Zugui Zhang
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View article: The Burden of Heart Failure in the US: Medical Costs and Health-Related Quality of Life
The Burden of Heart Failure in the US: Medical Costs and Health-Related Quality of Life Open
Background To quantify the economic burden and health-related quality of life (HRQoL) impact of heart failure (HF) in the U.S., stratified by age and diabetes status. Methods Using a micro-level, bottom-up prevalence-based approach from a …
View article: Prevalence and mortality rate of heart failure across demographic groups in the United States: 2001–2020
Prevalence and mortality rate of heart failure across demographic groups in the United States: 2001–2020 Open
View article: Multilevel factors associated with sleep duration and bedtime regularity in U.S. children with and without neurodevelopmental disorders: a nationally representative study
Multilevel factors associated with sleep duration and bedtime regularity in U.S. children with and without neurodevelopmental disorders: a nationally representative study Open
Background This study compared multilevel factors associated with sleep duration and bedtime regularity in children with and without neurological and developmental disorders (NDD) using a nationally representative sample. Methods We combin…
View article: Associations of maternal alcohol and non-prescribed substance use with early child growth
Associations of maternal alcohol and non-prescribed substance use with early child growth Open
Background: Perinatal alcohol and non-prescribed substance use may be detrimental to foetal and infant growth.Aim: This observational study investigated how combined and continued alcohol and non-prescribed substance use throughout antenat…
View article: Quality of life post heart failure diagnosis: population-level trends in the U.S.
Quality of life post heart failure diagnosis: population-level trends in the U.S. Open
HF reduces HRQoL by 6.55%, surpassing the clinically significant threshold of a 1-2% decrement. These findings highlight the potential of the HD Survey to inform public health monitoring and underscore the need for tailored interventions t…
View article: Application of interpretable machine learning algorithms to predict macroangiopathy risk in Chinese patients with type 2 diabetes mellitus
Application of interpretable machine learning algorithms to predict macroangiopathy risk in Chinese patients with type 2 diabetes mellitus Open
View article: Quality of Life Post Heart Failure Diagnosis: Population-Level Trends in the U.S
Quality of Life Post Heart Failure Diagnosis: Population-Level Trends in the U.S Open
Background. Individuals with heart failure (HF) experience various symptoms making both diagnosis and disease burden estimates challenging. While HF-specific patient-reported outcome measures (PROMs) are widely used, their focus on clinica…
View article: Neonatal Outcomes after Maternal Biomarker-Guided Preterm Birth Intervention: The AVERT PRETERM Trial
Neonatal Outcomes after Maternal Biomarker-Guided Preterm Birth Intervention: The AVERT PRETERM Trial Open
The AVERT PRETERM trial (NCT03151330) evaluated whether screening clinically low-risk pregnancies with a validated maternal blood biomarker test for spontaneous preterm birth (sPTB) risk, followed by preventive treatments for those screeni…
View article: Cost of Cardiovascular Disease Event and Cardiovascular Disease Treatment–Related Complication Hospitalizations in the United States
Cost of Cardiovascular Disease Event and Cardiovascular Disease Treatment–Related Complication Hospitalizations in the United States Open
BACKGROUND: Cardiovascular disease (CVD) is among the costliest conditions in the United States, and cost-effectiveness analyses can be used to assess economic impact and prioritize CVD treatments. We aimed to develop standardized, nationa…
View article: Neighborhood Environment and Poor Maternal Glycemic Control–Associated Complications of Gestational Diabetes Mellitus
Neighborhood Environment and Poor Maternal Glycemic Control–Associated Complications of Gestational Diabetes Mellitus Open
View article: Personalized Therapies in Hepatocellular Carcinoma: Insights from a Disulfidptosis-Related Signature
Personalized Therapies in Hepatocellular Carcinoma: Insights from a Disulfidptosis-Related Signature Open
Hepatocellular carcinoma (HCC) is the predominant pathological type of liver cancer with an unfavorable prognosis. Disulfidptosis is the newest cell death form and plays a vital role in tumorigenesis. However, the role of disulfidptosis-re…
View article: Cost‐Effectiveness of Icosapent Ethyl in REDUCE‐IT USA: Results From Patients Randomized in the United States
Cost‐Effectiveness of Icosapent Ethyl in REDUCE‐IT USA: Results From Patients Randomized in the United States Open
Background In 3146 REDUCE‐IT USA (Reduction of Cardiovascular Events With Icosapent Ethyl Intervention Trial USA) participants, icosapent ethyl (IPE) reduced first and total cardiovascular events by 31% and 36%, respectively, over 4.9 year…
View article: Primary care outreach and decision counseling for lung cancer screening
Primary care outreach and decision counseling for lung cancer screening Open
Introduction Lung cancer screening rates are very low despite a level B recommendation from the United States Preventive Services Task Force since 2013 and clear evidence that lung cancer screening reduces mortality. The Center for Medicar…
View article: Neonatal outcomes after maternal biomarker-guided preterm birth intervention: the AVERT PRETERM trial
Neonatal outcomes after maternal biomarker-guided preterm birth intervention: the AVERT PRETERM trial Open
The AVERT PRETERM trial ( NCT03151330 ) evaluated whether screening clinically low-risk pregnancies with a validated maternal blood biomarker test for spontaneous preterm birth (sPTB) risk, followed by preventive treatments for those scree…
View article: Identification of risk factors for infection after mitral valve surgery through machine learning approaches
Identification of risk factors for infection after mitral valve surgery through machine learning approaches Open
