Psychopharmacology
View article: Oxytocin receptor polymorphisms and pharmacogenetic tailoring: Enhancing Social Reward Deficits in Post-Traumatic Stress Disorder (PTSD)
Oxytocin receptor polymorphisms and pharmacogenetic tailoring: Enhancing Social Reward Deficits in Post-Traumatic Stress Disorder (PTSD) Open
In the shadowed aftermath of trauma, where social bonds fracture and anhedonia calcifies into isolation, oxytocin emerges not merely as a neuropeptide but as a molecular key to reclaiming human connection, yet its therapeutic promise in Po…
View article: EEG microstate analysis between patients with major depressive disorder, subclinical depression, and healthy controls
EEG microstate analysis between patients with major depressive disorder, subclinical depression, and healthy controls Open
Introduction Electroencephalography (EEG) microstates have emerged as potential biomarkers of large-scale brain network dynamics. However, their role in depression remains unclear due to inconsistent findings and limited replication. This …
View article: Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder
Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder Open
View article: Yoga as an Adjunct in Tobacco Cessation: A Narrative Review
Yoga as an Adjunct in Tobacco Cessation: A Narrative Review Open
Tobacco use remains one of the most significant preventable causes of morbidity and mortality worldwide, accounting for over eight million deaths annually. Despite extensive public health efforts, long-term cessation rates remain suboptima…
View article: Anomalous self-experience in substance-induced and primary psychotic disorders: a cross-sectional comparative study using the EASE interview
Anomalous self-experience in substance-induced and primary psychotic disorders: a cross-sectional comparative study using the EASE interview Open
ASEs are not exclusive to PPDs and may also manifest in SIP, particularly in the domain of "self-world boundary" disturbances. These findings challenge the assumption that self-disorders are unique to endogenous psychosis and highlight the…
View article: Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options
Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options Open
Customized treatment plans tailored to each patient's needs, preferences, goals and circumstances should be considered for the treatment of antipsychotic and mood stabilizer-associated weight gain.
View article: Perineuronal nets in the developing brain: implications for neurodevelopmental disorders
Perineuronal nets in the developing brain: implications for neurodevelopmental disorders Open
Here, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies. PNNs are dense extracellular matrix structures primarily found in the central nervous…
View article: From Fat to Brain: Adiponectin as a Mediator of Neuroplasticity in Depression
From Fat to Brain: Adiponectin as a Mediator of Neuroplasticity in Depression Open
Depression is a leading cause of global disability and is increasingly recognized as a multifactorial disorder characterized by fundamental disruptions in neuroplasticity, including diminished hippocampal neurogenesis, impaired synaptic pl…
View article: Deciphering the molecular tapestry of schizophrenia: integrating transcriptomics, neuroimaging, and clinical data for precision medicine
Deciphering the molecular tapestry of schizophrenia: integrating transcriptomics, neuroimaging, and clinical data for precision medicine Open
This study employed a multi-omics approach to investigate the molecular and functional underpinnings of schizophrenia by integrating blood transcriptomic profiles, neuroimaging-derived brain phenotypes, and clinical symptomatology. RNA seq…
View article: Smoking status and the onset of suicidal ideation among adults in Japan during the COVID-19 pandemic
Smoking status and the onset of suicidal ideation among adults in Japan during the COVID-19 pandemic Open
Smoking was associated with the onset of suicidal ideation among adults in Japan during the COVID-19 pandemic, with the association observed in men but not women.
View article: Cerebrospinal fluid NPTX2 and [18F]FDG PET track serotonergic vulnerability to neurodegeneration in prodromal Alzheimer’s disease
Cerebrospinal fluid NPTX2 and [18F]FDG PET track serotonergic vulnerability to neurodegeneration in prodromal Alzheimer’s disease Open
View article: Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis
Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis Open
The review found no significant cytokine differences (including IFN-γ, IL-1β, IL-2, IL-4, IL-8, IL-10, TGF-β1, TNF-α) between depressed individuals with or without suicidal ideation and controls. Variations likely reflect methodological di…
View article: Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction
Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction Open
Benzodiazepines are an important class of psychiatric medicines used widely for the treatment of anxiety and sleep disorders, but clinical use is limited by their significant liability for addiction and physical dependence. We identified a…
View article: Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice
Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice Open
Clinical case reports have linked isotretinoin to depressive symptoms. As acne incidence peaks in adolescence, we focused on adolescent exposure. However, prior studies on isotretinoin's effects in adolescents have yielded inconsistent res…
View article: N-Acetylcysteine as an Adjunct to Cognitive Behavioural Therapy (CBT) and Selective Serotonin Reuptake Inhibitor (SSRI) in Gaming Addiction: A Case Report
N-Acetylcysteine as an Adjunct to Cognitive Behavioural Therapy (CBT) and Selective Serotonin Reuptake Inhibitor (SSRI) in Gaming Addiction: A Case Report Open
Internet Gaming Disorder (IGD) is increasingly recognised as a behavioural addiction in adolescents. It is often linked to academic decline, social withdrawal, irritability, and mood disturbances. Psychotherapy remains the primary treatmen…
View article: The Administration of Melatonin Improved Depressive Behavior in Both Maximal Electroshock Seizure-Prone and Non-Seizure Mice After Undergoing Levetiracetam Treatment
The Administration of Melatonin Improved Depressive Behavior in Both Maximal Electroshock Seizure-Prone and Non-Seizure Mice After Undergoing Levetiracetam Treatment Open
Melatonin was found to reduce depressive behavior in both non-epileptic and epileptic groups. These results suggest that melatonin could be a potential therapeutic agent for countering the depressive effects of levetiracetam.
