Mode of action
View article: A REVIEW ON PHYTOCONSTITUENTS FOR THE MANAGEMENT OF PSORIASIS
A REVIEW ON PHYTOCONSTITUENTS FOR THE MANAGEMENT OF PSORIASIS Open
Psoriasis is now recognized as an immune-mediated condition, despite the fact that it was formerly believed to be primarily an epidermal keratinocyte issue. Vascular hyperplasia of the skin, epidermal keratinocytes, and penetration of neut…
View article: A REVIEW ON PHYTOCONSTITUENTS FOR THE MANAGEMENT OF PSORIASIS
A REVIEW ON PHYTOCONSTITUENTS FOR THE MANAGEMENT OF PSORIASIS Open
Psoriasis is now recognized as an immune-mediated condition, despite the fact that it was formerly believed to be primarily an epidermal keratinocyte issue. Vascular hyperplasia of the skin, epidermal keratinocytes, and penetration o…
View article: PD-Nanocatalyst Mediated Synthesis and Molecular Docking Studies of Benzimidazole Analogs as Antimicrobial Agents
PD-Nanocatalyst Mediated Synthesis and Molecular Docking Studies of Benzimidazole Analogs as Antimicrobial Agents Open
In the present work, benzimidazole derivatives have been synthesized via nano-[Fe3O4–dopamine–Pd] catalysis and characterized with different spectroscopic techniques like IR, NMR, and mass spectral studies. The antimicrobial activity…
View article: PD-Nanocatalyst Mediated Synthesis and Molecular Docking Studies of Benzimidazole Analogs as Antimicrobial Agents
PD-Nanocatalyst Mediated Synthesis and Molecular Docking Studies of Benzimidazole Analogs as Antimicrobial Agents Open
In the present work, benzimidazole derivatives have been synthesized via nano-[Fe3O4–dopamine–Pd] catalysis and characterized with different spectroscopic techniques like IR, NMR, and mass spectral studies. The antimicrobial activity of th…
View article: Hyaluronic Acid in Topical Applications: The Various Forms and Biological Effects of a Hero Molecule in the Cosmetics Industry
Hyaluronic Acid in Topical Applications: The Various Forms and Biological Effects of a Hero Molecule in the Cosmetics Industry Open
Background: Hyaluronan, or hyaluronic acid (HA), is a glycosaminoglycan with structural and signaling functions playing key roles in human skin homeostasis. It ensures hydration and biomechanical properties of this tissue as well as regula…
View article: H89 Reverses Multidrug Resistance in Colorectal Cancer by Inhibiting the ATPase Activity of ABCB1
H89 Reverses Multidrug Resistance in Colorectal Cancer by Inhibiting the ATPase Activity of ABCB1 Open
Background: Multidrug resistance (MDR) remains a major obstacle in cancer chemotherapy, and overexpression of ABCB1 plays a critical role in the pathogenesis of MDR. Despite decades of research, significant clinical progress in the develop…
View article: Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation
Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation Open
Introduction Sporoderm-Removed Ganoderma lucidum Spore Powder (S-GLSP), derived from the spores of the medically valued fungus Ganoderma lucidum, exhibits diverse pharmacological activities and shows considerable potential in the treatment…
View article: Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum
Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum Open
Background Fusarium oxysporum is a globally distributed soil-borne pathogen that causes substantial economic losses in cash crops. Bacillomycin D-C16, a natural antimicrobial lipopeptide produced by Bacillus subtilis , exhibited potent fun…
View article: Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria
Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria Open
Bedaquiline, an ATP synthase inhibitor, is the spearhead of transformative therapies against drug-resistant Mycobacterium tuberculosis . Here, we use remission spectroscopy to measure the energy-transducing cytochromes within unperturbed, …
View article: Biological Activity and Molecular Docking of 2-(3-Aryl)-1, 2, 4-Oxadiazol-5-yl)acetonitrile: Potential Antibacterial Agent Acting on Carbapenem Enzyme
Biological Activity and Molecular Docking of 2-(3-Aryl)-1, 2, 4-Oxadiazol-5-yl)acetonitrile: Potential Antibacterial Agent Acting on Carbapenem Enzyme Open
In this investigation, we report the study of molecular docking and the biological activity of 2-(3-aryl)-1,2,4-oxadiazol-5-yl)-acetonitrile 3a-h obtained from ethyl-2-cyanoacetate 2 and different amidoximes. The obtained compounds were sc…
View article: Investigating the pharmaceutical substances and action mechanisms of Changmaxifeng granules against tic disorders
