Zuoying Yuan
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View article: Piezo1 mediated scaffold-free rapid generation of self-mineralized bone organoids via activating Wnt signaling
Piezo1 mediated scaffold-free rapid generation of self-mineralized bone organoids via activating Wnt signaling Open
View article: Decellularized extracellular matrix bio-patch with strong and biodegradable wet adhesive interface for sutureless soft tissue defect repair
Decellularized extracellular matrix bio-patch with strong and biodegradable wet adhesive interface for sutureless soft tissue defect repair Open
Decellularized extracellular matrix-based bio-patches offer superior biocompatibility and bioactivity, making them an ideal implantation material for soft tissue defect repair. However, the fixation of these patches typically relies on sut…
View article: Polyphenol crosslinked carboxymethyl chitosan fibrous membrane for rapid hemostasis and infected wound healing
Polyphenol crosslinked carboxymethyl chitosan fibrous membrane for rapid hemostasis and infected wound healing Open
Developing advanced hemostatic materials that both facilitate more efficient haemostasis and anti-bacterial wound healing is essential for the treatment of severe trauma. Herein, we present a unique polyphenol crosslinked carboxymethyl chi…
View article: Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles
Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles Open
Local electrical stimulation (LES) is a widely used clinical method to treat peripheral nerve injury. However, existing plate electrodes (PE) usually suffer from low electronic transport efficiency, whereas acupuncture electrical stimulati…
View article: Oncostatin-M functionalized cryogel microspheres for promoting diabetic bone defects regeneration
Oncostatin-M functionalized cryogel microspheres for promoting diabetic bone defects regeneration Open
The ability of OSM/MS to promote endogenous stem cell recruitment, modulate the immune-osteogenesis microenvironment, and induce angiogenesis makes it a potent candidate for diabetic bone defects. The injectable and porous nature of OSM/MS…
View article: Bioinspired ultra-adhesive microneedle patch for long-lasting deep drug delivery
Bioinspired ultra-adhesive microneedle patch for long-lasting deep drug delivery Open
View article: Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling
Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling Open
Periodontitis is characterized by inflammation and alveolar bone loss, primarily caused by immune cells activated by oral bacteria, leading to an imbalance between osteogenesis and bone resorption. Traditional treatments have limited effic…
View article: Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects
Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects Open
3D aggregates optimize regenerative behaviors of in vitro cultured MSCs including cell adhesion, viability, proliferation, pluripotency and immunoregulation capacity, etc. Biomaterials hybridization endows MSC aggregates with tailored mech…
View article: Hydrogen bonding-mediated phase-transition gelatin-based bioadhesives to regulate immune microenvironment for diabetic wound healing
Hydrogen bonding-mediated phase-transition gelatin-based bioadhesives to regulate immune microenvironment for diabetic wound healing Open
Gelatin-based biomaterials have emerged as promising candidates for bioadhesives due to their biodegradability and biocompatibility. However, they often face limitations due to the uncontrollable phase transition of gelatin, which is domin…
View article: Transcutaneous Electrotherapy of Facial Nerve Injuries Based on Dissolvable Conductive Microneedles
Transcutaneous Electrotherapy of Facial Nerve Injuries Based on Dissolvable Conductive Microneedles Open
View article: Biodegradable all-natural hydrogel–mesh composite for wet tissues adhesion and infected wound healing
Biodegradable all-natural hydrogel–mesh composite for wet tissues adhesion and infected wound healing Open
The application of meshes in surgery is severely limited by complications associated with the non-absorbable nature, the lack of bioactivities, and the need of sutures and/or staples to fix meshes on tissues. In this contribution, a self-a…
View article: Geometric constraint-triggered collagen expression mediates bacterial-host adhesion
Geometric constraint-triggered collagen expression mediates bacterial-host adhesion Open
Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-ho…
View article: Extracellular Matrix Rigidities Regulate the Tricarboxylic Acid Cycle and Antibiotic Resistance of Three‐Dimensionally Confined Bacterial Microcolonies
Extracellular Matrix Rigidities Regulate the Tricarboxylic Acid Cycle and Antibiotic Resistance of Three‐Dimensionally Confined Bacterial Microcolonies Open
As a major cause of clinical chronic infection, microbial biofilms/microcolonies in host tissues essentially live in 3D‐constrained microenvironments, which potentially modulate their spatial self‐organization and morphodynamics. However, …
View article: Catch bond-inspired hydrogels with repeatable and loading rate-sensitive specific adhesion
Catch bond-inspired hydrogels with repeatable and loading rate-sensitive specific adhesion Open
View article: Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration
Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration Open
View article: Vascularized pulp regeneration via injecting simvastatin functionalized GelMA cryogel microspheres loaded with stem cells from human exfoliated deciduous teeth
Vascularized pulp regeneration via injecting simvastatin functionalized GelMA cryogel microspheres loaded with stem cells from human exfoliated deciduous teeth Open
View article: <p>Establishing an osteoimmunomodulatory coating loaded with aspirin on the surface of titanium primed with phase-transited lysozyme</p>
Establishing an osteoimmunomodulatory coating loaded with aspirin on the surface of titanium primed with phase-transited lysozyme Open
This study highlights the significant effects of appropriate surface characteristics on the regulation of osteogenesis and osteoimmunomodulation around an implant. Implant modification with ASA potentially provides superior strategies for …