Functional imaging
View article: marafathussain/RelationalConnectivityTransformer: DeepIQ: Neurocognitive Outcome Prediction from Functional MRI
marafathussain/RelationalConnectivityTransformer: DeepIQ: Neurocognitive Outcome Prediction from Functional MRI Open
This repository contains the Relational Connectivity Transformer (RCT), a novel Graph-Transformer model designed for predicting absolute and residual full-scale intelligence quotient (FSIQ), performance IQ (PIQ), and verbal IQ (VIQ) scores…
View article: Noninvasive imaging of amyloid-beta and tau in rodent and nonhuman primate models
Noninvasive imaging of amyloid-beta and tau in rodent and nonhuman primate models Open
Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates. The development of noninvasive imaging techniques for detecting pathological hallmarks, amyloid‐beta plaques and tau tangles in Alzheimer's di…
View article: A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension
A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension Open
The Risk Reduction for Alzheimer’s Disease (rrAD) trial included 513 cognitively normal, sedentary, hypertensive older adults (aged 60 to 85 years) with dementia risk factors. We utilized 420 high-quality baseline resting-state fu…
View article: A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension
A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension Open
The Risk Reduction for Alzheimer’s Disease (rrAD) trial included 513 cognitively normal, sedentary, hypertensive older adults (aged 60 to 85 years) with dementia risk factors. We utilized 420 high-quality baseline resting-state functional …
View article: Multidimensional analysis of brain activation patterns in different motor therapies using functional near-infrared spectroscopy
Multidimensional analysis of brain activation patterns in different motor therapies using functional near-infrared spectroscopy Open
Objective This study employed functional near-infrared spectroscopy (fNIRS) to systematically compare the effects of active movement (AM), passive movement (PM), and motor imagery (MI) on sensorimotor cortex excitability across three dimen…
View article: Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa
Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa Open
Difficulty with reversal learning (RL)—appropriately shifting behavior following outcome contingency changes—may represent a shared or distinct mechanism across eating disorder (ED) diagnoses. We tested whether RL-related neural correlates…
View article: Dynamic functional connectivity of the amygdala-hippocampal complex is associated with cognitive impairment in adolescents with Internet gaming disorder
Dynamic functional connectivity of the amygdala-hippocampal complex is associated with cognitive impairment in adolescents with Internet gaming disorder Open
Background The amygdala-hippocampal complex (AHC) plays a central role in the neural mechanisms underlying Internet Gaming Disorder (IGD), particularly in emotional regulation, memory processing, and reward-related functions. However, the …
View article: Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study
Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study Open
Major depressive disorder (MDD) is marked by cognitive and affective dysfunctions associated with altered prefrontal cortical activity. While high-definition transcranial direct current stimulation (HD-tDCS) shows promise in modulating the…
View article: Cellular and molecular associations with intrinsic brain organization
Cellular and molecular associations with intrinsic brain organization Open
Understanding how cellular and molecular architecture underpins the large-scale organization of human brain function is a central challenge in neuroscience. By integrating transcriptomic (microarray and single-nucleus RNA-sequencing), mole…
View article: Discordance Between Spatial and Population Correlations From Human Brain Imaging Data
Discordance Between Spatial and Population Correlations From Human Brain Imaging Data Open
It has become increasingly common to probe correlations between human brain imaging measures of receptor/protein binding and function using population‐level brain maps, typically drawn from independent cohorts to estimate correlations acro…
View article: Functional Brain Imaging Reveals Reconstitution of the Central Nervous Itch Network Upon Rifampicin Therapy in Hepatic Pruritus
Functional Brain Imaging Reveals Reconstitution of the Central Nervous Itch Network Upon Rifampicin Therapy in Hepatic Pruritus Open
View article: Supplemental Figure S5 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Supplemental Figure S5 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study Open
Clinical response correlates.
