Silicosis
View article: Galunisertib attenuates pulmonary fibrosis with silicosis in mouse via TGF-β/TRAF6/Beclin1 signaling pathway
Galunisertib attenuates pulmonary fibrosis with silicosis in mouse via TGF-β/TRAF6/Beclin1 signaling pathway Open
Objective Silicosis is characterized by silicon nodules and diffuse pulmonary fibrosis. To date, no effective therapy has been developed for the treatment of silicosis. This study aimed to investigate the effects of Galunisertib, a TGF-β r…
View article: Editorial for “Ventilation and Perfusion Defects on Phase‐Resolved Functional Lung ( <scp>PREFUL</scp> ) <scp>MRI</scp> Predict Silicosis Progression: A Prospective Pilot Study”
Editorial for “Ventilation and Perfusion Defects on Phase‐Resolved Functional Lung ( <span>PREFUL</span> ) <span>MRI</span> Predict Silicosis Progression: A Prospective Pilot Study” Open
View article: Ventilation and Perfusion Defects on Phase‐Resolved Functional Lung ( <scp>PREFUL</scp> ) <scp>MRI</scp> Predict Silicosis Progression: A Prospective Pilot Study
Ventilation and Perfusion Defects on Phase‐Resolved Functional Lung ( <span>PREFUL</span> ) <span>MRI</span> Predict Silicosis Progression: A Prospective Pilot Study Open
Background Silicosis is an occupational lung disease characterized by inflammation and fibrosis. As it is irreversible, early identification of high‐risk individuals is clinically important, but biomarkers for progression remain lacking. P…
View article: Multimodal Fusion of Chest X-Rays and Blood Biomarkers for Automated Silicosis Staging
Multimodal Fusion of Chest X-Rays and Blood Biomarkers for Automated Silicosis Staging Open
Background/Objectives: Silicosis, a fibrotic lung disease, is re-emerging globally, driven by an aggressive form linked to engineered stone processing that rapidly progresses to progressive massive fibrosis (PMF). The standard diagnostic a…
View article: Silicosis and Pulmonary Functions Among Residents Exposed to Dust in Saraburi Thailand
Silicosis and Pulmonary Functions Among Residents Exposed to Dust in Saraburi Thailand Open
Background: Silicosis is a lung disease caused by inhalation of crystalline silica dust, leading to lung fibrosis, respiratory symptoms, and impaired lung function. This study aimed to determine the prevalence of silicosis, asthma, and chr…
View article: Crystalline silica content of natural, engineered, and synthetic stone products and their relation to silicosis policy development
Crystalline silica content of natural, engineered, and synthetic stone products and their relation to silicosis policy development Open
Crystalline silica minerals – quartz, cristobalite, and tridymite – are hazardous when inhaled. They are at least an order of magnitude more toxic than crystalline silica-free inert mineral dusts. Workplace exposure to hazardous levels of …
View article: Silica exposure as a driver of inflammatory arthritis: insights from genetically susceptible mouse models 3289
Silica exposure as a driver of inflammatory arthritis: insights from genetically susceptible mouse models 3289 Open
Description Occupational exposure to silica is strongly associated with rheumatoid arthritis (RA), but causality remains unproven. To bridge this gap, we investigated whether pulmonary silicosis could induce RA-like arthritis in a mouse mo…
View article: Diagnosing Pleural Effusion Caused by Silicosis in a Long-Term Quarry Worker: A Case Report
Diagnosing Pleural Effusion Caused by Silicosis in a Long-Term Quarry Worker: A Case Report Open
View article: SOX18 influences the progression of silicosis through the regulation of lymphangiogenesis
SOX18 influences the progression of silicosis through the regulation of lymphangiogenesis Open
View article: Silicosis in Zambian ex-copper miners: A cross-sectional study
Silicosis in Zambian ex-copper miners: A cross-sectional study Open
Background. Dust exposure in copper mining, an important industry in Africa, poses a risk of silicosis and pulmonary tuberculosis (TB). Despite a number of reports on silicosis in Zambian copper miners since the 1960s, there has been no pu…
View article: Silicosis disease burden in Zambian ex-copper miners continues to persist: Need for policy and programmatic reform to address ongoing challenges
Silicosis disease burden in Zambian ex-copper miners continues to persist: Need for policy and programmatic reform to address ongoing challenges Open
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View article: Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis
Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis Open
Introduction Silicosis is a progressive fibrotic lung disease without effective treatment options, and its pathogenesis remains incompletely understood, particularly the role of endothelial cells (ECs). Methods Here, we utilized single-cel…
View article: A combination of silica and cigarette smoke extract exacerbates lung fibrosis: Unveiling a harmful synergy
A combination of silica and cigarette smoke extract exacerbates lung fibrosis: Unveiling a harmful synergy Open
Smoking could potentiate the profibrotic effects of silica in the lungs, including increasing the risk of cancer and silicosis. Crystalline silica-induced silicosis has been associated with lung fibrosis. Moreover, smoking is strongly link…
View article: Silicosis Struggles: Unravelling the Complex Clinical Journey of a Glass Factory Worker
Silicosis Struggles: Unravelling the Complex Clinical Journey of a Glass Factory Worker Open
Silicosis is a progressive, preventable occupational lung disease that affects workers in industries such as mining and construction. First reported in India in 1949, it is diagnosed through chest radiography and lung function tests, with …
View article: An Integrated Strategy for Preventing and Rehabilitating Dust-Induced Occupational Bronchopulmonary Diseases: A Scoping Review
An Integrated Strategy for Preventing and Rehabilitating Dust-Induced Occupational Bronchopulmonary Diseases: A Scoping Review Open
Background: Occupational bronchopulmonary diseases (OBPDs)—including pneumoconiosis, silicosis, and occupational COPD—remain a pressing public health issue, especially in regions with intensive mining, metallurgy, and construction industri…
