Overdiagnosis
View article: To what extent is ADHD overdiagnosed?
To what extent is ADHD overdiagnosed? Open
Increased ADHD diagnoses may reflect both improved recognition and potential overdiagnosis due to reliance on screening tools; comprehensive evaluations are essential to guide accurate diagnosis.
View article: To what extent is ADHD overdiagnosed?
To what extent is ADHD overdiagnosed? Open
Increased ADHD diagnoses may reflect both improved recognition and potential overdiagnosis due to reliance on screening tools; comprehensive evaluations are essential to guide accurate diagnosis.
View article: Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction
Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction Open
The modern era of medical research, characterized by the availability of big data and sophisticated statistical methodologies, is paradoxically vulnerable to fundamental structural flaws in experimental cohort construction, despite adheren…
View article: Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction
Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction Open
The modern era of medical research, characterized by the availability of big data and sophisticated statistical methodologies, is paradoxically vulnerable to fundamental structural flaws in experimental cohort construction, despite adheren…
View article: Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction
Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction Open
The modern era of medical research, characterized by the availability of big data and sophisticated statistical methodologies, is paradoxically vulnerable to fundamental structural flaws in experimental cohort construction, despite adheren…
View article: Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction
Restoring Reliability in Vaccine Safety Surveillance: Correcting Structural Bias in Medical Cohort Construction Open
The modern era of medical research, characterized by the availability of big data and sophisticated statistical methodologies, is paradoxically vulnerable to fundamental structural flaws in experimental cohort construction, despite adheren…
View article: THE IMPACT OF THE COVID-19 PANDEMIC AND THE WAR ON THE EARLY DETECTION OF THYROID CANCER IN UKRAINE (BASED ON AN ANALYSIS OF TEN YEARS OF DATA)
THE IMPACT OF THE COVID-19 PANDEMIC AND THE WAR ON THE EARLY DETECTION OF THYROID CANCER IN UKRAINE (BASED ON AN ANALYSIS OF TEN YEARS OF DATA) Open
Introduction. The problem of thyroid cancer requires increased attention to prevention and early detection of pathology. Aim. To analyze indicators of timely detection of thyroid cancer in Ukraine over the last decade. Materials and method…
View article: Systematic review of the literature on the role of testicular palpation during primary care consultations in the early detection of benign and malignant conditions affecting male endocrine and reproductive health : Systematic Review Protocol
Systematic review of the literature on the role of testicular palpation during primary care consultations in the early detection of benign and malignant conditions affecting male endocrine and reproductive health : Systematic Review Protocol Open
This protocol describes a systematic review of clinician-performed testicular examination in primary care for males aged 12 years and older. Target presentations include scrotal symptoms, an initial infertility work-up, risk factors such a…
View article: Integrating expert knowledge into large language models improves performance for psychiatric reasoning and diagnosis
Integrating expert knowledge into large language models improves performance for psychiatric reasoning and diagnosis Open
When used to predict psychiatric diagnoses from case vignettes, direct prompting of the LLMs yielded most true positive diagnoses but had significant overdiagnosis. Integrating expert-derived reasoning into the process using decision trees…
View article: Systematic review of the literature on the role of testicular palpation during primary care consultations in the early detection of benign and malignant conditions affecting male endocrine and reproductive health : Systematic Review Protocol
Systematic review of the literature on the role of testicular palpation during primary care consultations in the early detection of benign and malignant conditions affecting male endocrine and reproductive health : Systematic Review Protocol Open
This protocol describes a systematic review of clinician-performed testicular examination in primary care for males aged 12 years and older. Target presentations include scrotal symptoms, an initial infertility work-up, risk factors such a…
View article: How effective is breast cancer screening at reducing mortality in the UK?
How effective is breast cancer screening at reducing mortality in the UK? Open
Breast cancer screening programs in the UK reduce mortality significantly, especially among women aged 50-74, though challenges in balancing benefits and risks, such as overdiagnosis and sensitivity issues, persist.
