Explanipedia

Terminal microdeletion of chromosome 18 in a Malaysian boy characterized with few features of typical 18q- deletion syndrome: a case report Open

Azli Ismail, Fadly Ahid, Meow‐Keong Thong, Zubaidah Zakaria · 2023

Background The 18q- deletion syndrome is a rare congenital chromosomal disorder caused by a partial deletion of the long arm of chromosome 18. The diagnosis of a patient with this syndrome relies on the family medical history, physical exa…

Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia Open

Yuslina Mat Yusoff, Fadly Ahid, Zahidah Abu Seman, Julia Abdullah, Nor Rizan Kamaluddin , et al. · 2021

Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia Open

Yuslina Mat Yusoff, Fadly Ahid, Zahidah Abu Seman, Julia Abdullah, Nor Rizan Kamaluddin , et al. · 2021

Background Relapsed acute myeloid leukemia (AML) is associated with the acquisition of additional somatic mutations which are thought to drive phenotypic adaptability driving clonal selection during treatment and evolution of leukemic clon…

Factors Associated with Intention to Donate Hematopoietic Stem Cells among Blood Donors Open

Chuo Yew Ting, Yew Fong Lee, Chien Joo Lim, Rachel Sing‐Kiat Ting, Mohammad Masrin MD Zahrin , et al. · 2020

Introduction: Past studies pay little attention to the intention to donate hematopoietic stem cells (HSC) among blood donors. This study investigated the level of and the influence of socio-demographic characteristics, knowle…

HMGB1 and sRAGE: What are Their Links to Acute Myeloid Leukemia? Open

Zaridatul Aini Ibrahim, Kim Jun Cheng, Noor Atiqah Fakaruzi, Ariwibawa Kasmani Hashim, Shamsul Mohd Zain , et al. · 2019

Introduction: Acute myeloid leukemia (AML) is a disparate hematopoietic malignancy, with many subtypes and variable responsiveness to therapy. Identification of a targetable biomarker can be used to improve survival outcome of this disease…

Epidermal growth factor receptor (<em>EGFR</em>) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort Open

Zubaidah Zakaria, Muhamad Farid Zulkifle, Wan Atiqah Najiah Wan Hasan, Azlah Kamilah Azhari, Sayyidi Hamzi Abdul Raub , et al. · 2019

This study provides the first glimpse of EGFR alterations and expressions in a multi ethnic Malaysian TNBC patient cohort emphasising the need for the nationwide large scale EGFR expression evaluation in Malaysia.

Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer Open

Kamal Shaik Fakiruddin, Moon Nian Lim, Norshariza Nordin, Rozita Rosli, Zubaidah Zakaria , et al. · 2019

Mesenchymal stem cells (MSCs) are emerging as vehicles for anti-tumor cytotherapy; however, investigation on its efficacy to target a specific cancer stem cell (CSC) population in non-small cell lung cancer (NSCLC) is lacking. Using assays…

Identification of FLT3 and NPM1 Mutations in Patients with Acute Myeloid Leukaemia Open

Yuslina Mat Yusoff, Zahidah Abu Seman, Norodiyah Othman, Nor Rizan Kamaluddin, Ezalia Esa , et al. · 2019

Objective: The most frequent acquired molecular abnormalities and important prognostic indicators in patients with Acute Myeloid Leukaemia (AML) are fms-like tyrosine kinase-3 gene (FLT3) and nucleophosmin-1 (NPM1) mutations. Our study aim…

Anti-Proliferative Activity of Triterpenes Isolated from Clinicanthus nutans on Hep-G2 Liver Cancer Cells Open

Khairun Najwa Zakaria, Azura Amid, Zubaidah Zakaria, Parveen Jamal, Azli Ismail · 2019

Problem statement: Clinicanthus nutans has been used by Malaysian since long time ago. It is used to treat many diseases including cancer. Many studies carried out on its crude extract but no clear report on the specific secondary metaboli…

A microRNA-mRNA regulatory network explains the landscape of the de novo cytogenetically normal acute myeloid leukaemia Open

Ezalia Esa, Ariwibawa Kasmani Hashim, Zubaidah Zakaria, Alifah Nadia Abu Hassan, Yuslina Mat Yusoff , et al. · 2019

The association between dysregulated microRNAs (miRNAs) and cytogenetically normal acute myeloid leukaemia (CN-AML) is well reported. However, our understanding on the regulatory role of miRNAs in CN-AML pathway is still poor. The current …

Prevalence of BCR-ABL T315I Mutation in Malaysian Patients with Imatinib-Resistant Chronic Myeloid Leukemia Open

