Silibinin
View article: Ellagic Acid and Montelukast Mitigate Arsenic Trioxide-Induced Hepatotoxicity via Modulation of Oxidative Stress, Inflammatory Pathways, and Mitochondrial Apoptosis
Ellagic Acid and Montelukast Mitigate Arsenic Trioxide-Induced Hepatotoxicity via Modulation of Oxidative Stress, Inflammatory Pathways, and Mitochondrial Apoptosis Open
Although arsenic trioxide (As₂O₃) is an effective agent in treating acute promyelocytic leukemia, its use is limited by severe hepatotoxicity primarily mediated through oxidative stress, inflammatory responses, and apoptosis. Ellagic acid …
View article: A critical review of natural products driven correction of bile acid dysregulation: a therapeutic strategy for nonalcoholic fatty liver disease
A critical review of natural products driven correction of bile acid dysregulation: a therapeutic strategy for nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) represents a significant global health challenge. While two drugs (semaglutide, resmetirom) have recently been approved for nonalcoholic steatohepatitis (NASH), their clinical utility is constrained…
View article: Unveiling the therapeutic potential of silibinin in head and neck squamous cell carcinoma via network pharmacology
Unveiling the therapeutic potential of silibinin in head and neck squamous cell carcinoma via network pharmacology Open
Head and neck squamous cell carcinoma (HNSCC) exhibits a poor prognosis, with 5-year survival rates below 50%. This study employed network pharmacology to investigate the anti-HNSCC mechanism of silibinin, a plant-derived compound with est…
View article: The Vicious Circle of Metabolic Dysfunction-Associated Steatotic Liver Disease When Micronutrient Deficiency Drives Microbial Imbalance and Liver Injury
The Vicious Circle of Metabolic Dysfunction-Associated Steatotic Liver Disease When Micronutrient Deficiency Drives Microbial Imbalance and Liver Injury Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an escalating global health burden and a leading cause of chronic liver disease. Without intervention, MASLD can progress to steatohepatitis, fibrosis, cirrhosis, and hepa…
View article: Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design
Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design Open
Fucoidan extracted from brown algae has been shown to improve aerobic capacity and increase muscle size and strength in mice. Whether these beneficial effects translate to humans is unknown. This study investigated the effect of a resistan…
View article: Investigation of Antithrombotic Activity and In Vivo Effective Forms of Kaempferitrin Using FeCl3-Induced Rat Arterial Thrombosis and UHPLC-Q-Exactive Orbitrap MS
Investigation of Antithrombotic Activity and In Vivo Effective Forms of Kaempferitrin Using FeCl3-Induced Rat Arterial Thrombosis and UHPLC-Q-Exactive Orbitrap MS Open
Kaempferitrin (KAE) is a natural flavonol dirhamnopyranoside with various pharmacological activities, isolated from the antithrombotic fraction of Celastrus orbiculatus Thunb. This study aimed to investigate the antithrombotic activity and…
View article: The Dose-Response Effect of Aerobic Exercise on Neuroplasticity: An Analysis of The Mechanism of Drug Relapse Intervention Based on RCTs
The Dose-Response Effect of Aerobic Exercise on Neuroplasticity: An Analysis of The Mechanism of Drug Relapse Intervention Based on RCTs Open
Background: Drug relapse involves abnormal synaptic plasticity in reward circuits, including dysregulated glutamatergic signaling and BDNF expression in the nucleus accumbens and prefrontal cortex. Addictive behaviors correlate with hippoc…
View article: Silibinin Alleviates Liver Oxidative Stress in D-Galactose-Treated Kunming Mice via Microbiota Homeostasis in a Microbiota-Dependent Manner
Silibinin Alleviates Liver Oxidative Stress in D-Galactose-Treated Kunming Mice via Microbiota Homeostasis in a Microbiota-Dependent Manner Open
Hepatic oxidative stress is a key driver in liver injury pathogenesis, with D-galactose (D-gal) modeling serving as an established inducer of accelerated oxidative damage. Silibinin (SLB), a flavonolignan from milk thistle, shows therapeut…
View article: Impact of hyaluronic acid molecular weight on silibinin intranasal delivery via hybrid nanoparticle formulation
Impact of hyaluronic acid molecular weight on silibinin intranasal delivery via hybrid nanoparticle formulation Open
