Pharmacology
View article: Hub genes in a pan-cancer co-expression network show potential for predicting drug responses
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses Open
Dataset 1. Gene co-expression network data. It contains network nodes, weighted network and list of hubs. Dataset 2. qPCR data from independent validation, including MIQE and additional information.
View article: KCNQ2/3 Regulates the Synaptic Ecology of Drug Seeking in Addiction
KCNQ2/3 Regulates the Synaptic Ecology of Drug Seeking in Addiction Open
View article: Dataset on dextromethorphan as a novel pharmacological inhibitor of F1FO-ATPase
Dataset on dextromethorphan as a novel pharmacological inhibitor of F1FO-ATPase Open
This dataset contains data from the evaluation of the inhibitory effect of dextromethorphan (DXM) on the hydrolytic and synthesis activity of mitochondrial F1FO-ATPase, isolated from porcine heart. The aim of the research was to investigat…
View article: KCNQ2/3 Regulates the Synaptic Ecology of Drug Seeking in Addiction
KCNQ2/3 Regulates the Synaptic Ecology of Drug Seeking in Addiction Open
View article: Intact endogenous pain inhibition in complex regional pain syndrome type 1.
Intact endogenous pain inhibition in complex regional pain syndrome type 1. Open
Our results indicate that in individuals with chronic CRPS type 1, endogenous pain inhibition is intact and comparable with healthy individuals. Therefore, pathomechanisms underlying chronic CRPS are likely related to increased pain facili…
View article: In Vitro Evaluation of the Anthelmintic Activity of Rhus coriaria (Sumac) Extract against Marshallagia marshalli
In Vitro Evaluation of the Anthelmintic Activity of Rhus coriaria (Sumac) Extract against Marshallagia marshalli Open
Marshallagia marshalli, a common parasite in domestic and wild ruminants in Iran, causes parasitic gastroenteritis. Chemical medicines like Levamisole are used to treat this infection, but drug-resistant infections have led to research on …
View article: Comparing the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin for psoriasis.
Comparing the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin for psoriasis. Open
Methotrexate was more effective and persistent than were cyclosporine and acitretin in a real-world setting.
View article: Identification of prospective novel drug targets for immune thrombocytopenia by integrating plasma proteome.
Identification of prospective novel drug targets for immune thrombocytopenia by integrating plasma proteome. Open
Numerous efforts are still needed to identify novel therapies for treatment of ITP. These results indicate that DNAJC21 and NOTCH3 could be prospective therapeutic targets for managing ITP.
View article: Targeting vasomotor symptoms with the new drug fezolinetant - an expert overview.
Targeting vasomotor symptoms with the new drug fezolinetant - an expert overview. Open
Menopause is an inevitable event in the life of women who live long enough to reach this milestone. The experience of menopause varies amongst individuals. Menopause has a negative impact on women's life and is associated with symptoms inc…
View article: Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity
Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity Open
Diabetes, a prevalent metabolic disorder, can lead to irreversible complications if not treated promptly. In animal models, diabetes is commonly induced using alloxan or streptozotocin. Lead initially accumulates in soft tissues such as th…
View article: Acute effect of a multi-ingredient pre-workout supplement on pacing and kinetic expression during shorter and longer bouts of high intensity functional training.
Acute effect of a multi-ingredient pre-workout supplement on pacing and kinetic expression during shorter and longer bouts of high intensity functional training. Open
Although it did not affect repetitions completed, the multi-ingredient pre-workout supplement led to a greater volume load and faster overall repetition completion rate. These were primarily due to improvements surrounding rowing performan…
View article: Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury
Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury Open
Dopaminergic neurodegeneration is associated with oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell death. Allopregnanolone, a multifunctional neurosteroid, is involved in various biological processes within the body…
View article: Intervention of Astaxanthin-ioaded Flaxseed By-product Protein/Pectin Emulsion in Non-alcoholic Fatty Liver Disease
Intervention of Astaxanthin-ioaded Flaxseed By-product Protein/Pectin Emulsion in Non-alcoholic Fatty Liver Disease Open
To enhance the economic value of flaxseed processing by-products while addressing the challenges of astaxanthin's poor water solubility, low stability, and limited bioavailability, this study developed composite emulsifiers (FP/PCs) via el…
View article: Phytochemical screening and potential antimalarial properties of Blighia sapida extracts from Osun State, Nigeria
Phytochemical screening and potential antimalarial properties of Blighia sapida extracts from Osun State, Nigeria Open
Malaria continues to be a global health concern, especially in regions like sub-Saharan Africa, where reliance on traditional medicine for treatment remains widespread. This study focuses on the phytochemical screening and potential antima…
View article: Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts
Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts Open
In this work, aqueous and methanolic solvents are used to examine the phytochemical makeup and pharmacological potential of Caesalpinia bonducella seed extract. Long acknowledged for their therapeutic value, traditional medical systems lik…
View article: Anti-microbial activity Test against E. coli using Cow's Urine
Anti-microbial activity Test against E. coli using Cow's Urine Open
The accelerating global concern over antibiotic resistance necessitates a focused search for effective, non- conventional antimicrobial agents. This study investigated the antibacterial potential of cow urine a substance historically rever…
View article: Supplementary Figure S2 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer
Supplementary Figure S2 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer Open
Compound A modulates glucose metabolism and pERK signaling in MiaPaCa2 tumors after 3 days of treatment in the PET imaging cohort of animals
View article: Supplementary Figure S2 from Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors
Supplementary Figure S2 from Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors Open
Suppl. Fig. S2 with its legend on page 2
View article: Table S1 from Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures
Table S1 from Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures Open
Supplementary Table 1 drug concentrations
View article: Supplementary Fig.S2 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers
Supplementary Fig.S2 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers Open
Characterization of MW282 mAb, parental mAb of 9MW2821.
View article: Supplementary Table S1 from Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors
Supplementary Table S1 from Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors Open
Suppl. Table S1.
View article: Supplementary Data Figure S1 from Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures
Supplementary Data Figure S1 from Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures Open
Figure S1
View article: Figure S10 from Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors
Figure S10 from Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors Open
Pembrolizumab pharmacodynamic response in histoculture as measured by IFN gamma signature score
View article: Supplementary Figure 3 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
Supplementary Figure 3 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners Open
Supplementary Figure 3
View article: Table S1-S3 from Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody
Table S1-S3 from Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody Open
Antibody lists used in the flow cytometric analysis
View article: Supplementary Fig.S9 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers
Supplementary Fig.S9 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers Open
Affinity of 9MW2821 and enfortumab vedotin (EV) to recombinant human Fcγ and FcRn receptors based on surface plasmon resonance measurements.
View article: Supplementary Tables from SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
Supplementary Tables from SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models Open
Tables S1-S4
View article: Supplementary Figure Legends from Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody
Supplementary Figure Legends from Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody Open
Legends for supplementary figures S1-S9
View article: Supplementary Data from Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
Supplementary Data from Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors Open
Supplementary figures
View article: Supplementary Data from A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies
Supplementary Data from A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies Open
Supplementary Tables and Supplementary Methods