View article: Diagnostic accuracy of PSA derivatives for prostate cancer in patients with low prostate-specific antigen levels
Diagnostic accuracy of PSA derivatives for prostate cancer in patients with low prostate-specific antigen levels Open
Prostate-specific antigen (PSA) has long been used to screen for prostate cancer (PCa), yet its low diagnostic sensitivity in the so-called PSA “gray zone” often results in overdiagnosis or missed diagnoses. This study aimed to identify re…
View article: Frequency and survival of delayed breast cancer diagnosis in women participating at screening mammography in the Netherlands: a population-based study
Frequency and survival of delayed breast cancer diagnosis in women participating at screening mammography in the Netherlands: a population-based study Open
View article: How effective is breast cancer screening at reducing mortality in the UK?
How effective is breast cancer screening at reducing mortality in the UK? Open
Breast cancer screening programs in the UK reduce mortality significantly, especially among women aged 50-74, though challenges in balancing benefits and risks, such as overdiagnosis and sensitivity issues, persist.
View article: AI-Assisted Point of Care Ultrasound (POCUS) Vs. Mammography for Early Breast Cancer Detection: A Comparative Review
AI-Assisted Point of Care Ultrasound (POCUS) Vs. Mammography for Early Breast Cancer Detection: A Comparative Review Open
Background: Mammography (MG) is the current standard for population screening and mortality reduction, but sensitivity declines in dense breasts, and access can be limited in low-resource settings. Objective: Identify and synthesize publis…
View article: Overdiagnosis and Overtreatment of Thyroid Cancer, a Single City Experience in the Kurdistan Region/Iraq
Overdiagnosis and Overtreatment of Thyroid Cancer, a Single City Experience in the Kurdistan Region/Iraq Open
Background and aims The incidence of thyroid cancer (TC) has increased globally over the last three decades. Overdiagnosis appears to be the primary factor driving an increasing number of TC diagnoses. Most documented TC cases involve smal…
View article: Avoiding overdiagnosis of parathyroid carcinoma
Avoiding overdiagnosis of parathyroid carcinoma Open
The diagnosis of a non-metastatic parathyroid carcinoma requires the demonstration of invasive growth that defines malignancy. These include angioinvasion or vascular invasion (i.e., tumor penetrating the vessel wall and associated with th…
View article: The clinical diversity of Lyme disease – diagnostic and therapeutic challenges
The clinical diversity of Lyme disease – diagnostic and therapeutic challenges Open
Lyme disease is the most common tick-borne disease in Europe, including Poland, where it is endemic and poses a growing public health issue. Caused by Borrelia burgdorferi sensu lato, it is characterized by a wide variety of clinical prese…
View article: Characteristics associated with women undergoing their first mammography screening at a younger age
Characteristics associated with women undergoing their first mammography screening at a younger age Open
Breast cancer is the most commonly diagnosed cancer and a leading cause of cancer death among women. Kuwait has among the highest age-standardized incidence in the Gulf, yet mammography uptake remains low. The 2024 USPSTF recommends routin…
View article: Modern trends and innovations in breast cancer screening: from mammography to AI: a review
Modern trends and innovations in breast cancer screening: from mammography to AI: a review Open
Introduction : Breast cancer screening has played a key role in the early detection of the disease and reduction of mortality rates. Modern technologies have significantly changed screening methods, enhancing diagnostic outcomes and expand…
View article: Diagnosis and classification of neonatal seizures. English version
Diagnosis and classification of neonatal seizures. English version Open
Epileptic seizures are the most frequent neurological emergency in the neonatal period. In contrast to seizures in older children and adults they are mostly acute symptomatic seizures as a response to a prenatal or perinatal acute brain in…
