Zirui Wang
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View article: Correction: FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway
Correction: FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway Open
[This corrects the article DOI: 10.3389/fgene.2025.1514205.].
View article: Comparative Mitogenome Analysis of Colletotrichum Species Causing Anthracnose of Rubber Trees Unveils Distinct Species Complex-Specific Evolution Trajectories Within the Genus
Comparative Mitogenome Analysis of Colletotrichum Species Causing Anthracnose of Rubber Trees Unveils Distinct Species Complex-Specific Evolution Trajectories Within the Genus Open
Colletotrichum spp. are the causative agents of anthracnose of rubber trees, one of the most destructive diseases, resulting in substantial economic losses. To investigate the evolutionary characteristics of these pathogenic species, we fi…
View article: OpenVision 2: A Family of Generative Pretrained Visual Encoders for Multimodal Learning
OpenVision 2: A Family of Generative Pretrained Visual Encoders for Multimodal Learning Open
This paper provides a simplification on OpenVision's architecture and loss design for enhancing its training efficiency. Following the prior vision-language pretraining works CapPa and AIMv2, as well as modern multimodal designs like LLaVA…
View article: Analysis and comparison of the trends in burden of intracerebral hemorrhage in China from 1990 to 2021: results from the 2021 Global Burden of Disease Study
Analysis and comparison of the trends in burden of intracerebral hemorrhage in China from 1990 to 2021: results from the 2021 Global Burden of Disease Study Open
Objectives To analyze temporal trends in the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of intracerebral hemorrhage (ICH) in China from 1990 to 2021, and to evaluate risk factors and predict future trends.…
View article: Mitigation of multi-scale biases in cell-type deconvolution for spatially resolved transcriptomics using HarmoDecon
Mitigation of multi-scale biases in cell-type deconvolution for spatially resolved transcriptomics using HarmoDecon Open
Motivation The advent of spatially resolved transcriptomics (SRT) has revolutionized our understanding of tissue molecular microenvironments by enabling the study of gene expression in its spatial context. However, many SRT platforms lack …
View article: Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer
Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer Open
Luminal breast cancer (BC) with axillary lymph node (ALN) metastasis is typically treated with neoadjuvant chemotherapy (NAC). Theoretically, patients who achieve pathological lymph node complete response after NAC can be exempted from ALN…
View article: FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway
FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway Open
The pathogenesis and chemoresistance mechanisms of colon cancer (CC) are still unclear. Here, we find that a long non-coding RNA (lncRNA), FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1), is highly expressed in CC, which may be caused…
View article: The role of serum vitamins in mediating the effect of neurodegenerative diseases on subcortical brain volume
The role of serum vitamins in mediating the effect of neurodegenerative diseases on subcortical brain volume Open
These findings provide important insights into the effect sizes of vitamin D-mediated roles in AD and atrophy of subcortical structures. Interventions to increase serum vitamin D levels at a population level might attenuate damage to hippo…
View article: Network pharmacology approach to unveiling the mechanism of berberine in the amelioration of morphine tolerance.
Network pharmacology approach to unveiling the mechanism of berberine in the amelioration of morphine tolerance. Open
BBR, a key component of HLD, effectively suppressed microglial activation and neuro-inflammation by regulating the NF-κB and apoptosis signaling pathways, thereby delaying MT. This study offers a novel approach to enhance the clinical anal…
View article: OsPRDA1 Interacts With OsFSD2 To Promote Chloroplast Development by Regulating Chloroplast Gene Expression in Rice
OsPRDA1 Interacts With OsFSD2 To Promote Chloroplast Development by Regulating Chloroplast Gene Expression in Rice Open
View article: stDyer enables spatial domain clustering with dynamic graph embedding
stDyer enables spatial domain clustering with dynamic graph embedding Open
Spatially resolved transcriptomics (SRT) data provide critical insights into gene expression patterns within tissue contexts, necessitating effective methods for identifying spatial domains. We introduce stDyer, an end-to-end deep learning…
View article: Underlying mechanisms of high-carbohydrate diet-induced growth inhibition and metabolic dysregulation in grass carp (Ctenopharyngodon idella)
Underlying mechanisms of high-carbohydrate diet-induced growth inhibition and metabolic dysregulation in grass carp (Ctenopharyngodon idella) Open
View article: Somatostatin-14 Mitigates High-Fat Diet-Induced Lipid Metabolic Dysregulation in Swamp Eel (Monopterus Albus) Through Akt/Mtor-Mediated Coordination of Lipolytic and Lipogenic Flux
Somatostatin-14 Mitigates High-Fat Diet-Induced Lipid Metabolic Dysregulation in Swamp Eel (Monopterus Albus) Through Akt/Mtor-Mediated Coordination of Lipolytic and Lipogenic Flux Open
View article: Underlying mechanisms of high-carbohydrate diet-induced growth inhibition and metabolic dysregulation in grass carp (Ctenopharyngodon idella)
Underlying mechanisms of high-carbohydrate diet-induced growth inhibition and metabolic dysregulation in grass carp (Ctenopharyngodon idella) Open
View article: Multi-Scale Attention-Based Spectral Neural Network For Underwater Reverberation Suppression
Multi-Scale Attention-Based Spectral Neural Network For Underwater Reverberation Suppression Open
