Explanipedia

Machine learning predicts post-transplant muscle loss in hepatocellular carcinoma patients without sarcopenia Open

Jinyan Chen, Zhigang Hu, Huigang Li, Renyi Su, Zuyuan Lin , et al. · 2025

Objective Developing a machine learning model to predict post-transplant muscle loss in hepatocellular carcinoma patients. Background Liver transplantation is an effective treatment for selected HCC patients. However, severe muscle loss af…

Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application Open

Chenghao Cao, Di Lu, Huigang Li, Pan Shen, Jianyong Zhuo , et al. · 2025

Lung metastasis remains a leading cause of cancer mortality, driven not only by primary tumors but crucially by dynamic interactions within the premetastatic niche (PMN). Emerging evidence reveals that organ‐specific PMN formation precedes…

The Favorable Impact of HBcAb-Positive Grafts on Liver Transplantation for HBV-Related Hepatocellular Carcinoma Open

Huigang Li, Jianyong Zhuo, Weiliang Shen, Jinyan Chen, Peiru Zhang , et al. · 2025

Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma Open

Jinyan Chen, Huigang Li, Jianyong Zhuo, Zuyuan Lin, Zhigang Hu , et al. · 2024

Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is …

Body shape, fat distribution and sarcopenia and risk of liver cancer in European population: a Mendelian randomization study Open

Yong-Cai Liu, Chiyu He, Peiru Zhang, Zhigang Hu, Zuyuan Lin , et al. · 2024

Background Body shape, fat and muscle are likely associated with risk of liver cancer. Evidence for the impact of these factor is limited and controversial. Because conventional observational studies cannot sidestep the effect of confoundi…

Growth differentiation factor 7 alleviates the proliferation and metastasis of hepatocellular carcinoma Open

Jianyong Zhuo, Huigang Li, Peiru Zhang, Chiyu He, Wei Feng Shen , et al. · 2024

GDF7 is a potential biomarker for predicting superior outcomes in patients with HCC. GDF7 amplification is a potential therapeutic option for HCC.

FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury Open

Xinyu Yang, Hao Chen, Wei Shen, Yuanming Chen, Zuyuan Lin , et al. · 2024

Myosteatosis and muscle loss impact liver transplant outcomes in male patients with hepatocellular carcinoma Open

Di Lu, Zhihang Hu, Hao Chen, Abid Khan, Qingguo Xu , et al. · 2024

Background Sarcopenia is associated with unfavourable long‐term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not…

An inflammatory liquid fingerprint predicting tumor recurrence after liver transplantation for hepatocellular carcinoma Open

Modan Yang, Zuyuan Lin, Li Zhuang, Linhui Pan, Rui Wang , et al. · 2024

Tumor recurrence is a life‐threatening complication after liver transplantation (LT) for hepatocellular carcinoma (HCC). Precise recurrence risk stratification before transplantation is essential for the management of recipients. Here, we …

Chitinase-3 like-protein-1, a prognostic biomarker in patients with hepatocellular carcinoma and concomitant myosteatosis Open

Chiyu He, Zhihang Hu, Zuyuan Lin, Hao Chen, Chenghao Cao , et al. · 2024

Elevated CHI3L1 was negatively correlated with SMRA, and predicted poorer prognosis in Chinese population after LT for HCC, especially in those patients with concomitant myosteatosis. Monitoring serum CHI3L1 can predict prognosis and effec…

CCL16 inhibits tumor proliferation and metastasis in HCC by impacting CK19 phenotype Open

Huigang Li, Jianyong Zhuo, Peiru Zhang, Jinyan Chen, Zuyuan Lin , et al. · 2024

Evaluation of liver regeneration after hemi-hepatectomy by combining computed tomography and post-operative liver function Open

Wenzhi Shu, Yisu Song, Zuyuan Lin, Mengfan Yang, Binhua Pan , et al. · 2024

The adverse impact of perioperative body composition abnormalities on outcomes after split liver transplantation: a multicenter retrospective cohort study Open

Hao Chen, Zhihang Hu, Qingguo Xu, Chiyu He, Xinyu Yang , et al. · 2024

Background: Split liver transplantation (SLT) increases graft availability, but it’s safe and effective utilization is insufficiently documented. This study aimed to investigate the association between perioperative body composition abnorm…

Post-transplant hepatitis B virus reactivation impacts the prognosis of patients with hepatitis B-related hepatocellular carcinoma: a dual-centre retrospective cohort study in China Open

Huigang Li, Di Lu, Jingyan Chen, Junchi Zhang, Jianyong Zhuo , et al. · 2024

Background: Highly active hepatitis B virus (HBV) is known to be associated with poor outcomes in patients with hepatocellular carcinoma (HCC). This study aims to investigate the relationship between HBV status and HCC recurrence after liv…

The tumor inhibitory function of growth differentiation factors on hepatocellular carcinoma Open

Jianyong Zhuo, Huigang Li, Chiyu He, Wei Feng Shen, Peiru Zhang , et al. · 2023

Purpose Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies with very poor outcomes. Inflammatory factors play a huge role in the incidence and development of HCC. But, the tumor-protective functions of growth differen…