View article: Screening for lung cancer: A systematic review of overdiagnosis and its implications
Screening for lung cancer: A systematic review of overdiagnosis and its implications Open
Low‐dose computed tomography (LDCT) screening is increasingly used for early lung cancer detection targeted to high‐risk populations. Quantifying overdiagnosis, its potential harms, and economic consequences is important. We assessed the m…
View article: Distinguishing Suicidal Hanging from Homicidal Ligature Strangulation – A Diagnostic Accuracy Study of Autopsy and Scene Findings
Distinguishing Suicidal Hanging from Homicidal Ligature Strangulation – A Diagnostic Accuracy Study of Autopsy and Scene Findings Open
Introduction: Differentiating suicidal hanging from homicidal strangulation remains a critical challenge in forensic pathology due to overlapping scene findings, ligature patterns, and internal neck injuries. Accurate classification is ess…
View article: Distinguishing Suicidal Hanging from Homicidal Ligature Strangulation – A Diagnostic Accuracy Study of Autopsy and Scene Findings
Distinguishing Suicidal Hanging from Homicidal Ligature Strangulation – A Diagnostic Accuracy Study of Autopsy and Scene Findings Open
Introduction: Differentiating suicidal hanging from homicidal strangulation remains a critical challenge in forensic pathology due to overlapping scene findings, ligature patterns, and internal neck injuries. Accurate classification is ess…
View article: Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men
Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men Open
Approximately 7% of males globally suffer from male infertility, which is becoming more widely acknowledged as a clinical indicator of potential health hazards as well as a cause of reproductive failure. Among these, cancer has become a si…
View article: Perceptions and Misconceptions of PSA Screening in Switzerland: A Preference Epidemiology Study
Perceptions and Misconceptions of PSA Screening in Switzerland: A Preference Epidemiology Study Open
View article: A Practical Approach in Differentiating <scp>IBD</scp> From Other Causes of Enterocolitis
A Practical Approach in Differentiating <span>IBD</span> From Other Causes of Enterocolitis Open
Inflammatory bowel disease (IBD) is emerging in Asia, but there are many challenges in making the diagnosis. There is no gold standard for the diagnosis of IBD, which is often made based on a combination of clinical, endoscopic, radiologic…
View article: CNSM-06 WHEN BRAIN LESIONS AREN’T WHAT THEY SEEM: THE POWER OF COMBINING MRI AND RADIOACTIVE IODINE SCINTIGRAPHY FOR THYROID CANCER IN A RESOURCE-LIMITED SETTING
CNSM-06 WHEN BRAIN LESIONS AREN’T WHAT THEY SEEM: THE POWER OF COMBINING MRI AND RADIOACTIVE IODINE SCINTIGRAPHY FOR THYROID CANCER IN A RESOURCE-LIMITED SETTING Open
Background and Aims Accurate imaging is essential for the diagnosis, staging, and treatment planning of cancer. Magnetic Resonance Imaging (MRI) provides high-resolution anatomical detail and is preferred for evaluating intracranial lesion…
View article: 495 Indolent Hepatic Neoplasm with Mixed Hepatocellular and Cholangiolar Differentiation: A Previously Unrecognized Entity
495 Indolent Hepatic Neoplasm with Mixed Hepatocellular and Cholangiolar Differentiation: A Previously Unrecognized Entity Open
Introduction/Objective The current classification of biphasic hepatic tumors includes only combined hepatocellular-cholangiocarcinoma. In contrast, indolent or benign biphenotypic hepatic neoplasms remain unrecognized and unclassified. We …
View article: Evaluation of a Mammography-based Deep Learning Model for Breast Cancer Risk Prediction in a Triennial Screening Program.
Evaluation of a Mammography-based Deep Learning Model for Breast Cancer Risk Prediction in a Triennial Screening Program. Open
Background Deep learning risk algorithms for personalized breast cancer screening outperform traditional methods in retrospective evaluations, but triennial screening assessments are lacking. Purpose To evaluate the predictive ability of 3…