Evans Blue
View article: Safety evaluation and hypolipidemic ability of water-soluble blue pigment extracted by HPD-400 resin from Quambalaria cyanescens
Safety evaluation and hypolipidemic ability of water-soluble blue pigment extracted by HPD-400 resin from Quambalaria cyanescens Open
The oral administration of synthetic drugs can effectively reduce blood lipid levels, but adverse reactions may occur. Because of this, the hypolipidemic ability of natural products has been increasingly investigated. We evaluate the safet…
View article: Methylene blue reduces postoperative delirium in mice through neuroinflammation suppression and blood-brain barrier repair
Methylene blue reduces postoperative delirium in mice through neuroinflammation suppression and blood-brain barrier repair Open
View article: Figure 3 from T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy
Figure 3 from T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy Open
PTX chemotherapy increases LOX levels and activity in the lungs. Tumor-free, 8- to 10-week-old BALB/c mice (n = 4 mice/group) were treated with PTX or vehicle control, and lungs were removed after 72 hours. A, Lung sections w…
View article: Fatty Acid-binding Protein 4 Exacerbates Blood–brain Barrier Disruption Through the JNK/c-Jun/MMP12 Pathway After Traumatic Brain Injury
Fatty Acid-binding Protein 4 Exacerbates Blood–brain Barrier Disruption Through the JNK/c-Jun/MMP12 Pathway After Traumatic Brain Injury Open
Elevated circulating levels of fatty acid-binding protein 4 (FABP4) correlate with poor prognosis in brain injury patients. However, the molecular mechanisms by which FABP4 regulates blood-brain barrier (BBB) disruption after traumatic bra…
View article: Fingolimod reduces blood-brain barrier damage, inflammation, and neuronal death in experimental subarachnoid hemorrhage
Fingolimod reduces blood-brain barrier damage, inflammation, and neuronal death in experimental subarachnoid hemorrhage Open
Subarachnoid hemorrhage (SAH) is a severe form of hemorrhagic stroke associated with high morbidity and mortality. There are limited pharmacological treatment options available to prevent or treat secondary neurologic injury after SAH. We …
View article: A Gallium-68 Radiolabeled NOTA-Conjugated Evans Blue Derivative: Optimization of the Synthesis and Purification Approach
A Gallium-68 Radiolabeled NOTA-Conjugated Evans Blue Derivative: Optimization of the Synthesis and Purification Approach Open
View article: DDEL-13. Enhanced CNS delivery of therapeutic nanoparticles with focused ultrasound improves treatment efficacy in glioblastoma
DDEL-13. Enhanced CNS delivery of therapeutic nanoparticles with focused ultrasound improves treatment efficacy in glioblastoma Open
BACKGROUND Glioblastoma (GBM) is an aggressive primary malignant brain tumor with limited treatment options. Immunotherapy is a promising treatment modality. One such therapy in development is our novel multilamellar RNA lipid nanoparticle…
View article: Quercetin Protects Blood–Brain Barrier Integrity and Maintains Microvascular Permeability Following Traumatic Brain Injury
Quercetin Protects Blood–Brain Barrier Integrity and Maintains Microvascular Permeability Following Traumatic Brain Injury Open
Background Cerebral edema is a consequential outcome of traumatic brain injury (TBI) and may lead to intracranial hypertension, necessitating urgent medical attention. One of the primary causes of cerebral edema is microvascular hyperperme…
View article: Comparative Evaluation of Lipopolysaccharide Administration Methods to Induce Acute Lung Injury in Murine Models: Efficacy, Consistency, and Technical Considerations
Comparative Evaluation of Lipopolysaccharide Administration Methods to Induce Acute Lung Injury in Murine Models: Efficacy, Consistency, and Technical Considerations Open
CONTEXT: Direct preclinical lipopolysaccharide acute lung injury (ALI) models are commonly used to study acute respiratory distress syndrome. Differences in lipopolysaccharide delivery methods may impact lung injury severity and reproducib…
View article: Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice
Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice Open
Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many substances, including opioid medications. Here, we examined the…
View article: Correction to: Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats
Correction to: Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats Open
View article: A Novel Retrievable Drug Infusion Stent and Blood-Brain Barrier Portal for Antibody Therapies to the Spinal Cord
A Novel Retrievable Drug Infusion Stent and Blood-Brain Barrier Portal for Antibody Therapies to the Spinal Cord Open
BACKGROUND AND OBJECTIVES: The blood-brain barrier (BBB) is prohibitive to intravascular drug delivery. We hypothesized that isolation of spinal cord perfusion would focus on a higher effective dose while minimizing systemic toxicity and t…
View article: The Protective Effects of <scp><i>Lactobacillus reuteri</i></scp> Combined With <scp><i>Clostridium butyricum</i></scp> Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of <scp>5FU</scp>‐Induced Diarrhea
The Protective Effects of <span><i>Lactobacillus reuteri</i></span> Combined With <span><i>Clostridium butyricum</i></span> Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of <span>5FU</span>‐Induced Diarrhea Open
5‐Fluorouracil (5FU) is a commonly employed and highly effective chemotherapeutic agent in clinical oncology. Nevertheless, one of the most frequent and debilitating adverse effects associated with 5FU treatment is diarrhea. These gastroin…
View article: The History of the Evans Index
The History of the Evans Index Open
View article: Kinin B1 Receptor Agonist Enhances Blood-Brain Barrier Permeability in Healthy and Glioblastoma Environments
Kinin B1 Receptor Agonist Enhances Blood-Brain Barrier Permeability in Healthy and Glioblastoma Environments Open
Background/Objectives: The low permeability of the blood-brain barrier (BBB) represents a significant challenge to effective systemic chemotherapy for primary and metastatic brain cancers. Kinin receptors play a crucial role in modulating …
View article: Evans blue dye exclusion assay: Mechanisms, protocols, and applications in cell viability analysis
Evans blue dye exclusion assay: Mechanisms, protocols, and applications in cell viability analysis Open
Evans blue is a dye that has the ability to penetrate the damaged cell membranes of deceased cells, resulting in a distinct blue staining. The Evans Blue assay is a widely used technique in biology and medicine to assess vascular permeabil…
View article: Evans Blue Acts as a Selective Inhibitor of <scp>CaMKII</scp>‐α to Impede the Progression of <scp>TCL</scp> Identified by <scp>HTS</scp>
Evans Blue Acts as a Selective Inhibitor of <span>CaMKII</span>‐α to Impede the Progression of <span>TCL</span> Identified by <span>HTS</span> Open
T‐cell lymphoma (TCL) poses a significant challenge in clinical oncology, characterized by its aggressive behavior and resistance to conventional therapies. Despite considerable research efforts, the prognosis for TCL patients remains poor…
View article: Effectiveness of Using Methylene Blue Dyes in Papanicolaou Staining in Cytology of Ascites Fluid
Effectiveness of Using Methylene Blue Dyes in Papanicolaou Staining in Cytology of Ascites Fluid Open
Papanicolaou staining is routinely used in staining ascitic fluid to identify malignant cells. However, pale nucleus arise as a problem associated with Harris hematoxylin, causing the sample to be hard to see under microscope. Methylene bl…
View article: Panaxadiol Attenuates Brain Damage by Inhibiting Ferroptosis in a Rat Model of Cerebral Hemorrhage
Panaxadiol Attenuates Brain Damage by Inhibiting Ferroptosis in a Rat Model of Cerebral Hemorrhage Open
Intracerebral hemorrhage (ICH) is the most common subtype of hemorrhage stroke, with a high disability, morbidity and mortality rate globally. Panaxadiol (PD), a triterpenoid sapogenin monomer, is isolated from the roots of ginseng, which …
View article: Shengui Sansheng San alleviates the worsening of blood–brain barrier integrity resulted from delayed tPA administration through VIP/VIPR1 pathway
