Explanipedia

Preterm Birth and Malaria Susceptibility in Offspring of Uninfected Multigravid Women Open

Amadou Barry, Long Tran Dang, Youssoufa Sidibé, Djibrilla Issiaka, Santara Gaoussou , et al. · 2025

Importance Pregnancy malaria (PM) is associated with adverse pregnancy outcomes such as stillbirth, early neonatal death, preterm delivery (PTD), and low birthweight. PM also increases the risk of malaria infection in infants. However, it …

Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial Open

Jeff Skinner, Kassoum Kayentao, Aïssata Ongoïba, Sara A. Healy, Zonghui Hu , et al. · 2025

CIS43LS is a long-acting monoclonal antibody specific for the Plasmodium falciparum circumsporozoite protein expressed on sporozoites. We previously reported that CIS43LS is protective against P. falciparum infection as detected by thick b…

Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection Open

Myra Happe, Rebecca M. Lynch, Carl J. Fichtenbaum, Sonya L. Heath, Susan L. Koletar , et al. · 2025

BACKGROUNDHIV-1-specific broadly neutralizing monoclonal antibodies (bNAbs) have emerged as promising interventions with the potential to effectively treat and prevent HIV-1 infections. We conducted a phase I clinical trial evaluating the …

Causal Inference Over a Subpopulation: The Effect of Malaria Vaccine in Women During Pregnancy Open

Zonghui Hu, Dean Follmann · 2024

Preventing malaria during pregnancy is of critical importance, yet there are no approved malaria vaccines for pregnant women due to lack of efficacy results within this population. Conducting a randomized trial in pregnant women throughout…

Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria Open

Kassoum Kayentao, Aïssata Ongoïba, Anne C Preston, Sara A. Healy, Zonghui Hu , et al. · 2024

Subcutaneous administration of L9LS to children was protective against P. falciparum infection and clinical malaria over a period of 6 months. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov …

Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials Open

Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman , et al. · 2024

Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). We investigated the safety and immunogenicity of a heterologous prime-boost r…

A pseudo-response approach to constructing confidence intervals for the subset of patients expected to benefit from a new treatment Open

Wei Liu, Zhiwei Zhang, Zonghui Hu, Ping Xu, Calvin Cohen · 2024

In precision medicine, there is much interest in estimating the expected-to-benefit (EB) subset, i.e. the subset of patients who are expected to benefit from a new treatment based on a collection of baseline characteristics. There are many…

Protection from Malaria after Pre-Conception PfSPZ Vaccine Open

Halimatou Diawara, Sara A. Healy, Agnes Mwakingwe-Omari, Djibrilla Issiaka, Aye Diallo , et al. · 2024

433. Thromboinflammation in COVID-19 and association with death in patients on ECMO Open

Andrew P. Platt, Viviane Callier, Zonghui Hu, Seth Warner, Syndey R Stein , et al. · 2023

Background Critical illness in COVID-19 may require mechanical support with Extra-Corporeal Membrane Oxygenation (ECMO). Thromboinflammation, the interaction of thrombotic and inflammatory pathways, is seen in many conditions including sep…

Long-term persistence of transcriptionally active ‘defective’ HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy Open

Kanal Singh, Ven Natarajan, Robin Dewar, Adam Rupert, Yuden Badralmaa , et al. · 2023

Objectives: People with HIV-1 (PWH) on effective antiretroviral therapy (ART) continue to exhibit chronic systemic inflammation, immune activation, and persistent elevations in markers of HIV-1 infection [including HIV-DNA, cell-associated…

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial Open

Kirsten E. Lyke, Andrea A. Berry, Kaitlin Mason, Azza H. Idris, Mark O’Callahan , et al. · 2023

Winter Green Manure Decreases Subsoil Nitrate Accumulation and Increases N Use Efficiencies of Maize Production in North China Plain Open

Zonghui Hu, Zhao Qiu, Xinjian Zhang, Xiaoguang Ning, Hao Liang , et al. · 2023

Planting a deep-rooted green manure (GM) (more than 1.0 m depth) greatly improves soil fertility and reduces the loss of nutrients. However, few studies have examined the response of soil nitrogen (N) distribution in the soil profile and s…

Safety and Efficacy of a Monoclonal Antibody against Malaria in Mali Open

Kassoum Kayentao, Aïssata Ongoïba, Anne C Preston, Sara A. Healy, Safiatou Doumbo , et al. · 2022

CIS43LS was protective against P. falciparum infection over a 6-month malaria season in Mali without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT043291…

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria Open

Richard L Wu, Azza H. Idris, Nina M. Berkowitz, Myra Happe, Martin R. Gaudinski , et al. · 2022

