Inhibitory postsynaptic potential
View article: Cell-Type-Specific Transcriptomic Signatures in Prefrontal Cortex Reveal lncRNA-mediated Gene Silencing and Enhancer Activities Contributing to the Pathophysiology of Major Depressive Disorder
Cell-Type-Specific Transcriptomic Signatures in Prefrontal Cortex Reveal lncRNA-mediated Gene Silencing and Enhancer Activities Contributing to the Pathophysiology of Major Depressive Disorder Open
Table S1: lncRNA microarray expression data. Table S2: mRNA microarray expression data. Table S3: lncRNA Differential expression. Table S4: mRNA differential expression. Table S5: Inhibitory regulation of lncRNAs on mRNAs. Table S6: Cellul…
View article: Cell-Type-Specific Transcriptomic Signatures in Prefrontal Cortex Reveal lncRNA-mediated Gene Silencing and Enhancer Activities Contributing to the Pathophysiology of Major Depressive Disorder
Cell-Type-Specific Transcriptomic Signatures in Prefrontal Cortex Reveal lncRNA-mediated Gene Silencing and Enhancer Activities Contributing to the Pathophysiology of Major Depressive Disorder Open
Table S1: lncRNA microarray expression data. Table S2: mRNA microarray expression data. Table S3: lncRNA Differential expression. Tab…
View article: Dataset on dextromethorphan as a novel pharmacological inhibitor of F1FO-ATPase
Dataset on dextromethorphan as a novel pharmacological inhibitor of F1FO-ATPase Open
This dataset contains data from the evaluation of the inhibitory effect of dextromethorphan (DXM) on the hydrolytic and synthesis activity of mitochondrial F1FO-ATPase, isolated from porcine heart. The aim of the research was to investigat…
View article: Intact endogenous pain inhibition in complex regional pain syndrome type 1.
Intact endogenous pain inhibition in complex regional pain syndrome type 1. Open
Our results indicate that in individuals with chronic CRPS type 1, endogenous pain inhibition is intact and comparable with healthy individuals. Therefore, pathomechanisms underlying chronic CRPS are likely related to increased pain facili…
View article: Supplementary Tables & Figures from Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
Supplementary Tables & Figures from Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic Open
Includes Supplementary Tables S1-S3 and Supplementary Figures S1-S6
View article: Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids
Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids Open
Triple-negative breast cancer (TNBC) is known for being aggressive and potentially resistant to chemotherapy. This means that new ways to improve cancer treatments are a priority. So, the anticancer effect of binary combinations of fucoida…
View article: Fossil bears break free from inhibitory cascade constraints at least twice ( <i>Ursus minimus</i> and <i>Ursus deningeri</i> ) caused by dietary adaptations
Fossil bears break free from inhibitory cascade constraints at least twice ( <i>Ursus minimus</i> and <i>Ursus deningeri</i> ) caused by dietary adaptations Open
The inhibitory cascade model (ICM) predicts relative mammalian molar size and shows a relationship between relative molar size and diet. Bears do not follow the ICM. The aims of this study are to determine which bears, if any, adhere to th…
View article: Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory
Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory Open
Prosapip1 is a brain-specific protein, encoded by Lzts3 , localized to the postsynaptic density, where it promotes dendritic spine maturation in primary hippocampal neurons. However, nothing is known about the role of Prosapip1 in vivo. To…
View article: Accurate evaluation of neural sensitivity to weak alternating electric fields requires protocols accounting for input dependence
Accurate evaluation of neural sensitivity to weak alternating electric fields requires protocols accounting for input dependence Open
Background: Weak alternating electric fields (~1 V/m) modulate nervous system activity. Yet, the exact mechanism by which such low amplitude electric fields can modulate neural activity is still unknown despite the use of specific protocol…
View article: Department of Muscle Biochemistry: calixarenes as modulators of energy-dependent Са(2+)-transporting pumps in smooth muscles
Department of Muscle Biochemistry: calixarenes as modulators of energy-dependent Са(2+)-transporting pumps in smooth muscles Open
