Rheumatoid arthritis
View article: Unveiling multisystem involvement in polyarthritis: A case of rheumatoid arthritis with nutritional anemia and eczema
Unveiling multisystem involvement in polyarthritis: A case of rheumatoid arthritis with nutritional anemia and eczema Open
Rheumatoid Arthritis (RA) is an autoimmune systemic disorder that can present with multisystem involvement. A 20-year-old female presented with fever, multiple joint pains, morning stiffness, and fatigue. Laboratory findings showed elevate…
View article: The Role of Regulatory T Cell Dysregulation in the Development of Autoimmune Diseases
The Role of Regulatory T Cell Dysregulation in the Development of Autoimmune Diseases Open
Background: The regulatory T cells (Tregs), especially theCD4⁺ CD25^hi CD127^lo FOXP3⁺ Tregs subpopulation is principal in the process of ensuring the immune toleration and prevention of autoimmune diseases. Their impaired frequency, stabi…
View article: Unveiling multisystem involvement in polyarthritis: A case of rheumatoid arthritis with nutritional anemia and eczema
Unveiling multisystem involvement in polyarthritis: A case of rheumatoid arthritis with nutritional anemia and eczema Open
Rheumatoid Arthritis (RA) is an autoimmune systemic disorder that can present with multisystem involvement. A 20-year-old female presented with fever, multiple joint pains, morning stiffness, and fatigue. Laboratory findings showed elevate…
View article: The effect of therapeutic potential and safety of bone marrow-derived against adipose-derived mesenchymal stem cells in aged mice associated with septic arthritis
The effect of therapeutic potential and safety of bone marrow-derived against adipose-derived mesenchymal stem cells in aged mice associated with septic arthritis Open
Mesenchymal stem cells (MSCs) show potential for treating septic arthritis in aged populations, but their efficacy and safety in aged patients remain unclear. The objective of this study is to evaluate the therapeutic potential and safety …
View article: SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity
SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity Open
Background The comorbidity of rheumatoid arthritis (RA), a chronic autoimmune disease, with cervical cancer has garnered a lot of attention. Cervical cancer is much more common in RA patients than in the general population, which may be ca…
View article: Correction: Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis
Correction: Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis Open
View article: PO:26:097 | Ultrasound evaluation of temporomandibular disorders: comparative analysis between inflammatory and degenerative patterns in patients with and without rheumatological pathologies
PO:26:097 | Ultrasound evaluation of temporomandibular disorders: comparative analysis between inflammatory and degenerative patterns in patients with and without rheumatological pathologies Open
Background. Temporomandibular disorders (TMD) encompass a heterogeneous group of conditions with varying etiologies, either inflammatory or degenerative, that affect the temporomandibular joint (TMJ). Differentiating these mechanisms is cr…
View article: INITIAL CHARACTERISTICS OF PATIENTS WITH POLYARTICULAR FORM OF JUVENILE RHEUMATOID ARTHRITIS
INITIAL CHARACTERISTICS OF PATIENTS WITH POLYARTICULAR FORM OF JUVENILE RHEUMATOID ARTHRITIS Open
A chronic inflammatory joint disease, juvenile rheumatoid arthritis (JRA), is a major problem in modern pediatric rheumatology. The relevance of studying JRA is determined by its relatively high prevalence among other rheumatic diseases of…
View article: Angioedema as a Presenting Feature of Systemic Lupus Erythematosus With Myositis and Vasculitis—Successfully Treated With Mycophenolate and Prednisolone
Angioedema as a Presenting Feature of Systemic Lupus Erythematosus With Myositis and Vasculitis—Successfully Treated With Mycophenolate and Prednisolone Open
Introduction Angioedema is a rare manifestation of systemic lupus erythematosus (SLE). Myositis and vasculitis are uncommon manifestations of SLE. The former being a harbinger and feature of the latter has not been reported. Method A case …
View article: THE INTERRELATIONSHIP BETWEEN THE ORAL MICROBIOME AND RHEUMATOID ARTHRITIS: EXPLORING MUTUAL INFLUENCES AND CLINICAL IMPLICATIONS
THE INTERRELATIONSHIP BETWEEN THE ORAL MICROBIOME AND RHEUMATOID ARTHRITIS: EXPLORING MUTUAL INFLUENCES AND CLINICAL IMPLICATIONS Open
Introduction and objective: Periodontitis (PD) is caused by dysbiosis of the oral microbiome (OMB). The prevalence of PD is increased in RA patients. Both conditions have the ability to activate common inflammatory pathways. The OMB shift …
