Necrotizing enterocolitis
View article: Elevated DUOX2 levels correlate with necrotizing enterocolitis development
Elevated DUOX2 levels correlate with necrotizing enterocolitis development Open
Background Neonatal necrotizing enterocolitis (NEC) is a life-threatening intestinal disease primarily affecting preterm infants. Although the exact pathophysiology remains unclear, immune responses and redox reactions play crucial roles i…
View article: Gut Microbiota and Autism: Unlocking Connections
Gut Microbiota and Autism: Unlocking Connections Open
Background: Autism Spectrum Disorder (ASD) is a multifactorial neurodevelopmental condition in which genetic predisposition interacts with environmental factors. Among these, the gut microbiota has emerged as a crucial modulator of the mic…
View article: Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine
Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine Open
Extracellular vesicles (EVs) have emerged as promising therapeutic candidates for a range of neonatal diseases, including sepsis, necrotizing enterocolitis, hypoxic–ischemic encephalopathy (HIE), and bronchopulmonary dysplasia (BPD). Deriv…
View article: Cow’s milk protein intolerance unmasked by bovine-derived human milk fortifier and successfully rescued by human milk-based fortifier in a preterm infant
Cow’s milk protein intolerance unmasked by bovine-derived human milk fortifier and successfully rescued by human milk-based fortifier in a preterm infant Open
Preterm infants require human milk fortification to achieve adequate growth. Most fortifiers are bovine-derived and may trigger feeding intolerance or immunological reactions. We describe a 25+5 week, 720 g male infant who developed recurr…
View article: Data Management and Sharing Plan for: Reprogramming intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitis
Data Management and Sharing Plan for: Reprogramming intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitis Open
The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data.
View article: The microbiome’s hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis
The microbiome’s hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis Open
Necrotizing enterocolitis (NEC) is the most common surgical emergency in preterm infants; nonetheless, besides supportive measures, no treatment is available. NEC significantly increases length of hospitalization of preterm infants, causes…
View article: The evolving storyline of food protein–induced enterocolitis syndrome
The evolving storyline of food protein–induced enterocolitis syndrome Open
View article: An Explainable Machine Learning Model for Predicting Necrotizing Enterocolitis in Neonates Based on Complete Blood Count Parameters
An Explainable Machine Learning Model for Predicting Necrotizing Enterocolitis in Neonates Based on Complete Blood Count Parameters Open
Background Necrotising enterocolitis (NEC) is a major cause of morbidity and mortality in neonates, particularly among preterm infants. Identifying effective methods for early prediction is crucial for developing personalised treatment str…
View article: Predictive analytics characterize cardiovascular function and outcomes following cardiac surgery
Predictive analytics characterize cardiovascular function and outcomes following cardiac surgery Open
Background Using supervised machine learning, predictive models of cardiovascular and respiratory instability were previously created and display risk scores (CoMET score), characterizing the risk of clinical deterioration in the ensuing 1…
View article: Assessment of enteral nutrition in preterm infants with patent ductus arteriosus undergoing medical treatment
Assessment of enteral nutrition in preterm infants with patent ductus arteriosus undergoing medical treatment Open
Objective: The aim of this study was evaluate the effect of enteral nutrition during treatment in preterms under 32 weeks of gestation with patent ductus arteriosus receiving medical treatment. Material and Methods: Preterm newborns born b…
View article: Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Very Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study
Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Very Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study Open
Background: Early-onset neonatal sepsis (EONS), defined as systemic infection occurring within the first 72 hours of life, remains a major cause of morbidity and mortality in preterm infants. Increasing evidence indicates that the gut may …
View article: Risk Factors for Necrotizing Enterocolitis in Newborns Under 34 Weeks of Age in the Intensive Care Unit of the National Maternal Perinatal Institute, in the Period 2020–2022
Risk Factors for Necrotizing Enterocolitis in Newborns Under 34 Weeks of Age in the Intensive Care Unit of the National Maternal Perinatal Institute, in the Period 2020–2022 Open
The objective is to identify the risk factors associated with the development of necrotizing enter-ocolitis in newborns less than 34 weeks old in the INMP ICU during the period 2020-2022. The approach is basic, quantitative, non-experiment…
View article: Volvulus in very-low-birth-weight preterm infants enrolled in the German Neonatal Network: Prevalence, mortality, and outcome
Volvulus in very-low-birth-weight preterm infants enrolled in the German Neonatal Network: Prevalence, mortality, and outcome Open
Background: Volvulus is an emergency condition, but data on its prevalence and outcome in preterm infants are scarce. Methods: We analyseddata from the German Neonatal Network and conducted a PubMed literature search on the primary hospita…
View article: Prenatal Corticosteroid Use Improves the Severity and Complications of Necrotizing Enterocolitis in Preterm Infants: A Multicenter Clinical Study in China
Prenatal Corticosteroid Use Improves the Severity and Complications of Necrotizing Enterocolitis in Preterm Infants: A Multicenter Clinical Study in China Open
Our study is a retrospective multicenter observational cohort study to investigate effect of the use of antenatal corticosteroids (ACS) in preterm infants on the severity of necrotizing enterocolitis (NEC) and its associated complications.…
View article: Enterocolite necrosante em prematuros
Enterocolite necrosante em prematuros Open
Necrotizing enterocolitis (NEC), a complex disease characterized by severe gastrointestinal inflammation that primarily affects premature newborns, is notorious for its rapid onset, diagnostic challenges, and high mortality rate, posing a …
