Polyamine
View article: Minimal-tag probes for intracellular imaging of polyamines
Minimal-tag probes for intracellular imaging of polyamines Open
Polyamines (putrescine, spermidine, and spermine) are essential cellular polycations that regulate chromatin structure, RNA function, and organelle physiology. However, the lack of minimally perturbing probes has limited visualization of t…
View article: Minimal-tag probes for intracellular imaging of polyamines
Minimal-tag probes for intracellular imaging of polyamines Open
Polyamines (putrescine, spermidine, and spermine) are essential cellular polycations that regulate chromatin structure, RNA function, and organelle physiology. However, the lack of minimally perturbing probes has limited visualization of t…
View article: Minimal-tag probes for intracellular imaging of polyamines
Minimal-tag probes for intracellular imaging of polyamines Open
Polyamines (putrescine, spermidine, and spermine) are essential cellular polycations that regulate chromatin structure, RNA function, and organelle physiology. However, the lack of minimally perturbing probes has limited visualization of t…
View article: Cerrado fruit residues during fermentation with probiotic strains: prebiotic properties and polyamine production [pdf]
Cerrado fruit residues during fermentation with probiotic strains: prebiotic properties and polyamine production [pdf] Open
View article: A noncanonical polyamine from bacteria antagonizes host mitochondrial function
A noncanonical polyamine from bacteria antagonizes host mitochondrial function Open
View article: Optimizing polyamine delivery: Comparative effects of foliar spray and seed priming on cotton’s chromium stress resilience
Optimizing polyamine delivery: Comparative effects of foliar spray and seed priming on cotton’s chromium stress resilience Open
View article: Amino acid decarboxylation preserves <i>Salmonella</i> fitness during phagocyte-derived oxidative stress
Amino acid decarboxylation preserves <i>Salmonella</i> fitness during phagocyte-derived oxidative stress Open
Successful establishment of infection by non-typhoidal Salmonella depends upon its ability to resist the antimicrobial defenses of the host innate immune response. To withstand the membrane depolarization that potentiates the killing activ…
View article: Nitrogen Degradation Pathways in Actinomycetes: Key Components of Primary Metabolism Ensuring Survival in the Environment
Nitrogen Degradation Pathways in Actinomycetes: Key Components of Primary Metabolism Ensuring Survival in the Environment Open
Nitrogen is an essential element required for bacterial homeostasis. It serves as a building block for the biosynthesis of macromolecules and provides precursors for secondary metabolites. Actinomycetes have developed the ability to use va…
View article: Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer
Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer Open
Chemotherapy‐induced enrichment of cancer stem cells (CSCs) is a key mechanism underlying acquired chemoresistance and recurrence of epithelial ovarian cancer (OC). Although chemotherapy may enrich CSCs through selection or by inducing ded…
View article: Sabatier principle in designing CO <sub>2</sub> -philic but blocking membranes
Sabatier principle in designing CO <sub>2</sub> -philic but blocking membranes Open
Gas transport through polymers follows the sorption-diffusion mechanism, and gas-philic functional groups are often incorporated into polymers to enhance its solubility selectivity and thus separation efficiency. In contrast, we report tha…
View article: The Effect of Seed Priming with Polyamine Spermine on Key Photosynthetic Parameters in Fusarium culmorum Infected Winter Wheat
The Effect of Seed Priming with Polyamine Spermine on Key Photosynthetic Parameters in Fusarium culmorum Infected Winter Wheat Open
Photosynthesis is a primary plant physiological process, which can easily be affected by various environmental factors, including biotic stressors. The exogenous application of different substances like plant growth regulators might benefi…
View article: Mapping Epoxyquinoid Biosynthesis: Enzyme Functions Across Bacteria and Fungi
Mapping Epoxyquinoid Biosynthesis: Enzyme Functions Across Bacteria and Fungi Open
Epoxyquinoids are a unique class of natural products featuring an epoxide embedded within a quinone/quinol scaffold, typically as an epoxycyclohexenone (ECH). Their striking stereochemical diversity arises from multiple permutations of epo…
View article: <scp>ATP13A2</scp> is involved in intracellular polyamine transport in lung epithelial cells
<span>ATP13A2</span> is involved in intracellular polyamine transport in lung epithelial cells Open
Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy. In contrast, excess amounts of polyamines can be toxic to cells. ATP13A2 was recently ident…
View article: Response surface methodology optimization of L-arginine deiminase from Penicillium chrysogenum and the influence of phytohormones
Response surface methodology optimization of L-arginine deiminase from Penicillium chrysogenum and the influence of phytohormones Open
The study presents an optimization process to produce L-arginine deiminase (ADI) from the fungus Penicillium chrysogenum , focusing on the impact of growth parameters and the role of phytohormones and polyamines. ADI, an enzyme that cataly…
View article: Polyamine Metabolism in Cancer: Drivers of Immune Evasion, Ferroptosis, and Therapy Resistance
Polyamine Metabolism in Cancer: Drivers of Immune Evasion, Ferroptosis, and Therapy Resistance Open
