Zhe Chen
YOU?
Author Swipe
View article: Successful cure of a patient with tracheoesophageal fistula in cervical esophageal cancer: A case report and review of literature
Successful cure of a patient with tracheoesophageal fistula in cervical esophageal cancer: A case report and review of literature Open
BACKGROUND Tracheoesophageal fistula (TEF) is a life-threatening complication of advanced esophageal squamous cell carcinoma (ESCC). Cervical ESCC is rare and frequently diagnosed at an advanced stage. Managing cervical esophageal cancer (…
View article: Transient Staphylococcus aureus Infection Promotes Sustained Intervertebral Disc Degeneration Through the ATF-3/CHOP Pathway
Transient Staphylococcus aureus Infection Promotes Sustained Intervertebral Disc Degeneration Through the ATF-3/CHOP Pathway Open
Background: Infection with Staphylococcus aureus (S. aureus) is an important contributor to intervertebral disc degeneration (IDD). Endoplasmic reticulum stress (ERS) is a major pathway through which bacteria regulate cell fate. The aim of…
View article: Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation Open
Reactive oxygen species (ROS) play a pivotal role in multiple events during the progression of intervertebral disc degeneration (IDD). Hence, the precision treatment targets associated with ROS should be further explored to promote develop…
View article: Paraneoplastic Ma antigen 5 promotes cellular processes of primary cells in ovarian endometriosis
Paraneoplastic Ma antigen 5 promotes cellular processes of primary cells in ovarian endometriosis Open
This study investigates the role of paraneoplastic Ma antigen 5 (PNMA 5), a member of the PNMA family of proteins, in ovarian endometriosis (EM). These proteins are known to play a significant role in various physiological activities and a…
View article: Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study
Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study Open
Introduction It has been reported that individuals with type 1 diabetes (T1D) are at a higher risk of concomitant occurrence of other autoimmune diseases (AIDs). Currently, there is a lack of research investigating the causal relationship …
View article: Emodin: an alveolar macrophage protector in acute pancreatitis induced lung injury
Emodin: an alveolar macrophage protector in acute pancreatitis induced lung injury Open
Background: Emodin (EMO), an anthraquinone derivative from roots and leaves of various plants, has been widely used in many inflammatory diseases. Alveolar macrophages (AMs) play a critical role in maintaining alveolar homeostasis in the l…
View article: A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis
A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis Open
Insufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed o…
View article: Investigation and analysis of sleep and mental health status among MEFCs
Investigation and analysis of sleep and mental health status among MEFCs Open
Objective To investigate the sleep status and mental health of migrants elderly who followed their children (MEFC) and analyze the influencing factors. Methods A total of 583 MEFCs were surveyed using a general demographic questionnaire, t…
View article: MedS$^3$: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision
MedS$^3$: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision Open
Medical language models face critical barriers to real-world clinical reasoning applications. However, mainstream efforts, which fall short in task coverage, lack fine-grained supervision for intermediate reasoning steps, and rely on propr…
View article: Augmenting antitumor efficacy of Th17-derived Th1 cells through IFN-γ-induced type I interferon response network via IRF7
Augmenting antitumor efficacy of Th17-derived Th1 cells through IFN-γ-induced type I interferon response network via IRF7 Open
The importance of CD4 + T cells in cancer immunotherapy has gained increasing recognition. Particularly, a specific subset of CD4 + T cells coexpressing the T helper type 1 (Th1) and Th17 markers has demonstrated remarkable antitumor poten…
View article: Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis
Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis Open
Background The genetic association between psychiatric disorders and hemorrhoidal disease (HEM) is still not well known. The work aims to investigate their comorbidity at a genetic level. Methods Utilizing recent large-scale genome-wide as…
View article: [High STING expression exacerbates renal ischemia-reperfusion injury in mice by regulating the TLR4/NF-κB/NLRP3 pathway and promoting inflammation and apoptosis].
[High STING expression exacerbates renal ischemia-reperfusion injury in mice by regulating the TLR4/NF-κB/NLRP3 pathway and promoting inflammation and apoptosis]. Open
Renal STING expression is elevated in mice with renal IRI to exacerbate renal injury by regulating the TLR4/NF-κB/NLRP3 pathway and promoting inflammation and apoptosis in the renal tissues.
