Viral hepatitis
View article: THE EFFECT OF VIRAL HEPATITIS B AND C INFECTION ON LABOR PRODUCTIVITY IN PAKISTAN; EVIDENCE FROM KHYBER PAKHTUNKHWA
THE EFFECT OF VIRAL HEPATITIS B AND C INFECTION ON LABOR PRODUCTIVITY IN PAKISTAN; EVIDENCE FROM KHYBER PAKHTUNKHWA Open
View article: THE EFFECT OF VIRAL HEPATITIS B AND C INFECTION ON LABOR PRODUCTIVITY IN PAKISTAN; EVIDENCE FROM KHYBER PAKHTUNKHWA
THE EFFECT OF VIRAL HEPATITIS B AND C INFECTION ON LABOR PRODUCTIVITY IN PAKISTAN; EVIDENCE FROM KHYBER PAKHTUNKHWA Open
View article: Outcomes of a tribal community program on hepatitis C, HIV, and syphilis screening, confirmation testing, and treatment initiation for an underserved population
Outcomes of a tribal community program on hepatitis C, HIV, and syphilis screening, confirmation testing, and treatment initiation for an underserved population Open
Background American Indian and Alaska Native people are disproportionately impacted by hepatitis C, HIV, and syphilis, with rates 2.3, 1.9, and 6.4 times that of non-Hispanic White people, respectively. The objective was to describe the fi…
View article: Sex differences in alcohol-related liver disease, viral hepatitis, metabolic dysfunction-associated steatotic liver disease, and hepatocellular carcinoma
Sex differences in alcohol-related liver disease, viral hepatitis, metabolic dysfunction-associated steatotic liver disease, and hepatocellular carcinoma Open
Females are more susceptible to alcohol-related liver disease (ALD) owing to increased risk of alcohol dependence; decreased gastric first-pass effect and increased risk of producing hepatotoxic metabolites, higher alcohol bioavailability,…
View article: The Economics of Liver Fibrosis Diagnosis: Systematic Review of Non‐Invasive Test Cost‐Effectiveness
The Economics of Liver Fibrosis Diagnosis: Systematic Review of Non‐Invasive Test Cost‐Effectiveness Open
Hepatic diseases progress silently, leading to fibrosis, cirrhosis, and hepatocellular carcinoma. Although liver biopsy remains the gold standard for fibrosis assessment, it is limited by invasiveness and sampling variability. Non‐invasive…
View article: Comparative evaluation of viral hepatitis question responses: ChatGPT-4.5 outperforms three established models
Comparative evaluation of viral hepatitis question responses: ChatGPT-4.5 outperforms three established models Open
View article: Hepatocellular injury and metabolic dysregulation of selected biomarkers in Human Immune Virus-1 - Hepatitis C Virus co-infected individuals using heroin in Mombasa County, Kenya
Hepatocellular injury and metabolic dysregulation of selected biomarkers in Human Immune Virus-1 - Hepatitis C Virus co-infected individuals using heroin in Mombasa County, Kenya Open
Hepatocellular injury and metabolic dysregulation are significant complications in individuals co-infected with human immunodeficiency virus (HIV-1) and hepatitis C virus (HCV), particularly those who use injection heroin. However, this is…
View article: Role of Magnetic Resonance Elastography in the Assessment of Liver Fibrosis: A Descriptive Study
Role of Magnetic Resonance Elastography in the Assessment of Liver Fibrosis: A Descriptive Study Open
Context: Liver fibrosis is a key consequence of chronic liver diseases (CLDs), leading to cirrhosis and hepatocellular carcinoma. Early detection and accurate staging are crucial for management. Magnetic resonance elastography (MRE) offers…
View article: Management of refractory autoimmune hepatitis with rituximab: a case series
Management of refractory autoimmune hepatitis with rituximab: a case series Open
Background and aims Most patients with autoimmune hepatitis respond to the standard of care of prednisolone in combination with a thiopurine, or a second line of mycophenolate mofetil or tacrolimus. This study aims to add to the reported e…
View article: Immunogenicity and safety in animals of a lyophilized live attenuated hepatitis A vaccine following stabilizer optimization
Immunogenicity and safety in animals of a lyophilized live attenuated hepatitis A vaccine following stabilizer optimization Open
To evaluate the immunogenicity and safety profiles of lyophilized hepatitis A live attenuated vaccine (L-A-1 attenuated strain) after stabilizer formula optimization using non-human primates and various rodent models. Immunogenicity assess…
View article: Bulevirtide Monotherapy or in Combination for Chronic Hepatitis Delta: 2025 Update
Bulevirtide Monotherapy or in Combination for Chronic Hepatitis Delta: 2025 Update Open
