Phagocytosis
View article: Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs
Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs Open
This repository contains the data and the code used in Flavia's project. A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processed data…
View article: Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs
Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs Open
This repository contains the data and the code used in Flavia's project. A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processed data…
View article: Immunogenic cell death unlocks the potential for combined radiation and immunotherapy
Immunogenic cell death unlocks the potential for combined radiation and immunotherapy Open
Immunogenic cell death (ICD) enhances antitumor immunity by releasing tumor-associated antigens and activating the antitumor immune system response. Here, we develop a mathematical model to quantify the role of ICD in optimizing the effica…
View article: A CD47 antibody with minimized erythrocyte and thrombocyte toxicities
A CD47 antibody with minimized erythrocyte and thrombocyte toxicities Open
Introduction Blockade of the CD47/SIRPa axis has emerged as a promising approach to enhance macrophage-mediated anti-tumor activities in cancer immunotherapy. However, the clinical application of early CD47 antibodies has been associated w…
View article: MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia
MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia Open
Brain damage caused by hypoxia-ischemia is a serious complication for a newborn with possible life-long sequelae. To develop targeted neuroprotective strategies, it is essential to understand the mechanisms of injury, particularly the role…
View article: SodA promotes immune evasion of <i>Streptococcus suis</i> by suppressing ROS accumulation and GSDMD-mediated mitochondrial disruption in neutrophils
SodA promotes immune evasion of <i>Streptococcus suis</i> by suppressing ROS accumulation and GSDMD-mediated mitochondrial disruption in neutrophils Open
Streptococcus suis is a major swine pathogen that poses a serious threat to pig health. Resistance to oxidative stress and modulation of host immune responses are both critical for the survival of S. suis serotype 2 (SS2) strains during in…
View article: 4-HNE reduces phagocytosis through the expression of Synaptotagmin 1 in human monocyte-derived macrophages
4-HNE reduces phagocytosis through the expression of Synaptotagmin 1 in human monocyte-derived macrophages Open
Reactive oxygen species (ROS) react with polyunsaturated fatty acids (PUFA) and generate the reactive aldehyde 4-hydroxynonenal (4-HNE). 4-HNE is a potent modulator of cell signaling, proliferation, and death. Our transcriptomics analysis …
View article: Supplementary Figures S1-S17 from Reversal of Lactate and PD-1–mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer
Supplementary Figures S1-S17 from Reversal of Lactate and PD-1–mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer Open
Supplementary Figure S1. The majority of Pb-Cre; PTENfl/fl Trp53fl/fl mice are de novo resistant to ADT.Supplementary Figure S2. ADT/PI3Ki combination therapy halts prostate tumor growth up to 14 days, followed by development of resistance…
View article: p62 limits Salmonella Typhimurium in macrophages through its role in cell signalling
p62 limits Salmonella Typhimurium in macrophages through its role in cell signalling Open
The intracellular autophagy receptor p62 (also known as Sqstm1) plays a dual role in autophagic flux and downstream Toll-like receptor (TLR) signalling and has been implicated in modulating immune responses. However, its specific function …
View article: Supplementary Figure S2 from Intratumoral CD16<sup>+</sup> Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy
Supplementary Figure S2 from Intratumoral CD16<sup>+</sup> Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy Open
C1Q and PD-1 expression on CD16+ macrophages in on treatment biopsies of melanoma patients treated with PD-1 or PD-1+CTLA-4 ICB. Dynamics between pretreatment and early-during treatment biopsies on (a) CD16+ macrophages as a proportion of …
View article: Plexin C1 modulates metabolic programming for resolution of severe inflammation
Plexin C1 modulates metabolic programming for resolution of severe inflammation Open
Persistent, unresolved inflammatory processes disrupt the complex homeostatic state and lead to severe disease, ultimately resulting in organ failure, shock, and death. The mediators that monitor and control the programmed mechanisms in ti…
View article: Aging changes the mechanism that underlies JAK2 modulation of neutrophil function
Aging changes the mechanism that underlies JAK2 modulation of neutrophil function Open
Janus kinase 2 (JAK2) has been linked to various neutrophil functions, but the intracellular mechanisms underlying its modulation are unknown. Neutrophils are essential cells for host defense. Neutrophil effector functions include migratio…
View article: Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates
Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates Open
Shigella flexneri causes shigellosis, the second leading cause of diarrheal deaths worldwide. The pathogen invades colonic epithelial cells using a type III secretion system (T3SS) that delivers effector proteins to remodel host actin cyto…
View article: Supplementary video from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Supplementary video from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages Open
Macrophages phagocytose tumor cells.
