Cerebral edema
View article: Гістопатологічні зміни внутрішніх органів білих щурів після впливу курареподібних лікарських засобів
Гістопатологічні зміни внутрішніх органів білих щурів після впливу курареподібних лікарських засобів Open
Background. The relevance of the topic of diagnosing fatal poisoning with muscle relaxants in forensic medicine has emerged relatively recently and is due to an increase in the frequency of such cases in forensic medical practice. Analysis…
View article: The Role of Aquaporin Channels in Cytotoxic Brain Edema following Severe Head Trauma, Mechanisms and Potential Therapeutic Interventions
The Role of Aquaporin Channels in Cytotoxic Brain Edema following Severe Head Trauma, Mechanisms and Potential Therapeutic Interventions Open
View article: What are the most effective acute management strategies for reducing intracranial pressure in patients with traumatic brain injury?
What are the most effective acute management strategies for reducing intracranial pressure in patients with traumatic brain injury? Open
A variety of acute management strategies for reducing intracranial pressure in traumatic brain injury are evidenced, including hypertonic saline, decompressive craniectomy, and targeted temperature control, though the quality and conclusiv…
View article: What are the most effective acute management strategies for reducing intracranial pressure in patients with traumatic brain injury?
What are the most effective acute management strategies for reducing intracranial pressure in patients with traumatic brain injury? Open
A variety of acute management strategies for reducing intracranial pressure in traumatic brain injury are evidenced, including hypertonic saline, decompressive craniectomy, and targeted temperature control, though the quality and conclusiv…
View article: Comprehensive Overview of Hypernatremia: Pathophysiology, Diagnosis, and Management
Comprehensive Overview of Hypernatremia: Pathophysiology, Diagnosis, and Management Open
Hypernatremia, defined as an elevated serum sodium concentration, is a critical electrolyte imbalance with significant neurological and systemic effects. Effective management hinges on understanding the condition’s underlying aetiology, su…
View article: Data Sheet 1_Intracranial functional near-infrared spectroscopy: an animal feasibility study.docx
Data Sheet 1_Intracranial functional near-infrared spectroscopy: an animal feasibility study.docx Open
Introduction Functional Near-Infrared Spectroscopy (fNIRS) is widely used to monitor cerebral hemodynamics, however, it is limited by shallow penetration depth and susceptibility to hemodynamic noise from the scalp. A novel intracranial fN…
View article: Balanced multi-electrolyte solution versus normal saline for fluid therapy in aneurysmal subarachnoid hemorrhage: an influence on fluid and electrolytes balance and outcome
Balanced multi-electrolyte solution versus normal saline for fluid therapy in aneurysmal subarachnoid hemorrhage: an influence on fluid and electrolytes balance and outcome Open
Introduction Isotonic crystalloids are commonly used for maintaining fluid balance and cerebral perfusion pressure in critical care patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the relatively high concentration of chlo…
View article: The TREM1–AQP4 axis mediates neuroinflammatory injury and brain edema after experimental subarachnoid hemorrhage
The TREM1–AQP4 axis mediates neuroinflammatory injury and brain edema after experimental subarachnoid hemorrhage Open
View article: Table 1_Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree.docx
Table 1_Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree.docx Open
Introduction Alteplase is known to increase the risk of blood-brain barrier integrity disruption, potentiating hemorrhage and edema. Evolving edema reduces chances of good functional outcomes. There is a paucity of studies that investigate…
View article: Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree
Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree Open
Introduction Alteplase is known to increase the risk of blood-brain barrier integrity disruption, potentiating hemorrhage and edema. Evolving edema reduces chances of good functional outcomes. There is a paucity of studies that investigate…
View article: Posterior Reversible Encephalopathy Syndrome (PRES) and Intraventricular Hemorrhage in a Patient with Untreated Hypertension: A Case Report
Posterior Reversible Encephalopathy Syndrome (PRES) and Intraventricular Hemorrhage in a Patient with Untreated Hypertension: A Case Report Open
Background Posterior Reversible Encephalopathy Syndrome (PRES) is a neurotoxic condition characterized by headache, altered mental status, seizures, and visual disturbances, frequently associated with vasogenic edema on neuroimaging. Altho…