View article: Food protein-induced enterocolitis syndrome (FPIES) following COVID-19 infection: a case report
Food protein-induced enterocolitis syndrome (FPIES) following COVID-19 infection: a case report Open
Introduction Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated form of food allergy characterized by gastrointestinal manifestations following ingestion of the offending food. Most cases are identified during the fi…
View article: Development and validation of a nomogram for predicting necrotizing enterocolitis in premature infants with early-onset sepsis
Development and validation of a nomogram for predicting necrotizing enterocolitis in premature infants with early-onset sepsis Open
This study aimed to develop an effective individualized predictive nomogram for the occurrence of necrotizing enterocolitis (NEC) in premature infants with early-onset sepsis (EOS). A total of 238 premature infants meeting the inclusion cr…
View article: SII as a potential biomarker for distinguishing between Necrotisingenterocolitis and Food protein-inducedenterocolitis syndrome with abdominal gas signs
SII as a potential biomarker for distinguishing between Necrotisingenterocolitis and Food protein-inducedenterocolitis syndrome with abdominal gas signs Open
Background The initial clinical manifestations and abdominal imaging manifestations of neonatal necrotizing enterocolitis (NEC) and food protein enterocolitis syndrome (FPIES) are sometimes similar; However, their prognosis and treatment a…
View article: A novel kirkovirus may be associated with equine gastrointestinal disease
A novel kirkovirus may be associated with equine gastrointestinal disease Open
Background Many cases of equine enterocolitis are suspected to be infectious in nature, but no pathogen is identified in many cases. Objectives Perform next‐generation sequencing on faeces collected from cases of equine enterocolitis for t…
View article: Neuroendoscopic lavage: a single-center retrospective cohort in the USA
Neuroendoscopic lavage: a single-center retrospective cohort in the USA Open
View article: Outcomes of primary intestinal anastomosis versus stoma in necrotizing enterocolitis: A systematic review and meta-analysis
Outcomes of primary intestinal anastomosis versus stoma in necrotizing enterocolitis: A systematic review and meta-analysis Open
View article: Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs
Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs Open
Background Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants with a morality rate that approaches 50%. Arginine has been widely studied in the field of clinical nutrition as a supplement for p…
View article: Association between nonacidified standard and high‐protein human milk fortifiers and increased weight velocity relative to acidified human milk fortifiers in preterm infants: A retrospective cohort study
Association between nonacidified standard and high‐protein human milk fortifiers and increased weight velocity relative to acidified human milk fortifiers in preterm infants: A retrospective cohort study Open
Background Fortification of human milk is necessary for preterm infant growth. We evaluated the impact of an acidified human milk fortifier and nonacidified human milk fortifiers on growth velocity in preterm infants. Methods This retrospe…
View article: Cumulative Hydrocortisone Exposure and Early Brain Volumetrics in Very Low Birth Weight Infants: Associations with Neurodevelopmental Outcomes
Cumulative Hydrocortisone Exposure and Early Brain Volumetrics in Very Low Birth Weight Infants: Associations with Neurodevelopmental Outcomes Open
Background/Objectives: Systemic hydrocortisone (HCS) in very low birth weight (VLBW) infants is commonly used to treat early hypotension or prevent bronchopulmonary dysplasia. This study evaluated the associations between postnatal HCS exp…
View article: Effect of Slow Versus Rapid Advancement of Enteral Feeding on Intestinal Oxygenation in Preterm Infants
Effect of Slow Versus Rapid Advancement of Enteral Feeding on Intestinal Oxygenation in Preterm Infants Open
Background/Objectives: The optimal rate of enteral feeding advancement in preterm infants remains uncertain despite decades of clinical research. This uncertainty arises from concerns that rapid feeding progression may increase the risk of…
View article: Closed-Loop Automated Oxygen Control in Preterm Infants Receiving Non-Invasive Respiratory Support
Closed-Loop Automated Oxygen Control in Preterm Infants Receiving Non-Invasive Respiratory Support Open
Background/Objectives: Closed-loop automated oxygen control (CLAC) systems improve compliance with oxygen saturation targets and other outcomes in preterm ventilated infants. This narrative review aimed to explore the efficacy of CLAC syst…
View article: The BHMT2/MAT1A/AHSG axis promotes M1 macrophage activation and exacerbates necrotizing enterocolitis
The BHMT2/MAT1A/AHSG axis promotes M1 macrophage activation and exacerbates necrotizing enterocolitis Open
View article: Neonatal management of parvovirus B19-induced hydrops fetalis: a case report
Neonatal management of parvovirus B19-induced hydrops fetalis: a case report Open
Background Hydrops fetalis (HF) is a severe fetal condition, and congenital Parvovirus B19 (B19V) infection is a leading cause of the non-immune form (NIHF). The recent European B19V outbreak has had a substantial impact on obstetric and n…
View article: Risk Factors and Predictive Parameters of Necrotizing Enterocolitis in Preterm Infants—A Single-Center Retrospective Study
Risk Factors and Predictive Parameters of Necrotizing Enterocolitis in Preterm Infants—A Single-Center Retrospective Study Open
Background and Objectives: Necrotizing enterocolitis (NEC) represents a severe gastrointestinal emergency in preterm infants. The aim of this study was to identify risk factors and predictive parameters for NEC requiring surgery and to eva…
View article: Relative and Absolute Regulatory T Cells in Preterm Neonates with Necrotizing Enterocolitis
Relative and Absolute Regulatory T Cells in Preterm Neonates with Necrotizing Enterocolitis Open
The objective of this study was to compare the concentrations of relative and absolute regulatory T cells (Tregs) in preterm neonates diagnosed with necrotizing enterocolitis (NEC) with those in the control group. The study consisted of 60…