Zunera Zareen
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View article: Dynamics of Peripheral Lymphocyte Subsets from Birth until Old Age
Dynamics of Peripheral Lymphocyte Subsets from Birth until Old Age Open
The immune system is inexperienced before birth and tends to be tolerogenic, rather than immunogenic. After birth, the adaptive immune system develops while facing microbial challenges, but it can become impaired as old age progresses and …
View article: Multi-Organ Dysfunction in Cerebral Palsy
Multi-Organ Dysfunction in Cerebral Palsy Open
Cerebral Palsy (CP) describes a heterogenous group of non-progressive disorders of posture or movement, causing activity limitation, due to a lesion in the developing brain. CP is an umbrella term for a heterogenous condition and is, there…
View article: Bisphosphonate use in children with cerebral palsy
Bisphosphonate use in children with cerebral palsy Open
Based on the available evidence, there is very low certainty evidence that bisphosphonate treatment may improve bone health in children with cerebral palsy. We could only include one study with 14 participants in the assessment of the effe…
View article: An observational study of sleep in childhood post‐neonatal encephalopathy
An observational study of sleep in childhood post‐neonatal encephalopathy Open
Aim Neonatal encephalopathy (NE) is associated with altered cognitive, motor, sensory abilities and behavioural outcomes. This case‐control study aimed to assess whether Quality of Life (QoL) and sleep disorders are affected in older child…
View article: Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy
Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy Open
We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, children with cerebral palsy and age-matched controls. Using flow cytometry, we demonstrate alteration…
View article: Altered inflammasome activation in neonatal encephalopathy persists in childhood
Altered inflammasome activation in neonatal encephalopathy persists in childhood Open
Summary Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra and IL-18 are activated …
View article: Cytokine dysregulation in children with cerebral palsy
Cytokine dysregulation in children with cerebral palsy Open
Aim To examine pro‐ and anti‐inflammatory cytokines in children with cerebral palsy (CP) at baseline and in response to endotoxin (lipopolysaccharide), and correlate outcomes compared with age‐matched comparisons, to evaluate their ability…
View article: Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy
Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy Open
Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age co…
View article: Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy
Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy Open
Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age co…
View article: Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy
Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy Open
Objective: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age comp…
View article: Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy
Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy Open
Introduction: Neonatal encephalopathy (NE) is associated with coagulation abnormalities. We aimed to investigate the serial alterations in coagulation profiles in term infants with NE and correlate with their clinical outcomes. This was a …
View article: CHAMPION STUDY: Childhood Assessment of Multi-organ dysfunction Post Neonatal encephalopathy
CHAMPION STUDY: Childhood Assessment of Multi-organ dysfunction Post Neonatal encephalopathy Open
Neonatal brain injury is an important cause of neonatal death and disability such as cerebral palsy. Perinatal global hypoxic ischaemia associated with neonatal encephalopathy results in multi-organ dysfunction which may persists in later …
View article: Bisphosphonate use in children with cerebral palsy
Bisphosphonate use in children with cerebral palsy Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To examine the efficacy and safety of bisphosphonate therapy in the treatment of low BMD or secondary osteoporosis (or both) in children with cerebral …