Chronic hepatitis Delta (CHD) represents the most aggressive form of viral hepatitis. In the latest estimates, published in 2024 by the Polaris Observatory, the overall prevalence of the hepatitis Delta virus (HDV) in Hepatitis B surface a…
View article: Unraveling a mechanism underlying hepatitis E-associated kidney disease
Unraveling a mechanism underlying hepatitis E-associated kidney disease Open
Background and objective Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic manifestations, particularly renal disease. While the underlying pathomechanisms are sti…
View article: Nationwide Seroprevalence Study of Hepatitis B and Hepatitis C Viruses Among Blood Donors in Paraguay
Nationwide Seroprevalence Study of Hepatitis B and Hepatitis C Viruses Among Blood Donors in Paraguay Open
The true burden of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) in Paraguay remains poorly defined, hindering effective public health planning toward the WHO's 2030 elimination goal. This cross-sectional study aimed to establish a c…
View article: Evaluating Post-Transplant Outcomes in Elderly Liver Recipients Over 70: A Propensity-Score Matching Analysis
Evaluating Post-Transplant Outcomes in Elderly Liver Recipients Over 70: A Propensity-Score Matching Analysis Open
The rising prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hepatocellular Carcinoma in the elderly population has increased the demand for liver transplantation (LT) in patients over 70 years. Advanced ag…
View article: Comprehensive Transcriptomic and Epitranscriptomic Profiling of Hepatitis B Virus Transcripts in Two Hepatocellular Carcinoma Cell Lines
Comprehensive Transcriptomic and Epitranscriptomic Profiling of Hepatitis B Virus Transcripts in Two Hepatocellular Carcinoma Cell Lines Open
Background/Objectives: Despite extensive research on hepatitis B virus (HBV), its post-transcriptional regulatory mechanisms remain incompletely characterized, particularly regarding epitranscriptomic modifications. This study aims to syst…
View article: Evaluation of portal venous flow velocity before and after direct acting antiviral therapy in chronic hepatitis C: A cohort study
Evaluation of portal venous flow velocity before and after direct acting antiviral therapy in chronic hepatitis C: A cohort study Open
This study aimed to evaluate the changes in portal venous flow velocity before and after direct-acting antiviral (DAA) therapy in patients diagnosed with chronic hepatitis C (CHC). A total of 53 CHC patients (36 males, 17 females; mean age…
View article: Population-Specific Biomarker Dataset for Alcohol Use Disorder in Uzbekistan
Population-Specific Biomarker Dataset for Alcohol Use Disorder in Uzbekistan Open
This dataset contains anonymized hematological, biochemical, anthropometric and clinical data collected from 292 male patients with stage II alcohol use disorder (AUD) and 49 healthy controls in Uzbekistan. The dataset includes two patient…
View article: Temporal trends in transfusion-transmissible infections among blood donors in Jordan: A large-scale Amman-based surveillance update (2018–2019)
Temporal trends in transfusion-transmissible infections among blood donors in Jordan: A large-scale Amman-based surveillance update (2018–2019) Open
Transfusion-transmissible infections (TTIs) remain a global concern in blood safety. This study presents the largest Amman-based dataset on Royal Medical Services donors since 2016 (n = 49,296 donations) and the first to apply a monthly Ch…
View article: Direct acting antiviral drugs reduce CXCL10 gene expression and reverse metabolic dysfunction in chronic HCV-infected patients
Direct acting antiviral drugs reduce CXCL10 gene expression and reverse metabolic dysfunction in chronic HCV-infected patients Open
Background Hepatitis C virus (HCV) invades the host’s immune system and induces various metabolic changes. Therefore, we aimed to investigate the relative gene expression of the chemokine ligand CXCL10, along with some targeted metabolites…
View article: Circulatory microRNAs (miR-16 and miR-885) as Potential Diagnostic Markers for Acute Hepatitis C
Circulatory microRNAs (miR-16 and miR-885) as Potential Diagnostic Markers for Acute Hepatitis C Open
Background: The injunctive potential of circulating microRNAs (miRNAs) has raised intense investigation for their use as noninvasive biomarkers for liver diseases, especially for hepatitis C (HC). Objective: To determine the diagnostic acc…
View article: Hepatitis Vaccines: Recent Advances and Challenges
Hepatitis Vaccines: Recent Advances and Challenges Open
