Zuzana Saidak
YOU?
Author Swipe
View article: Salivary cell-free DNA methylation analysis for oncological monitoring of surgical resection of oral squamous cell carcinoma
Salivary cell-free DNA methylation analysis for oncological monitoring of surgical resection of oral squamous cell carcinoma Open
Objective Non-invasive analysis of tumor DNA in biological fluids offers promising perspectives for the oncological monitoring of cancer patients. Cancer-specific DNA methylation marks are detectable in the saliva of Oral Squamous Cell Car…
View article: Advancing cancer precision surgery with the tumor coagulome
Advancing cancer precision surgery with the tumor coagulome Open
Solid tumors generate a local and systemic procoagulant state, placing cancer patients at risk of hemostatic complications. The interplay between the tumor coagulome, a tumor-intrinsic determinant, and surgery-induced coagulopathy may infl…
View article: The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma
The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma Open
Objectives The tumor coagulome is an intrinsic characteristic of human tumors and a key determinant of cancer-associated thrombosis (CAT). Oral Squamous Cell Carcinoma (OSCC) establish a local procoagulant state that contributes to a broad…
View article: The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma
The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma Open
The local expression of coagulation-related genes defines the tumor coagulome. The tumor coagulome plays a pivotal role in cancer-associated thrombosis (CAT) and hemostatic complications, such as venous thromboembolism (VTE), which are fre…
View article: Transcriptional Induction of <i>SERPINE1</i> and Fibrinolysis Inhibition as Predominant Effects of Glucocorticoids on the Cancer Coagulome
Transcriptional Induction of <i>SERPINE1</i> and Fibrinolysis Inhibition as Predominant Effects of Glucocorticoids on the Cancer Coagulome Open
Fibrinolysis inhibition is a key consequence of cancer cell exposure to GC, possibly leading to the stabilization of the fibrin clot in cancer.
View article: An MRI Radiomics Approach to Predict the Hypercoagulable Status of Gliomas
An MRI Radiomics Approach to Predict the Hypercoagulable Status of Gliomas Open
Venous thromboembolic events are frequent complications of Glioblastoma Multiforme (GBM) and low-grade gliomas (LGGs). The overexpression of tissue factor (TF) plays an essential role in the local hypercoagulable phenotype that underlies t…
View article: The Tumor Coagulome as a Transcriptional Target and a Potential Effector of Glucocorticoids in Human Cancers
The Tumor Coagulome as a Transcriptional Target and a Potential Effector of Glucocorticoids in Human Cancers Open
Background: The coagulome, defined as the repertoire of genes that locally regulate coagulation and fibrinolysis, is a key determinant of vascular thromboembolic complications of cancer. In addition to vascular complications, the coagulome…
View article: Evaluation of Proton MR Spectroscopy for the Study of the Tongue Tissue in Healthy Subjects and Patients With Tongue Squamous Cell Carcinoma: Preliminary Findings
Evaluation of Proton MR Spectroscopy for the Study of the Tongue Tissue in Healthy Subjects and Patients With Tongue Squamous Cell Carcinoma: Preliminary Findings Open
Purpose To noninvasively assess spectroscopic and metabolic profiles of healthy tongue tissue and in an exploratory objective in nontreated and treated patients with tongue squamous cell carcinoma (SCC). Methods Fourteen healthy subjects (…
View article: Principe et applicabilité de la chirurgie de précision aux cancers de la tête et du cou
Principe et applicabilité de la chirurgie de précision aux cancers de la tête et du cou Open
La chirurgie est la modalité de traitement curatif la plus fréquemment utilisée dans les cancers de la tête et du cou. Elle est intégrée dans des schémas de stratification thérapeutique précis, mais la conduite de l’acte chirurgical et son…
View article: Editorial: Oral Oncology: From Precise Surgery to Precision Medicine and Surgery
Editorial: Oral Oncology: From Precise Surgery to Precision Medicine and Surgery Open
EDITORIAL article Front. Oral. Health, 28 April 2022Sec. Oral Cancers https://doi.org/10.3389/froh.2022.913172
View article: Utility of assessing <scp>CD3</scp><sup>+</sup> cell chimerism within the first months after allogeneic hematopoietic stem‐cell transplantation for acute myeloid leukemia
Utility of assessing <span>CD3</span><sup>+</sup> cell chimerism within the first months after allogeneic hematopoietic stem‐cell transplantation for acute myeloid leukemia Open
After allogeneic hematopoietic stem‐cell transplantation (alloHSCT), the chimerism assay is used to monitor cell engraftment and quantify the respective proportions of donor/recipient cells in blood or bone‐marrow samples. Here, we aimed t…
View article: Molecular Landscape of the Coagulome of Oral Squamous Cell Carcinoma
Molecular Landscape of the Coagulome of Oral Squamous Cell Carcinoma Open
Background: Hemostatic complications, ranging from thromboembolism to bleeding, are a significant source of morbidity and mortality in cancer patients. The tumor coagulome represents the multiple genes and proteins that locally contribute …
View article: Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)
Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC) Open
The perioperative period is the relatively short window of time, usually measured in days or weeks, around the surgical procedure. Despite its short duration, this time period is of great importance for cancer patients. From a biological p…
View article: Effets indésirables rhumatologiques associés aux inhibiteurs de points de contrôle immunitaire : impact sur la survie globale
Effets indésirables rhumatologiques associés aux inhibiteurs de points de contrôle immunitaire : impact sur la survie globale Open
View article: Analysis of Mesencephalic Astrocyte-derived Neurotrophic Factor in Multiple Myeloma
Analysis of Mesencephalic Astrocyte-derived Neurotrophic Factor in Multiple Myeloma Open
MANF was not validated as a biomarker of interest in MM patients. Its potential implication in myeloma pathogenesis should be investigated.
