Ang Li
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View article: JAZ2/JAZ4-MYC2.1 Module Mediates MeJA-Induced Alleviation of Chilling Injury in Peach Fruit ( <i>Prunus persica</i> )
JAZ2/JAZ4-MYC2.1 Module Mediates MeJA-Induced Alleviation of Chilling Injury in Peach Fruit ( <i>Prunus persica</i> ) Open
Methyl jasmonate (MeJA) has emerged as a promising agent for mitigating chilling injury (CI) in peach fruit (Prunus persica); however, the molecular mechanisms underlying the role of MYC2, a key transcriptional regulator of jasmonic acid (…
View article: N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression
N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression Open
In vitro transcribed messenger RNA (IVT mRNA) has emerged as a pivotal tool in mRNA-based therapies and has been extensively employed in gene function studies and genetic tool applications. However, the IVT process generates double-strande…
View article: An Autographa californica multiple nucleopolyhedrovirus-encoded microRNA, AcMNPV-miR-5, downregulates the expression of viral gene ac66
An Autographa californica multiple nucleopolyhedrovirus-encoded microRNA, AcMNPV-miR-5, downregulates the expression of viral gene ac66 Open
Four Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-encoded microRNAs (miRNAs) have been characterized previously. Here, we report the fifth AcMNPV-encoded miRNA, AcMNPV-miR-5 (Ac-miR-5), which downregulates the viral gene a…
View article: Effect of cobalt ions on TNF-α and IL-6 secretion by fibroblasts surrounding hip periprosthetic membrane
Effect of cobalt ions on TNF-α and IL-6 secretion by fibroblasts surrounding hip periprosthetic membrane Open
Aims The periprosthetic fibroblast-like cells (PPFs) play an important role in aseptic loosening after total hip arthroplasty (THA). However, little is known about fibroblast metabolism in aseptic loosening. Proinflammatory cytokines such …
View article: Home Tonometry Diurnal Intraocular Pressure Patterns, Patient Adherence, and Measurement Reliability in a Prospective Clinical Cohort
Home Tonometry Diurnal Intraocular Pressure Patterns, Patient Adherence, and Measurement Reliability in a Prospective Clinical Cohort Open
ICH2 is clinically useable and effective for detecting out-of-office IOP spikes, diurnal IOP patterns, and IOP variation.
View article: Identification of <scp><i>PpTHE1</i></scp>, a cell wall integrity sensor regulating the increased duration of harvest window in slow‐melting flesh peach, through the assembly of a chromosome‐level reference genome of <i>Prunus persica</i>
Identification of <span><i>PpTHE1</i></span>, a cell wall integrity sensor regulating the increased duration of harvest window in slow‐melting flesh peach, through the assembly of a chromosome‐level reference genome of <i>Prunus persica</i> Open
Summary Slow‐melting flesh (SMF) in peaches offers many advantages, including easy transportation, maintaining flavour after ripening, an extended harvest window, and reduced losses caused by fruit softening. However, the underlying molecu…
View article: Surveying patients’ experiences and perspectives on venous thromboembolism: gaps and opportunities in health delivery
Surveying patients’ experiences and perspectives on venous thromboembolism: gaps and opportunities in health delivery Open
View article: Habitat-specific modulation of sesquiterpenoid and polyacetylene biosynthesis in Atractylodes lancea (Thunb.) DC under understory cultivations: Implication for optimized plant morphology and bioactivity
Habitat-specific modulation of sesquiterpenoid and polyacetylene biosynthesis in Atractylodes lancea (Thunb.) DC under understory cultivations: Implication for optimized plant morphology and bioactivity Open
View article: The Degeneration of Paraspinal Muscles and Its Correlation with the Postoperative Clinical Outcomes Following Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF)
The Degeneration of Paraspinal Muscles and Its Correlation with the Postoperative Clinical Outcomes Following Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF) Open
Continuous atrophy was observed in both psoas major muscle and lumbar posterior muscles of fused segments as well as adjacent segments. However, by the end of the 12-month period after the operation, an improvement in fatty degeneration wa…
View article: Unveiling the social and environmental benefits of digital transformation in corporations
Unveiling the social and environmental benefits of digital transformation in corporations Open
In the context of the “dual-carbon” goal and the digital economy, exploring the impact of digital transformation on enterprises’ social and environmental responsibility is a key issue for achieving sustainable enterprise development and pr…