In this small trial, L9LS administered intravenously or subcutaneously protected recipients against malaria after controlled infection, without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; …

High-throughput imaging of mRNA at the single-cell level in human primary immune cells Open

Manasi Gadkari, Jing Sun, Adrian Carcamo, Hugh Alessi, Zonghui Hu , et al. · 2022

Measurement of gene expression at the single-cell level has advanced the study of transcriptional regulation programs in healthy and disease states. In particular, single-cell approaches have shed light on the high level of transcriptional…

A mixture distribution approach for assessing genetic impact from twin study Open

Zonghui Hu, Pengfei Li, Dean Follmann, Jing Qin · 2022

It is challenging to evaluate the genetic impacts on a biologic feature and separate them from environmental impacts. This is usually achieved through twin studies by assessing the collective genetic impact defined by the differential corr…

Optimization of the CIS43LS Malarial Monoclonal Antibody and Protection Against Malaria Open

Kirsten E. Lyke, Andrea A. Berry, Kaitlin Mason, Azza A. Idris, Mark O’Callahan , et al. · 2022

A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques Open

Peng Zhang, Elisabeth Narayanan, Qingbo Liu, Yaroslav Tsybovsky, Kristin L. Boswell , et al. · 2021

Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial Open

Mahamadou S. Sissoko, Sara A. Healy, Abdoulaye Katilé, Irfan Zaidi, Zonghui Hu , et al. · 2021

Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration Open

So Gun Hong, Noriko Sato, Fanny Legrand, Manasi Gadkari, Michelle Makiya , et al. · 2020

Glucocorticoids are considered first-line therapy in a variety of eosinophilic disorders. They lead to a transient, profound decrease in circulating human eosinophils within hours of administration. The phenomenon of glucocorticoid-induced…

High-throughput imaging of mRNA at the single-cell level in human primary immune cells Open

Manasi Gadkari, Jing Sun, Adrian Carcamo, Hugh Alessi, Zonghui Hu , et al. · 2020

Measurement of gene expression at the single-cell level has led to important advances in the study of transcriptional regulation programs in healthy and disease states. In particular, single-cell gene expression approaches have shed light …

Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial Open

Martin R. Gaudinski, Katherine V. Houser, Nicole A. Doria‐Rose, Grace Chen, Ro Shauna Rothwell , et al. · 2019

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses Open

Luis M. Franco, Manasi Gadkari, Katherine Howe, Jing Sun, Lela Kardava , et al. · 2019

Glucocorticoids remain the most widely used immunosuppressive and anti-inflammatory drugs, yet substantial gaps exist in our understanding of glucocorticoid-mediated immunoregulation. To address this, we generated a pathway-level map of th…

Transcript- and protein-level analyses of the response of human eosinophils to glucocorticoids Open

Manasi Gadkari, Michelle Makiya, Fanny Legrand, Kindra Stokes, Thomas Brown , et al. · 2018

Temporal Trends of Biomarkers and Between-Biomarker Associations Open

Zonghui Hu · 2018

Summary We are interested in the temporal trends of biomarkers that are related to disease progression, especially the association between two temporal trends. When biological mechanisms are lacking, no parametric forms of the temporal tre…

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults Open

Martin R. Gaudinski, Emily E. Coates, Katherine V. Houser, Grace Chen, Galina V. Yamshchikov , et al. · 2018

ClinicalTrials.gov NCT02599896.

qPCR in human eosinophils after glucocorticoid exposure Open

Luis M. Franco, Michelle Makiya, Kindra Stokes, Fanny Legrand, Manasi Gadkari , et al. · 2018

Eosinophils were isolated from the peripheral blood of each of five human subjects. Purified eosinophils were then incubated for 4 hours, followed by exposure to dexamethasone (0.5 mcM) or vehicle (culture medium) for an additional 30, 60,…

qPCR in human eosinophils after glucocorticoid exposure Open

Luis M. Franco, Michelle Makiya, Kindra Stokes, Fanny Legrand, Manasi Gadkari , et al. · 2018

Eosinophils were isolated from the peripheral blood of each of five human subjects. Purified eosinophils were then incubated for 4 hours, followed by exposure to dexamethasone (0.5 mcM) or vehicle (culture medium) for an additional 30, 60,…

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials Open

Martin R. Gaudinski, Katherine V. Houser, Kaitlyn M. Morabito, Zonghui Hu, Galina V. Yamshchikov , et al. · 2017

An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial Open

Adam DeZure, Emily E. Coates, Zonghui Hu, Galina V. Yamshchikov, Kathryn L. Zephir , et al. · 2017

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