View article: Reactive Oxygen Species Induced Upregulation of TRPV1 in Dorsal Root Ganglia Results in Low Back Pain in Rats
Reactive Oxygen Species Induced Upregulation of TRPV1 in Dorsal Root Ganglia Results in Low Back Pain in Rats Open
Increased ROS in DRGs play a primary pathological role in puncture-induced discogenic LBP, and excessive ROS-induced upregulation of TRPV1 in DRGs may be the underlying pathophysiological mechanism to cause nerve sensitization and discogen…
View article: Emodin: an alveolar macrophage protector in acute pancreatitis induced lung injury
Emodin: an alveolar macrophage protector in acute pancreatitis induced lung injury Open
Emodin (EMO), an anthraquinone derivative from roots and leaves of various plants, has been widely used in many inflammatory diseases. Alveolar macrophages (AMs) play a critical role in maintaining alveolar homeostasis in the lung. To inve…
View article: Construction of individualised care programmes for patients with pancreatic cancer with postoperative weight-loss control based on the Delphi method: a cross-sectional study in China
Construction of individualised care programmes for patients with pancreatic cancer with postoperative weight-loss control based on the Delphi method: a cross-sectional study in China Open
Background At present, clinical nutritional care for patients with pancreatic cancer focuses more on the observation of the effect of enteral parenteral nutrition, and there is a lack of personalised care plans for weight-loss control. We …
View article: [A case of duodenal ulcer as prominent manifestation of IgG4-related disease].
[A case of duodenal ulcer as prominent manifestation of IgG4-related disease]. Open
A case of IgG4-related disease presented with a duodenal ulcer to improve the understan-ding of IgG4-related diseases was reported. A 70-year-old male presented with cutaneous pruritus and abdominal pain for four years and blackened stools…
View article: Regulation of the JAK/STAT signaling pathway in spinal cord injury: an updated review
Regulation of the JAK/STAT signaling pathway in spinal cord injury: an updated review Open
Cytokines are involved in neural homeostasis and pathological processes associated with neuroinflammation after spinal cord injury (SCI). The biological effect of cytokines, including those associated with acute or chronic SCI pathologies,…
View article: RETRACTED: Spermatogonial stem-cell-derived neural-like cell transplantation enhances the functional recovery of a rat spinal cord injury model: characterization of evoked potentials
RETRACTED: Spermatogonial stem-cell-derived neural-like cell transplantation enhances the functional recovery of a rat spinal cord injury model: characterization of evoked potentials Open
Severe spinal cord injuries (SCIs) usually result in the temporary or permanent impairment of strength, sensation or autonomic functions below the sites of injuries. To date, a large number of therapeutic approaches have been used to ameli…
View article: Avian pathogenic Escherichia coli infection causes infiltration of heterophilic granulocytes of chick tracheal by the complement and coagulation cascades pathway
Avian pathogenic Escherichia coli infection causes infiltration of heterophilic granulocytes of chick tracheal by the complement and coagulation cascades pathway Open
Background Avian pathogenic Escherichia coli ( APEC ) causes tracheal damage and heterophilic granulocytic infiltration and inflammation in infected chicks. In this study, we infected chick tracheal tissue with strain AE17 and produced pat…
View article: Efficacy of percutaneous kyphoplasty on vertebral compression fractures with different bone mineral densities: a retrospective study
Efficacy of percutaneous kyphoplasty on vertebral compression fractures with different bone mineral densities: a retrospective study Open
Background This study was performed to investigate the clinical efficacy of percutaneous kyphoplasty (PKP) for vertebral compression fractures with different bone mineral densities (BMD). Methods We performed a retrospective analysis of 23…
View article: Preoperative prediction of residual back pain after vertebral augmentation for osteoporotic vertebral compression fractures: Initial application of a radiomics score based nomogram
Preoperative prediction of residual back pain after vertebral augmentation for osteoporotic vertebral compression fractures: Initial application of a radiomics score based nomogram Open
Background Most patients with osteoporotic vertebral compression fracture (OVCF) obtain pain relief after vertebral augmentation, but some will experience residual back pain (RBP) after surgery. Although several risk factors of RBP have be…
View article: The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration
The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration Open
Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely affects patient quality of life. The majority of people may suffer from LBP during their life-span, which leading to huge economic burdens to family and so…
View article: Epidemiological characteristics of traumatic spinal cord injuries in a multicenter retrospective study in northwest China, 2017–2020
Epidemiological characteristics of traumatic spinal cord injuries in a multicenter retrospective study in northwest China, 2017–2020 Open
Background Traumatic spinal cord injuries (TSCIs) are worldwide public health problems that are difficult to cure and impose a substantial economic burden on society. There has been a lack of extensive multicenter review of TSCI epidemiolo…
View article: Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling
Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling Open
Background context Low back pain, affecting nearly 40% of adults, mainly results from intervertebral disc degeneration (IVDD), while the pathogenesis of IVDD is still not fully elucidated. Recently, some researches have revealed that necro…