View article: Expression Analysis of Chlorophyll-Degradation-Related Genes in Prunus persica L. Peel and the Functional Verification of Key Genes
Expression Analysis of Chlorophyll-Degradation-Related Genes in Prunus persica L. Peel and the Functional Verification of Key Genes Open
With the evolution of consumer purchasing power and consumption concepts, external attributes such as fruit size, color, and peel smoothness have emerged as pivotal determinants influencing purchasing preferences; among these, the backgrou…
View article: N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression
N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression Open
In vitro transcribed messenger RNA (IVT mRNA) has emerged as a pivotal tool in mRNA-based therapies and has been extensively employed in gene function studies and genetic tool applications. However, the IVT process generates double-strande…
View article: Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis
Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis Open
Aggregation of TAR-DNA binding protein-43 (TDP-43) is a pathological feature present in nearly 97 % cases of amyotrophic lateral sclerosis (ALS), making it an attractive target for pathogenic studies and drug screening. Here, we have perfo…
View article: Mapping zygote-to-adult developmental cell phylogeny in Arabidopsis thaliana reveals a 3-cell rule of branching
Mapping zygote-to-adult developmental cell phylogeny in Arabidopsis thaliana reveals a 3-cell rule of branching Open
Similar to the evolutionary history of all species on Earth, the developmental lineage history of all cells in a multicellular organism is stored in a phylogenetic tree. Mapping the zygote-to-adult developmental cell phylogeny of a complex…
View article: The MYB transcription factor PpMYB5 regulates Pp4CL1/Pp4CL2 expression to promote lignin biosynthesis of fruit russeting in the flat nectarine
The MYB transcription factor PpMYB5 regulates Pp4CL1/Pp4CL2 expression to promote lignin biosynthesis of fruit russeting in the flat nectarine Open
Nectarine russeting is usually considered to be a non-invasive physiological disease that usually occurs on late maturing cultivars and seriously affects their appearance quality and commercial value. The cause of nectarine fruit rust is c…
View article: Comparative Cell Wall Polysaccharide Analyses and Transcriptome Profiling during Fruit Ripening Reveal the Molecular Basis of Mealiness in Peach
Comparative Cell Wall Polysaccharide Analyses and Transcriptome Profiling during Fruit Ripening Reveal the Molecular Basis of Mealiness in Peach Open
Mealy peaches are dry and flavorless, which reduces their consumer acceptance. A deeper understanding of the mechanism underlying mealiness is crucial to enhancing peach fruit quality. In this study, comparative profiling was conducted on …
View article: Analysis of Microstructure, Cell Wall Polysaccharides, and Candidate Cell Wall-related Genes in Clingstone-type and Freestone-type Stony Hard Peaches during Ripening
Analysis of Microstructure, Cell Wall Polysaccharides, and Candidate Cell Wall-related Genes in Clingstone-type and Freestone-type Stony Hard Peaches during Ripening Open
Stony hard (SH) peach ( Prunus persica ) fruits produce no ethylene and clingstone-type SH peaches have a crispy flesh texture; however, freestone-type SH peach fruits ripen to a soft, mealy state. During this study, we compared and analyz…
View article: Bounding the $K(p-1)$-local exotic Picard group at $p>3$
Bounding the $K(p-1)$-local exotic Picard group at $p>3$ Open
In this paper, we bound the descent filtration of the exotic Picard group $κ_n$, for a prime number p>3 and n=p-1. Our method involves a detailed comparison of the Picard spectral sequence, the homotopy fixed point spectral sequence, and a…
View article: An Intelligent Plant and Animal Identification Mobile Application for Increased Biodiversity Awareness and Safety using Machine Learning
An Intelligent Plant and Animal Identification Mobile Application for Increased Biodiversity Awareness and Safety using Machine Learning Open
Dangerous animal encounters have steadily increased over time and consumption of deadly plants is an important issue [12]. Our paper introduces a new mobile application that addresses the critical need for accurate animal and plant identif…
View article: Childhood Asthma and Type 1 Diabetes Mellitus: A Meta-analysis and Bidirectional Mendelian Randomization Study
Childhood Asthma and Type 1 Diabetes Mellitus: A Meta-analysis and Bidirectional Mendelian Randomization Study Open