View article: Cambium LBDs promote radial growth by regulating PLL-mediated pectin metabolism
Cambium LBDs promote radial growth by regulating PLL-mediated pectin metabolism Open
Plant growth originates from the interlinked action of cell division and cell growth. During radial growth of secondary tissues, bifacial cambial stem cells grow and divide to produce xylem and phloem precursors, which subsequently undergo…
View article: Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status
Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status Open
View article: Geographic provenance and environmental growing conditions as factors influencing phytochemical composition of Arabica green coffee beans
Geographic provenance and environmental growing conditions as factors influencing phytochemical composition of Arabica green coffee beans Open
This study explores how bioactive compounds in green coffee beans ( Coffea arabica L.) vary across different geographic regions, addressing the key question of how environmental factors shape coffee biochemistry and adaptation mechanisms t…
View article: Effect of Hydrogen-Rich Water Intake on the Polyamine Profile of Colostrum and Milk of Goat
Effect of Hydrogen-Rich Water Intake on the Polyamine Profile of Colostrum and Milk of Goat Open
The present study aimed to evaluate the effect of hydrogen-rich water (HRW) intake on the polyamine profile of colostrum and milk. Two groups of Gurcu goats were provided ad libitum access to normal water (NW) and HRW from the 21st day pre…
View article: TMIC-65. Polyamine acetylation bridges tumor and immune cell metabolism in glioblastoma
TMIC-65. Polyamine acetylation bridges tumor and immune cell metabolism in glioblastoma Open
Metabolic reprogramming in cancer cells not only sustains proliferative signaling but also modulates the anti-tumor immune response via secretion of immunomodulatory metabolites. Polyamines are small, positively charged metabolites synthes…
View article: EXTH-96. CT-2A sublines with divergent immune phenotypes: therapeutic implications for polyamine blockade
EXTH-96. CT-2A sublines with divergent immune phenotypes: therapeutic implications for polyamine blockade Open
Polyamines are small molecules that play a critical role in tumor progression and in the regulation of immune responses within the tumor microenvironment. Elevated levels of polyamines in cerebrospinal fluid and tumor tissue have been repo…
View article: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
Reprogramming neuroblastoma by diet-enhanced polyamine depletion Open
Neuroblastoma is a highly lethal childhood tumour derived from differentiation-arrested neural crest cells1,2. Like all cancers, its growth is fuelled by metabolites obtained from either circulation or local biosynthesis3,4…
View article: Integrated analysis of the metabolome and transcriptome reveals the effect of the polyamine biosynthesis pathway on the cold resistance regulation mechanism in Solanum habrochaites
Integrated analysis of the metabolome and transcriptome reveals the effect of the polyamine biosynthesis pathway on the cold resistance regulation mechanism in Solanum habrochaites Open
View article: Polyamine-dependent metabolic shielding regulates alternative splicing
Polyamine-dependent metabolic shielding regulates alternative splicing Open
Abbreviations: SF3A3: Splicing Factor 3a Subunit 3 CK1: Casein kinase 1 PUT: Putrescine SPD: Spermidine, SPM: Spermine, BENSpm: N1,N11-bis(ethyl)norspermine Computational Data: 0-molecular_docking (best binding poses) • SF3A3: binary compl…
View article: Involvement of Surface Receptors in the Uptake and Cellular Responses Induced by Cationic Polyamine-Based Carbon Dots in Macrophages
Involvement of Surface Receptors in the Uptake and Cellular Responses Induced by Cationic Polyamine-Based Carbon Dots in Macrophages Open
Cationic polyamine-based carbon dots (CDs) are increasingly being explored for biomedical applications. These ultrasmall (<10 nm) fluorescent nanoparticles, synthesized from organic precursors and functionalized with polyamines, possess a …
View article: Polyamine-dependent metabolic shielding regulates alternative splicing
Polyamine-dependent metabolic shielding regulates alternative splicing Open
Abbreviations: SF3A3: Splicing Factor 3a Subunit 3 CK1: Casein kinase 1 PUT: Putrescine SPD: Spermidine, SPM: Spermine, BENSpm: N1,N11-bis(ethyl)norspermine Computational Data: 0-molecular_docking (best binding poses) • SF3A3: binary compl…
View article: GABA is a key player regulating the TCA cycle and polyamine metabolism under combined heat-drought stress in tea plants
GABA is a key player regulating the TCA cycle and polyamine metabolism under combined heat-drought stress in tea plants Open
View article: Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Open
View article: SLC45A4 is a pain gene encoding a neuronal polyamine transporter
SLC45A4 is a pain gene encoding a neuronal polyamine transporter Open
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy 1 . They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulat…
View article: Evolution of polyamine resistance in <i>Staphylococcus aureus</i> through modulation of potassium transport
Evolution of polyamine resistance in <i>Staphylococcus aureus</i> through modulation of potassium transport Open
Microbes must adapt to diverse biotic and abiotic factors encountered in host environments. Polyamines are an abundant class of aliphatic molecules that play essential roles in fundamental cellular processes across the tree of life. Surpri…