Sedative
View article: The effectiveness of combined anesthesia with the use of inhaled anesthetic xenon and intravenous anesthetic dexmedetomidine during plastic surgery
The effectiveness of combined anesthesia with the use of inhaled anesthetic xenon and intravenous anesthetic dexmedetomidine during plastic surgery Open
A clinically and pharmacologically sound and rational combination of various anesthetics is of increasing interest in scientific and practical activities, as it makes it possible to more effectively achieve targeted therapy within the crit…
View article: Dexmedetomidine modulates gut microbiota and improves long-term survival in sepsis patients with pre-existing malignancies: a propensity-matched analysis
Dexmedetomidine modulates gut microbiota and improves long-term survival in sepsis patients with pre-existing malignancies: a propensity-matched analysis Open
Background The interplay between sedative agents and the gut microbiome may influence long-term outcomes in sepsis, but data are scarce. This study compared the effects of dexmedetomidine vs. propofol sedation on long-term survival in mech…
View article: A Randomized controlled non-inferiority study of midazolam combined with dezocine sedation Versus Propofol in patients with colorectal polyps undergoing colonoscopic resection
A Randomized controlled non-inferiority study of midazolam combined with dezocine sedation Versus Propofol in patients with colorectal polyps undergoing colonoscopic resection Open
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View article: A Randomized controlled non-inferiority study of midazolam combined with dezocine sedation Versus Propofol in patients with colorectal polyps undergoing colonoscopic resection
A Randomized controlled non-inferiority study of midazolam combined with dezocine sedation Versus Propofol in patients with colorectal polyps undergoing colonoscopic resection Open
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View article: Capnography-detected respiratory depression during procedural sedation with remimazolam versus propofol: a randomised trial
Capnography-detected respiratory depression during procedural sedation with remimazolam versus propofol: a randomised trial Open
Remimazolam, a novel ultra-short-acting benzodiazepine, has gained attention for its favourable safety profile, particularly its reduced risk of respiratory depression compared to propofol during procedural sedation. However, previous stud…
View article: Potential Confounding Effect of Opioid Pharmacokinetics on Emergence Delirium After Sevoflurane Anesthesia
Potential Confounding Effect of Opioid Pharmacokinetics on Emergence Delirium After Sevoflurane Anesthesia Open
View article: Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial
Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial Open
Background and Aims Remimazolam, a new ultra‐short‐acting benzodiazepine, is a safe and effective option for procedural sedation. Nevertheless, to date, no study has directly compared remimazolam and midazolam in diagnostic upper gastroint…
View article: Risk factors for morphine-associated sedation in intravenous patient-controlled analgesia for postoperative pain
Risk factors for morphine-associated sedation in intravenous patient-controlled analgesia for postoperative pain Open
Background Opioid-related oversedation is associated with respiratory depression and can lead to potentially catastrophic adverse events in hospitalized patients. This study aimed to investigate influential factors for postoperative sedati…
View article: Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System
Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System Open
This study evaluated the sedative activity of abietic acid (AA) through a thiopental sodium (TS)‐induced sleep model in mice. AA (5, 10, and 20 mg/kg) and diazepam (DZP) (2 mg/kg) were provided, followed by TS (20 mg/kg) after 30 min to in…
View article: <scp> <i>Chrysanthemum morifolium</i> </scp> extract protects <scp>HT22</scp> cells from oxidative stress and enhances sleep via <scp>GABAergic</scp> modulation: contribution of luteolin‐7‐glucoside
<span> <i>Chrysanthemum morifolium</i> </span> extract protects <span>HT22</span> cells from oxidative stress and enhances sleep via <span>GABAergic</span> modulation: contribution of luteolin‐7‐glucoside Open
BACKGROUND Chrysanthemum morifolium has long been utilized in traditional medicine for its antioxidant and sedative properties, yet its potential in sleep regulation and neuroprotection against oxidative stress remains underexplored. This …
View article: Comparison of Dexmedetomidine and Midazolam as Co-induction Agents to Propofol for Proseal Laryngeal Mask Airway Insertion: A Randomised Control Trial
Comparison of Dexmedetomidine and Midazolam as Co-induction Agents to Propofol for Proseal Laryngeal Mask Airway Insertion: A Randomised Control Trial Open
Introduction: The Laryngeal Mask Airway (LMA) is a supraglottic device designed to secure the airway during minor to moderate surgical procedures. Second-generation LMAs, such as the ProSeal LMA (PLMA), offer enhanced safety features, incl…
View article: Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial
Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial Open
Chinese Clinical Trial Registry (Registration number# ChiCTR2300069998); Date of Registration: 30/03/2023.