This study aimed to develop hybrid nanoparticles (LPNs) using hyaluronic acid (HA) of different molecular weights for intranasal delivery of silibinin (SLB) to glioma tumors. LPNs were prepared using low, medium, and high molecular weight …
View article: Isosilybin B: a potential novel therapeutic agent with hepatoprotective, anticancer and antifibrotic properties
Isosilybin B: a potential novel therapeutic agent with hepatoprotective, anticancer and antifibrotic properties Open
Background Silybum marianum (milk thistle) is a plant for centuries well known for its hepatoprotective effects. The extract from seeds, silymarin, and its major compound, silibinin, are well studied for their hepatoprotective and antifibr…
View article: Quercetin and silibinin ameliorate insulin resistance by stimulating fat browning via the β3-AR/AMPK pathway in palmitate-exposed 3T3-F442A adipocytes
Quercetin and silibinin ameliorate insulin resistance by stimulating fat browning via the β3-AR/AMPK pathway in palmitate-exposed 3T3-F442A adipocytes Open
Quercetin (QC) and silibinin (SLB), natural bioactive compounds from medicinal plants, show potential in improving IR. However, the molecular mechanisms underlying their IR-attenuating effects through adipocyte browning remain not fully el…
View article: The STAT3/TIMP1 inhibitor silibinin overcomes secondary immunoresistance to pembrolizumab in brain metastases from METex14 skipping mutated non-small cell lung cancer: a case report
The STAT3/TIMP1 inhibitor silibinin overcomes secondary immunoresistance to pembrolizumab in brain metastases from METex14 skipping mutated non-small cell lung cancer: a case report Open
Background Approximately 20% of patients with non-small cell lung cancer (NSCLC) are diagnosed with brain metastases (BM), which are associated with poor prognosis. Pembrolizumab has shown promising results in advanced NSCLC with PD-L1 ≥ 5…
View article: Enhanced therapeutic efficacy of silibinin loaded silica coated magnetic nanocomposites against Pseudomonas aeruginosa in Combination with Ciprofloxacin and HepG2 cancer cells
Enhanced therapeutic efficacy of silibinin loaded silica coated magnetic nanocomposites against Pseudomonas aeruginosa in Combination with Ciprofloxacin and HepG2 cancer cells Open
Silibinin, a major bioactive compound extracted from Silybum marianum, possesses notable antioxidant, antitumor, hepatoprotective, and antibacterial activities. However, its poor solubility limits its clinical applications. This study aime…
View article: Silibinin Anticancer Effects Through the Modulation of the Tumor Immune Microenvironment in Triple-Negative Breast Cancer
Silibinin Anticancer Effects Through the Modulation of the Tumor Immune Microenvironment in Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), remains a therapeutic challenge due to its aggressive nature, li…
View article: Silibinin-loaded cubosomes: a gateway to enhanced hepatoprotective activity
Silibinin-loaded cubosomes: a gateway to enhanced hepatoprotective activity Open
Background The liver is a vital organ that detoxifies drugs and xenobiotics. However, breaking down toxins creates byproducts that can damage the liver. Silibinin possesses a proven hepatoprotective and antioxidant effect as it inhibits th…
View article: <i>In Vitro</i> Leishmanicidal Effect of Silibinin: Disrupting Redox Balance via Trypanothione Reductase Inhibition
<i>In Vitro</i> Leishmanicidal Effect of Silibinin: Disrupting Redox Balance via Trypanothione Reductase Inhibition Open
Visceral leishmaniasis, caused by the parasite Leishmania infantum, is a life-threatening disease with limited therapeutic options that are often associated with toxicity and resistance. In this study, we investigated the in vitr…
View article: Natural anti-cancer products: insights from herbal medicine
Natural anti-cancer products: insights from herbal medicine Open
View article: Assessment of Oral Cancer Preventive Action Using Dietary Record of EGCG, Silibinin and Anthocyanin Containing Food Consumption Followed by a Targeted Dietary Intervention and Post Interventional Dietary Assessment - A Novel Investigative Study
Assessment of Oral Cancer Preventive Action Using Dietary Record of EGCG, Silibinin and Anthocyanin Containing Food Consumption Followed by a Targeted Dietary Intervention and Post Interventional Dietary Assessment - A Novel Investigative Study Open
Background: Oral cancer remains a significant public health concern, particularly in regions with high tobacco use and limited access to preventive care. Early identification of risk factors and effective community-based interventions are …