Yuslina Mat Yusoff, Zahidah Abu Seman, Norodiyah Othman, Nor Rizan Kamaluddin, Ezalia Esa , et al. · 2018

Objective: Chronic Myeloid Leukemia (CML) is caused by a reciprocal translocation between chromosomes 9 and 22, t(9;22) (q34;q11) which encodes for the BCR-ABL fusion protein. Discovery of Imatinib Mesylate (IM) as first line therapy has b…

Recombinant human growth hormone: a medical miracle or cause for concern? Open

Ganesh Chidambar Subramanian, Yuslina Mat Yusoff, Ezalia Esa, Zubaidah Zakaria, Stephen N. Ponnampalam · 2018

The availability of recombinant human growth hormone (GH) has expanded the use beyond growth hormone deficiency (GHD) to conditions that include, use in anti-aging formula and in sports to enhance athletic performance. The long-term safety…

High resolution single nucleotide polymorphism analysis of genomic aberrations in childhood acute lymphoblastic leukaemia Open

Zubaidah Zakaria, Nor Soleha Mohd Dali, Nursaedah Abdullah Aziz, Lailatul Hadziyah Mohd Pauzy, Julia Abdullah , et al. · 2018

Leukaemia is the sixth most frequent cancer in Malaysia and the commonest cancer in children. Acute Lymphoblastic Leukaemia (ALL) is one of the major causes of death in children. Acquired chromosomal abnormalities are the hallmark of ALL, …

Mutations of FLT3 and CKIT genes in core binding factor with acute myeloid leukemia: IMR experience Open

Zahidah Abu Seman, Yuslina Mat Yusoff, Nor Rizan Kamaluddin, Ezalia Esa, Julia Abdullah , et al. · 2018

Core binding factor (CBF) is a heterodimeric transcription factor made up of two subunits, CBFα (also known as RUNX-1) and CBFβ. CBF plays a role in the transcriptional activation of a number of genes required for normal hematopoietic diff…

De Novo Haemoglobin Sabine Presented With Chronic Haemolytic Anaemia: A Case Report Open

Norafiza Mohd Yasin, Yuslina Mat Yusoff, Ezalia Esa, Ermi Neiza Mohd Sahid, Nur Azura Suliman , et al. · 2018

Haemoglobin (Hb) Sabine is an unstable Hb variant that causes moderate haemolytic anaemia in heterozygous state. This haemoglobin is the result of a point mutation of β-globin gene at codon 91(CTG)->(CCG). This study describes a two-years-…

Molecular and Haematological Characterisation of Hb Malay in Malaysian Population Open

Yuslina Mat Yusoff, Faidatul Syazlin Abdul Hamid, Norafiza Mohd Yasin, Ezalia Esa, Nur Aisyah Aziz , et al. · 2018

Haemoglobin (Hb) Malay is a variant haemoglobin with a mutation in the globin gene causing substitution of serine for asparagine at codon 19 of the beta globin chain. This variant Hb was first described in 1989 and was designated after the…

A Sabahan Family With A Dominantly Inherited Β-Thalassemia Due To Haemoglobin Durham-N.C./Brescia [Β114(G16) Leu→Pro]: First Case Described In The Malaysian Population Open

Nurul Zawani Zaini, Syahzuwan Hassan, Faidatul Syazlin Abdul Hamid, Alifah Nadia Abu Hassan, Ezalia Esa , et al. · 2018

We describe a dominant thalassemia-like phenotype as a result of Hb Durham-N.C. which is caused by a single nucleotide substitution (C T G-C C G) at codon 114 resulting in leucine to proline substitution. Destabilization of heme pocket by …

Mesenchymal Stem Cell Expressing TRAIL as Targeted Therapy against Sensitised Tumour Open

Kamal Shaik Fakiruddin, Nadiah Ghazalli, Moon Nian Lim, Zubaidah Zakaria, Syahril Abdullah · 2018

Tapping into the ability of engineered mesenchymal stem cells (MSCs) to mobilise into the tumour has expanded the scope of cancer treatment. Engineered MSCs expressing tumour necrosis factor (TNF)-related apoptosis inducing ligand (MSC-TRA…

Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics Open

Nazilah Abdul Satar, Kamal Shaik Fakiruddin, Moon Nian Lim, Pooi Ling Mok, Norashikin Zakaria , et al. · 2018

Through the specific identification and direct targeting of cancer stem cells (CSCs), it is believed that a better treatment efficacy of cancer may be achieved. Hence, the present study aimed to identify a CSC subpopulation from adenocarci…

