Zongchao Liu
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View article: Proteomic profiling and scRNA sequencing identify signatures associated with Helicobacter pylori infection and risk of developing gastric cancer
Proteomic profiling and scRNA sequencing identify signatures associated with Helicobacter pylori infection and risk of developing gastric cancer Open
Objective: The key molecular events signifying the Helicobacter pylori-induced gastric carcinogenesis process are largely unknown. Methods: Bulk tissue-proteomics profiling were leveraged across multi-stage gastric lesions from Linqu (n &#…
View article: Pathologic complete response after neoadjuvant therapy for resectable esophageal squamous cell carcinoma: Endoscopic characteristics and implications
Pathologic complete response after neoadjuvant therapy for resectable esophageal squamous cell carcinoma: Endoscopic characteristics and implications Open
This study aimed to identify endoscopic characteristics and develop predictive models for detecting a pathologic complete response (pCR) after neoadjuvant therapy in patients with esophageal squamous cell carcinoma (ESCC). This study enrol…
View article: Integrating genetics and transcriptomics to decipher susceptibility genes for risk stratification of gastric cancer and effect modification of Helicobacter pylori treatment
Integrating genetics and transcriptomics to decipher susceptibility genes for risk stratification of gastric cancer and effect modification of Helicobacter pylori treatment Open
Funders are listed in the Acknowledgement.
View article: Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study Open
Objective: Based on multistage metabolomic profiling and Mendelian randomization analyses, the current study identified plasma metabolites that predicted the risk of developing gastric cancer (GC) and determined whether key metabolite leve…
View article: Population structure of <i>Helicobacter pylori</i> and antibiotic resistance-associated variants in a high-risk area of gastric cancer
Population structure of <i>Helicobacter pylori</i> and antibiotic resistance-associated variants in a high-risk area of gastric cancer Open
The increasing antibiotic resistance of Helicobacter pylori has had a serious impact on gastric cancer prevention. Our study aimed to profile the genomic characteristics and explore variants associated with resistance in H. pylori strains …
View article: Integrative metabolomics and microbiomics analysis reveals distinctive microbiota‐metabolites interactions in gastric carcinogenesis
Integrative metabolomics and microbiomics analysis reveals distinctive microbiota‐metabolites interactions in gastric carcinogenesis Open
Gastric microbiota and metabolites may interact and play collaborative roles in the carcinogenesis process. This study aims to investigate differential metabolites and microbes, as well as the possible roles of microbe‐metabolite interacti…
View article: Bioinformatics-based discovery of biomarkers and immunoinflammatory infiltrates in hip fractures complicating deep vein thrombosis: A STROBE
Bioinformatics-based discovery of biomarkers and immunoinflammatory infiltrates in hip fractures complicating deep vein thrombosis: A STROBE Open
Deep vein thrombosis due to hip fracture is a normally concomitant symptom when fracture arrival at middle-aged and olderly people, but its molecular mechanism is still not well explained. We hypothesized that there are several key biomark…
View article: <i>Helicobacter pylori</i> Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer
<i>Helicobacter pylori</i> Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer Open
Importance Helicobacter pylori treatment and nutrition supplementation may protect against gastric cancer (GC), but whether the beneficial effects only apply to potential genetic subgroups and whether high genetic risk may be counteracted …
View article: Unraveling the pivotal role of cellular senescence genes in intervertebral disc degeneration: insights from bioinformatics analysis and experimental validation
Unraveling the pivotal role of cellular senescence genes in intervertebral disc degeneration: insights from bioinformatics analysis and experimental validation Open
Intervertebral disc degeneration (IVDD) is a complex age-related physiological change involving mainly cellular senescence (CS), inflammation, impaired tissue biomechanical function, and degradation of the extracellular matrix, and is a ma…
View article: Resveratrol Promotes Proliferation and Differentiation of Pre-osteoblast MC3T3-E1 cells by Preventing Apoptosis
Resveratrol Promotes Proliferation and Differentiation of Pre-osteoblast MC3T3-E1 cells by Preventing Apoptosis Open
The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of pre-osteoblastic MC3T3-E1 cells, laying the groundwork for the treatment of osteopor…