Viral hepatitis constitutes a substantial global public health challenge. The etiological agents, referred to as hepatitis viruses, are primarily categorized into five types: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C vi…
View article: Circulatory microRNAs (miR-16 and miR-885) as Potential Diagnostic Markers for Acute Hepatitis C
Circulatory microRNAs (miR-16 and miR-885) as Potential Diagnostic Markers for Acute Hepatitis C Open
Background: The injunctive potential of circulating microRNAs (miRNAs) has raised intense investigation for their use as noninvasive biomarkers for liver diseases, especially for hepatitis C (HC). Objective: To determine the diagnostic acc…
View article: Impact of Distributing Test Result Reports for Chronic Viral Hepatitis on Awareness of Hepatitis Testing Among Non-Specialist Physicians
Impact of Distributing Test Result Reports for Chronic Viral Hepatitis on Awareness of Hepatitis Testing Among Non-Specialist Physicians Open
Background and Objectives: Patients who undergo hepatitis virus testing may remain unaware of their results in the absence of clinician feedback, particularly from non-specialists. To address this issue, we introduced patient-directed test…
View article: Complete response and HBsAg clearance of advanced hepatocellular carcinoma associated with hepatitis B by DEB−TACE combined systematic therapy: a case report
Complete response and HBsAg clearance of advanced hepatocellular carcinoma associated with hepatitis B by DEB−TACE combined systematic therapy: a case report Open
Background Systemic therapy is the standard treatment for patients with hepatitis B-related hepatocellular carcinoma (HCC) and portal vein invasion. Emerging evidence suggests that the combination of localized regional therapy, multikinase…
View article: Surpassing Viral Suppression: A Breakthrough from Interferon for the Treatment of Hepatitis B
Surpassing Viral Suppression: A Breakthrough from Interferon for the Treatment of Hepatitis B Open
Hepatitis B virus (HBV) remains a major global public health issue, posing significant threats to human health and quality of life. Its treatment has always been the focus of contemporary medicine. Compared with traditional antiviral drugs…
View article: Barriers and facilitators to hepatitis C patient engagement: interview study with General Practitioners in England
Barriers and facilitators to hepatitis C patient engagement: interview study with General Practitioners in England Open
There are people living with a previously diagnosed chronic hepatitis C infection who have been lost to follow up, and people who may have undiagnosed hepatitis C. General Practitioners (GPs) could help to support these patients into care,…
View article: Risk of hepatocellular carcinoma after direct-acting antiviral treatment for hepatitis C virus infection in people with HIV.
Risk of hepatocellular carcinoma after direct-acting antiviral treatment for hepatitis C virus infection in people with HIV. Open
Background To inform hepatocellular carcinoma (HCC) surveillance after hepatitis C virus (HCV) cure with direct-acting antivirals (DAA), we estimated HCC risk post-DAA in people with HIV with advanced liver fibrosis or cirrhosis under univ…
View article: Overcoming barriers and expanding opportunities in liver transplantation in Mexico
Overcoming barriers and expanding opportunities in liver transplantation in Mexico Open
Liver transplantation (LT) is the only curative treatment for end-stage liver disease. Although Mexico has made important strides in surgical capacity and institutional development, the country continues to report one of the lowest LT rate…
View article: Hepatic Dysfunction in Dengue Fever and Dengue Hemorrhagic Fever: A Cross-Sectional Study at a Tertiary-level Hospital
Hepatic Dysfunction in Dengue Fever and Dengue Hemorrhagic Fever: A Cross-Sectional Study at a Tertiary-level Hospital Open
Background: Dengue is the most prevalent mosquito-borne viral infection, endemic in South-East Asia and found in tropical and subtropical regions worldwide, predominantly in urban and peri-urban areas. In Bangladesh, dengue has emerged as …
View article: Epidemiologic Characteristics Determining the Choice of Direct-Acting Antiviral Therapy in HCV Patients: An Italian Real-World Evidence Study
Epidemiologic Characteristics Determining the Choice of Direct-Acting Antiviral Therapy in HCV Patients: An Italian Real-World Evidence Study Open
Pangenotypic direct-acting antivirals (pDAAs) have transformed hepatitis C virus (HCV) treatment. In Italy, sofosbuvir/velpatasvir (SOF/VEL) and glecaprevir/pibrentasvir (GLE/PIB) are available. While both show similar efficacy, difference…