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View article: Alveolar and Bronchial Nitric Oxide Parameters in Pre-Capillary Pulmonary Hypertension
Alveolar and Bronchial Nitric Oxide Parameters in Pre-Capillary Pulmonary Hypertension Open
Background: Exhaled NO concentrations at different flow rates can be used to calculate pulmonary NO dynamics in the conductive and peripheral airways and can be described by the total bronchial flux of NO (JawNO) and alveolar NO concentrat…
View article: A női kutatók helyzete Magyarországon és az Európai Unióban
A női kutatók helyzete Magyarországon és az Európai Unióban Open
A közelmúltban publikált adatok szerint a kutatók és mérnökök között a nők aránya hazánkban a legalacsonyabb az Európai Unión belül. Az alulreprezentáltság mögött több tényező, így strukturális akadályok, a munka és a magánélet összeegyezt…
View article: Role of Free Radicals in the Pathophysiology of OSA: A Narrative Review of a Double-Edged Sword
Role of Free Radicals in the Pathophysiology of OSA: A Narrative Review of a Double-Edged Sword Open
Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder, primarily characterized by recurrent episodes of upper airway obstruction during sleep. Individuals affected by OSA are at increased risk for a variety o…
View article: Role of Free Radicals in the Pathophysiology of OSAS: A Narrative Review of A Double-Edged Sword
Role of Free Radicals in the Pathophysiology of OSAS: A Narrative Review of A Double-Edged Sword Open
Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing 1 disorder (SDB), primarily characterized by recurrent episodes of upper airway obstruction 2 during sleep. Individuals affected by OSA are at increased risk for a…
View article: Comparison of healthcare costs of patients with COPD on maintenance inhaled therapies between 2011 and 2019 in Hungary using a nationwide database
Comparison of healthcare costs of patients with COPD on maintenance inhaled therapies between 2011 and 2019 in Hungary using a nationwide database Open
Introduction and objectives Medical costs of patients with chronic obstructive pulmonary disease (COPD) are high, however data from Eastern European countries are scarce. We aimed to study healthcare payments for patients with COPD on main…
View article: Right ventricular stroke work index in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: A retrospective observational study
Right ventricular stroke work index in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: A retrospective observational study Open
The right ventricular stroke work index (RVSWI) reflects the active work of the right ventricle (RV), but its clinical usefulness is not yet fully known in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hyperten…
View article: Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Syndrome Management: A Narrative Review
Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Syndrome Management: A Narrative Review Open
Background: Obstructive Sleep Apnea (OSA) is a prevalent disorder characterized by repetitive upper airway obstructions during sleep, leading to intermittent hypoxia and sleep fragmentation. Current treatments, particularly Continuous Posi…
View article: The Effect of Opioids and Benzodiazepines on Exacerbation Rate and Overall Survival in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Non-Invasive Ventilation
The Effect of Opioids and Benzodiazepines on Exacerbation Rate and Overall Survival in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Non-Invasive Ventilation Open
Background: There is a growing concern that opioids and benzodiazepines can depress the respiratory drive and could contribute to worsening respiratory failure and higher exacerbation frequency in COPD. However, the relationship between th…
View article: Assessment of bronchodilator responsiveness to salbutamol or ipratropium using different criteria in treatment-naïve patients with asthma and COPD
Assessment of bronchodilator responsiveness to salbutamol or ipratropium using different criteria in treatment-naïve patients with asthma and COPD Open
Fewer patients show BDR+ according to the 2021 criteria in comparison with the 2005 recommendations, and protocols for BDR testing may consider the assessment of response to both SABA and SAMA after 30 minutes.
View article: A krónikus obstruktív tüdőbetegség miatt fenntartó inhalációs kezelésben részesült betegek epidemiológiai és terápiás jellemzői 2011 és 2019 között Magyarországon
A krónikus obstruktív tüdőbetegség miatt fenntartó inhalációs kezelésben részesült betegek epidemiológiai és terápiás jellemzői 2011 és 2019 között Magyarországon Open
Bevezetés: A krónikus obstruktív tüdőbetegség (COPD) morbiditása és mortalitása a világon és hazánkban is emelkedik. A betegség kezelésének alapja a fenntartó inhalációs terápia és a betegek ezzel szembeni jó adherenciája, de hazánkban a k…
View article: Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension
Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension Open
Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cy…
View article: P42 Fixed versus variable pressure modes of long-term non-invasive ventilation in patients with chronic hypercapnic COPD
P42 Fixed versus variable pressure modes of long-term non-invasive ventilation in patients with chronic hypercapnic COPD Open
Long-term non-invasive ventilation (LT-NIV) is an emerging treatment for patients with chronic hypercapnic COPD. The ventilatory support can be delivered either through fixed pressure support or by continuously adjusting pressures to achi…
View article: Analysis of possible risk factors for the severity of paediatric obstructive sleep apnoea syndrome
Analysis of possible risk factors for the severity of paediatric obstructive sleep apnoea syndrome Open
View article: Combined Pulmonary Fibrosis and Emphysema: Comparative Evidence on a Complex Condition
Combined Pulmonary Fibrosis and Emphysema: Comparative Evidence on a Complex Condition Open
Combined pulmonary fibrosis and emphysema (CPFE) is a clinical syndrome characterized by upper lobe emphysema and lower lobe fibrosis manifested by exercise hypoxemia, normal lung volumes, and severe reduction of diffusion capacity of carb…
View article: Modeling of pulmonary deposition of agents of open and fixed dose triple combination therapies through two different low-resistance inhalers in COPD: a pilot study
Modeling of pulmonary deposition of agents of open and fixed dose triple combination therapies through two different low-resistance inhalers in COPD: a pilot study Open
Introduction Inhalation therapy is a cornerstone of treating patients with chronic obstructive pulmonary disease (COPD). Inhaler devices might influence the effectiveness of inhalation therapy. We aimed to model and compare the deposition …
View article: Mucolytics for acute exacerbations of chronic obstructive pulmonary disease: a meta-analysis
Mucolytics for acute exacerbations of chronic obstructive pulmonary disease: a meta-analysis Open
This meta-analysis explored the safety and effectiveness of mucolytics as an add-on treatment for chronic obstructive pulmonary disease (COPD) exacerbations. Based on a pre-registered protocol and following Cochrane methods, we systematica…
View article: Hypercapnia in COPD: Causes, Consequences, and Therapy
Hypercapnia in COPD: Causes, Consequences, and Therapy Open
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder that may lead to gas exchange abnormalities, including hypercapnia. Chronic hypercapnia is an independent risk factor of mortality in COPD, leading to epith…
View article: Postoperative respiratory complications in children with obstructive sleep apnoea syndrome
Postoperative respiratory complications in children with obstructive sleep apnoea syndrome Open
Comorbidities are more closely linked with PoRCs than OSA severity. In patients without comorbidity, PoRCs are associated with OSA severity and usually occur within the first 2 hours after the intervention.