View article: A quasi‐experimental study on the effectiveness of a standardized comprehensive sexuality education curriculum for primary school students
A quasi‐experimental study on the effectiveness of a standardized comprehensive sexuality education curriculum for primary school students Open
Introduction Although the importance of sexuality education has been recognized, Chinese rural students have limited access to sexual and reproductive information. This study aims to evaluate the effectiveness of a standardized comprehensi…
View article: Bioinformatics-Based Discovery of Intervertebral Disc Degeneration Biomarkers and Immune- Inflammatory Infiltrates
Bioinformatics-Based Discovery of Intervertebral Disc Degeneration Biomarkers and Immune- Inflammatory Infiltrates Open
Intervertebral disc degeneration (IVDD) is a common chronic disease in orthopedics, and its molecular mechanisms are still not well explained. This study's objective was to bioinformatics-based discovery of IVDD biomarkers and immune- infl…
View article: Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions
Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions Open
In this study, a panel was established including differential metabolites, genera, and their interactions, which may help to discriminate high-risk subjects for progression from mild lesions to advanced precancerous lesions in short-term a…
View article: Epimedium/Icariin promotes angiogenesis through HIF-1 signaling pathway
Epimedium/Icariin promotes angiogenesis through HIF-1 signaling pathway Open
Objective , With the help of network pharmacology and in vitro studies, this study aims to understand the mechanism by which Epimedium/ Icariin (EPI/ICA) promote angiogenesis through the HIF-1 signaling pathway, laying the groundwork for t…
View article: Will the adjustment of insertional pedicle screw positions affect the risk of adjacent segment diseases biomechanically? An in-silico study
Will the adjustment of insertional pedicle screw positions affect the risk of adjacent segment diseases biomechanically? An in-silico study Open
Background The fixation-induced biomechanical deterioration will increase the risk of adjacent segment diseases (ASD) after lumbar interbody fusion with Bilateral pedicle screw (BPS) fixation. The accurate adjustment of insertional pedicle…
View article: Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate
Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate Open
The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of preosteoblastic MC3T3-E1, laying the groundwork for the treatment of osteoporosis (O…
View article: Resveratrol induces proliferation and differentiation of mouse preosteoblast MC3T3-E1 by promoting autophagy
Resveratrol induces proliferation and differentiation of mouse preosteoblast MC3T3-E1 by promoting autophagy Open
Background: The MC3T3-E1 mouse pre-osteoblast can grow and differentiate more rapidly when resveratrol is present, according to study. Uncertainty exists over whether resveratrol (The following grouping is represented as Res) regulates the…
View article: Health economic evaluation on population-based Helicobacter pylori eradication and endoscopic screening for gastric cancer prevention
Health economic evaluation on population-based Helicobacter pylori eradication and endoscopic screening for gastric cancer prevention Open
Gastric cancer is a global public health burden, nearly one million new cases are diagnosed per year worldwide, of which 44% of cases occur in China. The prognosis of gastric cancer varies remarkably by the stage of cancer, and most of the…
View article: An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration Open
Intervertebral disc degeneration (IVDD) is the pathological basis of disc herniation, spinal stenosis, and other related diseases, and the lower back pain it produces lays a heavy financial burden on individuals and society. Thus, it is es…
View article: Urine proteomic signatures predicting the progression from premalignancy to malignant gastric cancer
Urine proteomic signatures predicting the progression from premalignancy to malignant gastric cancer Open
Funders are listed in the Acknowledgement.
View article: Effects of <i>Helicobacter pylori</i> eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study
Effects of <i>Helicobacter pylori</i> eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study Open
OBJECTIVE: This study aimed at examining the alterations in metabolomic profiles caused by treatment of H. pylori infection, and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up af…
View article: Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study
Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study Open
Rationale: Gastric cancer (GC) is preceded by a stepwise progression of precancerous gastric lesions. Distinguishing individuals with precancerous gastric lesions that have progression potential to GC is an important need. Perturbated lipi…