Cytokine
View article: The relationships between proinflammatory cytokines and depressive symptoms in adolescents with chronic pain.
The relationships between proinflammatory cytokines and depressive symptoms in adolescents with chronic pain. Open
Our findings suggest that IL-1β and IL-6 play critical roles in the pain experience. Interleukin-6 is more strongly associated with physical symptoms, and IL-1β is more related to fear-avoidance.
View article: The Role of Regulatory T Cell Dysregulation in the Development of Autoimmune Diseases
The Role of Regulatory T Cell Dysregulation in the Development of Autoimmune Diseases Open
Background: The regulatory T cells (Tregs), especially theCD4⁺ CD25^hi CD127^lo FOXP3⁺ Tregs subpopulation is principal in the process of ensuring the immune toleration and prevention of autoimmune diseases. Their impaired frequency, stabi…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus that degrade lacrimal and salivary funct…
View article: Figure S4 from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Figure S4 from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia Open
Figure S4 shows 1x104 A20 lymphoma cells were treated with the indicated doses of TAK-981 for 48 hours.
View article: Figure S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103
Figure S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103 Open
Immunofluorescence of 33 human lung tumor samples on a microarray probed with GT103.
View article: Supplementary Fig. S7 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis
Supplementary Fig. S7 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis Open
IVMT-Rx-3 suppressed tumor cell derived pro-inflammatory cytokines expression.
View article: Figure S3 from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Figure S3 from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia Open
Figure S3 shows Hallmark enrichment plot of RNA collected from naïve T cells from patients with CLL treated with TAK-981
View article: Table S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103
Table S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103 Open
Genes regulated by GT103 in total intratumoral B cells
View article: Table S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103
Table S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103 Open
Genes regulated by GT103 in CR2+ intratumoral B cells
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus that degrade lacrimal and salivary funct…
View article: Preoperative pembrolizumab (anti-PD-1 antibody) combined with chemoradiotherapy for esophageal squamous cell carcinoma: a phase 1/2 trial (PALACE-2)
Preoperative pembrolizumab (anti-PD-1 antibody) combined with chemoradiotherapy for esophageal squamous cell carcinoma: a phase 1/2 trial (PALACE-2) Open
The role of preoperative anti-PD-1 antibody (pembrolizumab) plus chemoradiotherapy (PPCT) in locally advanced, resectable esophageal squamous cell carcinoma (ESCC) is still unclear. We aimed to investigate the therapeutic effect and safety…
View article: Figure S2 from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Figure S2 from T Cell–intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia Open
Figure S2 shows Magnetically enriched CD3+ T cells were activated with 0.5 µg/mL αCD3/28 in the presence of TAK-981 or vehicle control for up to 96 h
View article: Figure S1 from S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
Figure S1 from S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells Open
The binding activity of S-531011 against various chemokine receptors, PD-1, PD-L1, CTLA4, or mouse CCR8
View article: Figure S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103
Figure S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103 Open
Deposition of intratumoral C3dg and C3d.
View article: Figure S4 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103
Figure S4 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103 Open
Gating strategy for detection of ADCP.
View article: Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection
Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection Open
Introduction The analysis of tumor-infiltrating lymphocytes often requires techniques that expand their numbers, potentially introducing bias. To address this, we performed a detailed analysis of minimally cultured TILs to evaluate whether…
View article: NLRP3 Inflammasome Activation in Chronic Inflammatory Diseases and Emerging Causative Role of Gut Dysbiosis
NLRP3 Inflammasome Activation in Chronic Inflammatory Diseases and Emerging Causative Role of Gut Dysbiosis Open
Background The NLRP3 inflammasome is a cytosolic sensor that mediates the maturation of pro-inflammatory cytokines IL-1β and IL-18. Chronic activation contributes to the pathogenesis of numerous noninfectious inflammatory diseases. Objecti…
View article: Macrophage migration inhibitory factor–CD74 axis drives vascular smooth muscle cell–induced M1 macrophage polarization to exacerbate intracranial aneurysm inflammation
Macrophage migration inhibitory factor–CD74 axis drives vascular smooth muscle cell–induced M1 macrophage polarization to exacerbate intracranial aneurysm inflammation Open
