Oxidative stress
View article: Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway.
Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway. Open
The findings of the study suggest that metformin protects ovarian granulosa cells against oxidative stress and apoptosis in the context of PCOS via activation of Nrf2-HO-1 pathway.
View article: ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling. Open
ACSF2 participates in crosstalk between oxidative stress and ferroptosis. This could be a potential therapeutic target for DN.
View article: Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats.
Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats. Open
These findings demonstrate that BMSC-Exos alleviate chronic visceral pain and comorbid anxiety in IBS rats, likely through Nrf-2/HO-1-mediated oxidative stress reduction in spinal neurons. These results highlight BMSC-Exos as a promising a…
View article: Comparative Analysis of Oxidative Stress Induced by Chemical and Surgical Castration in Male Dogs
Comparative Analysis of Oxidative Stress Induced by Chemical and Surgical Castration in Male Dogs Open
This study was conducted to investigate the effects of chemical and surgical castration on oxidative stress in male dogs. A total of ten healthy male dogs, aged between 1 and 3 years, were assigned to two distinct groups: Group Surg underw…
View article: Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury
Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury Open
Dopaminergic neurodegeneration is associated with oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell death. Allopregnanolone, a multifunctional neurosteroid, is involved in various biological processes within the body…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus that degrade lacrimal and salivary funct…
View article: Movie S4 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Movie S4 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression Open
PC-3 cell treated with HCQ, stained for Integrin αv (red), Gal-3 (green), EEA1 (magenta). Areas of 3-color colocalization are highlighted with white. Surfaces were reconstructed by Imaris.
View article: Movie S3 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Movie S3 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression Open
PC-3 cell treated with water, stained for Integrin αv (red), Gal-3 (green), EEA1 (magenta). Areas of 3-color colocalization are highlighted with white. Surfaces were reconstructed by Imaris.
View article: Antioxidant, Wound Healing and Cytotoxic Properties of Onosma heterophylla
Antioxidant, Wound Healing and Cytotoxic Properties of Onosma heterophylla Open
The study was aimed to determine the antioxidant, anticarcinogenic and wound healing activities of aqueous extracts prepared using Onosma heterophylla aerial parts. Aqueous extracts were prepared using infusion and maceration methods. Tota…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus that degrade lacrimal and salivary funct…
View article: Resveratrol Attenuates Cisplatin-Induced Oxidative Stress: Combined Effects in MDA-MB-231 Breast Cancer Cells
Resveratrol Attenuates Cisplatin-Induced Oxidative Stress: Combined Effects in MDA-MB-231 Breast Cancer Cells Open
Cisplatin, widely preferred in cancer treatment, is known to inhibit neoplastic cell proliferation while simultaneously causing harmful effects in normal cells. Various research has indicated that cisplatin-induced cytotoxicity is closely …
View article: Hesperidin and Its Polylactic- <i>co</i> -glycolic Acid-Nanoformulation Mitigate Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Stress and Inflammation in BALB/c Mice
Hesperidin and Its Polylactic- <i>co</i> -glycolic Acid-Nanoformulation Mitigate Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Stress and Inflammation in BALB/c Mice Open
View article: Melatonin mitigates cadmium-induced oxidative damage and modulates polysaccharide biosynthesis in Bletilla striata
Melatonin mitigates cadmium-induced oxidative damage and modulates polysaccharide biosynthesis in Bletilla striata Open
Introduction Cadmium (Cd), a highly toxic heavy metal, threatens ecosystems and human health. Bletilla striata ( B . striata ), a medicinal plant valued for its polysaccharide-rich rhizomes, exhibits significant tolerance to Cd stress. Mel…
View article: Integrated Antioxidants, Nanoparticle, and Antifreeze Protein Strategies Synergistically Enhance Cryotop Vitrification Outcomes of Porcine Parthenogenetic Embryos
Integrated Antioxidants, Nanoparticle, and Antifreeze Protein Strategies Synergistically Enhance Cryotop Vitrification Outcomes of Porcine Parthenogenetic Embryos Open
Porcine embryo cryopreservation remains challenging due to high lipid content, oxidative stress, and ice recrystallization that compromise post-thaw survival and developmental competence. We evaluated an integrated vitrification approach c…
View article: Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis
Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis Open
Background Current treatments for cirrhosis-a progressive disease marked by fibrosis and inflammation-are limited and non-specific. Jinqiancao granules (JQC), a traditional Chinese medicine used for hepatobiliary diseases, could provide a …
View article: Nanoencapsulation of mulberry ( <i>Morus alba</i> ) polyphenols potentiates neuroprotection against glyphosate‐induced oxidative and inflammatory brain injury in rats
Nanoencapsulation of mulberry ( <i>Morus alba</i> ) polyphenols potentiates neuroprotection against glyphosate‐induced oxidative and inflammatory brain injury in rats Open
BACKGROUND Polyphenols derived from Morus alba leaves exhibit strong antioxidant and neuroprotective activities, positioning them as promising candidates for mitigating neurotoxicity caused by environmental contaminants such as glyphosate.…
View article: Engineered resveratrol nanoantioxidants: intestinal targeted oral delivery system of mesalazine for inflammatory bowel disease via spatiotemporal-ecological regulation