View article: Explaining Uncertain Hepatoprotective Effects: When Silibinin Co-Administered with Other Drugs
Explaining Uncertain Hepatoprotective Effects: When Silibinin Co-Administered with Other Drugs Open
The results of the cell experiment showed that silibinin's liver protective effects were uncertain when it was combined with CBZ. FAERS database analysis revealed elevated risks of ADRs with silibinin co-administration, collectively highli…
View article: Synergistic inhibition of gastric cancer cell proliferation by concanavalin A and silibinin via attenuation of the JAK/STAT3 signaling pathway and molecular docking analysis
Synergistic inhibition of gastric cancer cell proliferation by concanavalin A and silibinin via attenuation of the JAK/STAT3 signaling pathway and molecular docking analysis Open
View article: Uncovering Silibinin's Protective Effects on the Liver: A Concise Review
Uncovering Silibinin's Protective Effects on the Liver: A Concise Review Open
View article: Silibinin enhanced the efficacy of albendazole in treating the muscular phase of experimental trichinellosis
Silibinin enhanced the efficacy of albendazole in treating the muscular phase of experimental trichinellosis Open
Trichinella spiralis is a parasitic nematode with a special life cycle. Both adults and larvae live in two different niches in the same host (intestinal and muscular). The parasite is known to manipulate the immune system of the host to be…
View article: Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism
Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism Open
In summary, our study highlights that carrier-free SIL-SOR-MPs demonstrate the ability to reverse the progression of MASLD and present a promising therapeutic strategy.
View article: Effects of Resveratrol, Caffeic Acid Phenethyl Ester and Silibinin on Isolated Human Umbilical Artery
Effects of Resveratrol, Caffeic Acid Phenethyl Ester and Silibinin on Isolated Human Umbilical Artery Open
Objective: The aim of this study was to compare the vasoactive effects of resveratrol, CAPE and silibinin on the basal tone and serotonin (5-HT) induced contractile responses of isolated human umbilical arteries. Material-Method: This stud…
View article: Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway
Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway Open
Apoptosis is a significant occurrence of cell death in the cerebral ischemia process, potentially revealing specific treatment points. Silibinin (SIL) has been proven to regulate a range of biological effects on inflammation, oxidative str…
View article: A New Class of Hybrid Anti-inflammatory Agents of Silibinin A Modified Using Gamma Irradiation
A New Class of Hybrid Anti-inflammatory Agents of Silibinin A Modified Using Gamma Irradiation Open
Silibinin is the major active constituent of the medicinal plant milk thistle seeds and possesses hepatoprotective functions. In this study, silibinin A was irradiated with gamma rays to produce 2 novel flavonolignans, silibinosins A (2) a…
View article: Retraction Note: Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1
Retraction Note: Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1 Open
View article: Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer
Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer Open
Objective This study aims to elucidate the role of SB in inhibiting CRC progression by targeting CAFs and elucidating the underlying mechanisms. Methods In this study, a spontaneous CRC model induced by AOM/DSS was used to evaluate the eff…
View article: Synergistic Anticancer Effects of Silibinin and Sulforaphane: Targeting Gastric Cancer via PI3K/AKT and ERK1/2 MAPK Pathway Inhibition and Molecular Docking Insights
Synergistic Anticancer Effects of Silibinin and Sulforaphane: Targeting Gastric Cancer via PI3K/AKT and ERK1/2 MAPK Pathway Inhibition and Molecular Docking Insights Open
In the current period of pharmaceutical discovery, herbal remedies have shown to be an unmatched supply of anticancer medications. By changing the tumor microenvironment and several signaling pathways, plants and their byproducts through a…
View article: Correction to “Activation of <scp>PGC</scp> ‐1 Alpha‐Dependent Mitochondrial Biogenesis Supports Therapeutic Effects of Silibinin Against Type I Diabetic Periodontitis”
Correction to “Activation of <span>PGC</span> ‐1 Alpha‐Dependent Mitochondrial Biogenesis Supports Therapeutic Effects of Silibinin Against Type I Diabetic Periodontitis” Open