Inflammation
View article: Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs
Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs Open
This repository contains the data and the code used in Flavia's project. A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processed data…
View article: Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs
Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs Open
This repository contains the data and the code used in Flavia's project. A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processed data…
View article: Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson's disease related transcriptional profile and functions
Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson's disease related transcriptional profile and functions Open
This repository contains the data and the code used in Ohtone Sohvi's project. A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processe…
View article: Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson's disease related transcriptional profile and functions
Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson's disease related transcriptional profile and functions Open
This repository contains the data and the code used in Ohtone Sohvi's project. A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processe…
View article: AI-Guided Discovery of Universal Atherosclerosis Convergence Pathways and Multi-Target Therapeutic Interventions
AI-Guided Discovery of Universal Atherosclerosis Convergence Pathways and Multi-Target Therapeutic Interventions Open
This computational framework presents ATHERO-RESTORE v1.0, a comprehensive AI-guided approach to identifying universal atherosclerosis convergence pathways and designing multi-target therapeutic interventions for cardiovascular disease (CV…
View article: The role of gap junction intercellular signalling in platelet-neutrophil interactions
The role of gap junction intercellular signalling in platelet-neutrophil interactions Open
Background Platelets are increasingly recognised for their roles beyond thrombosis and haemostasis, notably in modulating inflammation through direct interactions with innate immune cells. Connexins, a family of transmembrane proteins, for…
View article: Early and persistent thalamic astrocytic reactivity is a hallmark of post-traumatic epilepsy in mice
Early and persistent thalamic astrocytic reactivity is a hallmark of post-traumatic epilepsy in mice Open
Post-traumatic epilepsy (PTE) is a debilitating outcome of traumatic brain injury (TBI), but treatment remains elusive due to a limited understanding of its pathophysiology and the lack of reliable biomarkers. Reactive astrogliosis is a ha…
View article: Intraosseous Inflammatory Myofibroblastic Tumor of the Posterior Mandible: A Rare Case with Immunohistochemical Interpretation.
Intraosseous Inflammatory Myofibroblastic Tumor of the Posterior Mandible: A Rare Case with Immunohistochemical Interpretation. Open
Inflammatory myofibroblastic tumor (IMT), previously called an inflammatory pseudotumor, is an unusual, rare, benign, but aggressive tumor of soft tissue origin. It is histopathologically characterized by heterogeneous proliferation of myo…
View article: B-cell lymphoma-extra large expression correlated with protein kinase RNA-like ER kinase and ubiquitination signals in the type 1 diabetes mouse model.
B-cell lymphoma-extra large expression correlated with protein kinase RNA-like ER kinase and ubiquitination signals in the type 1 diabetes mouse model. Open
This study uncovers a new neuropathology underlying T1DM-associated DN: Bcl-XL activation associates PERK and ubiquitination marker upregulation in sensory neurons. Bcl-XL inactivation in nociceptors might be a potent…
View article: The relationships between proinflammatory cytokines and depressive symptoms in adolescents with chronic pain.
The relationships between proinflammatory cytokines and depressive symptoms in adolescents with chronic pain. Open
Our findings suggest that IL-1β and IL-6 play critical roles in the pain experience. Interleukin-6 is more strongly associated with physical symptoms, and IL-1β is more related to fear-avoidance.
View article: Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats.
Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats. Open
These findings demonstrate that BMSC-Exos alleviate chronic visceral pain and comorbid anxiety in IBS rats, likely through Nrf-2/HO-1-mediated oxidative stress reduction in spinal neurons. These results highlight BMSC-Exos as a promising a…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus that degrade lacrimal and salivary funct…
View article: Supplementary Fig. S7 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis
Supplementary Fig. S7 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis Open
IVMT-Rx-3 suppressed tumor cell derived pro-inflammatory cytokines expression.
View article: Figure S3 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Figure S3 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma Open
Figure S3 shows a reciprocal regulation of YAP1/TAZ-TEAD and β-catenin-TCF in SySa cells via luciferase assays.