Objectives: World-wide incidence and prevalence of both asthma and type 1 diabetes mellitus (T1DM) has been increasing in past decades. Association between the two diseases has been found in some but not other studies. We conducted a meta-…
View article: Preliminary Analysis, Combined with Omics of Chilling Injury Mechanism of Peach Fruits with Different Cold Sensitivities during Postharvest Cold Storage
Preliminary Analysis, Combined with Omics of Chilling Injury Mechanism of Peach Fruits with Different Cold Sensitivities during Postharvest Cold Storage Open
The storage of peach fruits at 4–5 °C can easily lead to chilling injury and greatly reduce the quality and commercial value of peach fruits. In this study, two kinds of peach fruits (CX and CM) were selected to analyze the mechanisms of c…
View article: Exosomal miRNA-146a-5p Derived from Senescent Hepatocellular Carcinoma Cells Promotes Aging and Inhibits Aerobic Glycolysis in Liver Cells via Targeting IRF7
Exosomal miRNA-146a-5p Derived from Senescent Hepatocellular Carcinoma Cells Promotes Aging and Inhibits Aerobic Glycolysis in Liver Cells via Targeting IRF7 Open
Hepatocellular carcinoma (HCC) is a major global health challenge. Chemotherapy can cause HCC cells to become senescent. Senescent HCC cells play an important role in inhibiting or promoting cancer by producing extracellular vesicles with …
View article: Identification and Validation of Nicotinamide metabolism-Related Gene Signatures as a Novel Prognostic Model for hepatocellular carcinoma
Identification and Validation of Nicotinamide metabolism-Related Gene Signatures as a Novel Prognostic Model for hepatocellular carcinoma Open
Background Nicotinamide (NAM) regulates redox and metabolic activities in the mitochondria. The intention of the research was to identify key genes that relate to nicotinamide in hepatocellular carcinoma (HCC). Methods Relevant clinical in…
View article: An effective strategy for identifying autogenous regulation of transcription factors in filamentous fungi
An effective strategy for identifying autogenous regulation of transcription factors in filamentous fungi Open
Transcription factors (TFs) play a crucial role in regulating gene expression in living organisms, and any malfunction in their functions can lead to severe physiological consequences. The regulation of TFs occurs at multiple levels, with …
View article: Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function
Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function Open
Alzheimer's disease (AD) and other forms of dementia represent major public health challenges but effective therapeutic options are limited. Pathological brain aging is associated with microvascular changes and impaired clearance systems. …
View article: A NAC transcription factor, PpNAC1, regulates the expression of PpMYB10.1 to promote anthocyanin biosynthesis in the leaves of peach trees in autumn
A NAC transcription factor, PpNAC1, regulates the expression of PpMYB10.1 to promote anthocyanin biosynthesis in the leaves of peach trees in autumn Open
Red leaves in autumn are characteristic of a very early-maturing ripening variety of peach ( Prunus persica ). Analysis of the genetic factors and molecular mechanisms associated with the red-leaf phenotype can help breed peach very early …
View article: Transcriptome-wide RNA structure probing with temporal resolution
Transcriptome-wide RNA structure probing with temporal resolution Open
Reactive small-molecule probes are widely used for RNA structure probing, however current approaches largely measure average RNA transcript dynamics and do not resolve structural differences that occur during folding or transcript maturati…
View article: Supplementary Data from Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins
Supplementary Data from Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins Open
Supplementary Figures S1-S3 and Supplementary Tables S1-S2.
View article: Data from Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins
Data from Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins Open
Genes that are differentially expressed in pancreatic cancers and under epigenetic regulation are of considerable biological and therapeutic interest. We used global gene expression profiling and epigenetic treatment of pancreatic cell lin…
View article: Data from Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins
Data from Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins Open
Genes that are differentially expressed in pancreatic cancers and under epigenetic regulation are of considerable biological and therapeutic interest. We used global gene expression profiling and epigenetic treatment of pancreatic cell lin…