In this scientific-historical review devoted to the recent achievements of the Muscle Biochemistry Department of the Palladin Institute of Biochemistry, the NAS of Ukraine, we synthesize findings from interdisciplinary investigations of in…
View article: Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1)
Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1) Open
Anion Exchanger 1 (AE1) is an elevator-type transporter that plays a key role in acid-base homeostasis of erythrocytes. Here, we report three high-resolution cryo-electron microscopy (cryo-EM) structures of distinct states of AE1: two inwa…
View article: Impact of distinct neurotransmitter release modes on neuronal signaling
Impact of distinct neurotransmitter release modes on neuronal signaling Open
Neuronal communication is governed by a diverse repertoire of neurotransmitter release modes, each with distinct molecular machinery and functional roles. Beyond rapid, high-fidelity synchronous release, asynchronous release supports susta…
View article: Mixed-Frequency rTMS Rapidly Modulates Multiscale EEG Biomarkers of Excitation–Inhibition Balance in Autism Spectrum Disorder: A Single-Case Report
Mixed-Frequency rTMS Rapidly Modulates Multiscale EEG Biomarkers of Excitation–Inhibition Balance in Autism Spectrum Disorder: A Single-Case Report Open
Background: Repetitive transcranial magnetic stimulation (rTMS) is an established neuromodulatory method, yet its multiscale neurophysiological effects in autism spectrum disorder (ASD) remain insufficiently characterized. Recent EEG analy…
View article: The order of things: phosphate release or the power stroke, which does actomyosin do first?
The order of things: phosphate release or the power stroke, which does actomyosin do first? Open
Myosins are a highly conserved super family of motor proteins that are responsible for driving a host of intracellular processes in eukaryotes, from muscle contraction to vesicular transport. Myosins can perform these tasks because they tr…
View article: Characterization of Novel Angiotensin-Converting Enzyme Inhibitory Peptides
Characterization of Novel Angiotensin-Converting Enzyme Inhibitory Peptides Open
View article: Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity
Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity Open
Synapses must be resilient to the challenges they confront during development, experience, disease, and aging. A conserved form of adaptive plasticity, observed at the glutamatergic Drosophila neuromuscular junction (NMJ), is expressed fol…
View article: The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action Open
Ketamine is the first glutamatergic agent in clinical use for major depression, but its primary target remains unclear. Further research is needed to develop more specific interventions with fewer side effects. Ketamine is a noncompetitive…
View article: Spinal Dorsal Horn Neurons Receiving Descending Input from the Primary Somatosensory Cortex Contribute to Aβ Fiber-Induced Neuropathic Allodynia in Male Rats
Spinal Dorsal Horn Neurons Receiving Descending Input from the Primary Somatosensory Cortex Contribute to Aβ Fiber-Induced Neuropathic Allodynia in Male Rats Open
Mechanical allodynia is the predominant symptom of neuropathic pain following peripheral nerve injury (PNI) and is characterized by pain evoked by innocuous sensory signals transmitted through low-threshold mechanoreceptive primary afferen…
View article: Intrabody-guided synapse proteomics defines pyramidal neuron input architecture and uncovers early remodeling in a mouse model of Alzheimer's disease
Intrabody-guided synapse proteomics defines pyramidal neuron input architecture and uncovers early remodeling in a mouse model of Alzheimer's disease Open
Across their proximal and distal dendritic domains, pyramidal neurons (PNs) integrate inputs that differ in morphology and function. Hippocampal CA1 PNs are among the earliest affected neurons in Alzheimer's disease (AD), but the molecular…
View article: Inhibitory Retrieval-Based Exposure Therapy for Patients With Posttraumatic Stress Disorder: Results From a Single-Case Experimental Design Study
Inhibitory Retrieval-Based Exposure Therapy for Patients With Posttraumatic Stress Disorder: Results From a Single-Case Experimental Design Study Open
This dataset originates from a single-case experimental study evaluating inhibitory retrieval (IR)–based exposure therapy and EPT-based exposure therapy for PTSD. It contains daily measures of PTSD symptoms, negative expectancies, and dist…