View article: Figure S6 from Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors
Figure S6 from Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors Open
A Neutrophil activation assay which measures the frequency CD11b high expression by flow on neutrophils isolated from whole blood
View article: Encapsulin protein MAV2054 enhances Mycobacterium avium virulence by promoting Cdc42-dependent epithelial cell invasion
Encapsulin protein MAV2054 enhances Mycobacterium avium virulence by promoting Cdc42-dependent epithelial cell invasion Open
Mycobacterium avium complex (MAC) organisms are widespread environmental pathogens associated with chronic pulmonary infections. Although M. avium is known to invade epithelial cells, the molecular mechanisms underlying this process remain…
View article: Figure S5 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Figure S5 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma Open
Figure S5 shows that there is no interdependency between YAP1/TAZ and β-catenin activation in control cell lines.
View article: Figure S6 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Figure S6 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma Open
Figure S6 shows that the mutual activation of YAP1/TAZ and β-catenin in SySa cells is impeded by knockdown of BAF complex subunits.
View article: Helile Formula: Anti-Helicobacter pylori Activity, Gut Microbiota Modulation, and Inflammatory Response Regulation
Helile Formula: Anti-Helicobacter pylori Activity, Gut Microbiota Modulation, and Inflammatory Response Regulation Open
To explore the effect and mechanism of the Helile Formula against Helicobacter pylori infection, we constructed a Helicobacter pylori-infected mouse model. After treatment with Helile and antibiotics, feces from each group of mice were col…
View article: Supplementary Fig. S1 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis
Supplementary Fig. S1 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis Open
Analytical data for IVMT-Rx-3
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus that degrade lacrimal and salivary funct…
View article: The dietary inflammatory index is associated with the presence and severity of coronary artery disease
The dietary inflammatory index is associated with the presence and severity of coronary artery disease Open
View article: Figure S1 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Figure S1 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma Open
Figure S1 shows that the SS18-SSX fusion protein regulates TEAD- and TCF-mediated transcriptional activity, both being important for SySa cell viability.
View article: Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels Open
Atherosclerosis serves as the core pathological basis of cardiovascular, cerebrovascular, and peripheral arterial diseases, posing a serious threat to human health. However, current mainstream treatments such as statin drugs and stent impl…
View article: Figure S4 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Figure S4 from Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma Open
Figure S4 shows that induction of hyperactive YAP1/TAZ or β-catenin variants does not alter the other's protein levels.
View article: A Glycan-Based Ligand Panel for Phenotypic Profiling and Selective Immunomodulation of Alveolar Macrophage
A Glycan-Based Ligand Panel for Phenotypic Profiling and Selective Immunomodulation of Alveolar Macrophage Open
The balance of alveolar macrophage (AM) polarization is severely disrupted in chronic in-flammatory diseases like bronchiectasis, where a persistent pro-inflammatory (M1) phe-notype perpetuates inflammation. To address this, we developed a…
View article: The effect of therapeutic potential and safety of bone marrow-derived against adipose-derived mesenchymal stem cells in aged mice associated with septic arthritis
The effect of therapeutic potential and safety of bone marrow-derived against adipose-derived mesenchymal stem cells in aged mice associated with septic arthritis Open
Mesenchymal stem cells (MSCs) show potential for treating septic arthritis in aged populations, but their efficacy and safety in aged patients remain unclear. The objective of this study is to evaluate the therapeutic potential and safety …
View article: Supplementary Figure S2 from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study
Supplementary Figure S2 from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study Open
Supplementary Figure S2 shows pre-surgery and 12-month biomarker concentrations correlated with the CTXD 12 months after surgery at Heidelberg.
View article: NLRP3 Inflammasome Activation in Chronic Inflammatory Diseases and Emerging Causative Role of Gut Dysbiosis
NLRP3 Inflammasome Activation in Chronic Inflammatory Diseases and Emerging Causative Role of Gut Dysbiosis Open
Background The NLRP3 inflammasome is a cytosolic sensor that mediates the maturation of pro-inflammatory cytokines IL-1β and IL-18. Chronic activation contributes to the pathogenesis of numerous noninfectious inflammatory diseases. Objecti…
View article: Hesperidin and Its Polylactic- <i>co</i> -glycolic Acid-Nanoformulation Mitigate Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Stress and Inflammation in BALB/c Mice
Hesperidin and Its Polylactic- <i>co</i> -glycolic Acid-Nanoformulation Mitigate Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Stress and Inflammation in BALB/c Mice Open