View article: Table S2 from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Table S2 from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages Open
Gene signatures used for ssGSEA
View article: The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells
The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells Open
The solute carrier (SLC)29A3 exports nucleosides from lysosomes into the cytosol, maintaining solute homeostasis and providing metabolic intermediates for cellular processes. Loss-of-function mutations in SLC29A3 cause H syndrome, characte…
View article: Preceding influenza infection impacts neutrophil response to <i>Aspergillus fumigatus</i> and <i>Staphylococcus aureus</i>
Preceding influenza infection impacts neutrophil response to <i>Aspergillus fumigatus</i> and <i>Staphylococcus aureus</i> Open
Influenza infection predisposes individuals to secondary pneumonia caused by a range of pathogens, including both bacterial and fungal organisms. Neutrophils are critical effector cells during infection. In this study, we analyzed the tran…
View article: Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes
Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes Open
Original western blot images of the article of Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes
View article: Supplementary Figures from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Supplementary Figures from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages Open
Supplementary Figures S1-7
View article: Anti-inflammatory activity of <i>Clonostachys rosea</i> culture medium extract in LPS-stimulated RAW 264.7 macrophage cells
Anti-inflammatory activity of <i>Clonostachys rosea</i> culture medium extract in LPS-stimulated RAW 264.7 macrophage cells Open
View article: The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia Open
Controversies over anti-amyloid immunotherapies underscore the need to elucidate their mechanisms of action. Here we demonstrate that Lecanemab, a leading anti-β-amyloid (Aβ) antibody, mediates amyloid clearance by activating microglial ef…
View article: Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes
Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes Open
Original western blot images of the article of Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes
View article: Table S1 from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Table S1 from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages Open
Clinical information of GBM patients included in this study
View article: Table S3 from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Table S3 from Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages Open
Information of TAMs harboring tumor-derived mutations
View article: TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression
TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression Open
Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterized by hyperactive immune cells and excessive autoantigen accumulation. Dendritic cells (DC) can recognize multiple autoantigens and then leading to an inflammator…
View article: Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice
Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice Open
Microglia and macrophages (M/M) play significant roles in intracerebral hemorrhage (ICH) injury, but the underlying mechanism is complicated and remains largely unknown. Lipocalin-2 (LCN2) expression elevates in M/M after ICH, yet its role…
View article: Highly Alkaline-Resistant Enterococcus faecalis Induces Compromised M1 Polarization and Phagocytosis of Macrophage via Z-DNA Binding Protein 1
Highly Alkaline-Resistant Enterococcus faecalis Induces Compromised M1 Polarization and Phagocytosis of Macrophage via Z-DNA Binding Protein 1 Open
Persistent apical periodontitis (PAP) of human teeth is related to Enterococcus faecalis (E. faecalis) with higher alkaline resistance. This study aimed to investigate how highly alkaline-resistant (HAR) E. faecalis modulates macrophage M1…
View article: Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection
Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection Open
The rapid evolution of SARS-CoV-2 and other respiratory RNA viruses limits the success of current vaccines and antibody-based therapies. Engineered decoy receptors based on soluble angiotensin-converting enzyme 2 (sACE2) offer promising al…
View article: Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs and CD8+ T cells
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs and CD8+ T cells Open
Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer thera…
View article: Exploring the biomarkers for diagnostic accuracy associated with glycolysis and macrophage polarization in pediatric sepsis and performing mechanistic studies
Exploring the biomarkers for diagnostic accuracy associated with glycolysis and macrophage polarization in pediatric sepsis and performing mechanistic studies Open
The pediatric sepsis (PS) is characterized by severe clinical symptoms and high mortality. There was a lack of studies on the mechanisms of glycolysis and macrophage polarization (MP) in PS. The focus of this study was to identify biomarke…