Zhuo Yu
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View article: Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma Located at Esophageal Varices Caused by Liver Cirrhosis
Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma Located at Esophageal Varices Caused by Liver Cirrhosis Open
View article: Nanodelivery of panobinostat induces cell cycle arrest and apoptosis to suppress hepatocellular carcinoma growth in mice
Nanodelivery of panobinostat induces cell cycle arrest and apoptosis to suppress hepatocellular carcinoma growth in mice Open
View article: Anti-stromal nanotherapeutics for hepatocellular carcinoma
Anti-stromal nanotherapeutics for hepatocellular carcinoma Open
View article: Newly Established Anoikis-Associated Genes Predict the Prognosis of Hepatocellular Carcinoma
Newly Established Anoikis-Associated Genes Predict the Prognosis of Hepatocellular Carcinoma Open
Despite the lack of mechanistic validation, our anoikis-linked RS model serves as a promising tool for predicting HCC prognosis in clinical practice, and provides valuable insights into the decision of individualized therapeutic app…
View article: Assessment of cognitive function in patients with schizophrenia based on virtual reality serious games: a prospective nonrandomized clinical trial
Assessment of cognitive function in patients with schizophrenia based on virtual reality serious games: a prospective nonrandomized clinical trial Open
Introduction Conventional neuropsychological tests for assessing cognitive function in schizophrenia face critical limitations in ecological validity and efficiency. We developed Fruit Pioneer , a virtual reality serious game simulating re…
View article: Chromosome-level genome assembly of Triplophysa scleroptera
Chromosome-level genome assembly of Triplophysa scleroptera Open
Triplophysa scleroptera is an endemic fish species in Qinghai Lake and the upper reaches of the Yellow River. However, studies on conservation and evolutionary genetics were seriously impeded by the absence of a reference genome. Here, by …
View article: Disaster nursing training for intern nurses: A narrative approach
Disaster nursing training for intern nurses: A narrative approach Open
View article: Corrigendum: Inhibition effect of AGEs formation in vitro by the two novel peptides EDYGA and DLLCIC derived from Pelodiscus sinensis
Corrigendum: Inhibition effect of AGEs formation in vitro by the two novel peptides EDYGA and DLLCIC derived from Pelodiscus sinensis Open
[This corrects the article DOI: 10.3389/fnut.2025.1537338.].
View article: Inhibition effect of AGEs formation in vitro by the two novel peptides EDYGA and DLLCIC derived from Pelodiscus sinensis
Inhibition effect of AGEs formation in vitro by the two novel peptides EDYGA and DLLCIC derived from Pelodiscus sinensis Open
The antioxidant activity of natural products is closely related to their antiglycation effects. This study aimed to examine the antiglycation activity and elucidate the underlying mechanisms of two specific peptides, EDYGA (Glu-Asp-Tyr-Gly…
View article: Nanodelivery of arsenic trioxide induces macrophage-governed cGAS-STING signaling to remodel immune microenvironment in hepatocellular carcinoma
Nanodelivery of arsenic trioxide induces macrophage-governed cGAS-STING signaling to remodel immune microenvironment in hepatocellular carcinoma Open
View article: Ferrochelatase Gene Variants Associated with Cholestasis in Adults: A Case Report
Ferrochelatase Gene Variants Associated with Cholestasis in Adults: A Case Report Open
We reported a case of recurrent liver dysfunction in an adult patient with a history of abnormal liver enzymes persisting for over ten years. The primary abnormalities included elevated levels of gamma-glutamyl transferase and alkaline pho…
View article: Experiences and attitudes of psychiatric nurses in caring for patients with repeated non-suicidal self-injury in China: a qualitative study
Experiences and attitudes of psychiatric nurses in caring for patients with repeated non-suicidal self-injury in China: a qualitative study Open
View article: [Research Progress of Comprehensive Follow-up Management Strategy on the Natural History of Simultaneous, Persistent Multiple Pulmonary Ground-glass Nodules].
[Research Progress of Comprehensive Follow-up Management Strategy on the Natural History of Simultaneous, Persistent Multiple Pulmonary Ground-glass Nodules]. Open
The development and change patterns as well as the disease course management of multiple ground-glass nodules (GGNs) in the lungs are currently hotspots and difficulties in clinical lung cancer research. Understanding the latest advancemen…
View article: Bile Acids and Liver Cancer: Molecular Mechanism and Therapeutic Prospects
Bile Acids and Liver Cancer: Molecular Mechanism and Therapeutic Prospects Open
Hepatocellular carcinoma (HCC) is a highly aggressive liver malignancy and one of the most lethal cancers globally, with limited effective therapeutic options. Bile acids (BAs), as primary metabolites of hepatic cholesterol, undergo entero…
View article: Assessing Cognitive Function by a Virtual Reality Serious Game System in Schizophrenia Patients at Stable Phase: A prospective nonrandomized clinical trial
Assessing Cognitive Function by a Virtual Reality Serious Game System in Schizophrenia Patients at Stable Phase: A prospective nonrandomized clinical trial Open
Background: Cognitive impairments are enduring characteristics and core deficits in patients of schizophrenia, particularly impairments in working memory and executive function. It is very important to accurately assess the true cognitive …
View article: Experience and attitude of psychiatric nurses in caring for patients with repeated non-suicidal self-injury in China: A qualitative study
Experience and attitude of psychiatric nurses in caring for patients with repeated non-suicidal self-injury in China: A qualitative study Open
Background: Theincidence of non-suicidal self-injury (NSSI) is high and often occurs repeatedly. Psychiatric nurses play a vital role in the care and treatment of NSSI patients, as they have the most frequent contact with patients. The att…
View article: [Predictive Value of the Huaxi Emotional Index in Assessing and Identifying High Suicide Risk Among Inpatients With Depression].