Investigating the pharmaceutical substances and action mechanisms of Changmaxifeng granules against tic disorders Open
BACKGROUND Tic disorders (TDs) are a type of neurological and psychiatric disorder characterized by vocal or motor tics in the head, body, or limbs. Clinical studies have shown that Changmaxifeng granules (CG) can treat TDs. However, the p…
View article: Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity
Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity Open
Antimicrobial resistance is a growing global health crisis driving the urgent need for effective broad-spectrum antibiotics. BWC0977 is a pyrazino-oxazinone based novel bacterial topoisomerase inhibitor (NBTI) currently in Phase 1 clinical…
View article: Methylparaben Modulates the Relationship Between Autophagy and Apoptosis in Head and Neck Squamous Cell Carcinoma Lines
Methylparaben Modulates the Relationship Between Autophagy and Apoptosis in Head and Neck Squamous Cell Carcinoma Lines Open
In light of the increasing incidence of head and neck cancer and the widespread occurrence of methylparabens (MeP) in the human environment, which mimic the action of endogenous estrogens, we investigated the effect of this compound on hea…
View article: Fermented Nettles: Bioactive Profile and Seasonal Variability
Fermented Nettles: Bioactive Profile and Seasonal Variability Open
In traditional horticulture, fermented nettles (FN) enhance plant growth and resilience. However, their precise mode of action remains unclear. This study aims to characterize the bioactive profile of FN and to evaluate their potential as …
View article: Triclabendazole inhibits succinate dehydrogenase <i>in vitro</i>
Triclabendazole inhibits succinate dehydrogenase <i>in vitro</i> Open
Succinate dehydrogenase (SDH, complex II), is essential for mitochondrial respiration. This study shows that triclabendazole and its primary metabolites inhibit SDH activity in mitochondria of the cestode Echinococcus multilocularis , whil…
View article: Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata)
Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata) Open
The Colorado potato beetle (CPB, Leptinotarsa decemlineata ) is a devastating super-pest of potato crops in the northern hemisphere. Chemical control methods are expensive, harmful to non-target species, and inefficient because CPB populat…
View article: Unbiased assessment of 2-arachidonoylglycerol in cardiovascular inflammation
Unbiased assessment of 2-arachidonoylglycerol in cardiovascular inflammation Open
2-arachidonoylglycerol (2-AG) is an endogenous modulator of inflammatory processes. Recent studies demonstrate its key role in inflammatory cardiovascular diseases, such as atherosclerosis and left ventricular remodelling. However, whether…
View article: Structure-Based Design and In silico Evaluation of Novel Donepezil Analogues as Potent Inhibitors of Human Acetylcholinesterase for Alzheimer's Disease Therapy
Structure-Based Design and In silico Evaluation of Novel Donepezil Analogues as Potent Inhibitors of Human Acetylcholinesterase for Alzheimer's Disease Therapy Open
Alzheimer's disease (AD) accounts for 60 to 70% of dementias worldwide. This condition is primarily associated with the decrease in acetylcholine (ACh) levels, due to the action of human acetylcholinesterase (AChE). The lack of a curative …
View article: An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP
An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP Open
The urgent need for original antimalarial therapies arises from the alarming spread of malaria parasite resistance to existing drugs. A promising candidate, UA2239, an acyclic nucleoside phosphonate with a guanine as nucleobase, demonstrat…
View article: Diospyrin: biosynthesis, distribution in the plant kingdom, and therapeutic potential
Diospyrin: biosynthesis, distribution in the plant kingdom, and therapeutic potential Open
Diospyrin, a naturally occurring bisnaphthoquinone, is chemically known as 5-hydroxy-6-(5-hydroxy-7-methyl-1,4-dioxonaphthalen-2-yl)-7-methylnaphthalene-1,4-dione. It was first isolated from the heartwood of Diospyros montana Roxb. (Ebenac…
View article: Biochemical and genetic characterization of Botrytis cinerea mutants resistant to the plant-derived pesticide trans-dehydromatricaria ester
Biochemical and genetic characterization of Botrytis cinerea mutants resistant to the plant-derived pesticide trans-dehydromatricaria ester Open
Botrytis cinerea is one of the top ten plant pathogens worldwide, with a broad host range. In modern agricultural production, it is typically controlled using chemical agents. However, the overuse of chemical fungicides has led to environm…