View article: Multi-system condition monitoring of marine engines: A unified deep learning framework introducing physical prior knowledge
Multi-system condition monitoring of marine engines: A unified deep learning framework introducing physical prior knowledge Open
Marine engines serve as the core components of marine propulsion system. However, in actual operation, it is impossible to accurately capture the internal operating state of the engine. This often results in delayed detection of combustion…
View article: SMAC-Hard: Enabling Mixed Opponent Strategy Script and Self-play on SMAC
SMAC-Hard: Enabling Mixed Opponent Strategy Script and Self-play on SMAC Open
The availability of challenging simulation environments is pivotal for advancing the field of Multi-Agent Reinforcement Learning (MARL). In cooperative MARL settings, the StarCraft Multi-Agent Challenge (SMAC) has gained prominence as a be…
View article: Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model
Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model Open
Background Motor impairments are the defining cardinal features of Parkinson's disease (PD), resulting from malfunction of the cortico‐basal ganglia circuit. Clinical data have demonstrated that electroacupuncture (EA) stimulation may bene…
View article: Improving Handwritten Text Recognition via 3D Attention and Multi-Scale Training
Improving Handwritten Text Recognition via 3D Attention and Multi-Scale Training Open
The segmentation-free research efforts for addressing handwritten text recognition can be divided into three categories: connectionist temporal classification (CTC), hidden Markov model and encoder-decoder methods. In this paper, inspired …
View article: Leveraging Structure Knowledge and Deep Models for the Detection of Abnormal Handwritten Text
Leveraging Structure Knowledge and Deep Models for the Detection of Abnormal Handwritten Text Open
Currently, the destruction of the sequence structure in handwritten text has become one of the main bottlenecks restricting the recognition task. The typical situations include additional specific markers (the text swapping modification) a…
View article: Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study
Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study Open
View article: Whole-liver histogram analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging for predicting progression in patients with cirrhosis
Whole-liver histogram analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging for predicting progression in patients with cirrhosis Open
Whole-liver histogram analysis of Gd-BOPTA-enhanced MRI may serve as a noninvasive analytical method to predict hepatic insufficiency in patients with cirrhosis.
View article: stDyer enables spatial domain clustering with dynamic graph embedding
stDyer enables spatial domain clustering with dynamic graph embedding Open
Spatially resolved transcriptomics (SRT) data provide critical insights into gene expression patterns within tissue contexts, necessitating effective methods for identifying spatial domains. Traditional clustering techniques often overlook…
View article: Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies
Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies Open
The UK Biobank (UKB) has the largest adult brain imaging dataset, which encompasses over 40,000 participants. A significant number of Mendelian randomization (MR) studies based on UKB neuroimaging data have been published to validate poten…
View article: Mandelonitrile lyase MDL2-mediated regulation of seed amygdalin and oil accumulation of Prunus Sibirica
Mandelonitrile lyase MDL2-mediated regulation of seed amygdalin and oil accumulation of Prunus Sibirica Open
Background The Prunus sibirica seeds with rich oils has great utilization, but contain amygdalin that can be hydrolyzed to release toxic HCN. Thus, how to effectively reduce seed amygdalin content of P. sibirica is an interesting question.…
View article: Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition
Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition Open
Spontaneous reversion from mild cognitive impairment (MCI) to normal cognition (NC) is little known. Based on the data of the Genetics of Personality Consortium and MCI participants from Alzheimer's Disease Neuroimaging Initiative, the aut…
View article: Study on partial load vortex and pressure pulsation characteristics of Francis turbine
Study on partial load vortex and pressure pulsation characteristics of Francis turbine Open
Under partial load condition of the Francis turbine, problems such as hydraulic vibration, noise, and high amplitude pressure pulsation that endanger the safe and efficient operation of the unit are inevitable during the transient process.…
View article: Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases
Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases Open
View article: Research trends on alphavirus receptors: a bibliometric analysis
Research trends on alphavirus receptors: a bibliometric analysis Open
Background Alphaviruses are a diverse group of pathogens that have garnered considerable attention due to their impact on human health. By investigating alphavirus receptors, researchers can elucidate viral entry mechanisms and gain import…
View article: Construction of a breast cancer predictive nomogram based on diverse cell death methods and reveal tumor microenvironment characterization
Construction of a breast cancer predictive nomogram based on diverse cell death methods and reveal tumor microenvironment characterization Open
Objective To develop a robust predictive model and nomogram for breast cancer (BC) linked to genes associated with diverse cell death methods. Methods The prognostic model was constructed using the LASSO Cox method. Model performance was a…