View article: Supplementary Video S1 from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Supplementary Video S1 from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma Open
40 min full dynamic Total-body PET imaging of healthy volunteers
View article: The quest for the best: manual, atlas- and spatial prior-based delineation of locus coeruleus
The quest for the best: manual, atlas- and spatial prior-based delineation of locus coeruleus Open
Despite advances in neuromelanin-sensitive brain imaging and a plethora of manual labelling, atlas- and signal intensity-based software solutions, the reliable non-invasive delineation of the locus coeruleus (LC) in the human brain stem re…
View article: Role of Action Observation Therapy in Cortical Reorganization in Patients with Stroke: A Narrative Review
Role of Action Observation Therapy in Cortical Reorganization in Patients with Stroke: A Narrative Review Open
Background: Stroke is a leading cause of long-term disability, often resulting in motor, cognitive, and emotional impairments due to cortical damage. Cortical reorganization, which is a key component of post-stroke recover…
View article: Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging
Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging Open
Light-field microscopy (LFM) enables high-throughput functional imaging by scanlessly encoding entire volumes in single snapshots. However, LFM’s computational burden and vulnerability to scattering limit its application to biological imag…
View article: Supplementary Video S2A from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Supplementary Video S2A from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma Open
40 min full dynamic Total-body PET imaging of Patient 1
View article: Molecular imaging of aortic fibroblast activation protein through 68Ga-FAPI-PET/CT: Association with aortic dilation
Molecular imaging of aortic fibroblast activation protein through 68Ga-FAPI-PET/CT: Association with aortic dilation Open
Our findings indicate that FAPI uptake is associated with aortic diameter and may provide preliminary insights into early aortic remodeling, suggesting its potential as a marker for future longitudinal studies.
View article: Supplemental Figure S1 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Supplemental Figure S1 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study Open
PDX models treated with PARPi therapies.
View article: Supplemental Figure S3 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Supplemental Figure S3 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study Open
Anatomic imaging corelates.
View article: Supplementary Video S2C from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Supplementary Video S2C from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma Open
40 min full dynamic Total-body PET imaging of Patient 6
View article: Supplemental Figure S4 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Supplemental Figure S4 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study Open
Baseline [18F]FTT imaging correlates.
View article: Supplemental Figure S6 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Supplemental Figure S6 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study Open
18F]FTT-PET on subject previously treated with PARPi.
View article: Comparative Study on Multimodal Imaging Applications in Dementia with Lewy Bodies: From Imaging Features to Clinical Practice Implications
Comparative Study on Multimodal Imaging Applications in Dementia with Lewy Bodies: From Imaging Features to Clinical Practice Implications Open
Objective: To explore the value of multimodal molecular imaging in diagnosing and differentiating dementia with Lewy bodies (DLB). Methods: A retrospective analysis was conducted on clinical data and multimodal molecular imaging of 40 prob…
View article: A novel multi-exposure-to-multi-mediator mediation model for imaging genetic study of brain disorders
A novel multi-exposure-to-multi-mediator mediation model for imaging genetic study of brain disorders Open
Common psychiatric and brain disorders are highly heritable and affected by a number of genetic risk factors, yet the mechanism by which these genetic factors contribute to the disorders through alterations in brain structure and function …
View article: Supplemental Figure S2 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study
Supplemental Figure S2 from [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study Open
Time between [18F]FTT imaging scans did not significantly impact SUV measurements.
View article: A novel multi-exposure-to-multi-mediator mediation model for imaging genetic study of brain disorders
A novel multi-exposure-to-multi-mediator mediation model for imaging genetic study of brain disorders Open
Common psychiatric and brain disorders are highly heritable and affected by a number of genetic risk factors, yet the mechanism by which these genetic factors contribute to the disorders through alterations in brain structure and function …
View article: Supplementary Tables S1-S3 from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Supplementary Tables S1-S3 from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer Open
Supplemental Tables S1-S3
View article: FigureS3 from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
FigureS3 from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer Open
FigureS3
View article: FigureS4 from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
FigureS4 from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer Open
FigureS4