Background Selecting features related to postoperative infection following cardiac surgery was highly valuable for effective intervention. We used machine learning methods to identify critical perioperative infection-related variables afte…
View article: The Association of Maternal Smoking and Drinking Changes During Pregnancy and Postpartum Breastfeeding Pattern and Duration
The Association of Maternal Smoking and Drinking Changes During Pregnancy and Postpartum Breastfeeding Pattern and Duration Open
Objectives: To conduct a secondary data analysis of how changes in smoking and drinking during pregnancy impact status of any breastfeeding and breastfeeding duration in a national cohort. Materials and Methods:…
View article: Association of Area Deprivation With Primary Hypertension Diagnosis Among Youth Medicaid Recipients in Delaware
Association of Area Deprivation With Primary Hypertension Diagnosis Among Youth Medicaid Recipients in Delaware Open
Importance The association between degree of neighborhood deprivation and primary hypertension diagnosis in youth remains understudied. Objective To assess the association between neighborhood measures of deprivation and primary hypertensi…
View article: Telemedicine and health disparities: Association between the area deprivation index and primary care telemedicine utilization during the COVID-19 pandemic
Telemedicine and health disparities: Association between the area deprivation index and primary care telemedicine utilization during the COVID-19 pandemic Open
Introduction: The rapid implementation of telemedicine during the COVID-19 pandemic may have exacerbated the existing health disparities. This study investigated the association between the area deprivation index (ADI), which serves as a m…
View article: The burden of cardiovascular disease attributable to high systolic blood pressure across China, 2005–18: a population-based study
The burden of cardiovascular disease attributable to high systolic blood pressure across China, 2005–18: a population-based study Open
For the Chinese translation of the abstract see Supplementary Materials section.
View article: Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma
Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma Open
Lung adenocarcinoma (LUAD) is the most common type of lung cancer and the leading cause of cancer incidence and mortality worldwide. Despite the improvement of traditional and immunological therapies, the clinical outcome of LUAD is still …
View article: Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension
Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension Open
View article: Effect of lipid-lowering medications in patients with coronary artery bypass grafting surgery outcomes
Effect of lipid-lowering medications in patients with coronary artery bypass grafting surgery outcomes Open
View article: An Efficient Approach for Optimizing the Cost-effective Individualized Treatment Rule Using Conditional Random Forest
An Efficient Approach for Optimizing the Cost-effective Individualized Treatment Rule Using Conditional Random Forest Open
Evidence from observational studies has become increasingly important for supporting healthcare policy making via cost-effectiveness (CE) analyses. Similar as in comparative effectiveness studies, health economic evaluations that consider …
View article: Effect of lipid-lowering Medications in patients with coronary artery bypass grafting surgery outcomes
Effect of lipid-lowering Medications in patients with coronary artery bypass grafting surgery outcomes Open
Background: Increased life expectancy and improved medical technology allow increasing numbers of elderly patients to undergo cardiac surgery. Elderly patients may be at greater risk of postoperative morbidity and mortality. Complications …
View article: Comprehensive analysis of pyroptosis regulation patterns and their influence on tumor immune microenvironment and patient prognosis in glioma
Comprehensive analysis of pyroptosis regulation patterns and their influence on tumor immune microenvironment and patient prognosis in glioma Open
Background Glioma is the most common intracranial malignancy with a poor prognosis. Although remarkable advances have been made in the study of diagnostic and prognostic biomarkers, the efficacy of current treatment strategies is still uns…
View article: Cost-effectiveness of Icosapent Ethyl for High-risk Patients With Hypertriglyceridemia Despite Statin Treatment
Cost-effectiveness of Icosapent Ethyl for High-risk Patients With Hypertriglyceridemia Despite Statin Treatment Open
This study suggests that, both in-trial and over the lifetime, IPE offers better cardiovascular outcomes than standard care in REDUCE-IT participants at common willingness-to-pay thresholds.
View article: Estimating Systolic Blood Pressure Intervention Trial Participant Posttrial Survival Using Pooled Epidemiologic Cohort Data
Estimating Systolic Blood Pressure Intervention Trial Participant Posttrial Survival Using Pooled Epidemiologic Cohort Data Open
Background Intensive systolic blood pressure treatment (<120 mm Hg) in SPRINT (Systolic Blood Pressure Intervention Trial) improved survival compared with standard treatment (<140 mm Hg) over a median follow‐up of 3.3 years. We projected l…
View article: Prognostic value of CCR2 as an immune indicator in lung adenocarcinoma: A study based on tumor‐infiltrating immune cell analysis
Prognostic value of CCR2 as an immune indicator in lung adenocarcinoma: A study based on tumor‐infiltrating immune cell analysis Open
Background Prognostic indicators in lung adenocarcinoma (LUAD) have been seeking under database analysis, and remarkable advance is on the way. Methods This study calculated the scores of stromal and immune components of the tumor microenv…
View article: Patient Selection for Intensive Blood Pressure Management Based on Benefit and Adverse Events
Patient Selection for Intensive Blood Pressure Management Based on Benefit and Adverse Events Open
View article: Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data
Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data Open
During CRISPR-directed gene editing, multiple gene repair mechanisms interact to produce a wide and largely unpredictable variety of sequence changes across an edited population of cells. Shortcomings inherent to previously available propo…