View article: Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models
Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models Open
Arginine 44 (R44) is a highly conserved residue in the human GABA transporter 1 (hGAT-1), a member of the solute carrier 6 (SLC6) family, which plays a critical role in regulating inhibitory neurotransmission in the central nervous system.…
View article: Kölliker–Fuse/Parabrachial Complex PACAP—Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension
Kölliker–Fuse/Parabrachial Complex PACAP—Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension Open
The calyx of Held is a giant axo-somatic synapse classically confined to the auditory brainstem. We recently identified morphologically similar calyx-like terminals in the extended amygdala (EA) that arise from the ventrolateral parabrachi…
View article: Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons
Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons Open
Background: Repetitive transcranial magnetic stimulation (rTMS) induces long-term changes in synapses, but the mechanisms behind these modifications are not fully understood. Although there has been progress in the development of multi-sca…
View article: Mesenchymal stem/stromal cells overexpressing leukemia inhibitory factor (LIF) promote arteriogenesis and functional recovery in a mouse model of critical hindlimb ischemia
Mesenchymal stem/stromal cells overexpressing leukemia inhibitory factor (LIF) promote arteriogenesis and functional recovery in a mouse model of critical hindlimb ischemia Open
LIF overexpression is a promising strategy to increase the potential of MSC in the treatment of CLI and for tissue repair.
View article: A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding
A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding Open
The cerebellar granular layer plays a central role in sensory processing and pattern separation through its distinctive feedforward architecture. Here, we present a biologically realistic computational model of the granular layer designed …
View article: Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice
Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice Open
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder with a strong genetic basis. Although SH3RF3 has been identified as an ASD candidate gene, its biological function and pathophysiological mechanisms rema…
View article: In Vitro Xanthine Oxidase Inhibition, DNA Protection, Anti‐Inflammatory, Antioxidant Activity, Phytochemical Analysis, and In Silico Studies of <i>Punica granatum</i> Peels and Flowers
In Vitro Xanthine Oxidase Inhibition, DNA Protection, Anti‐Inflammatory, Antioxidant Activity, Phytochemical Analysis, and In Silico Studies of <i>Punica granatum</i> Peels and Flowers Open
This study investigated the antioxidant, anti‐inflammatory activities, xanthine oxidase (XO) inhibition, DNA protective effects, and phytochemical contents of ethanol (E) and methanol (M) extracts of Punica granatum (pomegranate, PG). It a…
View article: Brain-wide mapping of developmental trajectories of cerebellar efferent projections
Brain-wide mapping of developmental trajectories of cerebellar efferent projections Open
Long-range cerebellar outputs are critical for shaping brain-wide functional architecture, influencing motor, cognitive, and affective domains. Proper cerebellar development and its efferent circuits are essential for brain maturation, and…
View article: Gating modulation and potentiation of amiodarone blockage of the Kv10.1 potassium channel bu KB130015, an amiodarone derived molecule
Gating modulation and potentiation of amiodarone blockage of the Kv10.1 potassium channel bu KB130015, an amiodarone derived molecule Open
Kv10.1 is a voltage-gated K+ channel whose structure-function relationships remain incompletely understood, and whose ectopic expression is linked to tumorigenesis. We have recently shown that the antiarrhythmic drug amiodarone …
View article: Design, synthesis, and computational insights into 3-acetyl-8-methoxy coumarin hybrids as potential anti-alzheimer’s agents
Design, synthesis, and computational insights into 3-acetyl-8-methoxy coumarin hybrids as potential anti-alzheimer’s agents Open
The most prevalent degenerative brain disease, Alzheimer's disease (AD), is characterized by cognitive function impairment. The ability to code new memories is lost in AD patients, and their lives are very challenging. Inhibitors of cholin…