View article: Lost in translation: toward clinically effective translational research
Lost in translation: toward clinically effective translational research Open
Despite the increased access to and variety of psychotropic drugs available for treatment of mood and anxiety disorders, the prevalence of these disorders is still rising, indicating that current treatment approaches are broadly ineffectiv…
View article: Effects of caffeine on neuroinflammation in anxiety and depression: a systematic review of rodent studies
Effects of caffeine on neuroinflammation in anxiety and depression: a systematic review of rodent studies Open
Anxiety and depression are the most prevalent mental illnesses in the contemporary world. Several animal models have been developed to understand the cellular and molecular mechanisms underlying these disorders and the effect of drugs in m…
View article: Dynamic functional connectivity and transcriptomic signatures reveal stage-dependent brain network dysfunction in Alzheimer’s disease spectrum
Dynamic functional connectivity and transcriptomic signatures reveal stage-dependent brain network dysfunction in Alzheimer’s disease spectrum Open
View article: Genetics and Neurobiology of Treatment-Resistant Depression—A Review
Genetics and Neurobiology of Treatment-Resistant Depression—A Review Open
Treatment-resistant depression (TRD), defined as the failure to achieve adequate response to at least two antidepressant trials, affects 20–30% of patients with major depressive disorder and poses substantial personal and socioeconomic bur…
View article: The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents
The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents Open
Psychedelics have garnered significant interest for their therapeutic potential in mental health conditions such as depression, anxiety, and post-traumatic stress disorder. While research has primarily focused on well-studied psychedelics,…
View article: Pharmacological inhibition of NaV1.8 by suzetrigine reveals potent analgesic potential without tolerance development in mice
Pharmacological inhibition of NaV1.8 by suzetrigine reveals potent analgesic potential without tolerance development in mice Open
View article: Correction: Antipsychotic‑Related Prolactin Changes: A Systematic Review and Dose–Response Meta‑analysis
Correction: Antipsychotic‑Related Prolactin Changes: A Systematic Review and Dose–Response Meta‑analysis Open
View article: Investigating antidiabetic drug targets as potential therapeutic modulators for schizophrenia
Investigating antidiabetic drug targets as potential therapeutic modulators for schizophrenia Open
Rationale Certain types of antidiabetic drugs (ADs) have been proven to improve cognitive functions and symptom dimensions in schizophrenia (SCZ). Objectives Schizophrenia is a major contributor to social functional impairment, and antipsy…
View article: Cerebral Aspergillosis: Diagnostic Challenges, Therapeutic Strategies, and Future Research
Cerebral Aspergillosis: Diagnostic Challenges, Therapeutic Strategies, and Future Research Open
Cerebral aspergillosis is a well-recognized and particularly severe manifestation of invasive aspergillosis, primarily affecting immunocompromised individuals. The condition is associated with high morbidity and mortality, largely due to d…
View article: Perturbations of Zinc Homeostasis and Onset of Neuropsychiatric Disorders
Perturbations of Zinc Homeostasis and Onset of Neuropsychiatric Disorders Open
Zinc (Zn2+) is a trace element essential for its catalytic, antioxidant, and immunomodulatory roles extending to synaptic signalling in the central nervous system. In this narrative review, we aim to offer the reader evidence linking pertu…
View article: (P7) the role of therapeutic drug monitoring in managing sexual dysfunctions related to pharmacological drugs
(P7) the role of therapeutic drug monitoring in managing sexual dysfunctions related to pharmacological drugs Open
Background Sexual dysfunctions are common among psychiatric patients, and they may be influenced by a variety of social, environmental, and cultural factors, as well as psychopathology-pharmacotherapy interaction. Medical professionals und…
View article: Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations
Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both upper and lower motor neurons. ALS is classically characterized by painless progressive weakness, causing impaired function of limbs, speech, sw…
View article: International Trends in Opioid Prescribing by Age and Sex from 2001 to 2019: An Observational Study Using Population-Based Databases from 18 Countries and One Special Administrative Region
International Trends in Opioid Prescribing by Age and Sex from 2001 to 2019: An Observational Study Using Population-Based Databases from 18 Countries and One Special Administrative Region Open
Opioid prescribing remains unbalanced across geographical regions; however, results suggest a tendency to convergence across countries/regions. Differences in opioid prescribing by sex and age were identified.
View article: Plasma Protein Patterns Associated with Paliperidone Palmitate Maintenance Therapy in Schizophrenia: A Prospective Cohort Study
Plasma Protein Patterns Associated with Paliperidone Palmitate Maintenance Therapy in Schizophrenia: A Prospective Cohort Study Open