Inhibition of NF-κB Signaling Reduces the Stemness Characteristics of Lung Cancer Stem Cells Open

Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Darius Widera, Badrul Hisham Yahaya · 2018

Cancer stem cells (CSCs) are a subpopulation of cancer cells that play a pivotal role in tumor development, invasion, metastasis, and recurrence. We and others have reported significant involvement of the NF-κB pathway in regulating CSCs o…

Thalassemia Distribution Based on Screening Programs in the Population of the East Malaysian State of Sabah Open

Lailatul Hadziyah Mohd Pauzy, Ezalia Esa, Nizmah Mahani Mokhri, Yuslina Mat Yusoff, Nurul Amira Jamaludin , et al. · 2018

Objective:The aim of the study is to examine the distribution of thalassemia in the indigenous population of Sabah where thalassemia is most prevalent in Malaysia based on screening programs carried out at the public health centers.Method:…

Circulating cytokines and small molecules follow distinct expression patterns in acute myeloid leukaemia Open

Mirazul Islam, Elsa Haniffah Mejia Mohamed, Ezalia Esa, Nor Rizan Kamaluddin, Shamsul Mohd Zain , et al. · 2017

Circulating analyte expression in AML significantly differs from normal, and follow distinct expression patterns.

Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton’s jelly mesenchymal stromal cells Open

Mathiyazhagan Rengasamy, Gurbind Singh, Noor Atiqah Fakharuzi, Bentham Science Publisher SiddikUzzaman, Sudha Balasubramanian , et al. · 2017

Effectiveness of imatinib mesylate over etoposide in the treatment of sensitive and resistant chronic myeloid leukaemia cells in vitro Open

Roslina Husaini, Munirah Ahmad, Zubaidah Zakaria · 2017

Chronic myeloid leukaemia (CML) is a form of leukaemia derived from the myeloid cell lineage. Imatinib mesylate, the breakpoint cluster region-abelson murine leukeamia kinase inhibitor, is a specific reagent used in the clinical treatment …

MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy Open

Ivyna Pau Ni Bong, Ching Ching Ng, Puteri Baharuddin, Zubaidah Zakaria · 2017

A Novel Missense Mutation of F 9 Gene in Hemophilia B Patients Open

Lam Kah Yuen, Zubaidah Zakaria, Yuslina Mat Yusoff · 2017

The severity of the disease was based on the coagulation factor levels.Five patients were severe (<1%), 2 patients were moderate (1%-5%) and 2 patients were mild (>5%).The concentration and the quality of the DNA were determined using a ND…

A blood-based gene expression and signaling pathway analysis to differentiate between high and low grade gliomas Open

Stephen N. Ponnampalam, Nor Rizan Kamaluddin, Zubaidah Zakaria, Vickneswaran Matheneswaran, Dharmendra Ganesan , et al. · 2016

The aims of the present study were to undertake gene expression profiling of the blood of glioma patients to determine key genetic components of signaling pathways and to develop a panel of genes that could be used as a potential blood-bas…

Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Open

Ivyna Pau Ni Bong, Ng Ching Ching, Shaik Kamal Fakiruddin, Lim Moon Nian, Zubaidah Zakaria · 2016

Multiple myeloma (MM) is a malignancy of B lymphocytes or plasma cells. Our array-based comparative genomic hybridization findings revealed chromosomal gains at 7q22.3 and 1q42.3, where nicotinamide (NAM) phosphoribosyltransferase (NAMPT) …

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines Open

Puteri Baharuddin, Nazilah Abdul Satar, Kamal Shaik Fakiruddin, Norashikin Zakaria, Moon Nian Lim , et al. · 2015

Natural compounds such as curcumin have the ability to enhance the therapeutic effectiveness of common chemotherapy agents through cancer stem-like cell (CSC) sensitisation. In the present study, we showed that curcumin enhanced the sensit…

A Novel Single Gene Deletion (−αMAL3.5) Giving Rise to Silent α Thalassemia Carrier Removing the Entire HBA2 Gene Observed in Two Chinese Patients with Hb H Disease: Case Report of Two Probands Open

Faidatul Syazlin Abdul Hamid, Rahimah Ahmad, Mohamed Saleem, Nur Aisyah Aziz, Syahira Lazira Omar , et al. · 2015

We report a novel deletion at the HBA2 presented with Hb H disease in two Malaysian- Chinese patients. The two unrelated probands were diagnosed with Hb H disease in a primary hematological screening for thalassemia. Results from routine m…

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