View article: Correction to: ASO Visual Abstract: Contribution of Genomics to the Surgical Management and Study of Oral Cancer
Correction to: ASO Visual Abstract: Contribution of Genomics to the Surgical Management and Study of Oral Cancer Open
International audience
View article: ASO Visual Abstract: Contribution of Genomics to the Surgical Management and Study of Oral Cancer
ASO Visual Abstract: Contribution of Genomics to the Surgical Management and Study of Oral Cancer Open
View article: DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU)
DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU) Open
Our study highlights the specific DNA Damage Response- and JAK- dependent induction of PD-L1 by 5-FU in HNSCC cells. This induction is regulated by the cytokine context and is potentially therapeutically actionable.
View article: Contribution of Genomics to the Surgical Management and Study of Oral Cancer
Contribution of Genomics to the Surgical Management and Study of Oral Cancer Open
View article: Rheumatic and musculoskeletal disorders induced by immune checkpoint inhibitors: Consequences on overall survival
Rheumatic and musculoskeletal disorders induced by immune checkpoint inhibitors: Consequences on overall survival Open
View article: A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment
A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment Open
View article: SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma
SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma Open
View article: Genomics and precision surgery for head and neck squamous cell carcinoma
Genomics and precision surgery for head and neck squamous cell carcinoma Open
The identification of the biological determinants that shape the response of tumors to medical therapies offers perspectives for better patient stratification and therapeutic targeting. Here, we discuss how genomics could help to improve t…
View article: ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma
ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma Open
The tumor microenvironment is an important determinant of glioblastoma (GBM) progression and response to treatment. How oncogenic signaling in GBM cells modulates the composition of the tumor microenvironment and its activation is unclear.…
View article: P14.92 Study of Glutaminergic and Glutamatergic Metabolism in 1H-MRS Monovoxel in the Most Aggressive Part of 62 Glioblastoma Before and After 18 months Treatment
P14.92 Study of Glutaminergic and Glutamatergic Metabolism in 1H-MRS Monovoxel in the Most Aggressive Part of 62 Glioblastoma Before and After 18 months Treatment Open
BACKGROUND To study the relationships between glutaminergic metabolism (Glx/tCr), tumor proliferation (tCho/tCr) and other metabolic activities in patients with glioblastoma (GBM). MATERIAL AND METHODS Patients: 62 patients with glioblasto…
View article: P14.81 Importance of early spectral variations during a longitudinal 60-month follow-up MRI and 1H-MRS in 135 treated glioblastoma patients
P14.81 Importance of early spectral variations during a longitudinal 60-month follow-up MRI and 1H-MRS in 135 treated glioblastoma patients Open
BACKGROUND To better understand glioblastomas tumor metabolism and metabolic responses to chemotherapy, radiotherapy and antiangiogenic treatments during a longitudinal 60-month follow-up MRI and 1H-MRS in 135 treated glioblastoma patients…
View article: A three-gene expression signature associated with positive surgical margins in tongue squamous cell carcinomas: Predicting surgical resectability from tumour biology?
A three-gene expression signature associated with positive surgical margins in tongue squamous cell carcinomas: Predicting surgical resectability from tumour biology? Open
View article: Early decrease in serum amphiregulin or vascular endothelial growth factor levels predicts sorafenib efficacy in hepatocellular carcinoma
Early decrease in serum amphiregulin or vascular endothelial growth factor levels predicts sorafenib efficacy in hepatocellular carcinoma Open
Sorafenib is the standard of care for the treatment of advanced hepatocellular carcinoma (HCC). However, identifying secreted biomarkers that predict sorafenib efficacy in all HCC patients remains challenging. It was recently reported that…
View article: A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates
A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates Open
Uric acid (UA) is the end product of the catabolism of purines, and its serum levels are commonly increased in cancer patients. We aimed to explore the transcriptional regulation of tumour uricogenesis in human tumours, and relate uricogen…
View article: Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours
Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours Open
Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context.