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View article: Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium Open
View article: Defining and assessing international classification of disease suicidality phenotypes for genetic studies
Defining and assessing international classification of disease suicidality phenotypes for genetic studies Open
Lists of applicable ICD codes for SI and SA were developed that complied with C-SSRS definitions. Real-world application of ICD codes can vary substantially, perhaps dependent on clinician training and on cohort characteristics. Consistent…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins
Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins Open
Suicidal thoughts and behaviors (STBs) represent a significant public health concern. This study aimed to examine the extent to which polygenic risk scores (PRSs) for suicide attempt and major depression (MD) explain variance in suicidal i…
View article: Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities
Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities Open
Objective Chronic pain is prevalent among people living with Parkinson's disease (PD). We analyzed data from 10,631 Australian individuals with PD to assess the prevalence, age and sex differences, severity, anatomical distribution, clinic…
View article: Insights from a nationwide study of 10,929 Australians living with Parkinson’s disease: Risk factors, comorbidities, and sex differences
Insights from a nationwide study of 10,929 Australians living with Parkinson’s disease: Risk factors, comorbidities, and sex differences Open
Summary Background Parkinson’s disease (PD) is a complex neurodegenerative condition with a heterogeneous clinical presentation and multifactorial aetiology. Despite substantial progress in PD research, the underlying causes and biological…
View article: Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults
Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults Open
Genome‐wide association studies (GWAS) have uncovered genetic variants associated with suicide attempt (SA) risk and regional brain volumes (RBVs). However, the extent of their genetic overlap remains unclear. To address this, we investiga…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: CD8<sup>+</sup>T cells mediate vaccination-induced lymphatic containment of latent <i>Mycobacterium tuberculosis</i> infection following immunosuppression, while B cells are dispensable
CD8<sup>+</sup>T cells mediate vaccination-induced lymphatic containment of latent <i>Mycobacterium tuberculosis</i> infection following immunosuppression, while B cells are dispensable Open
It is estimated that two billion people are latently infected with Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis (TB). Latent Mtb infection (LTBI) can occur in multiple organs, including the lymphatics. The risk o…
View article: Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium Open
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this lar…
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
View article: Recent Breakthroughs in Genetic and Brain Structural Correlates of Suicidal Behaviors: A Short Review
Recent Breakthroughs in Genetic and Brain Structural Correlates of Suicidal Behaviors: A Short Review Open
Suicide accounts for more than 700,000 deaths annually and is the fourth leading cause of death among individuals aged 15 to 29 years. Despite years of research to understand the etiology and pathophysiology of suicidal behavior, many ques…
View article: Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries Open
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globu…
View article: Defining and Assessing International Classification of Disease Suicidality Phenotypes for Genetic Studies
Defining and Assessing International Classification of Disease Suicidality Phenotypes for Genetic Studies Open
Background Suicidality, including suicidal ideation (SI), attempt (SA), and death (SD), represents complex and partially overlapping phenotypes. This complexity contributes to study population heterogeneity in suicidality research, impedin…