Background Intracranial aneurysms (IAs) develop and progress through pathological processes, including inflammation and abnormal changes in the vascular structure. The cytokine Macrophage Migration Inhibitory Factor (MIF) is implicated in …
View article: Tumor Necrosis Factor (TNF)-Alpha Inhibitors in Hidradenitis Suppurativa: A Systematic Review of Inflammatory Markers and Alternative Monitoring Strategies
Tumor Necrosis Factor (TNF)-Alpha Inhibitors in Hidradenitis Suppurativa: A Systematic Review of Inflammatory Markers and Alternative Monitoring Strategies Open
View article: Targeting the Interferon Pathway: Case Study of Anifrolumab Use in Sting-Associated Vasculopathy
Targeting the Interferon Pathway: Case Study of Anifrolumab Use in Sting-Associated Vasculopathy Open
Introduction STING-associated vasculopathy with onset in infancy (SAVI) is a rare monogenic autoinflammatory disease characterised by activation of the type I interferon (IFN-I) signalling pathway. Emerging evidence suggests that direct in…
View article: Diverse Effects of Various Toll-Like Receptor 2 Ligands on Neuronal Activity and Cell Death
Diverse Effects of Various Toll-Like Receptor 2 Ligands on Neuronal Activity and Cell Death Open
The role of Toll-like receptor 2 (TLR2) in the central nervous system (CNS) is critical in several conditions including neurological disorders such as pain, and neurodegenerative disorders such as Parkinson’s disease. Therefore, understand…
View article: TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases
TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases Open
Dysregulation of type I interferon (IFN-I) signaling has been implicated in the pathogenesis of multiple systemic autoimmune diseases, including systemic lupus erythematosus, Sjögren’s syndrome, and rheumatoid arthritis. Tripartite motif-c…
View article: The Three-Program Model of Dendritic Cell Function: Naive, Memory, and Tolerogenic Programs as Context-Dependent Immune Modes
The Three-Program Model of Dendritic Cell Function: Naive, Memory, and Tolerogenic Programs as Context-Dependent Immune Modes Open
Dendritic cells (DCs) integrate pathogen-derived cues, host damage signals, immune-complex feedback, and tissue-derived contextual information to decide among three functional programs: a naïve program, a memory program, and a tolerogenic …
View article: Elevated DUOX2 levels correlate with necrotizing enterocolitis development
Elevated DUOX2 levels correlate with necrotizing enterocolitis development Open
Background Neonatal necrotizing enterocolitis (NEC) is a life-threatening intestinal disease primarily affecting preterm infants. Although the exact pathophysiology remains unclear, immune responses and redox reactions play crucial roles i…
View article: The role of AIM2 inflammasome pathway-mediated pyroptosis on brain injury induced by severe acute pancreatitis in mice
The role of AIM2 inflammasome pathway-mediated pyroptosis on brain injury induced by severe acute pancreatitis in mice Open
View article: Figure 3 from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers
Figure 3 from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers Open
IL8 and VEGF signaling sustain AR pathway activation and modulate response to enzalutamide. Cells were treated with anti-IL8 nAb (5 μg/mL), anti-VEGF nAb (10 μg/mL) or the highest concentration of isotype-matched human IgG antibody. A,<…
View article: Supplementary Figure S1-S26 from Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors
Supplementary Figure S1-S26 from Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors Open
Supplementary Figure S1-S26
View article: Particulate Matter Increases Bone Morphogenetic Protein 2 in Lung Fibroblasts
Particulate Matter Increases Bone Morphogenetic Protein 2 in Lung Fibroblasts Open
Particulate matter less than 2.5 μm (PM 2.5 ) contributes to many chronic respiratory disorders, but the mechanisms for this are not fully understood. The actions of PM 2.5 on lung epithelial cells have been well studied, but their effect …
View article: Pan-cancer multi-omics characterization of calcyphosine and its revealed links to the immune microenvironment and regulatory networks in endometrial carcinoma
Pan-cancer multi-omics characterization of calcyphosine and its revealed links to the immune microenvironment and regulatory networks in endometrial carcinoma Open
Objective The calcium-dependent activator protein for secretion (CAPS) has emerged as a protein of interest in tumor biology; however, its functional significance in endometrial carcinoma (EC) remains largely unexplored. Methods We perform…
View article: NLRP1 Shapes Immune and Inflammatory Signatures in Human Melanoma but Not in Mouse Models
NLRP1 Shapes Immune and Inflammatory Signatures in Human Melanoma but Not in Mouse Models Open
Inflammasomes are multiprotein complexes that activate pro-caspase-1, leading to the maturation of the pro-inflammatory cytokines IL-1β and IL-18. Nlrp1, the first receptor identified with inflammasome-forming capacity, is highly expressed…