Dynamic immune cell profiling identified natural killer cell shift as the key event in early allograft dysfunction after liver transplantation Open

Di Lu, Xinyu Yang, Linhui Pan, Zhengxing Lian, Winyen Tan , et al. · 2023

Early allograft dysfunction (EAD) is a life‐threatening and fast‐developing complication after liver transplantation. The underlying mechanism needs to be better understood, and there has yet to be an efficient therapeutic target. This stu…

FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases Open

Wei Shen, Modan Yang, Hao Chen, Chiyu He, Huigang Li , et al. · 2023

Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology Open

Zhihang Hu, Modan Yang, Hao Chen, Chiyu He, Zuyuan Lin , et al. · 2023

Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer. In addition to the common mechanisms underlying tumor recurrence, another unavoidable problem is that the immunosuppressive t…

Metabolomic biomarkers for the diagnosis and post-transplant outcomes of AFP negative hepatocellular carcinoma Open

Zuyuan Lin, Huigang Li, Chiyu He, Modan Yang, Hao Chen , et al. · 2023

Background Early diagnosis for α-fetoprotein (AFP) negative hepatocellular carcinoma (HCC) remains a critical problem. Metabolomics is prevalently involved in the identification of novel biomarkers. This study aims to identify new and effe…

An Inflammatory Liquid Fingerprint Predicting Tumor Recurrence after Liver Transplantation for Hepatocellular Carcinoma Open

Modan Yang, Zuyuan Lin, Li Zhuang, Linhui Pan, Rui Wang , et al. · 2023

TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma Open

Huigang Li, Zuyuan Lin, Jianyong Zhuo, Modan Yang, Wei Feng Shen , et al. · 2023

TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC. A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC.

Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer Open

Di Lu, Zuyuan Lin, Rui Wang, Zun Chen, Jianyong Zhuo , et al. · 2022

Sarcopenia is prevalent in patients with hepatocellular carcinoma (HCC), and can adversely affect their outcomes. This study aims to explore the key mechanisms in the crosstalk between sarcopenia and HCC based on multi-omics profiling. A t…

Liver Organoids, Novel and Promising Modalities for Exploring and Repairing Liver Injury Open

Chiyu He, Di Lu, Zuyuan Lin, Hao Chen, Huigang Li , et al. · 2022

One Shoot, Two Birds: Alleviating Inflammation Caused by Ischemia/Reperfusion Injury to Reduce the Recurrence of Hepatocellular Carcinoma Open

Hao Chen, Di Lu, Xinyu Yang, Zhihang Hu, Chiyu He , et al. · 2022

Inflammation is crucial to tumorigenesis and the development of metastasis. Hepatic ischemia/reperfusion injury (IRI) is an unresolved problem in liver resection and transplantation which often establishes and remodels the inflammatory mic…

The distinct responsiveness of cytokeratin 19-positive hepatocellular carcinoma to regorafenib Open

Jianyong Zhuo, Di Lu, Zuyuan Lin, Xinyu Yang, Modan Yang , et al. · 2021

Single‐cell profiling reveals distinct immune phenotypes that contribute to ischaemia‐reperfusion injury after steatotic liver transplantation Open

Xinyu Yang, Di Lu, Rui Wang, Zhengxing Lian, Zuyuan Lin , et al. · 2021

Objectives The discrepancy between supply and demand of organ has led to an increased utilization of steatotic liver for liver transplantation (LT). Hepatic steatosis, however, is a major risk factor for graft failure due to increased susc…

Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients Open

Renyi Su, Xuyong Wei, Qiang Wei, Di Lü, Zuyuan Lin , et al. · 2021

Gut, adipose tissue and muscle are intricately intertwined in promoting NAFLD in LT cases. Further animal studies are needed to deepen our understanding of mechanisms in multi-organ crosstalk. High quality clinical trials are warrant for m…

Targeting tumor microenvironment as a treatment strategy for hepatocellular carcinoma Open

Zuyuan Lin, Xiaonan Xiang, Di Lu, Xiao Xu · 2020

Liver cancer was ranked the sixth most commonly diagnosed cancer with the fourth leading cause of cancer-related deaths worldwide in 2018 (1).Notably, hepatocellular carcinoma (HCC) constitutes 75-85% among all the liver cancer cases, and …

The Matching Status Between Donor and Recipient Hepatitis B Seroepidemiology Makes a Difference in Liver Transplantation for Hepatocellular Carcinoma Open

Di Lu, Fan Yang, Jianyong Zhuo, Modan Yang, Zuyuan Lin , et al. · 2020

INTRODUCTION: Antibody to hepatitis B core antigen (HBcAb) is known to be related with the prognosis for patients with hepatocellular carcinoma (HCC). This study aims to evaluate the prognostic capacity of HbcAb and other donor/recipient h…

C C motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells Open

Jianyong Zhuo, Di Lu, Zuyuan Lin, Beini Cen, Xuyong Wei , et al. · 2020

CCL16 could be a feasible plasma marker to predict the occurrence and progression of liver cirrhosis. CCL16 might impact liver cirrhosis through inactivating hepatic stellate cells.

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