Engineered resveratrol nanoantioxidants: intestinal targeted oral delivery system of mesalazine for inflammatory bowel disease via spatiotemporal-ecological regulation Open
Inflammatory bowel disease (IBD) is a life-threatening condition associated with excessive reactive oxygen species (ROS), chronic mucosal inflammation, and gut microbiota dysbiosis. The therapeutic potential of resveratrol (Rv) and mesalaz…
View article: Response mechanisms of Polygonatum kingianum to temperature stress: implications for cultivation practices
Response mechanisms of Polygonatum kingianum to temperature stress: implications for cultivation practices Open
Polygonatum kingianum , a medicinally significant herb indigenous to Yunnan, China, exhibits pronounced sensitivity to temperature affecting its bioactive compound accumulation and growth. However, the molecular mechanisms underlying its r…
View article: Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids
Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids Open
Triple-negative breast cancer (TNBC) is known for being aggressive and potentially resistant to chemotherapy. This means that new ways to improve cancer treatments are a priority. So, the anticancer effect of binary combinations of fucoida…
View article: Sub-chronic exposure to crude acetylene results in the development of deleterious cardio metabolic changes in Sprague Dawley rats
Sub-chronic exposure to crude acetylene results in the development of deleterious cardio metabolic changes in Sprague Dawley rats Open
Objective Calcium carbide-derived acetylene is widely used as an artificial fruit ripening agent despite its potential health risks. This study aimed to investigate the effects of sub-chronic exposure to crude acetylene on cardiometabolic …
View article: Quercetin Ameliorates Bromocriptine-Induced Disruptions in Neurobehaviour and Cerebellar Histomorphology in Rats
Quercetin Ameliorates Bromocriptine-Induced Disruptions in Neurobehaviour and Cerebellar Histomorphology in Rats Open
Bromocriptine is a dopamine agonist commonly used in the treatment of hyperprolactinaemia and Parkinson’s disease, but prolonged administration has been linked to oxidative stress and neuroinflammation, particularly within the cerebellum. …
View article: β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies
β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies Open
Mitochondria are essential for β-cell function, coupling glucose metabolism to ATP production and insulin secretion. In diabetes, β-cell mitochondrial dysfunction arises from oxidative stress, impaired quality control and disrupted dynamic…
View article: ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke Open
Perioperative stroke is a rare but serious complication with a rising incidence in aging populations. Although preclinical studies consistently demonstrate that anesthetics such as sevoflurane can induce neuroprotective preconditioning aga…
View article: Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes
Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes Open
Type 1 and type 2 diabetes are characterized by a profound loss of functional β-cell mass, driven by mechanisms that are still not fully understood. A spectrum of β-cell stressors drives this loss, including oxidative stress (OS). Unlike m…
View article: Comparative transcriptomics reveals key regulatory networks underlying cold stress adaptation in oil palm (Elaeis guineensis)
Comparative transcriptomics reveals key regulatory networks underlying cold stress adaptation in oil palm (Elaeis guineensis) Open
Introduction Climate change has exacerbated cold stress, which severely impairs plant development. Oil palm ( Elaeis guineensis ), a tropical crop highly sensitive to low temperatures, exhibits stunted growth and yield reductions under suc…
View article: Green-synthesized bimetallic Zinc Ferrite (franklinite) nanoparticles prevent drought-induced growth reduction and oxidative stress in Sorghum bicolor through improved nutrient content and the antioxidant defense
Green-synthesized bimetallic Zinc Ferrite (franklinite) nanoparticles prevent drought-induced growth reduction and oxidative stress in Sorghum bicolor through improved nutrient content and the antioxidant defense Open
View article: From pathogenesis to treatment: the emerging role of ferroptosis in Parkinson’s disease
From pathogenesis to treatment: the emerging role of ferroptosis in Parkinson’s disease Open
Parkinson’s disease (PD), the second most common neurodegenerative disorder worldwide, features gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) along with pathological α-synuclein (α-syn) aggregation. Rece…
View article: The Devil Lies in the Details: Small Structural and Chemical Changes in Iron Oxide Pigments Largely Alter the Biological Outcomes in Macrophages
The Devil Lies in the Details: Small Structural and Chemical Changes in Iron Oxide Pigments Largely Alter the Biological Outcomes in Macrophages Open
Because of their technical qualities, such as resistance to fading and to high temperatures, mineral pigments are still widely used. Among mineral pigments, iron oxide pigments represent a widely used class, because of their diversity of s…
View article: The Mechanism and Clinical Application of Licorice in the Treatment of Recurrent Aphthous Ulcers
The Mechanism and Clinical Application of Licorice in the Treatment of Recurrent Aphthous Ulcers Open
Recurrent Aphthous Ulcer (RAU), a common type of oral mucosal disease, has a significant impact on the quality of the general public. It is urgently to explore safe and effective treatment strategies. By comprehensiving description of trad…
View article: Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats
Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats Open
Background Tobacco heating systems (THSs) are increasingly being used as alternatives to conventional cigarettes (CIGs). In this study, we compared the effects of mainstream THS emissions and CIG smoke on the affective, locomotor, and cogn…