View article: Early prediction of space-occupying hemispheric infarction: Development and validation of the Malignant Edema Risk Assessment (MERA) score – Results from the PREDICT-MMI study
Early prediction of space-occupying hemispheric infarction: Development and validation of the Malignant Edema Risk Assessment (MERA) score – Results from the PREDICT-MMI study Open
Background Space-occupying hemispheric infarction is a severe complication after acute ischemic stroke (AIS) due to large-vessel occlusion (LVO). As decompressive hemicraniectomy improves outcome, early identification of patients at risk i…
View article: Sarcopenia modelling by portal vein ligation inducing hyperammonemia in rats
Sarcopenia modelling by portal vein ligation inducing hyperammonemia in rats Open
Sarcopenia is a progressive muscle wasting condition often associated with hyperammonemia. However, no approved animal models of sarcopenia with hyperammonemia were reported. This study aimed to provide a surgical modelling of sarcopenia w…
View article: O USO DA VENTILAÇÃO NÃO INVASIVA (VNI) NA INSUFICIÊNCIA CARDÍACA AGUDIZADA: UMA REVISÃO INTEGRATIVA
O USO DA VENTILAÇÃO NÃO INVASIVA (VNI) NA INSUFICIÊNCIA CARDÍACA AGUDIZADA: UMA REVISÃO INTEGRATIVA Open
A insuficiência cardíaca (IC) é um problema de saúde pública global, cuja descompensação aguda frequentemente culmina em edema agudo de pulmão cardiogênico (EAPC), uma emergência médica com alta morbimortalidade. A ventilação não invasiva …
View article: NXC736, a Functional Antagonist of S1P4, Attenuates Brain Injury in Mice with Permanent Ischemic Stroke
NXC736, a Functional Antagonist of S1P4, Attenuates Brain Injury in Mice with Permanent Ischemic Stroke Open
Stroke is the leading cause of death and long-term disability worldwide, with ischemic stroke accounting for nearly 87% of all cases. Vascular occlusion, a key pathological event in ischemic stroke, has been reliably reproduced in preclini…
View article: The role of the glymphatic system in cerebral ischemia: pathological implications and future perspectives
The role of the glymphatic system in cerebral ischemia: pathological implications and future perspectives Open
The glymphatic system (GS) consists of a paravascular fluid-exchange network that regulates cerebrospinal and interstitial fluid dynamics, clears metabolic waste, and modulates neuroinflammation. Aquaporin-4 (AQP-4), expressed in astrocyti…
View article: Diagnostic Pitfalls of CT in Malignant Superior Cerebellar Artery Infarction: Implications for Treatment Decisions and Future Management Strategies
Diagnostic Pitfalls of CT in Malignant Superior Cerebellar Artery Infarction: Implications for Treatment Decisions and Future Management Strategies Open
Background/Objectives: Superior cerebellar artery (SCA) infarction is a rare but clinically significant subtype of posterior circulation stroke. Extensive swelling in the SCA territory may cause downward brainstem compression and appear as…
View article: COMPLICATIONS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH COMBINED TRAUMATIC BRAIN INJURY
COMPLICATIONS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH COMBINED TRAUMATIC BRAIN INJURY Open
COMPLICATIONS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH COMBINED TRAUMATIC BRAIN INJURY Aliev Mansur Abdukholikovich Specialized scientific and practical center for neurosurgery and neurorehabilitation at the Samarkand State Medical Uni…
View article: Cerebral edema in maple syrup urine disease: spectrum of clinical presentation and treatment outcomes
Cerebral edema in maple syrup urine disease: spectrum of clinical presentation and treatment outcomes Open
Background Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder caused by a deficiency of branched-chain α-keto acid dehydrogenase complex activity. There is an accumulation of neurotoxic branched-chain amino acids and …
View article: COMPLICATIONS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH COMBINED TRAUMATIC BRAIN INJURY
COMPLICATIONS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH COMBINED TRAUMATIC BRAIN INJURY Open
COMPLICATIONS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH COMBINED TRAUMATIC BRAIN INJURY Aliev Mansur Abdukholikovich Specialized scientific and practical center for neurosurgery and neurorehabilitation at the Samarkand State Medical Uni…
View article: Table 1_Protective effects of salvianolic acid A on ischemic stroke: A meta-analysis of preclinical studies.docx
Table 1_Protective effects of salvianolic acid A on ischemic stroke: A meta-analysis of preclinical studies.docx Open