View article: SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway–targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trials
SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway–targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trials Open
Introduction Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) have shown efficacy in the treatment of migraine. However, certain comorbidities have been excluded from clinical trials or may pose potential risks…
View article: Hubungan Tingkat Kemandirian terhadap Kejadian Arthritis RheumatoidipadaiLansia diiwilayahikerja PuskesmasiTinangkung Utaraikabupaten Banggai Kepulauan
Hubungan Tingkat Kemandirian terhadap Kejadian Arthritis RheumatoidipadaiLansia diiwilayahikerja PuskesmasiTinangkung Utaraikabupaten Banggai Kepulauan Open
Independence refers to the freedom to act and the ability to control one’s own or a group’s activities to protect oneself or others from various diseases or conditions. Among the elderly, the ability to perform Activities of Daily Living (…
View article: Predicting arthritis risk with machine learning: Insights from the 2023 National Health Interview Survey data
Predicting arthritis risk with machine learning: Insights from the 2023 National Health Interview Survey data Open
Arthritis, a common chronic disease encompassing multiple subtypes of osteoarthritis and rheumatoid arthritis, was explored in this study as a risk-related factor based on data from the 2023 U.S. National Health Interview Survey (NHIS). Th…
View article: Mandatory Biological/Targeted Synthetic Disease-Modifying Antirheumatic Drugs Dose Reduction on Risk of Serious Infections in Patients with Rheumatoid Arthritis: A Nationwide Nested Case–Control Study
Mandatory Biological/Targeted Synthetic Disease-Modifying Antirheumatic Drugs Dose Reduction on Risk of Serious Infections in Patients with Rheumatoid Arthritis: A Nationwide Nested Case–Control Study Open
Background: We aimed to investigate the risk for a serious infection in rheumatoid arthritis (RA) patients after tapering the dose of biological/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). Methods: This nested ca…
View article: Machine learning-based prediction of response to Janus kinase inhibitors in patients with rheumatoid arthritis using clinical data
Machine learning-based prediction of response to Janus kinase inhibitors in patients with rheumatoid arthritis using clinical data Open
Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease with considerable heterogeneity in treatment response, leaving many patients unable to achieve remission or low disease activity. We aimed to develop a machine learning …
View article: Diagnostic Performance of Myeloperoxidase and Proteinase-3 Antibodies by ImmunoCAP Fluorescent Enzyme Immunoassay
Diagnostic Performance of Myeloperoxidase and Proteinase-3 Antibodies by ImmunoCAP Fluorescent Enzyme Immunoassay Open
Introduction Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are traditionally diagnosed by positive ANCA on indirect immunofluorescence (IIF) slides, followed by confirmatory specific immunoassay for myeloper…
View article: Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clusters
Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clusters Open
A key feature of rheumatoid arthritis (RA) is sexual dimorphism, with a higher incidence of RA in females. Myeloid cells are key drivers of the inflammatory effector phase of RA, but little is known about their contribution to a sexually d…
View article: Macrophage-centred crosstalk with infiltrating immune cells in rheumatoid arthritis and its regulation by mesenchymal stem cells
Macrophage-centred crosstalk with infiltrating immune cells in rheumatoid arthritis and its regulation by mesenchymal stem cells Open
View article: Pain Catastrophizing in Rheumatoid Arthritis and Spondyloarthritis Patients Receiving Biologic Therapy: A Cross-Sectional Study
Pain Catastrophizing in Rheumatoid Arthritis and Spondyloarthritis Patients Receiving Biologic Therapy: A Cross-Sectional Study Open
View article: PO:24:066 | Antibody profile in myositis and early risk of interstitial lung disease: clinical and laboratory correlations in patients with suspected rheumatologic disease
PO:24:066 | Antibody profile in myositis and early risk of interstitial lung disease: clinical and laboratory correlations in patients with suspected rheumatologic disease Open
Background. Interstitial lung disease (ILD) is a frequent comorbidity not only in idiopathic inflammatory myopathies (IIM) but also in other rheumatologic disorders such as Sjögren’s syndrome, systemic sclerosis, and rheumatoid arthritis. …
