaluation of lymph node metastasis in papillary thyroid carcinoma Open
Objective The purpose of this study was to evaluate the efficacy and clinical value of US, FNAC,FNA-Tg and FNAC + FNA-Tg, as well as the cutoff values of FNA-Tg to evaluate LN metastasis. Methods We analyzed the diagnostic value of differe…
View article: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy and immunoth…
View article: Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Neoadjuvant chemotherapy has emerged as a significant therapeutic approach in the management of lung cancer, aiming to improve outcomes through preoperative systemic treatment. However, the mechanisms underlying treatment efficacy and resi…
View article: Reviewer #2 (Public Review): Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Reviewer #2 (Public Review): Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Neoadjuvant chemotherapy has emerged as a significant therapeutic approach in the management of lung cancer, aiming to improve outcomes through preoperative systemic treatment. However, the mechanisms underlying treatment efficacy and resi…
View article: Reviewer #1 (Public Review): Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Reviewer #1 (Public Review): Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Neoadjuvant chemotherapy has emerged as a significant therapeutic approach in the management of lung cancer, aiming to improve outcomes through preoperative systemic treatment. However, the mechanisms underlying treatment efficacy and resi…
View article: IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma
IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma Open
View article: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Background Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy a…
View article: Correction to: The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
Correction to: The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data Open
View article: Survival benefit of surgery versus radiotherapy alone to patients with stage IA lung adenocarcinoma: a propensity score-matched analysis
Survival benefit of surgery versus radiotherapy alone to patients with stage IA lung adenocarcinoma: a propensity score-matched analysis Open
Objective: We compared the overall survival（OS） and cancer-specific survival(CSS) of patients who received radiotherapy and surgery respectively in a large population Methods: In this study, we counted the patients diagnosed with stage IA …
View article: The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data Open
Background Neoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not benefit. Therefore, it is important to screen patients suitable for NACT. Methods Single-cell …
View article: Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma <i>via</i> transcriptional activation of cytochrome P450 oxidoreductase
Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma <i>via</i> transcriptional activation of cytochrome P450 oxidoreductase Open
Background Lung adenocarcinoma is one of the most prevalent cancers while ferroptosis is crucial for cancer therapies. This study aims to investigate the function and mechanism of hepatic nuclear factor 4 alpha (HNF4A) in lung adenocarcino…
View article: The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data Open
Background Neoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not benefit. Therefore, it is important to screen patients suitable for NACT. Methods Single-cell …
View article: Survival Benefit of Surgery Versus Radiotherapy Alone to Patients with Stage IA Lung Adenocarcinoma: A Propensity Score-Matched Analysis
Survival Benefit of Surgery Versus Radiotherapy Alone to Patients with Stage IA Lung Adenocarcinoma: A Propensity Score-Matched Analysis Open
View article: CUX2/KDM5B/SOX17 Axis Affects the Occurrence and Development of Breast Cancer
CUX2/KDM5B/SOX17 Axis Affects the Occurrence and Development of Breast Cancer Open
Objective Abnormal expression of CUT-like homeobox 2 gene (CUX2) has been highlighted as potential clinical biomarkers in human cancers. Notably, the function of CUX2 has been less elucidated in breast cancer (BC). We focused on the role o…
View article: Cisplatin resistance-related multi-omics differences and the establishment of machine learning models
Cisplatin resistance-related multi-omics differences and the establishment of machine learning models Open
Objectives Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding of the causes of resistance to cisplatin, especially in lung adenocarcinoma (LUAD) and…
View article: LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma
LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma Open
Background: Lung adenocarcinoma (LUAD), the major subtype of lung cancer, is among the leading cause of cancer-related death worldwide. Energy-related metabolic reprogramming metabolism is a hallmark of cancer shared by numerous can…
View article: HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer
HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer Open
View article: Metformin inhibits human non-small cell lung cancer by regulating AMPK–CEBPB–PDL1 signaling pathway
Metformin inhibits human non-small cell lung cancer by regulating AMPK–CEBPB–PDL1 signaling pathway Open
View article: The clinical prognostic factors of patients with stage IB lung adenocarcinoma
The clinical prognostic factors of patients with stage IB lung adenocarcinoma Open
Age, sex, race, histological grade, surgery to the primary site, and tumor size combined with PL invasion were independent risk factors for stage IB ADC, based on which a nomogram was constructed to predict the prognosis.
View article: Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy
Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy Open
View article: Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation
Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation Open
Background Differences in genetics and microenvironment of LUAD patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new concepts for the treatme…
View article: Differences in Genetics and Microenvironment of Lung Adenocarcinoma Patients with or without TP53 Mutation
Differences in Genetics and Microenvironment of Lung Adenocarcinoma Patients with or without TP53 Mutation Open
Background: Differences in genetics and microenvironment of lung adenocarcinoma (LUAD) patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new c…