Zunhui Ke
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View article: RSV Vaccines: Targeting Prefusion F and G Proteins from Structural Design to Clinical Application
RSV Vaccines: Targeting Prefusion F and G Proteins from Structural Design to Clinical Application Open
Background: Respiratory syncytial virus (RSV) is a major pathogen of acute lower respiratory tract infection (LRTI) in infants, the elderly, and immunocompromised individuals. This review focuses on the progress of RSV vaccine development,…
View article: N terminus of SARS-CoV-2 nonstructural protein 3 interrupts RNA-driven phase separation of N protein by displacing RNA
N terminus of SARS-CoV-2 nonstructural protein 3 interrupts RNA-driven phase separation of N protein by displacing RNA Open
The connection between SARS-CoV-2 replication-transcription complexes and nucleocapsid (N) protein is critical for regulating genomic RNA replication and virion packaging over the viral life cycle. However, the mechanism that dynamically r…
View article: Biophysical and Biochemical Characterization of the Binding of the MarR-like Transcriptional Regulator Saro_0803 to the nov1 Promotor and Its Inhibition by Resveratrol
Biophysical and Biochemical Characterization of the Binding of the MarR-like Transcriptional Regulator Saro_0803 to the nov1 Promotor and Its Inhibition by Resveratrol Open
Saro_0803 is a transcriptional factor modulating the transcription of the stilbene-degrading enzyme gene nov1 in Novosphingobium aromaticivorans DSM 12444. Reportedly, Saro_0803 undergoes resveratrol-mediated dissociation from the nov1 pro…
View article: Erratum for Zhao et al., “Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1”
Erratum for Zhao et al., “Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1” Open
Volume 9, issue 1, e00169-21, https://doi.org/10.1128/Spectrum.00169-21, 2021. In the originally published version, a supplemental material file was posted and a list of supplemental material appeared on p. 10. On 14 July 2021, the article…
View article: Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1
Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1 Open
Nonstructural protein 1 (Nsp1) of severe acute respiratory syndrome coronaviruses (SARS-CoVs) is an important pathogenic factor that inhibits host protein translation by means of its C terminus. However, its N-terminal function remains elu…
View article: Systemic <i>In Silico</i> Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server
Systemic <i>In Silico</i> Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server Open
The emergence of the new coronavirus (nCoV-19) has impacted human health on a global scale, while the interaction between the virus and the host is the foundation of the disease. The viral genome codes a cluster of proteins, each with a un…
View article: Systemic in Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server
Systemic in Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server Open
The emergence of the new coronavirus (nCoV-19) has brought global impact on human health, whilst the interaction between the virus and the host is the foundation of the disease. The viral genome codes a cluster of proteins, each with a uni…
View article: Systemic in Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server
Systemic in Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server Open
The emergence of the new coronavirus (nCoV-19) has brought global impact on human health, whilst the interaction between the virus and the host is the foundation of the disease. The viral genome codes a cluster of proteins, each with a uni…
View article: Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining
Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining Open
Objective: Cancer is expected to be the leading cause of death worldwide within the 21st century and is the single most important obstacle to extending life expectancy. Unfortunately, the most effective approach to combating cancers…