View article: Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review
Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review Open
Background Premature neonates often require mechanical ventilation during intensive care. However, there is a lack of clinical consensus on the provision, type, and dosage of analgosedatives. The purpose of this scoping review is to assess…
View article: Comparing the Efficacy and Safety of Dexmedetomidine Versus Propofol for Sedation in Adult Patients Undergoing Cardiac Procedures: A Systematic Review
Comparing the Efficacy and Safety of Dexmedetomidine Versus Propofol for Sedation in Adult Patients Undergoing Cardiac Procedures: A Systematic Review Open
View article: Evolution of Pharmacologic Induction of Burst Suppression in Adult TBI: Barbiturate Coma Versus Modern Sedatives
Evolution of Pharmacologic Induction of Burst Suppression in Adult TBI: Barbiturate Coma Versus Modern Sedatives Open
Background: Severe traumatic brain injury (TBI) often leads to elevated intracranial pressure (ICP) that requires aggressive management. Inducing burst suppression with deep sedation is an established therapy for refractory intracranial hy…
View article: Evaluating the safety and efficacy of rapid bolus-only dexmedetomidine for pediatric EEG sedation: a retrospective study
Evaluating the safety and efficacy of rapid bolus-only dexmedetomidine for pediatric EEG sedation: a retrospective study Open
Dexmedetomidine is an α2-adrenergic receptor agonist known for its sedative and analgesic properties. It produces an EEG pattern resembling Stage II sleep without interfering with EEG interpretation, making it a preferred agent for pediatr…
View article: Remifentanil PCIA for labor analgesia: Does it work? Is it safe?
Remifentanil PCIA for labor analgesia: Does it work? Is it safe? Open
Background: Patient-controlled intravenous analgesia with remifentanil (RPCA) is increasingly considered as an alternative to epidural analgesia during labor. Its pharmacological profile—ultrashort half-life, rapid metabolism, and ease of …
View article: Analgesic and sedative drug dosing in critically ill patients with Acute Kidney Injury undergoing different modalities of Kidney Replacement Therapy
Analgesic and sedative drug dosing in critically ill patients with Acute Kidney Injury undergoing different modalities of Kidney Replacement Therapy Open
Critically ill patients frequently require analgesic and sedative medications to manage pain, agitation, and the stress associated with their condition. The onset of Acute Kidney Injury (AKI) can complicate the pharmacokinetics of these dr…
View article: Efficacy and recovery of remimazolam versus midazolam in sedated upper gastrointestinal endoscopy: a multicenter randomized controlled trial in Japan (RECOVER Study)
Efficacy and recovery of remimazolam versus midazolam in sedated upper gastrointestinal endoscopy: a multicenter randomized controlled trial in Japan (RECOVER Study) Open
Objectives Sedation is increasingly essential for gastrointestinal endoscopy. Remimazolam, an ultra-short-acting benzodiazepine, has a shorter pharmacokinetic half-life than midazolam. The aim of this study was to determine whether remimaz…
View article: Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial
Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial Open
View article: Comparison of remimazolam and dexmedetomidine for conscious sedation in elderly patients undergoing dental implant surgery: a prospective randomized controlled trial
Comparison of remimazolam and dexmedetomidine for conscious sedation in elderly patients undergoing dental implant surgery: a prospective randomized controlled trial Open
This study was registered at the Chinese Clinical Trials Registry (Registration ID: ChiCTR2400083062; Registration date: April 15, 2024).