[Predictive Value of the Huaxi Emotional Index in Assessing and Identifying High Suicide Risk Among Inpatients With Depression]. Open
HEI and NGASR demonstrate moderate agreement in assessing high suicide risk among depression patients. The HEI questionnaire effectively predicts high suicide risk in patients with depression, with 17 being the optimal cutoff value for ass…
View article: Bushen Formula promotes the decrease of HBsAg levels in patients with CHB by regulating Tfh cells and B-cell subsets
Bushen Formula promotes the decrease of HBsAg levels in patients with CHB by regulating Tfh cells and B-cell subsets Open
BSF have the higher percentage of HBsAg decline and HBeAg seroclearance in Peg-IFN-α-treated patients compared with treatment-naive patients. The potential immunoregulatory mechanism may correlate with promoting the interaction between Tfh…
View article: Late-onset Cholestasis with Paucity of Portal Area Secondary to HNF1β Deficiency in Adulthood: A Case Report
Late-onset Cholestasis with Paucity of Portal Area Secondary to HNF1β Deficiency in Adulthood: A Case Report Open
Hepatocyte nuclear factor 1β (HNF1β) is essential for biliary development, while its genetic defect triggers the dysplasia of interlobular bile ducts, leading to life-threatening hepatitis and cholestasis. To date, this disorder has mainly…
View article: Nanodelivery of Arsenic Trioxide Induces Macrophage-Governed Cgas-Sting Signaling to Remodel Immune Microenvironment in Hepatocellular Carcinoma
Nanodelivery of Arsenic Trioxide Induces Macrophage-Governed Cgas-Sting Signaling to Remodel Immune Microenvironment in Hepatocellular Carcinoma Open
View article: Prognostic and predictive biomarkers for anti-EGFR monoclonal antibody therapy in RAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
Prognostic and predictive biomarkers for anti-EGFR monoclonal antibody therapy in RAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis Open
View article: Integrating bulk and single-cell RNA sequencing data to establish necroptosis-related lncRNA risk model and analyze the immune microenvironment in hepatocellular carcinoma
Integrating bulk and single-cell RNA sequencing data to establish necroptosis-related lncRNA risk model and analyze the immune microenvironment in hepatocellular carcinoma Open
View article: <scp>d</scp> -lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma
<span>d</span> -lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma Open
The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype demonstrates great potential for remodeling the immunosuppressive tumor microenvironment (TME) of hepatocellular carcinoma (HCC). d -lactate (DL; a gut microbi…
View article: Case report: Multiple epstein-barr virus-associated smooth muscle tumours in a child with IL-2-inducible T-cell kinase mutation of undetermined clinical significance
Case report: Multiple epstein-barr virus-associated smooth muscle tumours in a child with IL-2-inducible T-cell kinase mutation of undetermined clinical significance Open
Background EBV-associated smooth muscle tumours (EBV-SMTs) are uncommon neoplasms associated with immunodeficiency. The pathogenesis of EBV-SMTs is poorly understood. IL-2-inducible T-cell kinase (ITK), a member of the Tec family of tyrosi…
View article: Lenalidomide promotes melarsoprol-activated cGAS-STING-mediated immunotherapy for hepatocellular carcinoma via attenuating TNF-α activity
Lenalidomide promotes melarsoprol-activated cGAS-STING-mediated immunotherapy for hepatocellular carcinoma via attenuating TNF-α activity Open
Current immunotherapy has limited efficacy in hepatocellular carcinoma (HCC) due to the immunosuppressive tumor microenvironment (TME). The activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator…
View article: Advances of multi-omics applications in hepatic precancerous lesions and hepatocellular carcinoma: The role of extracellular vesicles
Advances of multi-omics applications in hepatic precancerous lesions and hepatocellular carcinoma: The role of extracellular vesicles Open
Due to the lack of distinct early symptoms and specific biomarkers, most patients with hepatocellular carcinoma (HCC) are usually diagnosed at advanced stages, rendering the treatment ineffective and useless. Therefore, recognition of the …
View article: A novel association of pyroptosis-related gene signature with the prognosis of hepatocellular carcinoma
A novel association of pyroptosis-related gene signature with the prognosis of hepatocellular carcinoma Open
Background Hepatocellular carcinoma (HCC) is one of the global leading lethal tumors. Pyroptosis has recently been defined as an inflammatory programmed cell death, which is closely linked to cancer progression. However, the significance o…
View article: Tumor Microenvironment in Hepatocellular Carcinoma: Key Players for Immunotherapy
Tumor Microenvironment in Hepatocellular Carcinoma: Key Players for Immunotherapy Open
Hepatocellular carcinoma (HCC) remains a serious medical therapeutic challenge as conventional curative avenues such as surgery and chemotherapy only benefit for few patients with limited tumor burden. Immunotherapy achieves clinical progr…
View article: Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma Open
View article: Potential Similarities in Sex Difference in Key Genes and Their Expression, Network, EQTL and Pathways between COVID-19 and Chronic Kidney Disease Based on Mouse Model
Potential Similarities in Sex Difference in Key Genes and Their Expression, Network, EQTL and Pathways between COVID-19 and Chronic Kidney Disease Based on Mouse Model Open
COVID-19 and chronic kidney disease (CKD) share similarity in sex bias and key genes in the disease pathway of sex difference. We investigated the sex difference of molecular pathways of four key players of these two diseases using an exis…