Shengui Sansheng San alleviates the worsening of blood–brain barrier integrity resulted from delayed tPA administration through VIP/VIPR1 pathway Open
View article: Lymphatic mapping using patent blue dye injection for colon cancer
Lymphatic mapping using patent blue dye injection for colon cancer Open
View article: CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability
CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability Open
Acute pancreatitis can lead to systemic inflammation and multiple organ damage. Increased endothelial permeability is a hallmark of systemic inflammation. Several studies have demonstrated that cold-inducible RNA-binding protein (CIRP) fun…
View article: Dimethyl Fumarate Attenuates Cyclophosphamide‐Induced Bladder Damage and Enhances Cytotoxic Activity Against SH‐SY5Y Cells
Dimethyl Fumarate Attenuates Cyclophosphamide‐Induced Bladder Damage and Enhances Cytotoxic Activity Against SH‐SY5Y Cells Open
Cylophosphamide (CP)‐induced acute cystitis is a debilitating bladder dysfunction commonly observed in cancer patients, primarily resulting from oxidative damage and inflammation in the bladder tissue. Dimethyl fumarate (DMF) is a fumaric …
View article: Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator‐Induced Brain Hemorrhagic Transformation After Ischemic Stroke
Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator‐Induced Brain Hemorrhagic Transformation After Ischemic Stroke Open
Background Thrombolytic treatment with tissue plasminogen activator (tPA) is one of the approved pharmacological therapies for acute ischemic stroke. However, the use of tPA is limited due to hemorrhagic transformation (HT) and the narrow …
View article: Evans-Polanyi-like models for rapidly predicting barriers in xylopyranoses: Accelerating the development of kinetic models for hemicellulose pyrolysis
Evans-Polanyi-like models for rapidly predicting barriers in xylopyranoses: Accelerating the development of kinetic models for hemicellulose pyrolysis Open
This work elucidates Evans-Polanyi-like (EPL) relations to rapidly estimate the standard activation enthalpy of three ubiquitous reaction classes playing a central role in hemicellulose pyrolysis: ring-opening, ring contraction, and elimin…
View article: Evans-Polanyi-like models for rapidly predicting barriers of hemicellulose motifs under pyrolysis conditions based on the reactant reactivity parameters
Evans-Polanyi-like models for rapidly predicting barriers of hemicellulose motifs under pyrolysis conditions based on the reactant reactivity parameters Open
This work elucidates Evans-Polanyi-like (EPL) relations to rapidly estimate the standard activation enthalpy of three ubiquitous reaction classes playing a central role in hemicellulose pyrolysis: ring-opening, ring contraction, and elimin…
View article: Convective forces contribute to post‐traumatic degeneration after spinal cord injury
Convective forces contribute to post‐traumatic degeneration after spinal cord injury Open
Spinal cord injury (SCI) initiates a complex cascade of chemical and biophysical phenomena that result in tissue swelling, progressive neural degeneration, and formation of a fluid‐filled cavity. Previous studies show fluid pressure above …
View article: VILDAGLIPTIN IMPROVES DETRUSOR CONTRACTILITY IN A MOUSE MODEL OF CYCLOPHOSPHAMIDE-INDUCED OVERACTIVE BLADDER
VILDAGLIPTIN IMPROVES DETRUSOR CONTRACTILITY IN A MOUSE MODEL OF CYCLOPHOSPHAMIDE-INDUCED OVERACTIVE BLADDER Open
Objective: Overactive bladder (OAB) is a common urological disorder associated with detrusor overactivity linked to local tissue inflammation resulting in bladder hypersensitivity. The present study was aimed to investigate the therapeutic…
View article: Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border
Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border Open
These data reveal a novel mitochondrial ROS-driven mechanism by which Poldip2 induces ZO-1 tyrosine phosphorylation and promotes EC permeability following cerebral ischemia.
View article: Role of P2 X7 receptor during focused ultrasound induced blood brain barrier modulation
Role of P2 X7 receptor during focused ultrasound induced blood brain barrier modulation Open