Objective The aim of this study was to investigate the protective effects of salvianolic acid A (SalA) on cerebral ischemic injury following ischemic stroke (IS) and its possible mechanisms, providing a scientific basis for future clinical…
View article: Supplementary file 1_Protective effects of salvianolic acid A on ischemic stroke: A meta-analysis of preclinical studies.docx
Supplementary file 1_Protective effects of salvianolic acid A on ischemic stroke: A meta-analysis of preclinical studies.docx Open
Objective The aim of this study was to investigate the protective effects of salvianolic acid A (SalA) on cerebral ischemic injury following ischemic stroke (IS) and its possible mechanisms, providing a scientific basis for future clinical…
View article: Protective effects of salvianolic acid A on ischemic stroke: A meta-analysis of preclinical studies
Protective effects of salvianolic acid A on ischemic stroke: A meta-analysis of preclinical studies Open
Objective The aim of this study was to investigate the protective effects of salvianolic acid A (SalA) on cerebral ischemic injury following ischemic stroke (IS) and its possible mechanisms, providing a scientific basis for future clinical…
View article: Role of Cerebral Oximetry in Reducing Postoperative End-Organ Dysfunction After Major Non-Cardiac Surgery: A Randomised Controlled Trial
Role of Cerebral Oximetry in Reducing Postoperative End-Organ Dysfunction After Major Non-Cardiac Surgery: A Randomised Controlled Trial Open
Background/Objectives: An increasing number of older individuals require general anaesthesia for major non-cardiac surgery, with 20% displaying postoperative complications. Regional cerebral oxygen saturation (rSO2) correlates with the gol…
View article: Daily Optic Nerve Sheath Diameter Monitoring for Early Detection of Cerebral Edema in Preeclampsia and Eclampsia
Daily Optic Nerve Sheath Diameter Monitoring for Early Detection of Cerebral Edema in Preeclampsia and Eclampsia Open
Cerebral edema is a severe neurological complication of preeclampsia and eclampsia, and continues to be a major contributor to maternal morbidity and mortality worldwide. Conventional methods for monitoring intracranial pressure (ICP) are …
View article: Pathological changes and aquaporin-4 expression after bevacizumab treatment of traumatic penumbra in the rat brain
Pathological changes and aquaporin-4 expression after bevacizumab treatment of traumatic penumbra in the rat brain Open
The traumatic penumbra (TP) is a secondary injury zone surrounding the core area of traumatic brain injury (TBI) and plays a critical role in determining TBI outcomes. The primary pathological change in the TP is brain edema, which include…
View article: Assessment of the effectiveness of Glibenclamide in the treatment of non-lacunary ischemic stroke in patients with type 2 diabetes mellitus
Assessment of the effectiveness of Glibenclamide in the treatment of non-lacunary ischemic stroke in patients with type 2 diabetes mellitus Open
INTRODUCTION. It is well known that diabetes mellitus (DM) is not only one of the leading risk factors for the development of ischemic stroke (IS), but also the cause of its adverse outcomes. Along with this, with IS in people with diabete…
View article: The predictive value of serum ox-LDL and 25-(OH)-D levels for cerebral edema in patients with hypertensive cerebral hemorrhage
The predictive value of serum ox-LDL and 25-(OH)-D levels for cerebral edema in patients with hypertensive cerebral hemorrhage Open
[Objective] To analyze the predictive value of serum oxidation-modified low-density lipoprotein (ox-LDL) and 25-hydroxyvitamin D[25-(OH)-D] levels before minimally invasive hematoma evacuation in patients with hypertensive intracerebral he…
View article: Fingolimod reduces blood-brain barrier damage, inflammation, and neuronal death in experimental subarachnoid hemorrhage
Fingolimod reduces blood-brain barrier damage, inflammation, and neuronal death in experimental subarachnoid hemorrhage Open
Subarachnoid hemorrhage (SAH) is a severe form of hemorrhagic stroke associated with high morbidity and mortality. There are limited pharmacological treatment options available to prevent or treat secondary neurologic injury after SAH. We …
View article: Aquaporin-4 Regulates Edema, Sustains Astrocyte Differentiation, and Constrains Immunosuppressive Remodeling in Glioblastoma
Aquaporin-4 Regulates Edema, Sustains Astrocyte Differentiation, and Constrains Immunosuppressive Remodeling in Glioblastoma Open
Vasogenic cerebral edema is a severe complication that affects most patients with glioblastoma (GBM). It leads to an increase in intracranial pressure, neurological deficits, and increased mortality rates. While there is considerable resea…