View article: Non-Coding RNA in Type 2 Diabetes Cardio–Renal Complications and SGLT2 Inhibitor Response
Non-Coding RNA in Type 2 Diabetes Cardio–Renal Complications and SGLT2 Inhibitor Response Open
Type 2 diabetes mellitus (T2DM) is characterized by an uncontrolled increase in blood glucose levels and insulin resistance in cells of various tissues. Vascular complications in T2DM have an inflammatory nature. Drugs with different mecha…
View article: Bacillus-Based Biocontrol Agents Mediate Pathogen Killing by Biodegradable Antimicrobials from Macrolactin Family
Bacillus-Based Biocontrol Agents Mediate Pathogen Killing by Biodegradable Antimicrobials from Macrolactin Family Open
The transition to organic farming is one of the most desirable achievements of our time. Rational use of organic farming approaches not only enables a reduction in costs and increased yields but also limits the risks associated with the us…
View article: Drug mode of action and resource constraints modulate antimicrobial resistance evolution
Drug mode of action and resource constraints modulate antimicrobial resistance evolution Open
An increasingly important goal in the design of antimicrobial treatment regimens is to minimise the probability of resistance evolving, without harming individual patients' outcomes. A key characteristic to consider when choosing an antibi…
View article: Metabolomic analysis of conditioned media of HepaRG cells under the toxic action of benz[a]pyrene under the cytoprotective action of cytochrome CYP1A and CYP3A inhibitors and an arylhydrocarbon receptor agonist
Metabolomic analysis of conditioned media of HepaRG cells under the toxic action of benz[a]pyrene under the cytoprotective action of cytochrome CYP1A and CYP3A inhibitors and an arylhydrocarbon receptor agonist Open
Introduction. Benz[a]pyrene is one of the most dangerous carcinogens of group I according to the IARC classification; it is metabolically activated by enzymes of the cytochrome system P450 (CYP) with the formation of reactive metabolites c…
View article: Yeast–secreted compounds with antifungal activity – screening, genetic parts, biosynthetic pathways and regulation
Yeast–secreted compounds with antifungal activity – screening, genetic parts, biosynthetic pathways and regulation Open
Awareness is rising that antifungal resistance poses a threat to agriculture, food safety, biodiversity and human health. There is a limited number of antifungals available and resistance to all of them has been reported. The development o…
View article: Determination of lethal concentration and physiological responses of golden mussels (Limnoperna fortunei) exposed to the molluscicide MXD-100®
Determination of lethal concentration and physiological responses of golden mussels (Limnoperna fortunei) exposed to the molluscicide MXD-100® Open
Since its introduction to Brazil in 1998, the golden mussel ( Limnoperna fortunei ) has caused significant ecological and economic impacts, demanding effective control strategies. The compound MXD-100, based on tannins and quaternary ammon…
View article: Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens
Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens Open
In the intensifying global crisis of antimicrobial resistance (AMR), the “old” antibiotic fosfomycin has regained prominence because of its unique mechanism of action and potent activity against numerous multidrug-resistant (MDR) pathogens…
View article: Quercetin alleviates ulcerative colitis via regulating gut microbiota and tryptophan metabolism
Quercetin alleviates ulcerative colitis via regulating gut microbiota and tryptophan metabolism Open
Quercetin, a natural flavonoid in traditional Chinese medicinal plants, has shown promise in alleviating ulcerative colitis symptoms despite uncertainties about its exact mode of action. This study explored how quercetin influences tryptop…
View article: The Virulence‐Associated CAP/PR1‐Like Proteins From <i>Cytospora chrysosperma</i> Target a Subunit of RNA Polymerase II to Suppress Plant Immunity
The Virulence‐Associated CAP/PR1‐Like Proteins From <i>Cytospora chrysosperma</i> Target a Subunit of RNA Polymerase II to Suppress Plant Immunity Open
Plant pathogenesis‐related 1 (PR1) proteins are members of the CAP protein superfamily and are widely used immune markers. The precise function and mode of action of CAP proteins, however, remains poorly understood. In Cytospora chrysosper…