View article: Global workplace health and safety policies for silicosis elimination and way forward
Global workplace health and safety policies for silicosis elimination and way forward Open
Silicosis is an incurable occupational lung disease caused by prolonged exposure to respirable crystalline silica (RCS). It is the oldest known occupational disease, yet its elimination remains a global public health concern. Workers in tr…
View article: Case report: silicosis complicated by bronchial stones and tracheoesophageal fistula
Case report: silicosis complicated by bronchial stones and tracheoesophageal fistula Open
Silicosis is one of the most serious occupational respiratory diseases worldwide. This article reports a patient with a long history of cough and sputum production who ended up with bronchial stones and a tracheoesophageal fistula (TEF). T…
View article: Serum Krebs von den Lungen-6 as a potential biomarker for early diagnosis of silicosis: a case-control study
Serum Krebs von den Lungen-6 as a potential biomarker for early diagnosis of silicosis: a case-control study Open
Serum KL-6 may serve as a potential biomarker for early silicosis diagnosis. Its diagnostic performance is significantly improved when combined with CRP ad ACE, offering a potential multi-biomarker approach for enhanced detection in the ea…
View article: Case series of acute and accelerated silicosis among ramming mass workers from West Bengal
Case series of acute and accelerated silicosis among ramming mass workers from West Bengal Open
Ramming mass has 95-99% silica content. It is produced by crushing boulders. These boulders are mined mainly in the West Bardhhaman, West Bengal; Chot Nagpur plateau of Jharkhand, during crushing, producing granules of various sizes in spe…
View article: Targeting acid sphingomyelinase/ceramide/S1P ameliorates silica-induced pulmonary fibrosis through Hippo/YAP signaling pathway in mice
Targeting acid sphingomyelinase/ceramide/S1P ameliorates silica-induced pulmonary fibrosis through Hippo/YAP signaling pathway in mice Open
Silicosis is irreversible lung disease caused by exposure to dust-containing silica particles. Our study aims to explore the potential effects of acid sphingomyelinase (aSMase), ceramide (Cer) and sphingosine-1-phosphate (S1P) on silica-in…
View article: Silicosis research priorities for health care, research, and health and safety professionals, and for people exposed to silica in Australia: a research priority setting exercise
Silicosis research priorities for health care, research, and health and safety professionals, and for people exposed to silica in Australia: a research priority setting exercise Open
Objectives To identify the silicosis research priorities of people living with silicosis, workers at risk of silicosis, their partners and caregivers, and of health professionals and researchers. Study design Research priority setting exer…
View article: Correction: Serum concentrations of Krebs von den Lungen-6 as prognostic biomarker in patients with silicosis
Correction: Serum concentrations of Krebs von den Lungen-6 as prognostic biomarker in patients with silicosis Open
[This corrects the article DOI: 10.3389/fmed.2025.1579209.].
View article: Tetrandrine slows disease progression on high-resolution computed tomography and lung function decline in artificial stone-associated silicosis: a retrospective cohort study
Tetrandrine slows disease progression on high-resolution computed tomography and lung function decline in artificial stone-associated silicosis: a retrospective cohort study Open
Background Silicosis, a progressive fibrotic lung disease caused by silica dust inhalation, is a significant occupational health concern, particularly among artificial quartz stone workers. Tetrandrine, a bisbenzylisoquinoline alkaloid, is…
View article: High metabolic activity in positron emission tomography and systemic inflammation occurring years after exposure cessation in engineered stone silicosis
High metabolic activity in positron emission tomography and systemic inflammation occurring years after exposure cessation in engineered stone silicosis Open
View article: PGC1α inhibits SiO2-induced fibrosis by regulating the mitochondrial respiratory chain
PGC1α inhibits SiO2-induced fibrosis by regulating the mitochondrial respiratory chain Open
Silicosis is a fibrotic disease caused by long-term inhalation of SiO2 particles that currently has no effective treatment. Therefore, it is very important to elucidate its pathogenesis and develop novel therapeutic methods. Mac…
View article: Silicosis Mimicking Lung Malignancy: A Case Series
Silicosis Mimicking Lung Malignancy: A Case Series Open
Silicosis, an important occupational disease, is caused by inhalation of silicon dioxide and can lead to pulmonary inflammation and fibrosis. Silicosis can be misdiagnosed for malignant disease, as both can present with hypermetabolic lesi…
View article: Diosgenin ameliorates silica‐induced tuberculosis in rats
Diosgenin ameliorates silica‐induced tuberculosis in rats Open
Background Silicosis is an occupational lung disease that is caused by chronic exposure to silica dust. Silica‐exposed workers are at higher risk of developing TB, resulting in lung fibrosis and significant respiratory dysfunction. Diosgen…
View article: Silicosis: A public health emergency in India
Silicosis: A public health emergency in India Open
Occupational health is a public health emergency, long ignored in India, primarily as it is considered more of a class issue than a public health problem. The economic impact of mortality and morbidity associated with occupational diseases…
View article: Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis
Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis Open
ASV combined with QUE could alleviate silica-induced pulmonary inflammation and fibrosis in rats, with the protective mechanism potentially mediated through enhanced autophagy activation and suppressed pyroptosis pathway.
View article: Cutting for Stone
Cutting for Stone Open
Silicosis typically presents with parenchymal lung disease in workers exposed to silica. We present a rare case of isolated pleural and lymph node silicosis without parenchymal involvement in a stone fabrication worker. A 49-year-old man w…