View article: A Comparative Study between Intrathecal Bupivacaine with Dexmedetomidine and Intrathecal Bupivacaine with Buprenorphine for Post-operative Analgesia in Lower Abdominal Surgery
A Comparative Study between Intrathecal Bupivacaine with Dexmedetomidine and Intrathecal Bupivacaine with Buprenorphine for Post-operative Analgesia in Lower Abdominal Surgery Open
Background: Effective management of postoperative pain following lower abdominal surgeries remains a key component of perioperative care. Spinal anesthesia with bupivacaine provides satisfactory surgical…
View article: A Comparative Study between Intrathecal Bupivacaine with Dexmedetomidine and Intrathecal Bupivacaine with Buprenorphine for Post-operative Analgesia in Lower Abdominal Surgery
A Comparative Study between Intrathecal Bupivacaine with Dexmedetomidine and Intrathecal Bupivacaine with Buprenorphine for Post-operative Analgesia in Lower Abdominal Surgery Open
Background: Effective management of postoperative pain following lower abdominal surgeries remains a key component of perioperative care. Spinal anesthesia with bupivacaine provides satisfactory surgical anesthesia but limited postoperativ…
View article: Impact of non-immersive virtual reality on procedural pain, anxiety, and satisfaction in chronic low back pain patients: A quasi-experimental study
Impact of non-immersive virtual reality on procedural pain, anxiety, and satisfaction in chronic low back pain patients: A quasi-experimental study Open
Despite emerging interest in using virtual reality (VR) for managing chronic lower back pain (CLBP), the current evidence is insufficient to support the use of a non-immersive VR application. This study aimed to assess and compare the effe…
View article: Comparison of Postoperative Analgesic Outcomes with Intravenous Midazolam and Dexmedetomidine in Patients Undergoing Abdominal Hysterectomy Under Spinal Anaesthesia
Comparison of Postoperative Analgesic Outcomes with Intravenous Midazolam and Dexmedetomidine in Patients Undergoing Abdominal Hysterectomy Under Spinal Anaesthesia Open
Background: Effective postoperative pain control remains a major challenge following abdominal hysterectomy performed under spinal anaesthesia. Sedative adjuvants such as dexmedetomidine and midazolam are commonly used to prolong analgesia…
View article: Volatile sedation in critically ill adults undergoing mechanical ventilation: not all sedatives are equivalent, in sustainability!
Volatile sedation in critically ill adults undergoing mechanical ventilation: not all sedatives are equivalent, in sustainability! Open
View article: Vanillin Modulates the Sedative Effect of Diazepam, Possibly Through GABAergic Interaction Pathways in Thiopental Sodium‐Induced Sleeping Mice
Vanillin Modulates the Sedative Effect of Diazepam, Possibly Through GABAergic Interaction Pathways in Thiopental Sodium‐Induced Sleeping Mice Open
Insomnia is a common sleep disorder affecting approximately 10% of adults. This study aimed to evaluate the sedative effects of vanillin (VAN) and its combination with diazepam (DZP) in thiopental sodium (TS)‐induced sleeping mice. Mice re…
View article: Clinical Application Effect of Ciprofol Combined with Low-dose Esketamine in Painless Gastrointestinal Endoscopy
Clinical Application Effect of Ciprofol Combined with Low-dose Esketamine in Painless Gastrointestinal Endoscopy Open
Objective: To investigate the clinical application effect of ciprofol combined with low-dose esketamine in painless gastrointestinal endoscopy. Methods: A retrospective analysis was conducted on the clinical data of 160 patients who underw…
View article: Letter: From Descriptive Epidemiology to Clinical Imperative—Challenging the Paradigm of Pain and Sedative Use in Inflammatory Bowel Disease
Letter: From Descriptive Epidemiology to Clinical Imperative—Challenging the Paradigm of Pain and Sedative Use in Inflammatory Bowel Disease Open
View article: Efficacy and safety of esketamine in patients undergoing painless gastrointestinal endoscopy: a systematic review and meta-analysis of randomized controlled trials
Efficacy and safety of esketamine in patients undergoing painless gastrointestinal endoscopy: a systematic review and meta-analysis of randomized controlled trials Open
Background Esketamine, an intravenous anesthetic with analgesic properties, is increasingly used as an adjunct in painless gastrointestinal endoscopy. This systematic review and meta-analysis evaluated the efficacy and safety of esketamine…