View article: PO:25:079 | Anifrolumab in refractory dermatomyositis: a case report
PO:25:079 | Anifrolumab in refractory dermatomyositis: a case report Open
Background. Dermatomyositis is a rare autoimmune disease characterized by multisystem involvement. Treatment can be challenging, particularly in refractory cases unresponsive to conventional therapies, for which standardized management pro…
View article: An indole derivative of Ursolic acid, inhibits RANKL-induced osteoclast differentiation via modulating the Nrf2 and NFATc1/c-Fos axis: Targeting oxidative stress and osteoclastogenesis in managing rheumatoid arthritis
An indole derivative of Ursolic acid, inhibits RANKL-induced osteoclast differentiation via modulating the Nrf2 and NFATc1/c-Fos axis: Targeting oxidative stress and osteoclastogenesis in managing rheumatoid arthritis Open
View article: Prognostic role of baseline hemoglobin level for long-term mortality in newly diagnosed rheumatoid arthritis: a cohort study
Prognostic role of baseline hemoglobin level for long-term mortality in newly diagnosed rheumatoid arthritis: a cohort study Open
Background Patients with rheumatoid arthritis (RA) face an increased mortality risk compared to the general population. While anemia commonly occurs in patients with RA and is associated with disease activity in established diseases, the p…
View article: B Cell Differentiation Model for Identifying Predictors of Responses to Rituximab‐Mediated B Cell Depletion in Rheumatic Diseases
B Cell Differentiation Model for Identifying Predictors of Responses to Rituximab‐Mediated B Cell Depletion in Rheumatic Diseases Open
Rituximab (RTX), an anti‐CD20 monoclonal antibody, has been used to treat autoimmune diseases such as rheumatoid arthritis (RA). However, variability in therapeutic response to RTX remains a challenge. Here, a systems model is developed to…
View article: Unraveling Key Hub Genes of Rheumatoid Arthritis Using Integrated Bioinformatics Approaches
Unraveling Key Hub Genes of Rheumatoid Arthritis Using Integrated Bioinformatics Approaches Open
Rheumatoid Arthritisis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation, progressive cartilage degradation and bone erosion, resulting in significant joint dysfunction and disability. The pathogenic m…
View article: Ultrasound Detection of Vascular Changes and Cardiovascular Risk Assessment in Rheumatoid Arthritis Patients
Ultrasound Detection of Vascular Changes and Cardiovascular Risk Assessment in Rheumatoid Arthritis Patients Open
This study investigates vascular alterations and cardiovascular risk in patients with rheumatoid arthritis (RA) using high-resolution carotid ultrasound. RA is associated with accelerated atherosclerosis and a disproportionately high burde…
View article: Are Glucocorticoids Associated with Worse Survival among Rheumatoid Arthritis Patients with Lung Cancer Treated with Immune Checkpoint Inhibitors?
Are Glucocorticoids Associated with Worse Survival among Rheumatoid Arthritis Patients with Lung Cancer Treated with Immune Checkpoint Inhibitors? Open
Objective Glucocorticoids are commonly used for rheumatoid arthritis (RA) treatment and to palliate some malignancies, but it is unclear whether glucocorticoids attenuate the benefits of immune checkpoint inhibitor (ICI) cancer therapy. We…
View article: Ultrasound Detection of Vascular Changes and Cardiovascular Risk Assessment in Rheumatoid Arthritis Patients
Ultrasound Detection of Vascular Changes and Cardiovascular Risk Assessment in Rheumatoid Arthritis Patients Open
This study investigates vascular alterations and cardiovascular risk in patients with rheumatoid arthritis (RA) using high-resolution carotid ultrasound. RA is associated with accelerated atherosclerosis and a disproportionately high burde…
View article: Corticosteroid insensitivity in obese asthma: potential mechanisms and therapeutic perspectives
Corticosteroid insensitivity in obese asthma: potential mechanisms and therapeutic perspectives Open
Asthma is a heterogeneous condition influenced by multiple clinical and biological factors, and obesity has emerged as a major modifier that worsens symptoms and increases the risk of exacerbations. This review aimed to examine the mechani…
View article: Upadacitinib‐Related Osteonecrosis of the Jaw
Upadacitinib‐Related Osteonecrosis of the Jaw Open
Background Upadacitinib is a Janus kinase ( JAK ) inhibitor, part of a class of medications that modulate immune system signalling. These drugs are commonly used to manage inflammatory conditions such as rheumatoid arthritis and ulcerative…