View article: Pulmonary vascular remodeling and right ventricular adaptation in precapillary pulmonary hypertension
Pulmonary vascular remodeling and right ventricular adaptation in precapillary pulmonary hypertension Open
Background: In precapillary pulmonary hypertension (PH) as pulmonary arterial hypertension (PAH), chronic thromboembolic PH (CTPEH) and PH due to hypoxia and lung disease (HPH) the different pathomechanisms of vascular remodeling result in…
View article: Assessing Treatment Success or Failure as an Outcome in Randomised Clinical Trials of COPD Exacerbations. A Meta-Epidemiological Study
Assessing Treatment Success or Failure as an Outcome in Randomised Clinical Trials of COPD Exacerbations. A Meta-Epidemiological Study Open
A recently published ERS core outcome set recommends that all trials of COPD exacerbation management should assess the treatment success (or “cure” of the exacerbation), defined as a dichotomous measure of the overall outcome of an exacerb…
View article: ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations
ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations Open
Clinical trials evaluating the management of acute exacerbations of COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, a consensus-base…
View article: Jobb kamrai adaptáció pulmonalis artériás hypertoniában
Jobb kamrai adaptáció pulmonalis artériás hypertoniában Open
Összefoglaló. Pulmonalis artériás hypertoniában (PAH) a tüdőartériák falának átépülése az elsődleges patofiziológiai eltérés, amely a pulmonalis vascularis rezisztencia (PVR) és a pulmonalis nyomás progresszív emelkedéséhez vezet. Ez a nyo…
View article: Circulating Survivin Protein Levels in Lung Cancer Patients Treated With Platinum-Based Chemotherapy
Circulating Survivin Protein Levels in Lung Cancer Patients Treated With Platinum-Based Chemotherapy Open
The survivin protein contributes to the development and progression of tumors. Protein expression and mRNA levels correlate with clinicopathological parameters and survival of cancer patients. Our purpose was to evaluate whether circulatin…
View article: The Role of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 in Obstructive Sleep Apnoea
The Role of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 in Obstructive Sleep Apnoea Open
Intermittent hypoxia in obstructive sleep apnoea (OSA) is related to inflammation and metabolic abnormalities. Soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) is involved in anti-inflammatory and metabolic processes. Ho…
View article: Blood eosinophils on hospital admission for COPD exacerbation do not predict the recurrence of moderate and severe relapses
Blood eosinophils on hospital admission for COPD exacerbation do not predict the recurrence of moderate and severe relapses Open
Background and objective The relationship between hospitalisation with an eosinophilic acute exacerbation of COPD (AE-COPD) and future relapses is unclear. We aimed to explore this association by following 152 patients for 12 months after …
View article: The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea
The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea Open
Biological functions of hyaluronic acid (HA) depend on its molecular size. High-molecular weight HA (HMW-HA) is an important component of the endothelial wall and has anti-inflammatory and antioxidant properties. Under inflammation or hypo…
View article: Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: the COS-AECOPD ERS Task Force study protocol
Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: the COS-AECOPD ERS Task Force study protocol Open
Randomised controlled trials (RCTs) on the management of COPD exacerbations evaluate heterogeneous outcomes, often omitting those that are clinically important and patient relevant. This limits their usability and comparability. A core out…
View article: Impact of Clinical Factors on Generic and Disease-Specific Quality of Life in COPD and Asthma-COPD Overlap with Exacerbations
Impact of Clinical Factors on Generic and Disease-Specific Quality of Life in COPD and Asthma-COPD Overlap with Exacerbations Open
Purpose . The health-related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD) is worsened by frequent exacerbations, and it can be affected by the concomitant presence of bronchial asthma (asthma-COPD overlap (ACO)). …
View article: Growth factors in pulmonary arterial hypertension: Focus on preserving right ventricular function
Growth factors in pulmonary arterial hypertension: Focus on preserving right ventricular function Open
Pulmonary arterial hypertension (PAH) is a rare and progressive disease, characterized by increased vascular resistance leading to right ventricle (RV) failure. The extent of right ventricular dysfunction crucially influences disease progn…
View article: The Repeatability of Inspiration Performance Through Different Inhalers in Patients with Chronic Obstructive Pulmonary Disease and Control Volunteers
The Repeatability of Inspiration Performance Through Different Inhalers in Patients with Chronic Obstructive Pulmonary Disease and Control Volunteers Open
Background: Inhalation therapy is a cornerstone of treating patients with chronic obstructive pulmonary disease (COPD). Inhaler types and through-device inhalation parameters influence airway drug delivery. We aimed to measure the repeatab…